diff --git a/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/project/programme.csv b/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/project/programme.csv
index e69de29bb2..6a9c855a03 100644
--- a/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/project/programme.csv
+++ b/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/project/programme.csv
@@ -0,0 +1,25 @@
+rcn;code;title;shortTitle;language
+664331;H2020-EU.3.3.2.;Un approvisionnement en électricité à faible coût et à faibles émissions de carbone;Low-cost, low-carbon energy supply;fr
+664355;H2020-EU.3.3.7.;Absorción por el mercado de la innovación energética - explotación del Programa Energía Inteligente - Europa Europe;Market uptake of energy innovation;es
+664323;H2020-EU.3.3.1.;Ridurre il consumo di energia e le emissioni di carbonio grazie all'uso intelligente e sostenibile;Reducing energy consumption and carbon footprint;it
+664233;H2020-EU.2.3.2.3.;Wsparcie innowacji rynkowych;Supporting market-driven innovation;pl
+664199;H2020-EU.2.1.5.1.;Tecnologías para las fábricas del futuro;Technologies for Factories of the Future;es
+664235;H2020-EU.3.;PRIORITÉ «Défis de société»;Societal Challenges;fr
+664355;H2020-EU.3.3.7.;"Assorbimento di mercato dell'innovazione energetica - iniziative fondate sul programma ""Energia intelligente - Europa""";Market uptake of energy innovation;it
+664355;H2020-EU.3.3.7.;"Markteinführung von Energieinnovationen – Aufbau auf ""Intelligente Energie – Europa";Market uptake of energy innovation;de
+664235;H2020-EU.3.;"PRIORIDAD ""Retos de la sociedad""";Societal Challenges;es
+664231;H2020-EU.2.3.2.2.;Mejorar la capacidad de innovación de las PYME;Enhancing the innovation capacity of SMEs;es
+664223;H2020-EU.2.3.;LIDERAZGO INDUSTRIAL - Innovación en la pequeña y mediana empresa;Innovation in SMEs;es
+664323;H2020-EU.3.3.1.;Réduire la consommation d'énergie et l'empreinte carbone en utilisant l'énergie de manière intelligente et durable;Reducing energy consumption and carbon footprint;fr
+664323;H2020-EU.3.3.1.;Reducir el consumo de energía y la huella de carbono mediante un uso inteligente y sostenible;Reducing energy consumption and carbon footprint;es
+664215;H2020-EU.2.1.6.4.;Beitrag der europäischen Forschung zu internationalen Weltraumpartnerschaften;Research in support of international space partnerships;de
+664213;H2020-EU.2.1.6.3.;Permettere lo sfruttamento dei dati spaziali;;it
+664213;H2020-EU.2.1.6.3.;Permettre l'exploitation des données spatiales;Enabling exploitation of space data;fr
+664231;H2020-EU.2.3.2.2.;Zwiększenie zdolności MŚP pod względem innowacji;Enhancing the innovation capacity of SMEs;pl
+664231;H2020-EU.2.3.2.2.;Rafforzare la capacità di innovazione delle PMI;Enhancing the innovation capacity of SMEs;it
+664213;H2020-EU.2.1.6.3.;Grundlagen für die Nutzung von Weltraumdaten;Enabling exploitation of space data;de
+664211;H2020-EU.2.1.6.2.;Favorecer los avances en las tecnologías espaciales;Enabling advances in space technology;es
+664209;H2020-EU.2.1.6.1.;Assurer la compétitivité et l'indépendance de l'Europe et promouvoir l'innovation dans le secteur spatial européen;Competitiveness, non-dependence and innovation;fr
+664231;H2020-EU.2.3.2.2.;Renforcement de la capacité d'innovation des PME;Enhancing the innovation capacity of SMEs;fr
+664203;H2020-EU.2.1.5.3.;Tecnologías sostenibles, eficientes en su utilización de recursos y de baja emisión de carbono en las industrias de transformación de gran consumo energético;Sustainable, resource-efficient and low-carbon technologies in energy-intensive process industries;es
+664103;H2020-EU.1.2.1.;FET Open;FET Open;es
\ No newline at end of file
diff --git a/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/projects_subset.json b/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/projects_subset.json
index e69de29bb2..b8805b2db5 100644
--- a/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/projects_subset.json
+++ b/dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/projects_subset.json
@@ -0,0 +1,16 @@
+{"rcn":"229267","id":"894593","acronym":"ICARUS","status":"SIGNED","programme":"H2020-EU.3.4.7.","topics":"SESAR-ER4-31-2019","frameworkProgramme":"H2020","title":"INTEGRATED COMMON ALTITUDE REFERENCE SYSTEM FOR U-SPACE","startDate":"2020-05-01","endDate":"2022-07-31","projectUrl":"","objective":"ICARUS project proposes an innovative solution to the challenge of the Common Altitude Reference inside VLL airspaces with the definition of a new U-space service and its validation in a real operational environment. In manned aviation, the methods of determining the altitude of an aircraft are based on pressure altitude difference measurements (e.g. QFE, QNH and FL) referred to a common datum. \nThe UA flights superimpose a new challenge, since a small drone may take off and land almost from everywhere, hence reducing the original significance of QFE settings, introduced on behalf of manned pilots to display on the altimeter the 0-height at touchdown on the local runway. In fact, the possibility for n drones to take off at n different places would generate a series of n different QFE