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In RAU lesions, numerous tryptase-positive MCs were found in the sub-epithelial lamina propria, but MC numbers in the epithelium were low and present only in some RAU biopsies. MCs were also more numerous in RAU-inflammatory infiltrates (118+/-31 cells/mm2) than those seen in TU-inflammatory infiltrates (75+/-18 cells/mm2, P<0.001). MC activation/degranulation, as judged by diffuse extracellular tryptase staining, was a common feature within RAU-inflammatory infiltrates and at RAU-inflammatory infiltrates-connective tissue interfaces, which were often associated with connective tissue disruption. MC counts in the RAU connective tissue, lateral to the inflammatory infiltrates, were significantly greater than in the connective tissue of TUs and of control biopsies (124+/-36 vs 73+/-13 vs 69+/-21 cells/mm2, respectively; P<0.001). Overall, MCs were significantly increased in aphthae (116+/-26 cells/mm2) compared with TU lesions (72+/-11 cells/mm2, P<0.001) and controls (71+/-16 cells/mm2, P<0.001). In conclusion, MC numbers are increased in a typical topographical pattern, and the local MCs show signs of activation/degranulation suggesting active involvement of this cell type in RAU pathogenesis."}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Pathology and Forensic Medicine"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Cancer Research"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Oral 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Thus we investigate the role of online communication in reconfiguring the balance of power between the authority and Chinese citizens. Using systematic data collection and social network analysis, we characterize the microbloggers who contributed to the process, the network configuration, and the interplays between different stakeholders."}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"General Computer Science"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Sociology and Political Science"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Public 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This essay offers a contribution for standard-setters and the tax authority (fisco) by providing the basis for possible guidelines to be issued on the accounting treatment of bitcoin operations, as well as by defining the appropriate tax treatment; in addition, it makes a contribution for accounting professionals by suggesting the accounting policy to be adopted in these operations. Here, the analysis of the characteristics of bitcoins is compared with the guidelines and concepts of IFRS, in order to elaborate the recommendation for accounting treatment, and it suggests that the most adequate procedure would be that of foreign currency, which would go against the tax treatment adopted up until now by the Brazilian Internal Revenue Service (Receita Federal) or the Internal Revenue Service (IRS) of the United States of America (USA), which suggest treating virtual currencies as goods and not as currencies. 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It is shown that several cirrus clouds successively form in the region due to adiabatic cooling and large-scale uplift rather than from convective anvils. The structure of the uplift is tied to the equatorial response (equatorial wave excitation) to a potential vorticity intrusion from the midlatitudes. Sensitivity tests are then performed to assess the relative importance of the choice of the microphysics parameterization and of the initial and boundary conditions. The initial dynamical conditions (wind and temperature) essentially control the horizontal location and area of the cloud. However, the choice of the microphysics scheme influences the ice water content and the cloud vertical position. Last, the fair agreement with the observations allows to estimate the cloud impact in the TTL in the simulations. The cirrus clouds have a small but not negligible impact on the radiative budget of the local TTL. However, for this particular case, the cloud radiative heating does not significantly influence the simulated dynamics. This result is due to (1) the lifetime of air parcels in the cloud system, which is too short to significantly influence the dynamics, and (2) the fact that induced vertical motions would be comparable to or smaller than the typical mesoscale motions present. Finally, the simulation also provides an estimate of the vertical redistribution of water by the cloud and the results emphasize the importance in our case of both rehydration and dehydration in the vicinity of the cirrus.\n </jats:p>"}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Atmospheric Science"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Cirrus"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Weather Research and Forecasting 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These effects result in premature and ectopic ORN differentiation. It is shown further that exogenous Runx1 expression in cultured olfactory neural progenitors causes an expansion of the mitotic cell population. In agreement with these findings, exogenous Runx1 expression also promotes cortical neural progenitor cell proliferation without inhibiting neuronal differentiation. These effects are phenocopied by a chimeric protein containing ETO, the eight twenty one transcriptional repressor, fused to the Runx1 DNA-binding domain, which suggests the involvement of transcription repression mechanisms. Consistent with this possibility, Runx1 represses transcription driven by the promoter of the cell cycle inhibitor p21 Cip 1 in cortical progenitors. 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,{"journal":{"issnOnline":"2044-5377","vol":"94-B","issnLinking":null,"edition":null,"issnPrinted":"0301-620X","dataInfo":null,"conferencedate":null,"iss":null,"ep":"847","sp":"842","conferenceplace":null,"name":"The Journal of Bone and Joint Surgery. British volume"},"format":[],"source":[{"dataInfo":null,"value":"Crossref"},{"dataInfo":null,"value":null}],"description":[{"dataInfo":null,"value":"We present our early experience of arthroscopic reduction of the dislocated hip in very young infants with developmental dysplasia of the hip (DDH).