A review of the species of Hydrometra Latreille occurring in Colombia, with a key to species and distribution map (Hemiptera: Heteroptera: Hydrometridae)
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Results: We used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5 to 1.1 % higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4 % lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5 days, while the standard analysis including all sequence-based variants took more than three months. Conclusions: The split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds.
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The increase of private health care plans and the implementation of the \"Smiling Brazil\" Program, the largest public oral health care program in the world, could have influenced this increase in access. However, we do not yet know if inequalities in the use of dental health services persist after the improvement in access. The aims of this study are to analyze socioeconomic differences for dental health service use between 2003 and 2008 in S\\xe3o Paulo and to examine changes in these associations since the implementation of the Smiling Brazil program in 2003. \\n__Method:__ Data was obtained via two household health surveys (ISA-Capital 2003 and ISA-Capital 2008) which investigated living conditions, lifestyle, health status and use of health care services. Logistic regression was used to analyze associations between socioeconomic factors and dental services use. Additionally, trends from 2003 to 2008 regarding socioeconomic characteristics and dental health service use"}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-07"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "language": {"classid": "en", "classname": "en", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["https://www.narcis.nl/publication/RecordID/oai%3Arepub.eur.nl%3A94722", "urn:NBN:nl:ui:15-1765/94722", "10.1186/s12913-016-1928-y", "http://repub.eur.nl/pub/94722/REPUB_94722_OA.pdf", "1765/94722", "eur:oai:repub.eur.nl:94722"], "source": [], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Socioeconomic inequalities in dental health services in Sao Paulo, Brazil, 2003-2008"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:datasetarchive", "classname": "sysimport:crosswalk:datasetarchive", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:dataCite_resource", "schemename": "dnet:dataCite_resource"}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1016/s0304-3975(97)00182-5"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "scp-number", "classname": "scp-number", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "0002794431"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "urn", "classname": "urn", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "urn:nbn:nl:ui:25-1aa61067-2f77-4f9b-a8ce-1e04c7c672a8"}], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|openaire____::c6df70599aa984f16ee52b4b86d2e89f", "value": "DANS (Data Archiving and Networked Services)"}], "id": "50|DansKnawCris::6eec7225f3b545e6441dd8b7f39d25d2", "subject": [], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Aceto", "name": "L.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Aceto, L."}, {"surname": "Groote", "name": "J. 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A large variety of studies suggest that biofilm formation by NTHi may be an important step in the pathogenesis of this bacterium. However, the underlying mechanisms involved in this process are poorly elucidated. In this study, we used a transposon mutant library to identify bacterial genes involved in biofilm formation. The growth and biofilm formation of 4,172 transposon mutants were determined, and the involvement of the identified genes in biofilm formation was validated in in vitro experiments. Here, we present experimental data showing that increased bacterial lysis, through interference with peptidoglycan synthesis, results in elevated levels of extracellular DNA, which increased biofilm formation. Interestingly, similar results were obtained with subinhibitory concentrations of beta-lactam antibiotics, known to interfere with peptidoglycan synthesis, but such an effect does not appear with other classes of antibiotics. These results indicate that treatment with beta-lactam antibiotics, especially for beta-lactam-resistant NTHi isolates, might increase resistance to antibiotics by increasing biofilm formation. IMPORTANCE Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of beta-lactam antibiotics, which are often prescribed to treat H. influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when beta-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for beta-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}], "format": [], "journal": {"issnPrinted": "2379-5042", "conferencedate": "", "vol": "2", "conferenceplace": "", "name": "Msphere", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2017-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": 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"dnet:dataCite_title"}, "value": "Bacterial Lysis through Interference with Peptidoglycan Synthesis Increases Biofilm Formation by Nontypeable Haemophilus influenzae"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:datasetarchive", "classname": "sysimport:crosswalk:datasetarchive", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:dataCite_resource", "schemename": "dnet:dataCite_resource"}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "urn", "classname": "urn", "schemeid": "dnet:pid_types", "schemename": 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Warmer and relatively arid conditions prevailed during the Medieval Climate Anomaly (MCA, ca. 900-1300 AD), with a significant development of xerophytes and Mediterranean vegetation and limited deciduous tree formations (mesophytes). The Little Ice Age (LIA, 1300-1800 AD) was generally colder and moister, with an expansion of deciduous taxa and cold-adapted montane conifers. Two major phases occurred within this period: (i) a transition MCA-LIA, characterized by fluctuating, moist conditions and relatively cold temperatures (ca. 1300 and 1600 AD); and (ii) a second period, characterized by the coldest and most humid conditions, coinciding with maximum (recent) glacier advances (ca. 1600-1800 AD). Glaciers retreated after the LIA when warmer and more arid conditions dominated, interrupted by a short-living cooling episode during the late 19th to early 20th centuries. Some records suggest a response to solar activity with colder and slightly moister conditions during solar minima. Centennial-scale hydrological fluctuations are in phase with reconstructions of NAO variability, which appears to be one of the main climate mechanisms influencing rainfall variations in the region during the last millennium. \\xa9 2012 Author(s)."}], "format": [], "journal": {"issnPrinted": "1814-9324", "conferencedate": "", "vol": "8", "conferenceplace": "", "name": "Climate of the Past", "iss": "2 special issue", "sp": "683", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "700", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-03-30"}, "coverage": [], "publisher": 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String iteration is a variation on the original binary version of the Kleene star operation $p^* q$ obtained by restricting the first argument to be a non-empty sequence of atomic actions. We show that, for every positive integer $k$, bisimulation equivalence over the set of processes in this language with loops of length at most $k$ is finitely axiomatizable, provided that the set of actions is finite. We also offer an infinite equational theory that completely axiomatizes bisimulation equivalence over the whole language. 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In this study we not only aim to investigate if children's advertising exposure indeed affects their materialism, but also how it affects their materialism (i.e., by studying the mediating effects of advertised product desire and perceived reality of advertising). The study investigates 8- to 11-year-olds, because these children are in the midst of consumer development. Unlike previous studies, it focuses on the longitudinal rather than the cross-sectional relations. A sample of 466 children (ages 8-11 years; 55% girls) participated in a two-wave online survey with a one-year interval. We asked children questions about advertising and material possessions. We used structural equation modeling to study the relationship between these variables. Results indicated that children's advertising exposure increases materialism. 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In this study we not only aim to investigate if children's advertising exposure indeed affects their materialism, but also how it affects their materialism (i.e., by studying the mediating effects of advertised product desire and perceived reality of advertising). The study investigates 8- to 11-year-olds, because these children are in the midst of consumer development. Unlike previous studies, it focuses on the longitudinal rather than the cross-sectional relations. A sample of 466 children (ages 8-11 years; 55% girls) participated in a two-wave online survey with a one-year interval. We asked children questions about advertising and material possessions. We used structural equation modeling to study the relationship between these variables. Results indicated that children's advertising exposure increases materialism. The effect of children\\u2019s advertising exposure is mediated by advertised product desire: children's advertising exposure leads to an increase in advertised product desire that enhances materialism. The effect of children's advertising exposure is not mediated by perceived reality of advertising: children's advertising exposure does not lead to an increase perceived reality of advertising, yet, perceived reality of advertising does enhance materialism. 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"trust": ""}, "key": "10|opendoar____::269d837afada308dd4aeab28ca2d57e4", "value": "LSHTM Research Online"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["https://researchonline.lshtm.ac.uk/id/eprint/11161/1/Buprenorphine%20maintenance%20versus%20placebo%20or%20methadone%20maintenance%20for%20opioid%20dependence_GREEN%20VoR.pdf"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": 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{"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://researchonline.lshtm.ac.uk/id/eprint/11161/1/Buprenorphine%20maintenance%20versus%20placebo%20or%20methadone%20maintenance%20for%20opioid%20dependence_GREEN%20VoR.pdf"}], "dateoftransformation": "2020-03-05T20:28:44.964Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"BACKGROUND: Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of opioid dependent individuals, differing results are reported concerning its relative effectiveness indicating the need for an integrative review. OBJECTIVES: To evaluate the effects of buprenorphine maintenance against placebo and methadone maintenance in retaining patients in treatment and in suppressing illicit drug use. SEARCH STRATEGY: We searched the following databases up to 2001, inclusive: Cochrane Drugs and Alcohol Review Group Register, the Cochrane Controlled Trials Register, MEDLINE, EMBASE, Current Contents, Psychlit, CORK [www. state.vt.su/adap/cork], Alcohol and Drug Council of Australia (ADCA) [www.adca.org.au], Australian Drug Foundation (ADF -VIC) [www.adf.org.au], Centre for Education and Information on Drugs and Alcohol (CEIDA) [www.ceida.net.au], Australian Bibliographic Network (ABN), and Library of Congress databases, available NIDA monographs and the College on Problems of Drug Dependence Inc. proceedings, the reference lists of all identified studies and published reviews and authors of identified RCT's were asked about any other published or unpublished relevant RCT. SELECTION CRITERIA: Randomised clinical trials of buprenorphine maintenance compared with either placebo or methadone maintenance for opioid dependence. DATA COLLECTION AND ANALYSIS: Reviewers evaluated the papers separately and independently, rating methodological quality of concealment of allocation; data were extracted independently for meta-analysis and double-entered. MAIN RESULTS: Thirteen studies met the inclusion criteria, all were randomised clinical trials, all but one were double-blind. The method of concealment of allocation was not clearly described in 11 of the studies, otherwise methodological quality was good. Buprenorphine given in flexible doses appeared statistically significantly less effective than methadone in retaining patient in treatment (RR= 0.82; 95% CI: 0.69-0.96). Low dose buprenorphine is not superior to low dose methadone. High dose buprenorphine does not retain more patients than low dose methadone, but may suppress heroin use better. There was no advantage for high dose buprenorphine over high dose methadone in retention (RR=0.79; 95% CI:0.62-1.01), and high dose buprenorphine was inferior in suppression of heroin use. Buprenorphine was statistically significantly superior to placebo medication in retention of patients in treatment at low doses (RR=1.24; 95% CI: 1.06-1.45), high doses (RR=1.21; 95% CI: 1.02-1.44), and very high doses (RR=1.52; 95% CI: 1.23-1.88). However, only high and very high dose buprenorphine suppressed heroin use significantly above placebo. REVIEWERS' CONCLUSIONS: Buprenorphine is an effective intervention for use in the maintenance treatment of heroin dependence, but it is not more effective than methadone at adequate dosages."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "application/pdf"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, 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"value":"AbstractWe study equational axiomatizations of bisimulation equivalence for the language obtained by extending Milner's basic CCS with string iteration. String iteration is a variation on the original binary version of the Kleene star operation p\\u2217q obtained by restricting the first argument to be a non-empty sequence of atomic actions. We show that, for every positive integer k, bisimulation equivalence over the set of processes in this language with loops of length at most k is finitely axiomatizable, provided that the set of actions is finite. We also offer an infinite equational theory that completely axiomatizes bisimulation equivalence over the whole language. We prove that this result cannot be improved upon by showing that no finite equational axiomatization of bisimulation equivalence over basic CCS with string iteration can exist, unless the set of actions is empty."}], "format": [], "journal": {"issnPrinted": "03043975", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Theoretical Computer Science", "iss": "1-2", "sp": "339", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "374", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", 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"dateofcollection": "2018-11-10T05:10:17.902Z", "fulltext": [], "dateoftransformation": "2020-02-27T19:29:46.391Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "SummarySIRT1 is a NAD+-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. Here, we tested whether deletion of PARP-2, an alternative NAD+-consuming enzyme, impacts on NAD+ bioavailability and SIRT1 activity. Our results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes. However, this increase was not due to changes in NAD+ levels, but to an increase in SIRT1 expression, as PARP-2 acts as a direct negative regulator of the SIRT1 promoter. PARP-2 deletion in mice increases SIRT1 levels, promotes energy expenditure, and increases mitochondrial content. Furthermore, PARP-2\\u2212/\\u2212 mice were protected against diet-induced obesity. Despite being insulin sensitized, PARP-2\\u2212/\\u2212 mice were glucose intolerant due to a defective pancreatic function. 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Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of opioid dependent individuals, differing results are reported concerning its relative effectiveness indicating the need for an integrative review. OBJECTIVES: To evaluate the effects of buprenorphine maintenance against placebo and methadone maintenance in retaining patients in treatment and in suppressing illicit drug use. SEARCH STRATEGY: We searched the following databases up to 2001, inclusive: Cochrane Drugs and Alcohol Review Group Register, the Cochrane Controlled Trials Register, MEDLINE, EMBASE, Current Contents, Psychlit, CORK [www. state.vt.su/adap/cork], Alcohol and Drug Council of Australia (ADCA) [www.adca.org.au], Australian Drug Foundation (ADF -VIC) [www.adf.org.au], Centre for Education and Information on Drugs and Alcohol (CEIDA) [www.ceida.net.au], Australian Bibliographic Network (ABN), and Library of Congress databases, available NIDA monographs and the College on Problems of Drug Dependence Inc. proceedings, the reference lists of all identified studies and published reviews and authors of identified RCT's were asked about any other published or unpublished relevant RCT. SELECTION CRITERIA: Randomised clinical trials of buprenorphine maintenance compared with either placebo or methadone maintenance for opioid dependence. DATA COLLECTION AND ANALYSIS: Reviewers evaluated the papers separately and independently, rating methodological quality of concealment of allocation; data were extracted independently for meta-analysis and double-entered. MAIN RESULTS: Thirteen studies met the inclusion criteria, all were randomised clinical trials, all but one were double-blind. The method of concealment of allocation was not clearly described in 11 of the studies, otherwise methodological quality was good. Buprenorphine given in flexible doses appeared statistically significantly less effective than methadone in retaining patient in treatment (RR= 0.82; 95% CI: 0.69-0.96). Low dose buprenorphine is not superior to low dose methadone. High dose buprenorphine does not retain more patients than low dose methadone, but may suppress heroin use better. There was no advantage for high dose buprenorphine over high dose methadone in retention (RR=0.79; 95% CI:0.62-1.01), and high dose buprenorphine was inferior in suppression of heroin use. Buprenorphine was statistically significantly superior to placebo medication in retention of patients in treatment at low doses (RR=1.24; 95% CI: 1.06-1.45), high doses (RR=1.21; 95% CI: 1.02-1.44), and very high doses (RR=1.52; 95% CI: 1.23-1.88). However, only high and very high dose buprenorphine suppressed heroin use significantly above placebo. REVIEWER'S CONCLUSIONS: Buprenorphine is an effective intervention for use in the maintenance treatment of heroin dependence, but it is not more effective than methadone at adequate dosages."