corresponding to different heights of ground pressures referred to the take-off “Home points”. Therefore for a large number drones, new methodologies and procedures shall be put in place. The ICARUS defines a new U-space U3 service tightly coupled with the interface of the existing U-space services (e.g. Tracking, and Flight Planning services). The users of ICARUS service shall be remote pilots competent to fly in BVLOS in the specific category of UAS operations and ultralight GA pilots potentially sharing the same VLL airspace. \nThe ICARUS proposed approach foresees the realization of DTM service embedded in an Application Program Interface (API) that can be queried by UAS pilot/operator (or by drone itself) based on the actual positioning of the UA along its trajectory, computed by the (E)GNSS receiver. The output of the DTM service would provide information on distance from ground/obstacles in combination with the common altitude reference.\nAccuracy, continuity, integrity and availability requirements for GNSS-based altimetry together with accuracy and resolution requirements of the DTM to be provided by ICARUS service are key topics of the study.","totalCost":"1385286,25","ecMaxContribution":"1144587,5","call":"H2020-SESAR-2019-2","fundingScheme":"SESAR-RIA","coordinator":"E-GEOS SPA","coordinatorCountry":"IT","participants":"TOPVIEW SRL;TELESPAZIO SPA;DRONERADAR SP Z O.O.;EUROCONTROL - EUROPEAN ORGANISATION FOR THE SAFETY OF AIR NAVIGATION;EUROUSC ESPANA SL;POLITECNICO DI MILANO;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","participantCountries":"IT;PL;BE;ES","subjects":""}
+{"rcn":"229284","id":"897004","acronym":"ISLand","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Isolation and Segregation Landscape. Archaeology of quarantine in the Indian Ocean World","startDate":"2020-11-01","endDate":"2023-10-31","projectUrl":"","objective":"The proposed research presents an experimental and completely novel investigation within the historical archaeology,\napplied to isolated contexts. The main objective of ISLand is to provide a new way of thinking about human interactions\nwithin colonial empires and bringing colonial studies into dialogue with medical history and the emerging concept of\nhealthscaping. It seeks to do so by studying quarantine facilities in the Indian Ocean World during the long nineteenth\ncentury, a crucial period for the history of European empires in that region and a flashpoint for the conceptualization of\nmodern public health. Quarantine, traditionally viewed as merely a mechanism for the control of disease, will be analyzed as\nthe outward material response to important changes taking place socially, ecologically, and politically at the time.\nThe project is a part of an international, interdisciplinary effort, combining history, archaeology, and anthropology. The\nresearcher will tap numerous archival sources and archaeological data from selected sites, examine them through social and\nspatial analysis, and systematically analyze a test case in Mauritius through the most innovative methods that target\nlandscape and standing archaeology.\nThe broader impacts of ISLand have relevance for current European approaches to the migration crisis, where the threat of\ndisease has been ignited as a potentially debilitating consequence of immigration from extra-European countries. The\ntraining-through-research project at the Stanford University, the top institution where acquiring knowledge and skills in\nhistorical archaeology, will allow the applicant to develop into a position of professional maturity with a specific\ninterdisciplinary set of skills. With the support of the host institutions in EU, the researcher will promote historical archaeology\nin European academy, stimulating new approaches in usual archaeological research and an interdisciplinary approach with\ncultural anthropology.","totalCost":"253052,16","ecMaxContribution":"253052,16","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-GF","coordinator":"UNIVERSITEIT VAN AMSTERDAM","coordinatorCountry":"NL","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229281","id":"896300","acronym":"STRETCH","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Smart Textiles for RETrofitting and Monitoring of  Cultural Heritage Buildings","startDate":"2020-09-01","endDate":"2022-08-31","projectUrl":"","objective":"This project aims to develop novel techniques using smart multifunctional materials for the combined seismic-plus-energy retrofitting, and Structural Health Monitoring (SHM) of the European cultural heritage buildings (CHB). The need for upgrading the existing old and CHB is becoming increasingly important for the EU countries, due to: (1) their poor structural performance during recent earthquakes (e.g. Italy, Greece) or other natural hazards (e.g. extreme weather conditions) that have resulted in significant economic losses, and loss of human lives; and (2) their low energy performance which increases significantly their energy consumption (buildings are responsible for 40% of EU energy consumption). Moreover, the SHM of the existing buildings is crucial for