r3d100010557 Universal PBM Resource for Oligonucleotide Binding Evaluation UniPROBE http://thebrain.bwh.harvard.edu/uniprobe/ FAIRSHARING_doi:10.25504/FAIRsharing.8zf3ny RRID:OMICS_00546 RRID:SCR_005803 RRID:nif-0000-03611 The UniPROBE (Universal PBM Resource for Oligonucleotide Binding Evaluation) database hosts data generated by universal protein binding microarray (PBM) technology on the in vitro DNA binding specificities of proteins. This initial release of the UniPROBE database provides a centralized resource for accessing comprehensive data on the preferences of proteins for all possible sequence variants ('words') of length k ('k-mers'), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In total, the database currently hosts DNA binding data for 406 nonredundant proteins from a diverse collection of organisms, including the prokaryote Vibrio harveyi, the eukaryotic malarial parasite Plasmodium falciparum, the parasitic Apicomplexan Cryptosporidium parvum, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, mouse, and human. The database's web tools (on the right) include a text-based search, a function for assessing motif similarity between user-entered data and database PWMs, and a function for locating putative binding sites along user-entered nucleotide sequences uniprobe@genetics.med.harvard.edu disciplinary 2008-05 eng 2 Life Sciences 204 Microbiology, Virology and Immunology 21 Biology 22 Medicine http://the_brain.bwh.harvard.edu/index.html Images Raw data Scientific and statistical data formats Structured graphics other dataProvider DNA biology cells gene ontology molecular mouse protein Brigham and Women's Hospital, Bulyk Laboratory Bulyk Lab USA general technical non-profit http://thebrain.bwh.harvard.edu/ http://the_brain.bwh.harvard.edu/contact.html Downloads http://thebrain.bwh.harvard.edu/uniprobe/downloads.php open open ODC https://opendatacommons.org/licenses/pddl/1-0/ other http://thebrain.bwh.harvard.edu/uniprobe/academic-license.php closed other yes none http://the_brain.bwh.harvard.edu/uniprobe/about.php yes unknown UniPROBE is covered by Thomson Reuters Data Citation Index. 2013-12-02 2022-12-14