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "application/pdf"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, 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"dateofcollection": "2020-03-03T12:35:37.548Z", "fulltext": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "http://eprints.whiterose.ac.uk/98102/1/Angew.%20Chem.%202016%2C%20128%2C%204816-4820.pdf"}], "dateoftransformation": "2020-03-05T21:40:55.294Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "A highly efficient cap-exchange approach for preparing compact, dense polyvalent mannose-capped quantum dots (QDs) has been developed. The resulting QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC-SIGN and DC-SIGNR (collectively termed as DC-SIGN/R) using a sensitive, ratiometric F\\xf6rster resonance energy transfer (FRET) assay. The QD probes specifically bind DC-SIGN, but not its closely related receptor DC-SIGNR, which is further confirmed by its specific blocking of DC-SIGN engagement with the Ebola virus glycoprotein. Tuning the QD surface mannose valency reveals that DC-SIGN binds more efficiently to densely packed mannosides. A FRET-based thermodynamic study reveals that the binding is enthalpy-driven. This work establishes QD FRET as a rapid, sensitive technique for probing structure and thermodynamics of multivalent protein\\u2013ligand interactions."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "application/pdf"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", 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"trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Anthelmintics"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Macrocyclic lactones"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": 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"pid": [], "rank": 4, "affiliation": [], "fullname": "Hashem, Shaima"}, {"surname": "Andre\\u0301", "name": "Franc\\u0327ois", "pid": [], "rank": 5, "affiliation": [], "fullname": "Andr\\xe9, Fran\\xe7ois"}, {"surname": "Lespine", "name": "Anne", "pid": [], "rank": 6, "affiliation": [], "fullname": "Lespine, Anne"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|openaire____::8f87e10869299a5fe80b315695296b88", "value": "Elsevier"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://dx.doi.org/10.1016/j.ijpddr.2016.09.001"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|openaire____::437f4b072b1aa198adcbc35910ff3b98", "value": "CORE"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-11-09T09:48:56.28Z", "fulltext": [], "dateoftransformation": "2020-02-27T19:44:40.709Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "AbstractMacrocyclic lactones (ML) are important anthelmintics used in animals and humans against parasite nematodes, but their therapeutic success is compromised by the spread of ML resistance. Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in\\xa0vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}], "format": [], "journal": {"issnPrinted": "22113207", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "International Journal for Parasitology: Drugs and Drug Resistance", "iss": "3", "sp": "299", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "313", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": 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"dateoftransformation": "2020-03-05T22:53:48.852Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"BACKGROUND: Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of opioid dependent individuals, differing results are reported concerning its relative effectiveness indicating the need for an integrative review. OBJECTIVES: To evaluate the effects of buprenorphine maintenance against placebo and methadone maintenance in retaining patients in treatment and in suppressing illicit drug use. SEARCH STRATEGY: We searched the following databases up to 2001, inclusive: Cochrane Drugs and Alcohol Review Group Register, the Cochrane Controlled Trials Register, MEDLINE, EMBASE, Current Contents, Psychlit, CORK [www. state.vt.su/adap/cork], Alcohol and Drug Council of Australia (ADCA) [www.adca.org.au], Australian Drug Foundation (ADF -VIC) [www.adf.org.au], Centre for Education and Information on Drugs and Alcohol (CEIDA) [www.ceida.net.au], Australian Bibliographic Network (ABN), and Library of Congress databases, available NIDA monographs and the College on Problems of Drug Dependence Inc. proceedings, the reference lists of all identified studies and published reviews and authors of identified RCT's were asked about any other published or unpublished relevant RCT. SELECTION CRITERIA: Randomised clinical trials of buprenorphine maintenance compared with either placebo or methadone maintenance for opioid dependence. DATA COLLECTION AND ANALYSIS: Reviewers evaluated the papers separately and independently, rating methodological quality of concealment of allocation; data were extracted independently for meta-analysis and double-entered. MAIN RESULTS: Thirteen studies met the inclusion criteria, all were randomised clinical trials, all but one were double-blind. The method of concealment of allocation was not clearly described in 11 of the studies, otherwise methodological quality was good. Buprenorphine given in flexible doses appeared statistically significantly less effective than methadone in retaining patient in treatment (RR= 0.82; 95% CI: 0.69-0.96). Low dose buprenorphine is not superior to low dose methadone. High dose buprenorphine does not retain more patients than low dose methadone, but may suppress heroin use better. There was no advantage for high dose buprenorphine over high dose methadone in retention (RR=0.79; 95% CI:0.62-1.01), and high dose buprenorphine was inferior in suppression of heroin use. Buprenorphine was statistically significantly superior to placebo medication in retention of patients in treatment at low doses (RR=1.24; 95% CI: 1.06-1.45), high doses (RR=1.21; 95% CI: 1.02-1.44), and very high doses (RR=1.52; 95% CI: 1.23-1.88). However, only high and very high dose buprenorphine suppressed heroin use significantly above placebo. REVIEWER'S CONCLUSIONS: Buprenorphine is an effective intervention for use in the maintenance treatment of heroin dependence, but it is not more effective than methadone at adequate dosages."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "application/pdf"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, 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They are usually maintained with 10% fetal bovine serum (FBS) in vitro. Modified platelet-rich plasma (mPRP) would be a safe alternative to 10% FBS during SHEDs culture. Therefore, our study aimed to compare the proliferation and differentiation of SHEDs cultured in mPRP and FBS medium to explore an optimal concentration of mPRP for SHEDs maintenance. Platelets were harvested by automatic blood cell analyzer and activated by repeated liquid nitrogen freezing and thawing. The platelet-related cytokines were examined and analyzed by ELISA. SHEDs were extracted and cultured with different concentrations of mPRP or 10% FBS medium. Alkaline phosphatase (ALP) activity was measured. Mineralization factors, RUNX2 and OCN, were measured by real-time PCR. SHEDs were characterized with mesenchymal stem cells (MSCs) markers including vimentin, CD44, and CD105. mPRP at different concentrations (2, 5, 10, and 20%) enhanced the growth of SHEDs. Moreover, mPRP significantly stimulated ALP activity and promoted expression of RUNX2 and OCN compared with 10% FBS. mPRP could efficiently facilitate proliferation and differentiation of SHEDs, and 2% mPRP would be an optimal substitute for 10% FBS during SHEDs expansion and differentiation in clinical scale manufacturing."}], "format": [], "journal": {"issnPrinted": "1414-431X", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Brazilian Journal of Medical and Biological Research", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", 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The performance of both methods was analyzed based on two datasets: 1) a complete site x species matrix compiled from two studies in different land uses in the Amazon using direct analysis of field samples and trap cultures. 2) Total number of AMF morphotypes detected by both methods in published manuscripts across several ecosystems. From dataset 1, direct analysis of field samples revealed 57 morphotypes, whereas only 21 of these were detected by trap culture. Community variation (beta diversity) analysis revealed that field samples are far more sensitive in detecting shifts in AMF community composition among land uses than trap cultures in the Amazon region, with the combined results of both methods being not better than that obtained only by direct analysis of field samples. 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"10|driver______::bee53aa31dc2cbb538c10c2b65fa5824", "value": "DOAJ-Articles"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2020-03-15T08:56:22.261Z", "fulltext": [], "dateoftransformation": "2020-03-15T12:41:38.508Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Abstract Objective This study analyzed the maintenance of lateral incisors in the dental rehabilitation of individuals with cleft lip and palate. Material and Methods The study was conducted on a tertiary craniofacial center and comprised retrospective analysis of panoramic and periapical radiographs of Caucasoid individuals with non-syndromic complete unilateral cleft lip and palate, analyzing all radiographs available on the records of each individual, from the first to the last up to 12 years of age. Overall, 2,826 records were reviewed to achieve a sample of 1,000 individuals. Among these, 487 individuals presented the permanent lateral incisors on both cleft and non-cleft sides, which were included in this study. Results The results were evaluated in percentages and by descriptive statistics. The association between maintenance of the lateral incisor and timing of alveolar bone graft were analyzed by the t test. Among the 487 individuals, 265 had not completed treatment, 62 presented insufficient information, and 44 concluded the treatment elsewhere. Among the remaining 116 individuals, the lateral incisor was extracted from 88 (75.86%) of them on the cleft side (CS) and from 23 (19.83%) people on the non-cleft side (NCS). The age at accomplishment of alveolar bone graft was significantly associated with maintenance of the lateral incisor on the cleft side (p<0.01). Most extractions were indicated because of the inadequate positioning on the CS and for midline correction on the NCS. Rehabilitation was primarily completed by orthodontic movement (53 individuals on the CS and 13 individuals on the NCS). Conclusion In conclusion, the lateral incisor on the cleft side was not maintained in most individuals. Positive relationship was observed between extraction of the lateral incisor and age at accomplishment of the alveolar bone graft, suggesting the need to anticipate the initial radiographic evaluation to enhance its maintenance and reduce the procedures required for rehabilitation."}], "format": [], "journal": {"issnPrinted": "1678-7765", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Journal of Applied Oral Science", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-05-01"}, "coverage": 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"", "invisible": false, "trust": ""}, "value": "2012-08-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|driver______::bee53aa31dc2cbb538c10c2b65fa5824", "value": "DOAJ-Articles"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2020-03-15T10:45:17.338Z", "fulltext": [], "dateoftransformation": "2020-03-15T14:07:40.174Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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MATERIAL AND METHODS: Test groups consisted of aqueous and ethanolic Aroeira extracts and saline (control). For edema quantification, 18 rats received an intravenous injection of Evan's Blue. After 30 min, the extracts and saline were injected on the dorsum of the rats, which were then sacrificed after 3 and 6 h. Readings were performed in a spectrophotometer. For subcutaneous implantation, 30 rats received a polyethylene tube containing the extracts on their dorsum and then they were killed after 7 and 28 days. The samples were processed for histological analysis and evaluated with a light microscope. The inflammatory infiltrate was quantified. RESULTS: There were no statistically significant differences between aqueous extract and saline groups in relation to edema quantification in the different periods (p>0.05). Ethanolic solution resulted in more edema independently of the experimental period (p<0.05). Histological analysis showed similar results on the 7-day period for the 3 groups. There was a notable reduction on inflammatory cell number for saline and aqueous extract groups at 28 days. CONCLUSION: The aqueous extract showed biocompatible properties similar to those of saline."}], "format": [], "journal": {"issnPrinted": "1678-7757", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Journal of Applied Oral Science", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1678-7765", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-08-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Evaluation of tissue reaction to Aroeira (Myracrodruon urundeuva) extracts: a histologic and edemogenic study"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", 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Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in\\xa0vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}], "format": [], "journal": {"issnPrinted": "2211-3207", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "International Journal for Parasitology: Drugs and Drug Resistance", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, 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"2020-03-15T07:29:01.314Z", "fulltext": [], "dateoftransformation": "2020-03-15T15:16:33.261Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"Abstract
Background
Mental health problems are a worldwide public health burden. The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15\\u201316 and mental health three years later.
Methods
Longitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000\\u20132001 (
Results
In boys, the number of hours spent on physical activity per week at age 15\\u201316 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18\\u201319 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18\\u201319 according to weekly hours of physical activity at age 15\\u201316 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15\\u201316 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18\\u201319, but the differences were not statistically significant after adjustments.
Conclusion
Weekly hours of physical activity at age 15\\u201316 years was weakly associated with mental health at three-year follow-up in boys. Results encourage a search for further knowledge about physical activity as a possible protective factor in relation to mental health problems in adolescence.
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R.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Nelson J.R. Fagundes"}, {"surname": "", "name": "", "pid": [], "rank": 2, "affiliation": [], "fullname": "Alice Tagliani-Ribeiro"}, {"surname": "", "name": "", "pid": [], "rank": 3, "affiliation": [], "fullname": "Rohina Rubicz"}, {"surname": "", "name": "", "pid": [], "rank": 4, "affiliation": [], "fullname": "Larissa Tarskaia"}, {"surname": "Crawford", "name": "Michael H.", "pid": [], "rank": 5, "affiliation": [], "fullname": "Michael H. Crawford"}, {"surname": "Salzano", "name": "Francisco M.", "pid": [], "rank": 6, "affiliation": [], "fullname": "Francisco M. Salzano"}, {"surname": "Bonatto", "name": "Sandro L.", "pid": [], "rank": 7, "affiliation": [], "fullname": "Sandro L. 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Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population."}], "format": [], "journal": {"issnPrinted": "1678-4685", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Genetics and Molecular Biology", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Sociedade Brasileira de Gen\\xe9tica"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:doaj.org/article:890de7eabf9b4658b8ce208d6641178c"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Genetics and Molecular Biology, Vol 41, Iss 1 suppl 1, Pp 206-214"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "How strong was the bottleneck associated to the peopling of the Americas? 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"key": "10|doajarticles::1c6d69b7645cde261d6e598085f9020d", "value": "Pesquisa Agropecu\\xe1ria Brasileira"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2004000300001", "https://doaj.org/toc/0100-204X", "https://doaj.org/toc/1678-3921"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": 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"description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Despite the presence of a family of defense proteins, Phaseolus vulgaris can be attacked by bruchid insects resulting in serious damage to stored grains. The two distinct active forms of a-amylase inhibitors, a-AI1 and a-AI2, in P. vulgaris show different specificity toward a-amylases. Zabrotes subfasciatus a-amylase is inhibited by a-AI2 but not by a-AI1. In contrast, porcine a-amylase is inhibited by a-AI1 but not by a-AI2. The objective of this work was to understand the molecular basis of the specificity of two inhibitors in P. vulgaris (a-AI1 and a-AI2) in relation to a-amylases. Mutants of a-AI2 were made and expressed in tobacco plants. The results showed that all the a-AI2 mutant inhibitors lost their activity against the insect a-amylases but none exhibited activity toward the mammalian a-amylase. The replacement of His33 of a-AI2 with the a-AI1-like sequence Ser-Tyr-Asn abolished inhibition of Z. subfasciatus a-amylase. From structural modeling, the conclusion is that the size and complexity of the amylase-inhibitor interface explain why mutation of the N-terminal loop and resultant abolition of Z. subfasciatus a-amylase inhibition are not accompanied by gain of inhibitory activity against porcine a-amylase.Background: Use of whole-genome sequence data is expected to increase persistency of genomic prediction across generations and breeds but affects model performance and requires increased computing time. In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step. Results: We used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5 to 1.1 % higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4 % lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5 days, while the standard analysis including all sequence-based variants took more than three months. Conclusions: The split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds.