assessing continuously their structural integrity and thus to provide information for planning cost effective and sustainable maintenance decisions. Since replacing the old buildings with new is not financially feasible, and even it is not allowed for CHB, their lifetime extension requires considering simultaneously both structural and energy retrofitting. It is noted that the annual cost of repair and maintenance of existing European building stock is estimated to be about 50% of the total construction budget, currently standing at more than €300 billion. To achieve cost effectiveness, STRETCH explores a novel approach, which integrates technical textile reinforcement with thermal insulation systems and strain sensors to provide simultaneous structural-plus-energy retrofitting combined with SHM, tailored for masonry cultural heritage building envelopes. The effectiveness of the proposed retrofitting system will be validated experimentally and analytically. Moreover, draft guidelines and recommendations for determining future research on the use of smart composite materials for the concurrent retrofitting (structural-plus-energy) and SHM of the existing cultural heritage buildings envelopes will be proposed.","totalCost":"183473,28","ecMaxContribution":"183473,28","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION","coordinatorCountry":"BE","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229265","id":"892890","acronym":"RhythmicPrediction","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Rhythmic prediction in speech perception: are our brain waves in sync with our native language?","startDate":"2021-01-01","endDate":"2022-12-31","projectUrl":"","objective":"Speech has rhythmic properties that widely differ across languages. When we listen to foreign languages, we may perceive them to be more musical, or rather more rap-like than our own. Even if we are unaware of it, the rhythm and melody of language, i.e. prosody, reflects its linguistic structure. On the one hand, prosody emphasizes content words and new information with stress and accents. On the other hand, it is aligned to phrase edges, marking them with boundary tones. Prosody hence helps the listener to focus on important words and to chunk sentences into phrases, and phrases into words. In fact, prosody is even used predictively, for instance to time the onset of the next word, the next piece of new information, or the total remaining length of the utterance, so the listener can seamlessly start their own speaking turn. \nSo, the listener, or rather their brain, is actively predicting when important speech events will happen, using prosody. How prosodic rhythms are exploited to predict speech timing, however, is unclear. No link between prosody and neural predictive processing has yet been empirically made. One hypothesis is that rhythm, such as the alternation of stressed and unstressed syllables, helps listeners time their attention. Similar behavior is best captured by the notion of an internal oscillator which can be set straight by attentional spikes. While neuroscientific evidence for the relation of neural oscillators to speech processing is starting to emerge, no link to the use of prosody nor predictive listening exists, yet. Furthermore, it is still unknown how native language knowledge affects cortical oscillations, and how oscillations are affected by cross-linguistic differences in rhythmic structure. The current project combines the standing knowledge of prosodic typology with the recent advances in neuroscience on cortical oscillations, to investigate the role of internal oscillators on native prosody perception, and active speech prediction.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"UNIVERSITE DE GENEVE","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229235","id":"886828","acronym":"ASAP","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Advanced Solutions for Asphalt Pavements","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"The Advanced Solutions for Asphalt Pavements (ASAP) project involves the development of a unique road paving technology which will use a bio-bitumen rejuvenator to rejuvenate aged asphalt bitumen.  This technology will help to extend the lifespan of asphalt pavements (roads) and will reduce the environmental and economic impact of roads and road maintenance processes. Recycling and self-healing processes will replace fossil fuel dependent technology. Self-healing will involve rejuvenating aged asphalt bitumen using a bio-rejuvenator developed using microalgae oils (rejuvenating bio-oil). Microalgae has been selected because of its fast growth, versatility and ability to survive within hostile environments, such as wastewater.  \n\nASAP will utilise microalgae, cultivated within the wastewater treatment process, as a source of the rejuvenating bio-oil. The solvent (Soxhlet) processes will be used to extract the oil from the microalgae. To ensure the efficiency of the oil extraction process, an ultrasonication process will be used to pre-treat the microalgae. The suitability of rejuvenating bio-oil as a replacement for the bitumen rejuvenator (fossil fuel based) will be ascertained via a series of standard bituminous and accelerated tests. A rejuvenator-binder diffusion numerical model will be developed, based on the Delft Lattice concrete diffusion model, to determine the conditions required for rejuvenation to occur and to ascertain the healing rate of the asphalt binder. These parameters will facilitate the selection and optimisation of the asphalt self-healing systems (specifically the amount of bio-oil rejuvenator and time required) to achieve full rejuvenation. \n\nThis novel approach will benchmark the effectiveness of this intervention against existing asphalt design and maintenance processes and assess feasibility. The ASAP project presents an opportunity to revolutionise road design and maintenance processes and reduce its environmental and financial costs.","totalCost":"187572,48","ecMaxContribution":"187572,48","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO","coordinatorCountry":"NL","participants":"","participantCountries":"","subjects":""}
+{"rcn":null,"id":"886776","acronym":null,"status":null,"programme":"H2020-EU.2.1.4.","topics":null,"frameworkProgramme":"H2020","title":"BIO-Based pESTicides production for sustainable agriculture management plan","startDate":"2020-05-01","endDate":"2023-04-30","projectUrl":"","objective":"The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. \nBIOVITIS, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. \nBIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). \nThe BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.\nTo assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. \nA Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.\nThe adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.","totalCost":"4402772,5","ecMaxContribution":"3069653","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"BIOVITIS","coordinatorCountry":"FR","participants":"MERCIER FRERES SARL;FUNDACION TECNALIA RESEARCH & INNOVATION;LAMBERTI SPA;EURION CONSULTING;CIAOTECH Srl;STOWARZYSZENIE ZACHODNIOPOMORSKI KLASTER CHEMICZNY ZIELONA CHEMIA;NORDZUCKER AG;INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN","participantCountries":"FR;ES;IT;PL;DE","subjects":""}
+{"rcn":null,"id":"886776","acronym":null,"status":null,"programme":"H2020-EU.3.2.6.","topics":"BBI-2019-SO3-D4","frameworkProgramme":"H2020","title":"BIO-Based pESTicides production for sustainable agriculture management plan","startDate":"2020-05-01","endDate":"2023-04-30","projectUrl":"","objective":"The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. \nBIOVITIS, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. \nBIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). \nThe BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.\nTo assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. \nA Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.\nThe adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.","totalCost":"4402772,5","ecMaxContribution":"3069653","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"BIOVITIS","coordinatorCountry":"FR","participants":"MERCIER FRERES SARL;FUNDACION TECNALIA RESEARCH & INNOVATION;LAMBERTI SPA;EURION CONSULTING;CIAOTECH Srl;STOWARZYSZENIE ZACHODNIOPOMORSKI KLASTER CHEMICZNY ZIELONA CHEMIA;NORDZUCKER AG;INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN","participantCountries":"FR;ES;IT;PL;DE","subjects":""}
+{"rcn":"229276","id":"895426","acronym":"DisMoBoH","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Dissecting the molecular building principles of locally formed transcriptional hubs","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"Numerous DNA variants have already been identified that modulate inter-individual molecular traits – most prominently gene expression. However, since finding mechanistic interpretations relating genotype to phenotype has proven challenging, the focus has shifted to higher-order regulatory features, i.e. chromatin accessibility, transcription factor (TF) binding and 3D chromatin interactions. This revealed at least two enhancer types: “lead” enhancers in which the presence of genetic variants modulates the activity of entire chromatin domains, and “dependent” ones in which variants induce subtle changes, affecting DNA accessibility, but not transcription. Although cell type-specific TFs are likely important, it remains unclear which sequence features are required to establish such enhancer hierarchies, and under which circumstances genetic variation results in altered enhancer-promoter contacts and differential gene expression.  Here, we propose to investigate the molecular mechanisms that link DNA variation to TF binding, chromatin topology, and gene expression response. We will leverage data on enhancer hierarchy and sequence-specific TF binding to identify the sequence signatures that define “lead” enhancers. The results will guide the design of a synthetic locus that serves as an in vivo platform to systematically vary the building blocks of local transcriptional units: i) DNA sequence – including variations in TF binding site affinity and syntax, ii) molecular interactions between TFs, and iii) chromatin conformation. To validate our findings, we will perform optical reconstruction of chromatin architecture for a select number of DNA variants.  