\n\nEight dislocated hips, which had failed attempts at closed reduction, were treated by arthroscopy of the hip in five children with a mean age of 5.8 months (4 to 7). A two-portal technique was used, with a medial sub-adductor portal for a 2.7 mm cannulated system with a 70° arthroscope and an anterolateral portal for the instruments. Following evaluation of the key intra-articular structures, the hypertrophic ligamentum teres and acetabular pulvinar were resected, and a limited release of the capsule was performed prior to reduction of the hip. All hips were reduced by a single arthroscopic procedure, the reduction being confirmed on MRI scan. None of the hips had an inverted labrum. The greatest obstacle to reduction was a constriction of the capsule. At a mean follow-up of 13.2 months (9 to 24), all eight hips remained stable. Three developed avascular necrosis. The mean acetabular index decreased from 35.5° (30° to 40°) pre-operatively to 23.3° (17° to 28°).\n\nThis study demonstrates that arthroscopic reduction is feasible using two standardised portals. Longer follow-up studies are necessary to evaluate the functional results."}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Surgery"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Orthopedics and Sports 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After an fMRI experiment has been designed and carried out, the resulting data must be passed through various analysis steps before the experimenter can get answers to questions about experimentally related activations at the individual or multi-subject level. This paper gives a brief overview of the most commonly used analysis pipeline: data pre-processing, temporal linear modelling and activation thresholding. For more details, see Jezzard et al [1]. fMRI Data In a typical fMRI session a low-resolution functional volume is acquired every few seconds. (MR volumes are often also referred to as ‘‘images’’ or ‘‘scans’’). Over the course of the experiment, 100 volumes or more are typically recorded. In the simplest possible experiment, some images will be taken whilst stimulation (for the remainder of this chapter, reference to ‘‘stimulation’’ should be taken to include also the carrying out of physical or cognitive activity) is applied, and some will be taken with the subject at rest. Because the images are taken using an MR sequence which is sensitive to changes in local blood oxygenation level (BOLD imaging; see Chapters 2 and 3 in Jezzard et al [1]), parts of the images taken during stimulation should show increased intensity, compared with those taken whilst at rest. The parts of these images that show increased intensity should correspond to the brain areas which are activated by the stimulation. The goal of fMRI analysis is to detect, in a robust, sensitive and valid way, those parts of the brain that show increased intensity at the points in time that stimulation was applied. A single volume is made up of individual cuboid elements called voxels (Figure 1). An fMRI data set from a single session can either be thought of as t volumes, one taken every few seconds, or as v voxels, each with an associated time series of t time points. It is important to be able to conceptualize both of these representations, as some analysis steps make more sense when thinking of the data in one way, and others make more sense the other way. An example time-series from a single voxel is shown in Figure 2. Image intensity is shown on the y axis, and time (in scans) on the x axis. As described above, for some of the time points, stimulation was applied, (the higher intensity periods), and at some time points the subject was at rest. As well as the effect of the stimulation being clear, the high frequency noise is also apparent. The aim of fMRI analysis is to identify in which voxels’ time-series the signal of interest is significantly greater than the noise 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Mathematical evaluation of the Mossbauer spectra showed distinct regularities in the changes of Mossbauer parameters, thus indicating the presence of two subspectra with very similar spectral behaviour. High sensitivity of the Nd2O3 phase to the moisture and atmosphere CO2 was demonstrated by FT-IR spectroscopy."}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Mechanical Engineering"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"General Materials Science"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Mechanics of Materials"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Coprecipitation"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Materials science"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Spectral line"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Mössbauer spectroscopy"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"X-ray crystallography"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Solid solution"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Infrared spectroscopy"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Oxide"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":null,"provenanceaction":{"blank":false,"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"},"trust":"0.50058734"},"value":"chemistry.chemical_compound"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":null,"provenanceaction":{"blank":false,"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"},"trust":"0.50058734"},"value":"chemistry"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Spectroscopy"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Analytical chemistry"}],"author":[{"surname":"Musić","affiliation":null,"fullname":"S. 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Skepticism toward the Fancy’s dominance in mental life expresses the successful maturation of the adult. (5) It is considered a gatherer of “raw materials” that are to be shaped into something permanent and beautiful by the Imagination."}],"subject":[{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Literary criticism"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Aesthetics"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Skepticism"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":null,"provenanceaction":{"blank":false,"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"},"trust":"0.601421"},"value":"media_common.quotation_subject"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":null,"provenanceaction":{"blank":false,"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"},"trust":"0.601421"},"value":"media_common"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"French revolution"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Mental life"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Art"},{"qualifier":{"blank":false,"classid":"keywords","classname":"keywords","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":null,"value":"Poetry"}],"author":[{"surname":"Robinson","affiliation":null,"fullname":"Jeffrey C. 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