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Mental health problems are a worldwide public health burden. Among adults some evidence suggests that physical activity is a protective factor in relation to mental health problems. The same body of literature is not present among adolescents. With regard to prevention of mental health problems it is important to identify vulnerable groups that need special attention. If physical activity can be a preventive strategy,\\nknowledge of physical activity in subgroups of adolescents is important. With an increasing influx of immigrants to the Western parts of the world, cultural/ethnic background has become an important factor when studying health and health behaviour in a public health perspective. Inequality in health has also been a subject of increased attention during the last years, thus it is of great importance to study the significance of sociodemographic factors."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2010-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": 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The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15\\u201316 and mental health three years later. \\n\\nMethods:\\n\\nLongitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000\\u20132001 (n = 3811). The follow-up in 2003\\u20132004 was conducted partly at school and partly through mail. A total of 2489 (1112 boys and 1377 girls) participated in the follow-up. Mental health was measured by the Strengths and Difficulties Questionnaire with an impact supplement. Physical activity was measured by a question on weekly hours of physical activity outside of school, defined as exertion \"to an extent that made you sweat and/or out of breath\". Adjustments were made for well-documented confounders and mental health at baseline. \\n\\nResults:\\n\\nIn boys, the number of hours spent on physical activity per week at age 15\\u201316 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18\\u201319 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18\\u201319 according to weekly hours of physical activity at age 15\\u201316 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15\\u201316 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18\\u201319, but the differences were not statistically significant after adjustments. \\n\\nConclusion:\\n\\nWeekly hours of physical activity at age 15\\u201316 years was weakly associated with mental health at three-year follow-up in boys. 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The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15\\u201316 and mental health three years later. \\n\\nMethods:\\n\\nLongitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000\\u20132001 (n = 3811). The follow-up in 2003\\u20132004 was conducted partly at school and partly through mail. A total of 2489 (1112 boys and 1377 girls) participated in the follow-up. Mental health was measured by the Strengths and Difficulties Questionnaire with an impact supplement. Physical activity was measured by a question on weekly hours of physical activity outside of school, defined as exertion \"to an extent that made you sweat and/or out of breath\". 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Adjustments were made for well-documented confounders and mental health at baseline.\\n \\n \\n Results\\n In boys, the number of hours spent on physical activity per week at age 15\\u201316 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18\\u201319 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18\\u201319 according to weekly hours of physical activity at age 15\\u201316 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15\\u201316 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18\\u201319, but the differences were not statistically significant after adjustments.\\n \\n \\n Conclusion\\n Weekly hours of physical activity at age 15\\u201316 years was weakly associated with mental health at three-year follow-up in boys. 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The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15\\u201316 and mental health three years later. \\n\\nMethods:\\n\\nLongitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000\\u20132001 (n = 3811). The follow-up in 2003\\u20132004 was conducted partly at school and partly through mail. A total of 2489 (1112 boys and 1377 girls) participated in the follow-up. Mental health was measured by the Strengths and Difficulties Questionnaire with an impact supplement. Physical activity was measured by a question on weekly hours of physical activity outside of school, defined as exertion \"to an extent that made you sweat and/or out of breath\". Adjustments were made for well-documented confounders and mental health at baseline. \\n\\nResults:\\n\\nIn boys, the number of hours spent on physical activity per week at age 15\\u201316 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18\\u201319 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18\\u201319 according to weekly hours of physical activity at age 15\\u201316 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15\\u201316 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18\\u201319, but the differences were not statistically significant after adjustments. \\n\\nConclusion:\\n\\nWeekly hours of physical activity at age 15\\u201316 years was weakly associated with mental health at three-year follow-up in boys. Results encourage a search for further knowledge about physical activity as a possible protective factor in relation to mental health problems in adolescence."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2007-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": 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"inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "In this paper, we present the results from a high horizontal resolution numerical simulation of the northwestern Mediterranean using a z-level, non-hydrostatic, primitive equation ocean model (DieCAST). The high resolution allows an accurate representation of the submarine canyons that presides in the region. The model is one-way coupled to a large scale model of the Mediterranean Sea through open boundaries and uses the atmospheric forcing fields provided in terms of HIRLAM outputs by the Spanish National Institute of Meteorology. Results show that the model can successfully reproduce the complex general circulation characteristics of the area, including the modifications induced by canyons in their vicinity and other phenomena observed such as instabilities and coastal trapped waves. The sea surface temperature is similar to satellite observations except that simulated temperatures are slightly warmer near the coast than observations and colder near the open boundaries. An important topic of this work is the computation of the shelf-slope exchanges, which are able to renew shelf waters in a few months."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Peer Reviewed"}], "format": [], "journal": {"issnPrinted": "1812-0784", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "Ocean Science", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1812-0792", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "This work is licensed under a Creative Commons Attribution 3.0 Unported license."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Boron nitride is a promising material for nanotechnology applications due to its two-dimensional graphene-like, insulating, and highly-resistant structure. Recently it has received a lot of attention as a substrate to grow and isolate graphene as well as for its intrinsic UV lasing response. Similar to carbon, one-dimensional boron nitride nanotubes (BNNTs) have been theoretically predicted and later synthesised. Here we use first principles simulations to unambiguously demonstrate that i) BN nanotubes inherit the highly efficient UV luminescence of hexagonal BN; ii) the application of an external perpendicular field closes the electronic gap keeping the UV lasing with lower yield; iii) defects in BNNTS are responsible for tunable light emission from the UV to the visible controlled by a transverse electric field (TEF). Our present findings pave the road towards optoelectronic applications of BN-nanotube-based devices that are simple to implement because they do not require any special doping or complex growth."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "We acknowledge financial support also from the European Research Council Advanced Grant DYNamo (ERC-2010-AdG-267374), Spanish Grant (FIS2010-21282-C02-01), Grupos Consolidados UPV/EHU del Gobierno Vasco (IT578-13), Ikerbasque and the European Commission project CRONOS (Grant number 280879-2). Computational time was granted by i2basque and BSC Red Espanola de Supercomputacion and GENCI-IDRIS (Nos. 100063 and No. 091827). A. M. acknowledges funding by MIUR FIRB Grant No. RBFR12SW0J."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Peer Reviewed"}], "format": [], "journal": {"issnPrinted": "2045-2322", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2013-01-01"}, "coverage": [], "publisher": 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We analyse two variants of such an extension and carry out a phenomenological study of regions of the parameter space satisfying current direct and indirect constraints, employing state-of-the-art two-loop RGE evolution and GMSB boundary conditions. We find that due to the appearance of non-decoupled D-terms it is possible to obtain a 125.5\\xa0GeV Higgs with stops below 2\\xa0TeV, while the uncoloured sparticles could still lie within reach of the LHC. We compare the contributions of the stop sector and the non-decoupled D-terms to the Higgs mass, and study their effect on the Higgs couplings. 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animals and humans against parasite nematodes, but their therapeutic success is compromised by the spread of ML resistance. Some ABC transporters, such as P-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp1) has been crystallized, and its drug-modulated ATPase function characterized in vitro revealed Cel-Pgp1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:prodinra.inra.fr:387545"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "International Journal for Parasitology: Drugs and Drug Resistance 3 (6), 299-313. 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Our present findings pave the road towards optoelectronic applications of BN-nanotube-based devices that are simple to implement because they do not require any special doping or complex growth\\nWe acknowledge financial support also from the European Research Council Advanced Grant DYNamo (ERC-2010-AdG-267374), Spanish Grant (FIS2010-21282-C02-01), Grupos Consolidados UPV/EHU del Gobierno Vasco (IT578-13), Ikerbasque and the European Commission project CRONOS (Grant number 280879-2). Computational time was granted by i2basque and BSC Red Espanola de Supercomputacion and GENCI-IDRIS (Nos. 100063 and No. 091827). A. 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"schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "International audience; The present paper describes the features and implementation of SmartVox an application designed to help vocal ensembles learn and perform polyphonic music.Technically, SmartVox is a distributed web application that delivers audiovisual scores through the performer\\u2019s mobile devices. From a singer\\u2019s point of view, this setup allows for the synergy between visual and acoustic stimuli, which facilitates the interpretive and performative processes, particularly in polyphonic passages. It also enables spatial separation of the performers (cori spezzati), and speeds up the learning process of unfamiliar musical materials (e.g. microtonal tuning, texts in a foreign language).The ubiquity of smartphones makes such a distributed system affordable and allows the use of SmartVox in multiple contexts, from professional ensembles to pedagogical and recreational practices."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2017-05-24"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "HAL CCSD"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01660184v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "TENOR 2017"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://hal.archives-ouvertes.fr/hal-01660184"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "TENOR 2017, May 2017, Coru\\xf1a, Spain. 2017"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "SMARTVOX - A Web-Based Distributed Media Player as Notation Tool For Choral Practices"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1016/S0370-2693(01)00807-3"}], "contributor": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Institut de Physique Nucl\\xe9aire de Lyon\\n (\\nIPNL\\n)\\n\\n ; 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Recently it has received a lot of attention as a substrate to grow and isolate graphene as well as for its intrinsic UV lasing response. Similar to carbon, one-dimensional boron nitride nanotubes (BNNTs) have been theoretically predicted and later synthesised. Here we use first principles simulations to unambiguously demonstrate that i) BN nanotubes inherit the highly efficient UV luminescence of hexagonal BN; ii) the application of an external perpendicular field closes the electronic gap keeping the UV lasing with lower yield; iii) defects in BNNTS are responsible for tunable light emission from the UV to the visible controlled by a transverse electric field (TEF). 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\\nConsejo Superior de Investigaciones Cient\\xedficas [Spain]\\n (\\nCSIC\\n)\\n-Universidad de las Islas Baleares\\n (\\nUIB\\n)\\n"}], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::9766527f2b5d3e95d4a733fcfb77bd7e", "value": "INRIA a CCSD electronic archive server"}], "id": "50|od_______165::22ada9a6f80dad93f03b97f72543d8b4", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "[ SDU.OCEAN ] Sciences of the Universe [physics]/Ocean, Atmosphere"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Jordi", "name": "A.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Jordi , A."}, {"surname": "Basterretxea", "name": "G.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Basterretxea , G."}, {"surname": "Orfila", "name": "A.", "pid": [], "rank": 3, "affiliation": [], "fullname": "Orfila , A."}, {"surname": "Tintore\\u0301", "name": "J.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Tintor\\xe9 , J."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::9766527f2b5d3e95d4a733fcfb77bd7e", "value": "INRIA a CCSD electronic archive server"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["https://hal.archives-ouvertes.fr/hal-00298576", "https://hal.archives-ouvertes.fr/hal-00298576/document", "https://hal.archives-ouvertes.fr/hal-00298576/file/os-2-173-2006.pdf"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2006-10-17"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::9766527f2b5d3e95d4a733fcfb77bd7e", "value": "INRIA a CCSD electronic archive server"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-04-05T09:14:20.078Z", "fulltext": [], "dateoftransformation": "2020-03-05T18:16:37.315Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "\\nInternational audience\\n\\nIn this paper, we present the results from a high horizontal resolution numerical simulation of the northwestern Mediterranean using a z-level, non-hydrostatic, primitive equation ocean model (DieCAST). The high resolution allows an accurate representation of the submarine canyons that presides in the region. The model is one-way coupled to a large scale model of the Mediterranean Sea through open boundaries and uses the atmospheric forcing fields provided in terms of HIRLAM outputs by the Spanish National Institute of Meteorology. Results show that the model can successfully reproduce the complex general circulation characteristics of the area, including the modifications induced by canyons in their vicinity and other phenomena observed such as instabilities and coastal trapped waves. The sea surface temperature is similar to satellite observations except that simulated temperatures are slightly warmer near the coast than observations and colder near the open boundaries. An important topic of this work is the computation of the shelf-slope exchanges, which are able to renew shelf waters in a few months."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2006-10-17"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"lastupdatetimestamp": 0, "author": [{"surname": "David", "name": "Marion A.", "pid": [], "rank": 1, "affiliation": [], "fullname": "David , Marion A."}, {"surname": "Orlowski", "name": "Ste\\u0301phane", "pid": [], "rank": 2, "affiliation": [], "fullname": "Orlowski , St\\xe9phane"}, {"surname": "Prichard", "name": "Roger K.", "pid": [], "rank": 3, "affiliation": [], "fullname": "Prichard , Roger K."}, {"surname": "Hashem", "name": "Shaima", "pid": [], "rank": 4, "affiliation": [], "fullname": "Hashem , Shaima"}, {"surname": "Andre\\u0301", "name": "Franc\\u0327ois", "pid": [], "rank": 5, "affiliation": [], "fullname": "Andr\\xe9 , Fran\\xe7ois"}, {"surname": "Lespine", "name": "Anne", "pid": [], "rank": 6, "affiliation": [], "fullname": "Lespine , Anne"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": 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Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in\\xa0vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "HAL CCSD"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01451654v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "International journal for parasitology. 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From a singer\\u2019s point of view, this setup allows for the synergy between visual and acoustic stimuli, which facilitates the interpretive and performative processes, particularly in polyphonic passages. It also enables spatial separation of the performers (cori spezzati), and speeds up the learning process of unfamiliar musical materials (e.g. microtonal tuning, texts in a foreign language).The ubiquity of smartphones makes such a distributed system affordable and allows the use of SmartVox in multiple contexts, from professional ensembles to pedagogical and recreational practices."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2017-05-24"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "HAL CCSD"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01660184v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "TENOR"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://hal.archives-ouvertes.fr/hal-01660184"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "TENOR, May 2017, Coru\\xf1a, Spain"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "SMARTVOX - A Web-Based Distributed Media Player as Notation Tool For Choral Practices"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1063/1.2130751"}], "contributor": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Dipartimento du Fisica ; 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We use data from direct numerical simulations up to Taylor\\\\'s Reynolds number 280 following the evolution of about two million passive tracers advected by the flow over a time span of about three decades. We present data for both the separation distance and the relative velocity statistics. Statistics are measured along the particle pair trajectories both as a function of time and as a function of their separation, i.e. at fixed scales. We compare and contrast both sets of statistics in order to gain an insight into the mechanisms governing the separation process. We find very high levels of intermittency in the early stages, that is, for travel times up to order ten Kolmogorov time scales. The fixed scale statistics allow us to quantify anomalous corrections to Richardson diffusion in the inertial range of scales for those pairs that separate rapidly. 