By simultaneously perturbing co-dependent features, this proposal will provide novel mechanistic insights into the formation of local transcriptional hubs.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-RI","coordinator":"ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229288","id":"898218","acronym":"devUTRs","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Uncovering the roles of 5′UTRs in translational control during early zebrafish development","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"Following fertilisation, metazoan embryos are transcriptionally silent, and embryogenesis is controlled by maternally deposited factors. Developmental progression requires the synthesis of new mRNAs and proteins in a coordinated fashion. Many posttranscriptional mechanisms regulate the fate of maternal mRNAs, but it is less understood how translational control shapes early embryogenesis. In eukaryotes, translation starts at the mRNA 5′ end, consisting of the 5′ cap and 5′ untranslated region (UTR). Protein synthesis is primarily regulated at the translation initiation step by elements within the 5′UTR. However, the role of 5′UTRs in regulating the dynamics of mRNA translation during vertebrate embryogenesis remains unexplored. For example, all vertebrate ribosomal protein (RP) mRNAs harbor a conserved terminal oligopyrimidine tract (TOP) in their 5′UTR. RP levels must be tightly controlled to ensure proper organismal development, but if and how the TOP motif mediates RP mRNA translational regulation during embryogenesis is unclear. Overall, we lack a systematic understanding of the regulatory information contained in 5′UTRs. In this work, I aim to uncover the 5′UTR in vivo rules for mRNA translational regulation during zebrafish embryogenesis. I propose to apply imaging and biochemical approaches to characterise the role of the TOP motif in RP mRNA translational regulation during embryogenesis and identify the trans-acting factor(s) that bind(s) to it (Aim 1). To systematically assess the contribution of 5′UTRs to mRNA translational regulation during zebrafish embryogenesis, I will couple a massively parallel reporter assay of 5′UTRs to polysome profiling (Aim 2). By integrating the translational behaviour of 5′UTR reporters throughout embryogenesis with sequence-based regression models, I anticipate to uncover novel cis-regulatory elements in 5′UTRs with developmental roles.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"UNIVERSITAT BASEL","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229261","id":"893787","acronym":"HOLYHOST","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Welfare and Hosting buildings in the “Holy Land”  between the 4th and the 7th c. AD","startDate":"2020-10-01","endDate":"2022-09-30","projectUrl":"","objective":"Between the 4th and the 7th century AD, many hospices dedicated to the poor, elderly, strangers and travelers were built in the countryside, along roads, around and inside cities. They were commissioned by the Church, rich pious men and women concerned by the redeem of their sins, as well as emperors who saw this as a guarantee of social stability. Welfare is thus an important phenomena of Late Antiquity, abundantly mentioned by ancient literary sources and inscriptions, particularly in the eastern part of the Empire. However, the buildings that provided shelter and care to the needy have not yet received sufficient attention from archaeologists. Except for buildings which were identified by their inventors as hostels dedicated to pilgrims, they are still invisible in the field. \nThe aim of the HOLYHOST research project is to bring this social history’s main topic on the field of archaeology. It will address the welfare issue through the archaeological and architectural survey and study of Ancient welfare and hosting establishments’ remains, in the Holy Land (Palestine and Jordan) and around. This work will contribute to a better understanding of the practices linked to hospitality, welfare, accommodation and care in Antiquity. Moreover, such establishments served as models for medieval and modern Islamic, Jewish and Christian waqf institutions (religious endowment), and welfare continues to be highly relevant nowadays, through issues still at the heart of contemporary challenges debated in Europe: poverty, social exclusion, migrant crisis, principle of reception and hospitality. This interdisciplinary and diachronic research project will thus offer many new research perspectives, in terms of history of architecture, evolution of care practices, social and political regulations.","totalCost":"196707,84","ecMaxContribution":"196707,84","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"UNIVERSITE PARIS I PANTHEON-SORBONNE","coordinatorCountry":"FR","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229282","id":"896189","acronym":"MICADO","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Microbial contribution to