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The MSV-MIDAS model is estimated via maximum likelihood methods.The estimation relies on a slightly modified version of Hamilton\\u2019s recursive filter.We use Monte Carlo simulations to assess the robustness of the estimation procedure and related test-statistics. The results show that ML provides accurateestimates, but they suggest some caution in the tests on the parameters involved inthe transition probabilities. We apply this new model to thedetection and forecastof business cycle turning points. We properly detect recessions in United States and United Kingdom by exploiting the link between GDP growth and higher frequency variables from financial and energy markets. Spread term is aparticularly usefulindicator to predict recessions in the United States, while stock returns have the strongest explanatory power around British turning points."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2015-06-22"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": 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"2018-04-04T15:41:58.595Z", "fulltext": [], "dateoftransformation": "2020-03-05T20:07:35.655Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"This paper introduces a Markov-switching model in which transition probabilities depend on higher frequency indicators and their lags through polynomial weight-ing schemes. The MSV-MIDAS model is estimated via maximum likelihood (ML) methods. The estimation relies on a slightly modified version of Hamilton's recursive filter. We use Monte Carlo simulations to assess the robustness of the estimation procedure and related test statistics. The results show that ML provides accurate estimates, but they suggest some caution in interpreting the tests of the parameters involved in the transition probabilities. We apply this new model to the detection and forecasting of business cycle turning points in the United States. We properly detect recessions by exploiting the link between GDP growth and higher frequency variables from financial and energy markets. The spread term is a particularly useful indicator to predict recessions in the United States. The empirical evidence also supports the use of functional polynomial weights in the MIDAS specification of the transition probabilities."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-09-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "HAL CCSD"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01358595v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://hal.archives-ouvertes.fr/hal-01358595"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Revisiting the transitional dynamics of business-cycle phases with mixed frequency data"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1016/S0370-2693(01)00807-3"}], "contributor": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Institut de Physique Nucl\\xe9aire de Lyon\\n (\\nIPNL\\n)\\n\\n ; 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Submitted to Phys. Rev. Lett.\\nAlthough CP violation in the B meson system has been well established by the B factories, there has been no direct observation of time reversal violation. The decays of entangled neutral B mesons into definite flavor states ($B^0$ or $\\\\bar{B}^0$), and $J/\\\\psi K_S^0$ or $c\\\\bar{c} K_S^0$ final states (referred to as $B_+$ or $B_-$), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, $\\\\bar{B}^0 \\\\rightarrow B_-$ and $B_- \\\\rightarrow \\\\bar{B}^0$, as a function of the time difference between the two B decays. Using 468 million $B\\\\bar{B}$ pairs produced in $\\\\Upsilon(4S)$ decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding $\\\\Delta S_T^+ = -1.37 \\\\pm 0.14 (stat.) \\\\pm 0.06 (syst.)$ and $\\\\Delta S_T^- = 1.17 \\\\pm 0.18 (stat.) \\\\pm 0.11 (syst.)$. These nonzero results represent the first direct observation of T violation in the B meson system, through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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"dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "[ SDV ] Life Sciences [q-bio]"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Calus", "name": "Mario P. L.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Calus , Mario P. L."}, {"surname": "Bouwman", "name": "Aniek C.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Bouwman , Aniek C."}, {"surname": "Schrooten", "name": "Chris", "pid": [], "rank": 3, "affiliation": [], "fullname": "Schrooten , Chris"}, {"surname": "Veerkamp", "name": "Roel F.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Veerkamp , Roel F."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::9766527f2b5d3e95d4a733fcfb77bd7e", "value": "INRIA a CCSD electronic archive server"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["https://hal.archives-ouvertes.fr/hal-01341383", "https://hal.archives-ouvertes.fr/hal-01341383/document", "https://hal.archives-ouvertes.fr/hal-01341383/file/12711_2016_Article_225.pdf"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::9766527f2b5d3e95d4a733fcfb77bd7e", "value": "INRIA a CCSD electronic archive server"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-04-04T15:53:20.027Z", "fulltext": [], "dateoftransformation": "2020-03-05T23:23:59.768Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "\\nInternational audience\\n\\nBackgroundUse of whole-genome sequence data is expected to increase persistency of genomic prediction across generations and breeds but affects model performance and requires increased computing time. In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step.ResultsWe used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5\\xa0to\\xa01.1\\xa0% higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4\\xa0% lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5\\xa0days, while the standard analysis including all sequence-based variants took more than three\\xa0months.ConclusionsThe split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "HAL CCSD"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01341383v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "EISSN: 1297-9686"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Genetics Selection Evolution"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, 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Recently it has received a lot of attention as a substrate to grow and isolate graphene as well as for its intrinsic UV lasing response. Similar to carbon, one-dimensional boron nitride nanotubes (BNNTs) have been theoretically predicted and later synthesised. Here we use first principles simulations to unambiguously demonstrate that i) BN nanotubes inherit the highly efficient UV luminescence of hexagonal BN; ii) the application of an external perpendicular field closes the electronic gap keeping the UV lasing with lower yield; iii) defects in BNNTS are responsible for tunable light emission from the UV to the visible controlled by a transverse electric field (TEF). 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The high resolution allows an accurate representation of the submarine canyons that presides in the region. The model is one-way coupled to a large scale model of the Mediterranean Sea through open boundaries and uses the atmospheric forcing fields provided in terms of HIRLAM outputs by the Spanish National Institute of Meteorology. Results show that the model can successfully reproduce the complex general circulation characteristics of the area, including the modifications induced by canyons in their vicinity and other phenomena observed such as instabilities and coastal trapped waves. The sea surface temperature is similar to satellite observations except that simulated temperatures are slightly warmer near the coast than observations and colder near the open boundaries. An important topic of this work is the computation of the shelf-slope exchanges, which are able to renew shelf waters in a few months."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2006-10-17"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"value": "International audience; Macrocyclic lactones (ML) are important anthelmintics used in animals and humans against parasite nematodes, but their therapeutic success is compromised by the spread of ML resistance. Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in\\xa0vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Elsevier"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:HAL:hal-01451654v1"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "ISSN: 2211-3207"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "International journal for parasitology. 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The discovery of a 125.5 GeV Higgs with standard model-like couplings andnaturalness considerations motivate gauge extensions of the MSSM. We analysetwo variants of such an extension and carry out a phenomenological study ofregions of the parameter space satisfying current direct and indirectconstraints, employing state-of-the art two-loop RGE evolution and GMSBboundary conditions. We find that due to the appearance of non-decoupledD-terms it is possible to obtain a 125.5 GeV Higgs with stops below 2 TeV,while the uncolored sparticles could still lie within reach of the LHC. Wecompare the contributions of the stop sector and the non-decoupled D-terms tothe Higgs mass, and study their effect on the Higgs couplings. 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Submitted to Phys. Rev. Lett.; Although CP violation in the B meson system has been well established by the B factories, there has been no direct observation of time reversal violation. The decays of entangled neutral B mesons into definite flavor states ($B^0$ or $\\\\bar{B}^0$), and $J/\\\\psi K_S^0$ or $c\\\\bar{c} K_S^0$ final states (referred to as $B_+$ or $B_-$), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, $\\\\bar{B}^0 \\\\rightarrow B_-$ and $B_- \\\\rightarrow \\\\bar{B}^0$, as a function of the time difference between the two B decays. Using 468 million $B\\\\bar{B}$ pairs produced in $\\\\Upsilon(4S)$ decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding $\\\\Delta S_T^+ = -1.37 \\\\pm 0.14 (stat.) \\\\pm 0.06 (syst.)$ and $\\\\Delta S_T^- = 1.17 \\\\pm 0.18 (stat.) \\\\pm 0.11 (syst.)$. These nonzero results represent the first direct observation of T violation in the B meson system, through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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L.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Calus, Mario P. L."}, {"surname": "Bouwman", "name": "Aniek C.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Bouwman, Aniek C."}, {"surname": "Schrooten", "name": "Chris", "pid": [], "rank": 3, "affiliation": [], "fullname": "Schrooten, Chris"}, {"surname": "Veerkamp", "name": "Roel F.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Veerkamp, Roel F."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::7e7757b1e12abcb736ab9a754ffb617a", "value": "Hyper Article en Ligne"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["https://hal.archives-ouvertes.fr/hal-01341383", "https://hal.archives-ouvertes.fr/hal-01341383/document", "https://hal.archives-ouvertes.fr/hal-01341383/file/12711_2016_Article_225.pdf"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::7e7757b1e12abcb736ab9a754ffb617a", "value": "Hyper Article en Ligne"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2019-07-27T14:15:08.792Z", "fulltext": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://hal.archives-ouvertes.fr/hal-01341383/document"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "https://hal.archives-ouvertes.fr/hal-01341383/file/12711_2016_Article_225.pdf"}], "dateoftransformation": "2019-07-30T10:15:45.374Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "International audience; BackgroundUse of whole-genome sequence data is expected to increase persistency of genomic prediction across generations and breeds but affects model performance and requires increased computing time. In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step.ResultsWe used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5\\xa0to\\xa01.1\\xa0% higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4\\xa0% lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5\\xa0days, while the standard analysis including all sequence-based variants took more than three\\xa0months.ConclusionsThe split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, 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"instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-11T08:32:15.261Z", "fulltext": [], "dateoftransformation": "2018-08-29T16:51:34.05Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"Objectives This study evaluated subcutaneous tissue response to Aroeira (Myracrodruon urundeuva) extract employing edemogenic and histological analyses. Material and methods Test groups consisted of aqueous and ethanolic Aroeira extracts and saline (control). For edema quantification, 18 rats received an intravenous injection of Evan's Blue. After 30 min, the extracts and saline were injected on the dorsum of the rats, which were then sacrificed after 3 and 6 h. Readings were performed in a spectrophotometer. For subcutaneous implantation, 30 rats received a polyethylene tube containing the extracts on their dorsum and then they were killed after 7 and 28 days. The samples were processed for histological analysis and evaluated with a light microscope. The inflammatory infiltrate was quantified. Results There were no statistically significant differences between aqueous extract and saline groups in relation to edema quantification in the different periods (p>0.05). Ethanolic solution resulted in more edema independently of the experimental period (p<0.05). Histological analysis showed similar results on the 7-day period for the 3 groups. There was a notable reduction on inflammatory cell number for saline and aqueous extract groups at 28 days. 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L."}, {"surname": "Bouwman", "name": "Aniek C.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Bouwman, Aniek C."}, {"surname": "Schrooten", "name": "Chris", "pid": [], "rank": 3, "affiliation": [], "fullname": "Schrooten, Chris"}, {"surname": "Veerkamp", "name": "Roel F.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Veerkamp, Roel F."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://europepmc.org/articles/PMC4926307"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-06-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-13T04:51:09.291Z", "fulltext": [], "dateoftransformation": "2018-08-29T18:39:14.858Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Background Use of whole-genome sequence data is expected to increase persistency of genomic prediction across generations and breeds but affects model performance and requires increased computing time. In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step. Results We used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5\\xa0to\\xa01.1\\xa0% higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4\\xa0% lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5\\xa0days, while the standard analysis including all sequence-based variants took more than three\\xa0months. Conclusions The split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds. Electronic supplementary material The online version of this article (doi:10.1186/s12711-016-0225-x) contains supplementary material, which is available to authorized users."}], "format": [], "journal": {"issnPrinted": "0999-193X", "conferencedate": "", "vol": "48", "conferenceplace": "", "name": "Genetics, Selection, Evolution : GSE", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1297-9686", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-06-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", 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false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Efficient genomic prediction based on whole-genome sequence data using split-and-merge Bayesian variable selection"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", 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"Zhang", "name": "Ming", "pid": [], "rank": 3, "affiliation": [], "fullname": "Zhang, Ming"}, {"surname": "Neres", "name": "Joa\\u0303o", "pid": [], "rank": 4, "affiliation": [], "fullname": "Neres, Jo\\xe3o"}, {"surname": "Sar", "name": "Astrid M.", "pid": [], "rank": 5, "affiliation": [], "fullname": "Sar, Astrid M"}, {"surname": "Raadsen", "name": "Susanne A.", "pid": [], "rank": 6, "affiliation": [], "fullname": "Raadsen, Susanne A"}, {"surname": "Hartkoorn", "name": "Ruben C.", "pid": [], "rank": 7, "affiliation": [], "fullname": "Hartkoorn, Ruben C"}, {"surname": "Ryabova", "name": "Olga B.", "pid": [], "rank": 8, "affiliation": [], "fullname": "Ryabova, Olga B"}, {"surname": "Vocat", "name": "Anthony", "pid": [], "rank": 9, "affiliation": [], "fullname": "Vocat, Anthony"}, {"surname": "Decosterd", "name": "Laurent A.", "pid": [], "rank": 10, "affiliation": [], "fullname": "Decosterd, Laurent A"}, {"surname": "Widmer", "name": "Nicolas", "pid": [], "rank": 11, "affiliation": [], "fullname": "Widmer, Nicolas"}, {"surname": "Buclin", "name": "Thierry", "pid": [], "rank": 12, "affiliation": [], "fullname": "Buclin, Thierry"}, {"surname": "Bitter", "name": "Wilbert", "pid": [], "rank": 13, "affiliation": [], "fullname": "Bitter, Wilbert"}, {"surname": "Andries", "name": "Koen", "pid": [], "rank": 14, "affiliation": [], "fullname": "Andries, Koen"}, {"surname": "Pojer", "name": "Florence", "pid": [], "rank": 15, "affiliation": [], "fullname": "Pojer, Florence"}, {"surname": "Dyson", "name": "Paul J.", "pid": [], "rank": 16, "affiliation": [], "fullname": "Dyson, Paul J"}, {"surname": "Cole", "name": "Stewart T.", "pid": [], "rank": 17, "affiliation": [], "fullname": "Cole, Stewart T"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://europepmc.org/articles/PMC3958311"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2014-02-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-11T11:32:00.492Z", "fulltext": [], "dateoftransformation": "2018-08-29T19:41:29.552Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose 2-epimerase. Here, we synthesized a new series of piperazine-containing benzothiazinones (PBTZ) and show that, like BTZ043, the preclinical candidate PBTZ169 binds covalently to DprE1. The crystal structure of the DprE1-PBTZ169 complex reveals formation of a semimercaptal adduct with Cys387 in the active site and explains the irreversible inactivation of the enzyme. Compared to BTZ043, PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). When combined with other TB drugs, PBTZ169 showed additive activity against M.\\xa0tuberculosis in vitro except with bedaquiline (BDQ) where synergy was observed. A new regimen comprising PBTZ169, BDQ and pyrazinamide was found to be more efficacious than the standard three drug treatment in a murine model of chronic disease. PBTZ169 is thus an attractive drug candidate to treat TB in humans. Subject Categories Microbiology, Virology & Host Pathogen Interaction; Pharmacology & Drug Discovery"}], "format": [], "journal": {"issnPrinted": "1757-4676", "conferencedate": "", "vol": "6", "conferenceplace": "", "name": "EMBO Molecular Medicine", "iss": "3", "sp": "372", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1757-4684", "ep": "383", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2014-02-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Towards a new combination therapy for tuberculosis with next generation benzothiazinones"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmid", "classname": "pmid", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "26990806"}, {"dataInfo": 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The resulting QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC\\u2010SIGN and DC\\u2010SIGNR (collectively termed as DC\\u2010SIGN/R) using a sensitive, ratiometric F\\xf6rster resonance energy transfer (FRET) assay. The QD probes specifically bind DC\\u2010SIGN, but not its closely related receptor DC\\u2010SIGNR, which is further confirmed by its specific blocking of DC\\u2010SIGN engagement with the Ebola virus glycoprotein. Tuning the QD surface mannose valency reveals that DC\\u2010SIGN binds more efficiently to densely packed mannosides. A FRET\\u2010based thermodynamic study reveals that the binding is enthalpy\\u2010driven. This work establishes QD FRET as a rapid, sensitive technique for probing structure and thermodynamics of multivalent protein\\u2013ligand interactions."}], "format": [], "journal": {"issnPrinted": "1433-7851", "conferencedate": "", "vol": "55", "conferenceplace": "", "name": "Angewandte Chemie (International Ed. in English)", "iss": "15", "sp": "4738", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1521-3773", "ep": "4742", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-03-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", 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"dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2007-07-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-09T13:09:56.823Z", "fulltext": [], "dateoftransformation": "2018-08-30T01:37:41.001Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"Background Mental health problems are a worldwide public health burden. The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15\\u201316 and mental health three years later. Methods Longitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000\\u20132001 (n = 3811). The follow-up in 2003\\u20132004 was conducted partly at school and partly through mail. A total of 2489 (1112 boys and 1377 girls) participated in the follow-up. Mental health was measured by the Strengths and Difficulties Questionnaire with an impact supplement. Physical activity was measured by a question on weekly hours of physical activity outside of school, defined as exertion \"to an extent that made you sweat and/or out of breath\". Adjustments were made for well-documented confounders and mental health at baseline. Results In boys, the number of hours spent on physical activity per week at age 15\\u201316 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18\\u201319 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18\\u201319 according to weekly hours of physical activity at age 15\\u201316 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15\\u201316 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18\\u201319, but the differences were not statistically significant after adjustments. Conclusion Weekly hours of physical activity at age 15\\u201316 years was weakly associated with mental health at three-year follow-up in boys. Results encourage a search for further knowledge about physical activity as a possible protective factor in relation to mental health problems in adolescence."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "7", "conferenceplace": "", "name": "BMC Public Health", "iss": "", "sp": "155", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1471-2458", "ep": "155", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2007-07-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "BioMed Central"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:pubmedcentral.nih.gov:1955440"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "BMC Public Health"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "The association between weekly hours of physical activity and mental health: A three-year follow-up study of 15\\u201316-year-old students in the city of Oslo, Norway"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmid", "classname": "pmid", 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"deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-04-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-15T02:59:16.126Z", "fulltext": [], "dateoftransformation": "2018-08-30T02:39:11.807Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Abstract Objective This study analyzed the maintenance of lateral incisors in the dental rehabilitation of individuals with cleft lip and palate. Material and Methods The study was conducted on a tertiary craniofacial center and comprised retrospective analysis of panoramic and periapical radiographs of Caucasoid individuals with non-syndromic complete unilateral cleft lip and palate, analyzing all radiographs available on the records of each individual, from the first to the last up to 12 years of age. Overall, 2,826 records were reviewed to achieve a sample of 1,000 individuals. Among these, 487 individuals presented the permanent lateral incisors on both cleft and non-cleft sides, which were included in this study. Results The results were evaluated in percentages and by descriptive statistics. The association between maintenance of the lateral incisor and timing of alveolar bone graft were analyzed by the t test. Among the 487 individuals, 265 had not completed treatment, 62 presented insufficient information, and 44 concluded the treatment elsewhere. Among the remaining 116 individuals, the lateral incisor was extracted from 88 (75.86%) of them on the cleft side (CS) and from 23 (19.83%) people on the non-cleft side (NCS). The age at accomplishment of alveolar bone graft was significantly associated with maintenance of the lateral incisor on the cleft side (p<0.01). Most extractions were indicated because of the inadequate positioning on the CS and for midline correction on the NCS. Rehabilitation was primarily completed by orthodontic movement (53 individuals on the CS and 13 individuals on the NCS). Conclusion In conclusion, the lateral incisor on the cleft side was not maintained in most individuals. Positive relationship was observed between extraction of the lateral incisor and age at accomplishment of the alveolar bone graft, suggesting the need to anticipate the initial radiographic evaluation to enhance its maintenance and reduce the procedures required for rehabilitation."}], "format": [], "journal": {"issnPrinted": "1678-7757", "conferencedate": "", "vol": "26", "conferenceplace": "", "name": "Journal of Applied Oral Science", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1678-7765", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-04-01"}, 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"dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Dental health services"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Dental care"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Inequalities in health care services"}, {"dataInfo": 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"Moise\\u0301s", "pid": [], "rank": 3, "affiliation": [], "fullname": "Goldbaum, Mois\\xe9s"}, {"surname": "Azevedo Barros", "name": "Marilisa Berti", "pid": [], "rank": 4, "affiliation": [], "fullname": "de Azevedo Barros, Marilisa Berti"}, {"surname": "Gianini", "name": "Reinaldo Jose\\u0301", "pid": [], "rank": 5, "affiliation": [], "fullname": "Gianini, Reinaldo Jos\\xe9"}, {"surname": "Cesar", "name": "Chester Luiz Galva\\u0303o", "pid": [], "rank": 6, "affiliation": [], "fullname": "Cesar, Chester Luiz Galv\\xe3o"}, {"surname": "Mackenbach", "name": "Johan P.", "pid": [], "rank": 7, "affiliation": [], "fullname": "Mackenbach, Johan P."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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"classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-13T14:33:43.886Z", "fulltext": [], "dateoftransformation": "2018-08-30T03:52:36.376Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Background Access to, and use of, dental health services in Brazil have improved since 2003. The increase of private health care plans and the implementation of the \\u201cSmiling Brazil\\u201d Program, the largest public oral health care program in the world, could have influenced this increase in access. However, we do not yet know if inequalities in the use of dental health services persist after the improvement in access. The aims of this study are to analyze socioeconomic differences for dental health service use between 2003 and 2008 in S\\xe3o Paulo and to examine changes in these associations since the implementation of the Smiling Brazil program in 2003. Method Data was obtained via two household health surveys (ISA-Capital 2003 and ISA-Capital 2008) which investigated living conditions, lifestyle, health status and use of health care services. Logistic regression was used to analyze associations between socioeconomic factors and dental services use. Additionally, trends from 2003 to 2008 regarding socioeconomic characteristics and dental health service use were explored. Results Overall, dental health service use increased between 2003 and 2008 and was at both time points more common among those who had higher income, better education, better housing conditions, private health care plans and were Caucasian. Inequalities in use of dental health care did not decrease over time. Among the reasons for not seeking dental care, not having teeth and financial difficulty were more common in lower socioeconomic groups, while thinking it was unnecessary was more common in higher socioeconomic groups. Conclusions The Brazilian oral health policy is still in a period of expansion and seems to have contributed slightly to increased dental health service use, but has not influenced socioeconomic inequalities in the use of these services. Acquiring deeper knowledge about inequalities in dental health service use will contribute to better understanding of potential barriers to reducing them. Electronic supplementary material The online version of this article (doi:10.1186/s12913-016-1928-y) contains supplementary material, which is available to authorized users."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "16", "conferenceplace": "", "name": "BMC Health Services Research", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1472-6963", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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"Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-13T18:26:05.733Z", "fulltext": [], "dateoftransformation": "2018-08-30T05:30:36.107Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of \\u03b2-lactam antibiotics, which are often prescribed to treat H.\\xa0influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when \\u03b2-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for \\u03b2-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults. A large variety of studies suggest that biofilm formation by NTHi may be an important step in the pathogenesis of this bacterium. However, the underlying mechanisms involved in this process are poorly elucidated. In this study, we used a transposon mutant library to identify bacterial genes involved in biofilm formation. The growth and biofilm formation of 4,172 transposon mutants were determined, and the involvement of the identified genes in biofilm formation was validated in in vitro experiments. Here, we present experimental data showing that increased bacterial lysis, through interference with peptidoglycan synthesis, results in elevated levels of extracellular DNA, which increased biofilm formation. Interestingly, similar results were obtained with subinhibitory concentrations of \\u03b2-lactam antibiotics, known to interfere with peptidoglycan synthesis, but such an effect does not appear with other classes of antibiotics. These results indicate that treatment with \\u03b2-lactam antibiotics, especially for \\u03b2-lactam-resistant NTHi isolates, might increase resistance to antibiotics by increasing biofilm formation. IMPORTANCE Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of \\u03b2-lactam antibiotics, which are often prescribed to treat H.\\xa0influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when \\u03b2-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for \\u03b2-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "2", "conferenceplace": "", "name": "mSphere", "iss": "1", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "2379-5042", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2017-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", 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"deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357", "value": "PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-06-13T16:32:55.324Z", "fulltext": [], "dateoftransformation": "2018-08-30T08:27:50.134Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Macrocyclic lactones (ML) are important anthelmintics used in animals and humans against parasite nematodes, but their therapeutic success is compromised by the spread of ML resistance. Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in\\xa0vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Graphical abstract Ivermectin (red spheres) binding to Cel-Pgp-1 (blue ribbon: N-term, yellow ribbon: C-term).Image 1"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Highlights \\u2022 Cel-Pgp-1 cristal provides a valuable tool to study anthelmintic interactions. \\u2022 Cel-Pgp-1 recognizes a broad panel of anthelmintics, including macrocyclic lactones. \\u2022 Cel-Pgp-1 is predicted to transport MLs and contribute to anthelmintic resistance. \\u2022 Sugars in avermectins increase the affinity to Cel-Pgp-1 compared with moxidectin. \\u2022 These data provide a basis for modelling ABC homologs in parasitic nematodes."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "6", "conferenceplace": "", "name": "International Journal for Parasitology: Drugs and Drug Resistance", "iss": "3", "sp": "299", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "2211-3207", "ep": "313", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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Recently it has received a lot of attention as a substrate to grow and isolate graphene as well as for its intrinsic UV lasing response. Similar to carbon, one-dimensional boron nitride nanotubes (BNNTs) have been theoretically predicted and later synthesised. Here we use first principles simulations to unambiguously demonstrate that i) BN nanotubes inherit the highly efficient UV luminescence of hexagonal BN; ii) the application of an external perpendicular field closes the electronic gap keeping the UV lasing with lower yield; iii) defects in BNNTS are responsible for tunable light emission from the UV to the visible controlled by a transverse electric field (TEF). 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Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. 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They are usually maintained with 10% fetal bovine serum (FBS) in vitro. Modified platelet-rich plasma (mPRP) would be a safe alternative to 10% FBS during SHEDs culture. Therefore, our study aimed to compare the proliferation and differentiation of SHEDs cultured in mPRP and FBS medium to explore an optimal concentration of mPRP for SHEDs maintenance. Platelets were harvested by automatic blood cell analyzer and activated by repeated liquid nitrogen freezing and thawing. The platelet-related cytokines were examined and analyzed by ELISA. SHEDs were extracted and cultured with different concentrations of mPRP or 10% FBS medium. Alkaline phosphatase (ALP) activity was measured. Mineralization factors, RUNX2 and OCN, were measured by real-time PCR. SHEDs were characterized with mesenchymal stem cells (MSCs) markers including vimentin, CD44, and CD105. mPRP at different concentrations (2, 5, 10, and 20%) enhanced the growth of SHEDs. 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A large variety of studies suggest that biofilm formation by NTHi may be an important step in the pathogenesis of this bacterium. However, the underlying mechanisms involved in this process are poorly elucidated. In this study, we used a transposon mutant library to identify bacterial genes involved in biofilm formation. The growth and biofilm formation of 4,172 transposon mutants were determined, and the involvement of the identified genes in biofilm formation was validated in in vitro experiments. Here, we present experimental data showing that increased bacterial lysis, through interference with peptidoglycan synthesis, results in elevated levels of extracellular DNA, which increased biofilm formation. Interestingly, similar results were obtained with subinhibitory concentrations of \\u03b2-lactam antibiotics, known to interfere with peptidoglycan synthesis, but such an effect does not appear with other classes of antibiotics. These results indicate that treatment with \\u03b2-lactam antibiotics, especially for \\u03b2-lactam-resistant NTHi isolates, might increase resistance to antibiotics by increasing biofilm formation. IMPORTANCE Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of \\u03b2-lactam antibiotics, which are often prescribed to treat H. influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when \\u03b2-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for \\u03b2-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", 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These results indicate that treatment with \\u03b2-lactam antibiotics, especially for \\u03b2-lactam-resistant NTHi isolates, might increase resistance to antibiotics by increasing biofilm formation. IMPORTANCE Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of \\u03b2-lactam antibiotics, which are often prescribed to treat H. influenzae infections, increase biofilm formation through a similar mechanism. 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Using 468 X 10(6) B (B) over bar pairs produced in Y(4S) decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding Delta S-T(+) = -137 +/- 0.14(stat) +/- 0.06(syst) and Delta S-T(-) = 1.17 +/- 0.18(stat) +/- 0.11(syst). 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In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step. Results: We used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5 to 1.1 % higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4 % lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5 days, while the standard analysis including all sequence-based variants took more than three months. Conclusions: The split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds.