continental wetland carbon budget","startDate":"2021-01-04","endDate":"2023-01-03","projectUrl":"","objective":"Continental wetlands are major carbon dioxide sinks but the second largest source of methane. Monitoring of wetland methane emissions revealed large inter-site variability that is hard to explain in the framework of current biogeochemical theories. Methane production in wetlands is an anaerobic microbial driven process involving a complex set of microbial metabolisms depending on the availability of (i) energy (via the presence of specific redox couples), (ii) organic substrates and (iii) specific microbial communities. To understand the complexity of microbial drivers on wetland methane emissions and quantify their contribution, the MICADO project will set up a multidisciplinary approach linking isotope organic geochemistry and environmental microbiology to assess microbial functioning in situ. As an organic geochemist I have developed an innovative approach to trace in situ microbial activity via compound specific carbon isotope analysis of microbe macromolecules and organic metabolites. The host institution is a leader in France in environmental microbiology and biogeochemistry developing high-throughput metagenomics and microbial rate assessments, for which I will be trained during the MICADO project. These techniques are highly complementary and combined they will provide a comprehensive knowledge on microbial metabolisms involved in organic matter degradation encompassing their complexity and interactions. This will revisit the relationships between organic substrate availability and microbial communities and will contribute at estimating the impact of microbial activity on wetland methane emissions. This project will give me the opportunity to acquire fundamental knowledge and to develop original lines of research that will consolidate my position as an independent scientist in biogeochemistry.","totalCost":"196707,84","ecMaxContribution":"196707,84","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","coordinatorCountry":"FR","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229249","id":"891624","acronym":"CuTAN","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Copper-Catalyzed Multicomponent Reactions in Tandem Processes for Target Molecule Synthesis","startDate":"2021-02-01","endDate":"2023-01-31","projectUrl":"","objective":"The invention of processes that can form several bonds, stereocentres and rings in a single process is key to a sustainable future in synthetic chemistry. Multicomponent reactions and tandem procedures are two strategies that enable the rapid build-up of molecular complexity from simple reagents. By combining these two strategies into a single procedure, the diversity, complexity and value of products can be further enhanced along with the efficiency and economy of their construction. In this project, Dr Satpathi will develop novel copper-catalyzed multicomponent couplings of unsaturated hydrocarbons (e.g. allenes, enynes) with imines and boron reagents. These procedures will provide high-value amine products with universally high regio-, diastero- and enantiocontrol. The products will bear a variety of synthetic handles, for example, amino, alkynyl/alkenyl, and boryl groups, thus the products are primed for subsequent transformation. Dr Satpathi will exploit this functionality in tandem intramolecular couplings (e.g. intramolecular Suzuki/Buchwald-Hartwig reactions) to provide core cyclic structures of drug molecules and natural products. Thus, through a tandem procedure of; 1) copper-catalyzed borofunctionalization, and; 2) subsequent transition-metal catalyzed cyclization, he will gain efficient access to highly sought-after complex molecules. Overall, the process will provide high-value, chiral, cyclic motifs from abundant, achiral, linear substrates. Finally, Dr Satpathi has identified the phthalide-isoquinoline family of alkaloids as target molecules to display the power of his tandem methodology. Dr Satpathi has devised a novel route, which begins with our tandem multifunctionalization/cyclization reaction, to provide a range of these important alkaloids. The chosen alkaloids are of particular interest as they display a range of bioactivities – for example as natural products, receptor antagonists and on-market drugs.","totalCost":"212933,76","ecMaxContribution":"212933,76","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"THE UNIVERSITY OF MANCHESTER","coordinatorCountry":"UK","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229239","id":"887259","acronym":"ALEHOOP","status":"SIGNED","programme":"H2020-EU.2.1.4.","topics":"BBI-2019-SO3-D3","frameworkProgramme":"H2020","title":"Biorefineries for the valorisation of macroalgal residual biomass and legume processing by-products to obtain new protein value chains for high-value food and feed applications","startDate":"2020-06-01","endDate":"2024-05-31","projectUrl":"","objective":"ALEHOOP provides the demonstration at pilot scale of both sustainable macroalgae and legume-based biorefineries for the recovery of low-cost dietary proteins from alga-based and plant residual biomass and their validation to meet market requirements of consumers and industry in the food and feed sectors. In these sectors, consumers are demanding affordable functional natural proteins from alternative sources and industry is demanding low-cost bio-based protein formulations with better performance and higher sustainability. \nCurrent protein demand for the 7.3 billion inhabitants of the world is approximately 202 Mt.  