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Carvalho", "pid": [], "rank": 2, "affiliation": [], "fullname": "Ara\\xfajo, Fernanda Montenegro de Carvalho"}, {"surname": "Cavalcanti", "name": "Luciano Pamplona Go\\u0301es", "pid": [], "rank": 3, "affiliation": [], "fullname": "Cavalcanti, Luciano Pamplona de G\\xf3es"}, {"surname": "Braga", "name": "Deborah Nunes Melo", "pid": [], "rank": 4, "affiliation": [], "fullname": "Braga, Deborah Nunes Melo"}, {"surname": "Perdiga\\u0303o", "name": "Anne Carolinne Bezerra", "pid": [], "rank": 5, "affiliation": [], "fullname": "Perdig\\xe3o, Anne Carolinne Bezerra"}, {"surname": "Santos", "name": "Flavia Barreto Dos", "pid": [], "rank": 6, "affiliation": [], "fullname": "Santos, Flavia Barreto dos"}, {"surname": "Nogueira", "name": "Fernanda Bruycker", "pid": [], "rank": 7, "affiliation": [], "fullname": "Nogueira, Fernanda de Bruycker"}, {"surname": "Esco\\u0301ssia", "name": "Kiliana Nogueira Farias Da", "pid": [], "rank": 8, "affiliation": [], "fullname": "Esc\\xf3ssia, Kiliana Nogueira Farias da"}, {"surname": "Guedes", "name": "Maria Izabel Florindo", "pid": [], "rank": 9, "affiliation": [], "fullname": "Guedes, Maria Izabel Florindo"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "http://creativecommons.org/licenses/by/4.0/"}, "url": ["http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300&lng=en&tlng=en"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-10-18"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-10-17T15:29:29.5Z", "fulltext": [], "dateoftransformation": "2020-03-05T17:09:49.618Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Cear\\xe1, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Cear\\xe1, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Cear\\xe1."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "text/html"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-10-18"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Instituto Oswaldo Cruz, Minist\\xe9rio da Sa\\xfade"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:scielo:S0074-02762018001100300"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Mem\\xf3rias do Instituto Oswaldo Cruz, Volume: 113, Issue: 11, Article number: e180320, Published: 18 OCT 2018"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Dengue 4 in Cear\\xe1, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}], "id": "50|od_______608::a09f60767c9565c03a40c6991f3d7c39", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Isolation with Migration model"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "coalescent analysis"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "native Siberians"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Fagundes", "name": "Nelson J. R.", "pid": [], "rank": 1, "affiliation": [], "fullname": "Fagundes, Nelson J.R."}, {"surname": "Tagliani-Ribeiro", "name": "Alice", "pid": [], "rank": 2, "affiliation": [], "fullname": "Tagliani-Ribeiro, Alice"}, {"surname": "Rubicz", "name": "Rohina", "pid": [], "rank": 3, "affiliation": [], "fullname": "Rubicz, Rohina"}, {"surname": "Tarskaia", "name": "Larissa", "pid": [], "rank": 4, "affiliation": [], "fullname": "Tarskaia, Larissa"}, {"surname": "Crawford", "name": "Michael H.", "pid": [], "rank": 5, "affiliation": [], "fullname": "Crawford, Michael H."}, {"surname": "Salzano", "name": "Francisco M.", "pid": [], "rank": 6, "affiliation": [], "fullname": "Salzano, Francisco M."}, {"surname": "Bonatto", "name": "Sandro L.", "pid": [], "rank": 7, "affiliation": [], "fullname": "Bonatto, Sandro L."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "http://creativecommons.org/licenses/by/4.0/"}, "url": ["http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200206&lng=en&tlng=en"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-01-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-04-22T15:08:13.708Z", "fulltext": [], "dateoftransformation": "2020-03-05T17:56:15.371Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Abstract In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "text/html"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Sociedade Brasileira de Gen\\xe9tica"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:scielo:S1415-47572018000200206"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Genetics and Molecular Biology, Volume: 41, Issue: 1 Supplement 1, Pages: 206-214, Published: 2018"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}], "id": "50|od_______608::c18e77bcf6417b170f22ed36a62ef13d", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Bacillus"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "degradation"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "manipueira"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "fertirrigation"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Vasconcellos", "name": "S. 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Thirty one microbial strains were isolated from manipueira, a liquid effluent of cassava processing factories. Among these strains, Bacillus licheniformis (isolate 2_2) and Rhodotorulla glutinis (isolate L1) were able to degrade 71% and 95% of added linamarin, respectively, within 7 days, showing high biodegradation activity and great potential for detoxification of cassava processing wastewaters."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "text/html"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2009-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Sociedade Brasileira de Microbiologia"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:scielo:S1517-83822009000400019"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Brazilian Journal of Microbiology, Volume: 40, Issue: 4, Pages: 879-883, Published: DEC 2009"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "In vitro degradation of linamarin by microorganisms isolated from cassava wastewater treatment lagoons"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - 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The performance of both methods was analyzed based on two datasets: 1) a complete site x species matrix compiled from two studies in different land uses in the Amazon using direct analysis of field samples and trap cultures. 2) Total number of AMF morphotypes detected by both methods in published manuscripts across several ecosystems. From dataset 1, direct analysis of field samples revealed 57 morphotypes, whereas only 21 of these were detected by trap culture. Community variation (beta diversity) analysis revealed that field samples are far more sensitive in detecting shifts in AMF community composition among land uses than trap cultures in the Amazon region, with the combined results of both methods being not better than that obtained only by direct analysis of field samples. 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a comparative study"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}], "id": "50|od_______608::de715689eb8cf69f5c93275d325a152b", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Inflammation"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Edema"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Medicinal plants"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Anacardiaceae"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Machado", "name": "Alessandra Cury", "pid": [], "rank": 1, "affiliation": [], "fullname": "Machado, Alessandra Cury"}, {"surname": "Dezan Junior", "name": "Eloi", "pid": [], "rank": 2, "affiliation": [], "fullname": "Dezan Junior, Eloi"}, {"surname": "Gomes-Filho", "name": "Joa\\u0303o Eduardo", "pid": [], "rank": 3, "affiliation": [], "fullname": "Gomes-Filho, Jo\\xe3o Eduardo"}, {"surname": "Cintra", "name": "Luciano Tavares Angelo", "pid": [], "rank": 4, "affiliation": [], "fullname": "Cintra, Luciano Tavares Angelo"}, {"surname": "Ruvie\\u0301re", "name": "Denise Belucio", "pid": [], "rank": 5, "affiliation": [], "fullname": "Ruvi\\xe9re, Denise Belucio"}, {"surname": "Zoccal", "name": "Renata", "pid": [], "rank": 6, "affiliation": [], "fullname": "Zoccal, Renata"}, {"surname": "Damante", "name": "Carla Andreotti", "pid": [], "rank": 7, "affiliation": [], "fullname": "Damante, Carla Andreotti"}, {"surname": "Jardim Junior", "name": "Elerson Gaetti", "pid": [], "rank": 8, "affiliation": [], "fullname": "Jardim Junior, Elerson Gaetti"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - 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MATERIAL AND METHODS: Test groups consisted of aqueous and ethanolic Aroeira extracts and saline (control). For edema quantification, 18 rats received an intravenous injection of Evan's Blue. After 30 min, the extracts and saline were injected on the dorsum of the rats, which were then sacrificed after 3 and 6 h. Readings were performed in a spectrophotometer. For subcutaneous implantation, 30 rats received a polyethylene tube containing the extracts on their dorsum and then they were killed after 7 and 28 days. The samples were processed for histological analysis and evaluated with a light microscope. The inflammatory infiltrate was quantified. RESULTS: There were no statistically significant differences between aqueous extract and saline groups in relation to edema quantification in the different periods (p>0.05). Ethanolic solution resulted in more edema independently of the experimental period (p<0.05). Histological analysis showed similar results on the 7-day period for the 3 groups. There was a notable reduction on inflammatory cell number for saline and aqueous extract groups at 28 days. CONCLUSION: The aqueous extract showed biocompatible properties similar to those of saline."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "text/html"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-08-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Faculdade De Odontologia De Bauru - 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T.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Li, H.T."}, {"surname": "Li", "name": "S. H.", "pid": [], "rank": 3, "affiliation": [], "fullname": "Li, S.H."}, {"surname": "Li", "name": "X.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Li, X."}, {"surname": "Duan", "name": "J. M.", "pid": [], "rank": 5, "affiliation": [], "fullname": "Duan, J.M."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "http://creativecommons.org/licenses/by/4.0/"}, "url": ["http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000604&lng=en&tlng=en"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-09-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2017-11-22T20:05:23.65Z", "fulltext": [], "dateoftransformation": "2020-03-05T18:32:46.905Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Stem cells from human exfoliated deciduous teeth (SHEDs) have great potential to treat various dental-related diseases in regenerative medicine. They are usually maintained with 10% fetal bovine serum (FBS) in vitro. Modified platelet-rich plasma (mPRP) would be a safe alternative to 10% FBS during SHEDs culture. Therefore, our study aimed to compare the proliferation and differentiation of SHEDs cultured in mPRP and FBS medium to explore an optimal concentration of mPRP for SHEDs maintenance. Platelets were harvested by automatic blood cell analyzer and activated by repeated liquid nitrogen freezing and thawing. The platelet-related cytokines were examined and analyzed by ELISA. SHEDs were extracted and cultured with different concentrations of mPRP or 10% FBS medium. Alkaline phosphatase (ALP) activity was measured. Mineralization factors, RUNX2 and OCN, were measured by real-time PCR. SHEDs were characterized with mesenchymal stem cells (MSCs) markers including vimentin, CD44, and CD105. mPRP at different concentrations (2, 5, 10, and 20%) enhanced the growth of SHEDs. Moreover, mPRP significantly stimulated ALP activity and promoted expression of RUNX2 and OCN compared with 10% FBS. mPRP could efficiently facilitate proliferation and differentiation of SHEDs, and 2% mPRP would be an optimal substitute for 10% FBS during SHEDs expansion and differentiation in clinical scale manufacturing."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "text/html"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-09-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Associa\\xe7\\xe3o Brasileira de Divulga\\xe7\\xe3o Cient\\xedfica"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:scielo:S0100-879X2016001000604"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Brazilian Journal of Medical and Biological Research, Volume: 49, Issue: 10, Article number: e5373, Published: 01 SEP 2016"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Investigation of modified platelet-rich plasma (mPRP) in promoting the proliferation and differentiation of dental pulp stem cells from deciduous teeth"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}], "id": "50|od_______608::ecbd7f91aa73268b8d3dfb4493862b0c", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Incisor"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Cleft lip"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Cleft palate"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:result_subject", "schemename": "dnet:result_subject"}, "value": "Oral rehabilitation"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Tereza", "name": "Guida Paola Genovez", "pid": [], "rank": 1, "affiliation": [], "fullname": "Tereza, Guida Paola Genovez"}, {"surname": "Santos", "name": "Marcos Anto\\u0302nio Corre\\u0302a Dos", "pid": [], "rank": 2, "affiliation": [], "fullname": "Santos, Marcos Ant\\xf4nio Corr\\xeaa dos"}, {"surname": "Winckler", "name": "Vivian Patricia Saldias Vargas", "pid": [], "rank": 3, "affiliation": [], "fullname": "Winckler, Vivian Patricia Saldias Vargas"}, {"surname": "Almeida", "name": "Ana Lu\\u0301cia Pompeia Fraga", "pid": [], "rank": 4, "affiliation": [], "fullname": "Almeida, Ana L\\xfacia Pompeia Fraga de"}, {"surname": "Dalben", "name": "Gisele Da Silva", "pid": [], "rank": 5, "affiliation": [], "fullname": "Dalben, Gisele da Silva"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "http://creativecommons.org/licenses/by/4.0/"}, "url": ["http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572018000100438&lng=en&tlng=en"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2018-05-07"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::996a7fa078cc36c46d02f9af3bef918b", "value": "Scientific Electronic Library Online - Brazil"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2018-07-07T15:09:37.426Z", "fulltext": [], "dateoftransformation": "2020-03-05T18:38:07.379Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Abstract Objective This study analyzed the maintenance of lateral incisors in the dental rehabilitation of individuals with cleft lip and palate. Material and Methods The study was conducted on a tertiary craniofacial center and comprised retrospective analysis of panoramic and periapical radiographs of Caucasoid individuals with non-syndromic complete unilateral cleft lip and palate, analyzing all radiographs available on the records of each individual, from the first to the last up to 12 years of age. Overall, 2,826 records were reviewed to achieve a sample of 1,000 individuals. Among these, 487 individuals presented the permanent lateral incisors on both cleft and non-cleft sides, which were included in this study. Results The results were evaluated in percentages and by descriptive statistics. The association between maintenance of the lateral incisor and timing of alveolar bone graft were analyzed by the t test. Among the 487 individuals, 265 had not completed treatment, 62 presented insufficient information, and 44 concluded the treatment elsewhere. Among the remaining 116 individuals, the lateral incisor was extracted from 88 (75.86%) of them on the cleft side (CS) and from 23 (19.83%) people on the non-cleft side (NCS). The age at accomplishment of alveolar bone graft was significantly associated with maintenance of the lateral incisor on the cleft side (p<0.01). Most extractions were indicated because of the inadequate positioning on the CS and for midline correction on the NCS. Rehabilitation was primarily completed by orthodontic movement (53 individuals on the CS and 13 individuals on the NCS). Conclusion In conclusion, the lateral incisor on the cleft side was not maintained in most individuals. 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"dnet:publication_resource"}}], "dateofcollection": "2017-09-25T14:02:01.908Z", "fulltext": [], "dateoftransformation": "2019-07-02T09:47:50.826Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value":"Background Mental health problems are a worldwide public health burden. The literature concerning the mental health benefits from physical activity among adults has grown. Adolescents are less studied, and especially longitudinal studies are lacking. This paper investigates the associations between weekly hours of physical activity at age 15?16 and mental health three years later. Methods Longitudinal self-reported health survey. The baseline study consisted of participants from the youth section of the Oslo Health Study, carried out in schools in 2000?2001 (n = 3811). The follow-up in 2003?2004 was conducted partly at school and partly through mail. A total of 2489 (1112 boys and 1377 girls) participated in the follow-up. Mental health was measured by the Strengths and Difficulties Questionnaire with an impact supplement. Physical activity was measured by a question on weekly hours of physical activity outside of school, defined as exertion \"to an extent that made you sweat and/or out of breath\". Adjustments were made for well-documented confounders and mental health at baseline. Results In boys, the number of hours spent on physical activity per week at age 15?16 was negatively associated with emotional symptoms [B (95%CI) = -0.09 (-0.15, -0.03)] and peer problems [B (95%CI) = -0.08 (-0.14, -0.03)] at age 18?19 after adjustments. In girls, there were no significant differences in SDQ subscales at age 18?19 according to weekly hours of physical activity at age 15?16 after adjustments. Boys and girls with five to seven hours of physical activity per week at age 15?16 had the lowest mean scores for total difficulties and the lowest percentage with high impact score at age 18?19, but the differences were not statistically significant after adjustments. Conclusion Weekly hours of physical activity at age 15?16 years was weakly associated with mental health at three-year follow-up in boys. Results encourage a search for further knowledge about physical activity as a possible protective factor in relation to mental health problems in adolescence."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "7", "conferenceplace": "", "name": "BMC Public Health", "iss": "", "sp": "155", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1471-2458", "ep": "155", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2007-07-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, 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Here, we synthesized a new series of piperazine-containing benzothiazinones (PBTZ) and show that, like BTZ043, the preclinical candidate PBTZ169 binds covalently to DprE1. The crystal structure of the DprE1-PBTZ169 complex reveals formation of a semimercaptal adduct with Cys387 in the active site and explains the irreversible inactivation of the enzyme. Compared to BTZ043, PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). When combined with other TB drugs, PBTZ169 showed additive activity against M.\\xa0tuberculosis in vitro except with bedaquiline (BDQ) where synergy was observed. A new regimen comprising PBTZ169, BDQ and pyrazinamide was found to be more efficacious than the standard three drug treatment in a murine model of chronic disease. PBTZ169 is thus an attractive drug candidate to treat TB in humans. 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Material and methods Test groups consisted of aqueous and ethanolic Aroeira extracts and saline (control). For edema quantification, 18 rats received an intravenous injection of Evan's Blue. After 30 min, the extracts and saline were injected on the dorsum of the rats, which were then sacrificed after 3 and 6 h. Readings were performed in a spectrophotometer. For subcutaneous implantation, 30 rats received a polyethylene tube containing the extracts on their dorsum and then they were killed after 7 and 28 days. The samples were processed for histological analysis and evaluated with a light microscope. The inflammatory infiltrate was quantified. Results There were no statistically significant differences between aqueous extract and saline groups in relation to edema quantification in the different periods (p>0.05). Ethanolic solution resulted in more edema independently of the experimental period (p<0.05). Histological analysis showed similar results on the 7-day period for the 3 groups. There was a notable reduction on inflammatory cell number for saline and aqueous extract groups at 28 days. Conclusion The aqueous extract showed biocompatible properties similar to those of saline."}], "format": [], "journal": {"issnPrinted": "1678-7757", "conferencedate": "", "vol": "20", "conferenceplace": "", "name": "Journal of Applied Oral Science", "iss": "4", "sp": "414", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1678-7765", "ep": "418", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, 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"main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Evaluation of tissue reaction to Aroeira (Myracrodruon urundeuva) extracts: a histologic and edemogenic study"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmc", "classname": "pmc", "schemeid": "dnet:pid_types", "schemename": 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"value": "Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of ?-lactam antibiotics, which are often prescribed to treat H.?influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when ?-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for ?-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults. A large variety of studies suggest that biofilm formation by NTHi may be an important step in the pathogenesis of this bacterium. However, the underlying mechanisms involved in this process are poorly elucidated. In this study, we used a transposon mutant library to identify bacterial genes involved in biofilm formation. The growth and biofilm formation of 4,172 transposon mutants were determined, and the involvement of the identified genes in biofilm formation was validated in in vitro experiments. Here, we present experimental data showing that increased bacterial lysis, through interference with peptidoglycan synthesis, results in elevated levels of extracellular DNA, which increased biofilm formation. Interestingly, similar results were obtained with subinhibitory concentrations of ?-lactam antibiotics, known to interfere with peptidoglycan synthesis, but such an effect does not appear with other classes of antibiotics. These results indicate that treatment with ?-lactam antibiotics, especially for ?-lactam-resistant NTHi isolates, might increase resistance to antibiotics by increasing biofilm formation. IMPORTANCE Most, if not all, bacteria form a biofilm, a multicellular structure that protects them from antimicrobial actions of the host immune system and affords resistance to antibiotics. The latter is especially disturbing with the increase in multiresistant bacterial clones worldwide. Bacterial biofilm formation is a multistep process that starts with surface adhesion, after which attached bacteria divide and give rise to biomass. The actual steps required for Haemophilus influenzae biofilm formation are largely not known. We show that interference with peptidoglycan biosynthesis increases biofilm formation because of the release of bacterial genomic DNA. Subinhibitory concentrations of ?-lactam antibiotics, which are often prescribed to treat H.?influenzae infections, increase biofilm formation through a similar mechanism. Therefore, when ?-lactam antibiotics do not reach their MIC in vivo, they might not only drive selection for ?-lactam-resistant clones but also increase biofilm formation and resistance to other antimicrobial compounds."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "2", "conferenceplace": "", "name": "mSphere", "iss": "1", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "2379-5042", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2017-01-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", 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"rank": 1, "affiliation": [], "fullname": "David, Marion A."}, {"surname": "Orlowski", "name": "St Phane", "pid": [], "rank": 2, "affiliation": [], "fullname": "Orlowski, St?phane"}, {"surname": "Prichard", "name": "Roger K.", "pid": [], "rank": 3, "affiliation": [], "fullname": "Prichard, Roger K."}, {"surname": "Hashem", "name": "Shaima", "pid": [], "rank": 4, "affiliation": [], "fullname": "Hashem, Shaima"}, {"surname": "Andr", "name": "Fran Ois", "pid": [], "rank": 5, "affiliation": [], "fullname": "Andr?, Fran?ois"}, {"surname": "Lespine", "name": "Anne", "pid": [], "rank": 6, "affiliation": [], "fullname": "Lespine, Anne"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": 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"2019-07-02T18:03:05.132Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Macrocyclic lactones (ML) are important anthelmintics used in animals and humans against parasite nematodes, but their therapeutic success is compromised by the spread of ML resistance. Some ABC transporters, such as p-glycoproteins (Pgps), are selected and overexpressed in ML-resistant nematodes, supporting a role for some drug efflux proteins in ML resistance. However, the role of such proteins in ML transport remains to be clarified at the molecular level. Recently, Caenorhabditis elegans Pgp-1 (Cel-Pgp-1) has been crystallized, and its drug-modulated ATPase function characterized in?vitro revealed Cel-Pgp-1 as a multidrug transporter. Using this crystal structure, we have developed an in silico drug docking model in order to study the binding of ML and other anthelmintic drugs to Cel-Pgp-1. All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1. Interestingly, interacting residues delineate a ML specific fingerprint involving H-bonds, including T1028. In particular, benzofurane and spiroketal moieties bound to specific sub-sites. When compared with the aglycone ML, such as moxidectin and ivermectin aglycone, avermectin anthelmintics have significant higher affinity for Cel-Pgp-1, likely due to the sugar substituent(s) that bind to a specific area involving H-bonds at Y771. Triclabendazole, closantel and emodepside bound with good affinities to different sub-sites in the inner chamber, partially overlapping with the ML binding site, suggesting that they could compete for Cel-Pgp-1-mediated ML transport. In conclusion, this work provides novel information on the role of nematode Pgps in transporting anthelmintics, and a valuable tool to predict drug-drug interactions and to rationally design new competitive inhibitors of clinically-relevant nematode Pgps, to improve anthelmintic therapeutics."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Graphical abstract Ivermectin (red spheres) binding to Cel-Pgp-1 (blue ribbon: N-term, yellow ribbon: C-term). Image 1"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Highlights ? Cel-Pgp-1 cristal provides a valuable tool to study anthelmintic interactions. ? Cel-Pgp-1 recognizes a broad panel of anthelmintics, including macrocyclic lactones. ? Cel-Pgp-1 is predicted to transport MLs and contribute to anthelmintic resistance. ? Sugars in avermectins increase the affinity to Cel-Pgp-1 compared with moxidectin. ? 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They are usually maintained with 10% fetal bovine serum (FBS) in vitro. Modified platelet-rich plasma (mPRP) would be a safe alternative to 10% FBS during SHEDs culture. Therefore, our study aimed to compare the proliferation and differentiation of SHEDs cultured in mPRP and FBS medium to explore an optimal concentration of mPRP for SHEDs maintenance. Platelets were harvested by automatic blood cell analyzer and activated by repeated liquid nitrogen freezing and thawing. The platelet-related cytokines were examined and analyzed by ELISA. SHEDs were extracted and cultured with different concentrations of mPRP or 10% FBS medium. Alkaline phosphatase (ALP) activity was measured. Mineralization factors, RUNX2 and OCN, were measured by real-time PCR. SHEDs were characterized with mesenchymal stem cells (MSCs) markers including vimentin, CD44, and CD105. mPRP at different concentrations (2, 5, 10, and 20%) enhanced the growth of SHEDs. 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Bruce"}, {"surname": "Zho", "name": "Dejian", "pid": [{"qualifier": {"classid": "ORCID", "classname": "ORCID"}, "value": "0000-0003-3314-9242"}], "rank": 9, "affiliation": [], "fullname": "Zhou, Dejian"}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://europepmc.org/articles/PMC4979658"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-03-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2017-09-25T16:15:20.935Z", "fulltext": [], "dateoftransformation": "2019-07-02T21:52:19.156Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Abstract A highly efficient cap?exchange approach for preparing compact, dense polyvalent mannose?capped quantum dots (QDs) has been developed. The resulting QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC?SIGN and DC?SIGNR (collectively termed as DC?SIGN/R) using a sensitive, ratiometric F?rster resonance energy transfer (FRET) assay. The QD probes specifically bind DC?SIGN, but not its closely related receptor DC?SIGNR, which is further confirmed by its specific blocking of DC?SIGN engagement with the Ebola virus glycoprotein. Tuning the QD surface mannose valency reveals that DC?SIGN binds more efficiently to densely packed mannosides. A FRET?based thermodynamic study reveals that the binding is enthalpy?driven. This work establishes QD FRET as a rapid, sensitive technique for probing structure and thermodynamics of multivalent protein?ligand interactions."}], "format": [], "journal": {"issnPrinted": "1433-7851", "conferencedate": "", "vol": "55", "conferenceplace": "", "name": "Angewandte Chemie (International Ed. in English)", "iss": "15", "sp": "4738", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1521-3773", "ep": "4742", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-03-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "John Wiley and Sons Inc."}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:europepmc.org:3953534"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Angewandte Chemie (International Ed. in English)"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein?Ligand Interactions"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmc", "classname": 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false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Dental health services"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Dental care"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Inequalities in health care services"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Health surveys"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Monteiro", "name": "Camila Nascimento", "pid": [], "rank": 1, "affiliation": [], "fullname": "Monteiro, Camila Nascimento"}, {"surname": "Beenackers", "name": "Mari Lle A.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Beenackers, Mari?lle A."}, {"surname": "Goldbaum", "name": "Mois S.", "pid": [], "rank": 3, "affiliation": [], "fullname": "Goldbaum, Mois?s"}, {"surname": "Azevedo Barros", "name": "Marilisa Berti", "pid": [], "rank": 4, "affiliation": [], "fullname": "de Azevedo Barros, Marilisa Berti"}, {"surname": "Gianini", "name": "Reinaldo Jos", "pid": [], "rank": 5, "affiliation": [], "fullname": "Gianini, Reinaldo Jos?"}, {"surname": "Cesar", "name": "Chester Luiz Galv O.", "pid": [], "rank": 6, "affiliation": [], "fullname": "Cesar, Chester Luiz Galv?o"}, {"surname": "Mackenbach", "name": "Johan P.", "pid": [], "rank": 7, "affiliation": [], "fullname": "Mackenbach, Johan P."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://europepmc.org/articles/PMC5142432"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2017-09-25T16:02:23.936Z", "fulltext": [], "dateoftransformation": "2019-07-02T22:26:52.735Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Background Access to, and use of, dental health services in Brazil have improved since 2003. The increase of private health care plans and the implementation of the ?Smiling Brazil? Program, the largest public oral health care program in the world, could have influenced this increase in access. However, we do not yet know if inequalities in the use of dental health services persist after the improvement in access. The aims of this study are to analyze socioeconomic differences for dental health service use between 2003 and 2008 in S?o Paulo and to examine changes in these associations since the implementation of the Smiling Brazil program in 2003. Method Data was obtained via two household health surveys (ISA-Capital 2003 and ISA-Capital 2008) which investigated living conditions, lifestyle, health status and use of health care services. Logistic regression was used to analyze associations between socioeconomic factors and dental services use. Additionally, trends from 2003 to 2008 regarding socioeconomic characteristics and dental health service use were explored. Results Overall, dental health service use increased between 2003 and 2008 and was at both time points more common among those who had higher income, better education, better housing conditions, private health care plans and were Caucasian. Inequalities in use of dental health care did not decrease over time. Among the reasons for not seeking dental care, not having teeth and financial difficulty were more common in lower socioeconomic groups, while thinking it was unnecessary was more common in higher socioeconomic groups. Conclusions The Brazilian oral health policy is still in a period of expansion and seems to have contributed slightly to increased dental health service use, but has not influenced socioeconomic inequalities in the use of these services. Acquiring deeper knowledge about inequalities in dental health service use will contribute to better understanding of potential barriers to reducing them. Electronic supplementary material The online version of this article (doi:10.1186/s12913-016-1928-y) contains supplementary material, which is available to authorized users."