Due to the rise in meat consumption more proteins are therefore required for animal feeding. To satisfy the current protein demand, Europe imports over 30 Mt of soy from the Americas each year mainly for animal feeding, entailing 95% dependency of EU on imported soy. Current sources of proteins are becoming unsustainable from an economic and environmental perspective for Europe resulting in concerns for sustainability and food security and leading to search for new alternative proteins. \nALEHOOP addresses the obtaining of proteins from green macroalgal blooms, brown seaweed by-products from algae processors and legume processing by-products (peas, lupines, beans and lentils) as alternative protein sources for animal feeding (case of green seaweed) and food applications (case of brown seaweed and legume by-products), since they are low cost and under-exploited biomass that do not compete with traditional food crops for space and resources. This will reduce EU´s dependency on protein imports and contribute to our raw material security. The new proteins will be validated in foods for elderly, sporty and overweight people, vegetarians and healthy consumers as well as for animal feed creating cross-sectorial interconnection between these value chains and supporting the projected business plan.","totalCost":"6718370","ecMaxContribution":"5140274,41","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"CONTACTICA S.L.","coordinatorCountry":"ES","participants":"CENTIV GMBH;ALGINOR ASA;FUNDACION TECNALIA RESEARCH & INNOVATION;INDUKERN,S.A.;ASOCIACION NACIONAL DE FABRICANTES DE CONSERVAS DE PESCADOS Y MARISCOS-CENTRO TECNICO NACIONAL DE CONSERVACION DE PRODUCTOS DE LA PESCA;BIOZOON GMBH;EIGEN VERMOGEN VAN HET INSTITUUT VOOR LANDBOUW- EN VISSERIJONDERZOEK;BIOSURYA SL;VYZKUMNY USTAV VETERINARNIHO LEKARSTVI;NUTRITION SCIENCES;TECHNOLOGICAL UNIVERSITY DUBLIN;GARLAN, S.COOP.;ISANATUR SPAIN SL;UNIVERSIDAD DE VIGO;UNIVERSIDAD DE CADIZ","participantCountries":"DE;NO;ES;BE;CZ;IE","subjects":""}
+{"rcn":"229239","id":"887259","acronym":"ALEHOOP","status":"SIGNED","programme":"H2020-EU.3.2.6.","topics":"BBI-2019-SO3-D3","frameworkProgramme":"H2020","title":"Biorefineries for the valorisation of macroalgal residual biomass and legume processing by-products to obtain new protein value chains for high-value food and feed applications","startDate":"2020-06-01","endDate":"2024-05-31","projectUrl":"","objective":"ALEHOOP provides the demonstration at pilot scale of both sustainable macroalgae and legume-based biorefineries for the recovery of low-cost dietary proteins from alga-based and plant residual biomass and their validation to meet market requirements of consumers and industry in the food and feed sectors. In these sectors, consumers are demanding affordable functional natural proteins from alternative sources and industry is demanding low-cost bio-based protein formulations with better performance and higher sustainability. \nCurrent protein demand for the 7.3 billion inhabitants of the world is approximately 202 Mt.  Due to the rise in meat consumption more proteins are therefore required for animal feeding. To satisfy the current protein demand, Europe imports over 30 Mt of soy from the Americas each year mainly for animal feeding, entailing 95% dependency of EU on imported soy. Current sources of proteins are becoming unsustainable from an economic and environmental perspective for Europe resulting in concerns for sustainability and food security and leading to search for new alternative proteins. \nALEHOOP addresses the obtaining of proteins from green macroalgal blooms, brown seaweed by-products from algae processors and legume processing by-products (peas, lupines, beans and lentils) as alternative protein sources for animal feeding (case of green seaweed) and food applications (case of brown seaweed and legume by-products), since they are low cost and under-exploited biomass that do not compete with traditional food crops for space and resources. This will reduce EU´s dependency on protein imports and contribute to our raw material security. The new proteins will be validated in foods for elderly, sporty and overweight people, vegetarians and healthy consumers as well as for animal feed creating cross-sectorial interconnection between these value chains and supporting the projected business plan.","totalCost":"6718370","ecMaxContribution":"5140274,41","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"CONTACTICA S.L.","coordinatorCountry":"ES","participants":"CENTIV GMBH;ALGINOR ASA;FUNDACION TECNALIA RESEARCH & INNOVATION;INDUKERN,S.A.;ASOCIACION NACIONAL DE FABRICANTES DE CONSERVAS DE PESCADOS Y MARISCOS-CENTRO TECNICO NACIONAL DE CONSERVACION DE PRODUCTOS DE LA PESCA;BIOZOON GMBH;EIGEN VERMOGEN VAN HET INSTITUUT VOOR LANDBOUW- EN VISSERIJONDERZOEK;BIOSURYA SL;VYZKUMNY USTAV VETERINARNIHO LEKARSTVI;NUTRITION SCIENCES;TECHNOLOGICAL UNIVERSITY DUBLIN;GARLAN, S.COOP.;ISANATUR SPAIN SL;UNIVERSIDAD DE VIGO;UNIVERSIDAD DE CADIZ","participantCountries":"DE;NO;ES;BE;CZ;IE","subjects":""}