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "16", "conferenceplace": "", "name": "BMC Health Services Research", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "1472-6963", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-12-01"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "BioMed Central"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:europepmc.org:4095602"], "source": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "BMC Health Services Research"}], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Socioeconomic inequalities in dental health services in Sao Paulo, Brazil, 2003?2008"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmc", "classname": "pmc", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "PMC4926307"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1186/s12711-016-0225-x"}], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}], "id": "50|od_______908::b331440083ff90d987942554a6ef0e60", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Research Article"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Calus", "name": "Mario P. L.", "pid": [{"qualifier": {"classid": "ORCID", "classname": "ORCID"}, "value": "0000-0002-3213-704X"}], "rank": 1, "affiliation": [], "fullname": "Calus, Mario P. L."}, {"surname": "Bouwman", "name": "Aniek C.", "pid": [], "rank": 2, "affiliation": [], "fullname": "Bouwman, Aniek C."}, {"surname": "Schrooten", "name": "Chris", "pid": [], "rank": 3, "affiliation": [], "fullname": "Schrooten, Chris"}, {"surname": "Veerkamp", "name": "Roel F.", "pid": [], "rank": 4, "affiliation": [], "fullname": "Veerkamp, Roel F."}], "instance": [{"refereed": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "hostedby": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "accessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "license": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "url": ["http://europepmc.org/articles/PMC4926307"], "distributionlocation": "", "processingchargecurrency": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2016-06-01"}, "collectedfrom": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c", "value": "Europe PubMed Central"}, "processingchargeamount": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "instancetype": {"classid": "0001", "classname": "Article", "schemeid": "dnet:publication_resource", "schemename": "dnet:publication_resource"}}], "dateofcollection": "2017-09-25T16:18:06.421Z", "fulltext": [], "dateoftransformation": "2019-07-02T22:46:54.79Z", "description": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Background Use of whole-genome sequence data is expected to increase persistency of genomic prediction across generations and breeds but affects model performance and requires increased computing time. In this study, we investigated whether the split-and-merge Bayesian stochastic search variable selection (BSSVS) model could overcome these issues. BSSVS is performed first on subsets of sequence-based variants and then on a merged dataset containing variants selected in the first step. Results We used a dataset that included 4,154,064 variants after editing and de-regressed proofs for 3415 reference and 2138 validation bulls for somatic cell score, protein yield and interval first to last insemination. In the first step, BSSVS was performed on 106 subsets each containing ~39,189 variants. In the second step, 1060 up to 472,492 variants, selected from the first step, were included to estimate the accuracy of genomic prediction. Accuracies were at best equal to those achieved with the commonly used Bovine 50k-SNP chip, although the number of variants within a few well-known quantitative trait loci regions was considerably enriched. When variant selection and the final genomic prediction were performed on the same data, predictions were biased. Predictions computed as the average of the predictions computed for each subset achieved the highest accuracies, i.e. 0.5?to?1.1?% higher than the accuracies obtained with the 50k-SNP chip, and yielded the least biased predictions. Finally, the accuracy of genomic predictions obtained when all sequence-based variants were included was similar or up to 1.4?% lower compared to that based on the average predictions across the subsets. By applying parallelization, the split-and-merge procedure was completed in 5?days, while the standard analysis including all sequence-based variants took more than three?months. Conclusions The split-and-merge approach splits one large computational task into many much smaller ones, which allows the use of parallel processing and thus efficient genomic prediction based on whole-genome sequence data. The split-and-merge approach did not improve prediction accuracy, probably because we used data on a single breed for which relationships between individuals were high. Nevertheless, the split-and-merge approach may have potential for applications on data from multiple breeds. 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Enucleation is frequently the only management option for this condition, resulting in blindness and psychosocial distress. Even when the cornea remains grossly intact, visual function could also be impaired by a high degree of myopia and keratoconus. Deafness is another common feature and results in combined sensory deprivation. Using autozygosity mapping, we identified mutations in PRDM5 in families with BCS. We demonstrate that regulation of expression of extracellular matrix components, particularly fibrillar collagens, by PRDM5 is a key molecular mechanism that underlies corneal fragility in BCS and controls normal corneal development and maintenance. ZNF469, encoding a zinc finger protein of hitherto undefined function, has been identified as a quantitative trait locus for central corneal thickness, and mutations in this gene have been demonstrated in Tunisian Jewish and Palestinian kindreds with BCS. 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The resulting QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC?SIGN and DC?SIGNR (collectively termed as DC?SIGN/R) using a sensitive, ratiometric F?rster resonance energy transfer (FRET) assay. The QD probes specifically bind DC?SIGN, but not its closely related receptor DC?SIGNR, which is further confirmed by its specific blocking of DC?SIGN engagement with the Ebola virus glycoprotein. Tuning the QD surface mannose valency reveals that DC?SIGN binds more efficiently to densely packed mannosides. A FRET?based thermodynamic study reveals that the binding is enthalpy?driven. 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observation of time-reversal violation. The decays of entangled neutral B mesons into definite flavor states ( B 0 or \\xaf\\xaf\\xaf B 0 ), and J / \\u03c8 K 0 L or c \\xaf c K 0 S final states (referred to as B + or B \\u2212 ), allow comparisons between the probabilities of four pairs of T -conjugated transitions, for example, \\xaf\\xaf\\xaf B 0 \\u2192 B \\u2212 and B \\u2212 \\u2192 \\xaf\\xaf\\xaf B 0 , as a function of the time difference between the two B decays. Using 468 \\xd7 10 6 B \\xaf\\xaf\\xaf B pairs produced in \\u03a5 ( 4 S ) decays collected by the BABAR detector at SLAC, we measure T -violating parameters in the time evolution of neutral B mesons, yielding \\u0394 S + T = \\u2212 1.37 \\xb1 0.14 ( stat ) \\xb1 0.06 ( syst ) and \\u0394 S \\u2212 T = 1.17 \\xb1 0.18 ( stat ) \\xb1 0.11 ( syst ) . These nonzero results represent the first direct observation of T violation through the exchange of initial and final states in transitions that can only be connected by a T -symmetry transformation."}], "format": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "8 p."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "application/pdf"}], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "2012-11-19"}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "American Physical Society"}, "language": {"classid": "eng", "classname": "English", "schemeid": "dnet:languages", "schemename": "dnet:languages"}, "bestaccessright": {"classid": "OPEN", "classname": "Open Access", "schemeid": "dnet:access_modes", "schemename": "dnet:access_modes"}, "country": [], "extraInfo": [], "originalId": ["oai:diposit.ub.edu:2445/133262"], "source": [], "context": [], "title": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "main title", "classname": "main title", "schemeid": "dnet:dataCite_title", "schemename": "dnet:dataCite_title"}, "value": "Observation of Time-Reversal Violation in the B0 Meson System"}]} +{"dataInfo": {"provenanceaction": {"classid": "sysimport:crosswalk:repository", "classname": "sysimport:crosswalk:repository", "schemeid": "dnet:provenanceActions", "schemename": "dnet:provenanceActions"}, "deletedbyinference": false, "inferred": true, "inferenceprovenance": "dedup-similarity-result-levenstein", "invisible": false, "trust": "0.9"}, "resourcetype": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "pid": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "doi", "classname": "doi", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "10.1103/PhysRevLett.109.211801"}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "pmid", "classname": "pmid", "schemeid": "dnet:pid_types", "schemename": "dnet:pid_types"}, "value": "23215586"}], "contributor": [], "resulttype": {"classid": "publication", "classname": "publication", "schemeid": "dnet:result_typologies", "schemename": "dnet:result_typologies"}, "relevantdate": [], "collectedfrom": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "key": "10|opendoar____::89fcd07f20b6785b92134bd6c1d0fa42", "value": "Archivio Istituzionale"}], "id": "50|od_______970::4a33e89a1336f15c6c259086b34890ad", "subject": [{"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "qualifier": {"classid": "keyword", "classname": "keyword", "schemeid": "dnet:subject_classification_typologies", "schemename": "dnet:subject_classification_typologies"}, "value": "Physics and Astronomy (all)"}], "embargoenddate": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "lastupdatetimestamp": 0, "author": [{"surname": "Lees", "name": "J. 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The decays of entangled neutral B mesons into definite flavor states ($B^0$ or $\\\\bar{B}^0$), and $J/\\\\psi K_S^0$ or $c\\\\bar{c} K_S^0$ final states (referred to as $B_+$ or $B_-$), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, $\\\\bar{B}^0 \\\\rightarrow B_-$ and $B_- \\\\rightarrow \\\\bar{B}^0$, as a function of the time difference between the two B decays. Using 468 million $B\\\\bar{B}$ pairs produced in $\\\\Upsilon(4S)$ decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding $\\\\Delta S_T^+ = -1.37 \\\\pm 0.14 (stat.) \\\\pm 0.06 (syst.)$ and $\\\\Delta S_T^- = 1.17 \\\\pm 0.18 (stat.) \\\\pm 0.11 (syst.)$. These nonzero results represent the first direct observation of T violation through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation."}, {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": "Comment: 7 pages, 3 postscript figures, 1 table, appendix with 4 pages containing supplementary material. Accepted by Phys. Rev. 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We use data from direct numerical simulations up to Taylor's Reynolds number 280 following the evolution of about two million passive tracers advected by the flow over a time span of about three decades. We present data for both the separation distance and the relative velocity statistics. Statistics are measured along the particle pair trajectories both as a function of time and as a function of their separation, i.e. at fixed scales. We compare and contrast both sets of statistics in order to gain an insight into the mechanisms governing the separation process. We find very high levels of intermittency in the early stages, that is, for travel times up to order ten Kolmogorov time scales. The fixed scale statistics allow us to quantify anomalous corrections to Richardson diffusion in the inertial range of scales for those pairs that separate rapidly. 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In Cear\\xe1, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Cear\\xe1, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. 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The decays of entangled neutral B mesons into definite flavor states (B(0) or B(0)), and J/\\u03c8K(L)(0) or ccK(S)(0) final states (referred to as B(+) or B(-)), allow comparisons between the probabilities of four pairs of T-conjugated transitions, for example, B(0) \\u2192 B(-) and B(-) \\u2192 B(0), as a function of the time difference between the two B decays. Using 468 \\xd7 10(6) BB pairs produced in \\u03a5(4S) decays collected by the BABAR detector at SLAC, we measure T-violating parameters in the time evolution of neutral B mesons, yielding \\u0394S(T)(+) = -1.37 \\xb1 0.14(stat) \\xb1 0.06(syst) and \\u0394S(T)(-) = 1.17 \\xb1 0.18(stat) \\xb1 0.11(syst). These nonzero results represent the first direct observation of T violation through the exchange of initial and final states in transitions that can only be connected by a T-symmetry transformation."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, 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Here, we tested whether deletion of PARP-2, an alternative NAD(+)-consuming enzyme, impacts on NAD(+) bioavailability and SIRT1 activity. Our results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes. However, this increase was not due to changes in NAD(+) levels, but to an increase in SIRT1 expression, as PARP-2 acts as a direct negative regulator of the SIRT1 promoter. PARP-2 deletion in mice increases SIRT1 levels, promotes energy expenditure, and increases mitochondrial content. Furthermore, PARP-2(-/-) mice were protected against diet-induced obesity. Despite being insulin sensitized, PARP-2(-/-) mice were glucose intolerant due to a defective pancreatic function. Hence, while inhibition of PARP activity promotes oxidative metabolism through SIRT1 activation, the use of PARP inhibitors for metabolic purposes will require further understanding of the specific functions of different PARP family members."}], "format": [], "journal": {"issnPrinted": "", "conferencedate": "", "vol": "", "conferenceplace": "", "name": "", "iss": "", "sp": "", "edition": "", "dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "issnOnline": "", "ep": "", "issnLinking": ""}, "dateofacceptance": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", "schemeid": "", "schemename": ""}, "deletedbyinference": false, "inferred": false, "inferenceprovenance": "", "invisible": false, "trust": ""}, "value": ""}, "coverage": [], "publisher": {"dataInfo": {"provenanceaction": {"classid": "", "classname": "", 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The increase of private health care plans and the implementation of the \\u201cSmiling Brazil\\u201d Program, the largest public oral health care program in the world, could have influenced this increase in access. However, we do not yet know if inequalities in the use of dental health services persist after the improvement in access. The aims of this study are to analyze socioeconomic differences for dental health service use between 2003 and 2008 in Sao Paulo and to examine changes in these associations since the implementation of the Smiling Brazil program in 2003. Data was obtained via two household health surveys (ISA-Capital 2003 and ISA-Capital 2008) which investigated living conditions, lifestyle, health status and use of health care services. Logistic regression was used to analyze associations between socioeconomic factors and dental services use. Additionally, trends from 2003 to 2008 regarding socioeconomic characteristics and dental health service use were explored. Overall, dental health service use increased between 2003 and 2008 and was at both time points more common among those who had higher income, better education, better housing conditions, private health care plans and were Caucasian. Inequalities in use of dental health care did not decrease over time. Among the reasons for not seeking dental care, not having teeth and financial difficulty were more common in lower socioeconomic groups, while thinking it was unnecessary was more common in higher socioeconomic groups. The Brazilian oral health policy is still in a period of expansion and seems to have contributed slightly to increased dental health service use, but has not influenced socioeconomic inequalities in the use of these services. 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Technically, SmartVox is a distributed web application that delivers audiovisual scores through the performer's mobile devices. From a singer's point of view, this setup allows for the synergy between visual and acoustic stimuli, which facilitates the interpretive and performative processes, particularly in polyphonic passages. It also enables spatial separation of the performers (cori spezzati ), and speeds up the learning process of unfamiliar musical materials (e.g. microtonal tuning, texts in a foreign language). 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