+{"rcn":"229258","id":"892834","acronym":"DENVPOC","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"qPCR Microfluidics point-of-care platform for dengue diagnosis","startDate":"2020-05-18","endDate":"2022-05-17","projectUrl":"","objective":"As a result of Global climate change and fast urbanization, global outbreaks of Dengue (DENV)/ Zika(ZIKV)/Chikungunya(CHIKV) virus have the potential to occur. The most common pathway of these infections in humans is through the female Aedes mosquito vector. DENV is an exanthematous febrile disease with varied clinical manifestations and progressions . Due to similarities in symptoms between DENV and ZIKV and CHIKV, it is difficult to make a differential diagnosis, impeding appropriate, timely medical intervention. Furthermore, cross-reactivity with ZIKV, which was recently related to microcephaly, is a serious issue. In 2016, in Brazil alone, there were 4180 microcephaly cases reported instead of 163 cases, more in line with yearly expected projections , , Thus, the sooner an accurate diagnostic which differentiates DENV from the other manifestations is critical; most especially at the early stages of the infection, to have a reliable diagnosis in pregnant women. In 2016, the OMS emergency committee declared that the outbreaks and the potentially resultant neurological disorders in Brazil were an important international state of emergency in public health, as a result of the associated secondary effects; these diseases became a Global concern. This project allows developing a highly and fast Multiplex qPCR POC platform by using FASTGENE technology with a minimal amount of patient serotype. It would reduce the time of analysis (30 to 90’ for a standard) and costs. Additionally, the sample preprocessing and thermalization will shorten real-time PCR amplification time and will be integrated within the microfluidic systems.  This platform can result in a commercialized product whereupon a main market target would be pregnant women and people living or traveling through/from outbreak risk areas.","totalCost":"196707,84","ecMaxContribution":"196707,84","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-SE","coordinator":"BFORCURE","coordinatorCountry":"FR","participants":"","participantCountries":"","subjects":""}
+{"rcn":"229280","id":"895716","acronym":"DoMiCoP","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"The Diffusion of Migration Control Practice. Actors, Processes and Effects.","startDate":"2021-03-01","endDate":"2023-02-28","projectUrl":"","objective":"DoMiCoP develops new understandings and perspectives to study migration control in practice in the European Union by asking one main question: how and why do communities of practice develop and diffuse the knowledge required to put migration control into action? Unlike the nexus between expert knowledge, epistemic communities and policy formulation, the nexus between everyday knowledge, communities of practice and policy implementation has not yet received systematic scholarly attention. My project bridges that gap by focusing on intermediate arenas in which communities of practice take shape most notably the meetings and trainings that gather state and non-state actors involved in putting asylum, detention and removal into practice. By building on field-based methodologies (interviews and participant observations), DoMiCoP sheds ethnographic light on the role that ‘learning from abroad’ plays in the implementation of migration control in the EU. My project’s aim is threefold: 1) Identifying arenas at intermediate levels in which communities of practice take shape; 2) Analysing the communities of practice by focusing on the configurations of actors and organizations involved, the motivations underlying their involvement, the process of knowledge development in interaction, the conflicts and negotiations; 3) Revealing the role of non-state organizations (private for profit and not-for-profit). From a theoretical point of view, this project goes beyond the classical view of the implementation as a test to assess the effectiveness of policy transfers towards an analysis of policy transfer at that level of policy-making. From an empirical point of view, the project expands knowledge about less-studied venues of policy-making and provides original thick descriptions. From a methodological point of view, the project engages with qualitative methods for the study of policy diffusion and aims at responding to their main challenges through participant observation.","totalCost":"163673,28","ecMaxContribution":"163673,28","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"EUROPEAN UNIVERSITY INSTITUTE","coordinatorCountry":"IT","participants":"","participantCountries":"","subjects":""}
\ No newline at end of file