{

    "indexed": {
      "date-parts": [
        [
          2022,
          4,
          5
        ]
      ],
      "date-time": "2022-04-05T11:07:00Z",
      "timestamp": 1649156820730
    },
    "reference-count": 63,
    "publisher": "Public Library of Science (PLoS)",
    "issue": "5",
    "license": [
      {
        "start": {
          "date-parts": [
            [
              2020,
              5,
              29
            ]
          ],
          "date-time": "2020-05-29T00:00:00Z",
          "timestamp": 1590710400000
        },
        "content-version": "vor",
        "delay-in-days": 0,
        "URL": "http://creativecommons.org/licenses/by/4.0/"
      }
    ],
    "funder": [
      {
        "DOI": "10.13039/501100001602",
        "name": "Science Foundation Ireland",
        "doi-asserted-by": "crossref",
        "award": [
          "SFI/12/RC/2273"
        ]
      },
      {
        "DOI": "10.13039/501100001602",
        "name": "Science Foundation Ireland",
        "doi-asserted-by": "crossref",
        "award": [
          "SFI/12/RC/2273"
        ]
      },
      {
        "DOI": "10.13039/501100001602",
        "name": "Science Foundation Ireland",
        "doi-asserted-by": "crossref",
        "award": [
          "SFI/12/RC/2273"
        ]
      },
      {
        "DOI": "10.13039/501100001602",
        "name": "Science Foundation Ireland",
        "doi-asserted-by": "crossref",
        "award": [
          "SFI/12/RC/2273"
        ]
      }
    ],
    "content-domain": {
      "domain": [
        "www.plosone.org"
      ],
      "crossmark-restriction": false
    },
    "short-container-title": [
      "PLoS ONE"
    ],
    "DOI": "10.1371/journal.pone.0233284",
    "type": "journal-article",
    "created": {
      "date-parts": [
        [
          2020,
          5,
          29
        ]
      ],
      "date-time": "2020-05-29T17:53:47Z",
      "timestamp": 1590774827000
    },
    "page": "e0233284",
    "update-policy": "http://dx.doi.org/10.1371/journal.pone.corrections_policy",
    "source": "Crossref",
    "is-referenced-by-count": 13,
    "title": [
      "Vancomycin and nisin A are effective against biofilms of multi-drug resistant Staphylococcus aureus isolates from human milk"
    ],
    "prefix": "10.1371",
    "volume": "15",
    "author": [
      {
        "ORCID": "http://orcid.org/0000-0003-4107-0278",
        "authenticated-orcid": true,
        "given": "Angeliki",
        "family": "Angelopoulou",
        "sequence": "first",
        "affiliation": [

        ]
      },
      {
        "given": "Des",
        "family": "Field",
        "sequence": "additional",
        "affiliation": [

        ]
      },
      {
        "given": "Mariana",
        "family": "Pérez-Ibarreche",
        "sequence": "additional",
        "affiliation": [

        ]
      },
      {
        "ORCID": "http://orcid.org/0000-0001-8317-6455",
        "authenticated-orcid": true,
        "given": "Alicja K.",
        "family": "Warda",
        "sequence": "additional",
        "affiliation": [

        ]
      },
      {
        "given": "Colin",
        "family": "Hill",
        "sequence": "additional",
        "affiliation": [

        ]
      },
      {
        "given": "R. Paul",
        "family": "Ross",
        "sequence": "additional",
        "affiliation": [

        ]
      }
    ],
    "member": "340",
    "published-online": {
      "date-parts": [
        [
          2020,
          5,
          29
        ]
      ]
    },
    "reference": [
      {
        "issue": "7–8",
        "key": "pone.0233284.ref001",
        "doi-asserted-by": "crossref",
        "first-page": "509",
        "DOI": "10.1016/S0899-9007(00)00363-4",
        "article-title": "Breast milk: a truly functional food",
        "volume": "16",
        "author": "B. Lönnerdal",
        "year": "2000",
        "journal-title": "Nutrition"
      },
      {
        "key": "pone.0233284.ref002",
        "first-page": "1",
        "volume-title": "Mastitis: causes and management",
        "author": "WHO",
        "year": "2000"
      },
      {
        "issue": "1–2",
        "key": "pone.0233284.ref003",
        "doi-asserted-by": "crossref",
        "first-page": "115",
        "DOI": "10.1038/pr.2014.178",
        "article-title": "Human milk and infant intestinal mucosal glycans guide succession of the neonatal intestinal microbiota",
        "volume": "77",
        "author": "DS Newburg",
        "year": "2015",
        "journal-title": "Pediatr Res"
      },
      {
        "issue": "7",
        "key": "pone.0233284.ref004",
        "doi-asserted-by": "crossref",
        "first-page": "647",
        "DOI": "10.1001/jamapediatrics.2017.0378",
        "article-title": "Association between breast milk bacterial communities and establishment and development of the infant gut microbiome",
        "volume": "171",
        "author": "PS Pannaraj",
        "year": "2017",
        "journal-title": "JAMA Pediatr"
      },
      {
        "issue": "Suppl 2:",
        "key": "pone.0233284.ref005",
        "doi-asserted-by": "crossref",
        "first-page": "S69",
        "DOI": "10.1542/peds.2008-1315i",
        "article-title": "Why mothers stop breastfeeding: mothers' self-reported reasons for stopping during the first year",
        "volume": "122",
        "author": "R Li",
        "year": "2008",
        "journal-title": "Pediatrics"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref006",
        "doi-asserted-by": "crossref",
        "first-page": "83",
        "DOI": "10.1007/s00430-017-0532-z",
        "article-title": "The microbiology and treatment of human mastitis",
        "volume": "207",
        "author": "A Angelopoulou",
        "year": "2018",
        "journal-title": "Med Microbiol Immunol"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref007",
        "doi-asserted-by": "crossref",
        "first-page": "169",
        "DOI": "10.3920/BM2013.0036",
        "article-title": "Probiotics for human lactational mastitis",
        "volume": "5",
        "author": "L Fernández",
        "year": "2014",
        "journal-title": "Benef Microbes"
      },
      {
        "issue": "15",
        "key": "pone.0233284.ref008",
        "doi-asserted-by": "crossref",
        "first-page": "4650",
        "DOI": "10.1128/AEM.02599-07",
        "article-title": "Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation",
        "volume": "74",
        "author": "E Jiménez",
        "year": "2008",
        "journal-title": "Appl Environ Microbiol"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref009",
        "doi-asserted-by": "crossref",
        "first-page": "406",
        "DOI": "10.1177/0890334415585078",
        "article-title": "Metagenomic analysis of milk of healthy and mastitis-suffering women",
        "volume": "31",
        "author": "E Jiménez",
        "year": "2015",
        "journal-title": "J Hum Lact"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref010",
        "doi-asserted-by": "crossref",
        "first-page": "176",
        "DOI": "10.1086/589241",
        "article-title": "Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers",
        "volume": "47",
        "author": "R Datta",
        "year": "2008",
        "journal-title": "Clin Infect Dis"
      },
      {
        "issue": "4",
        "key": "pone.0233284.ref011",
        "doi-asserted-by": "crossref",
        "DOI": "10.1128/microbiolspec.GPP3-0023-2018",
        "article-title": "Staphylococcal biofilms",
        "volume": "6",
        "author": "M. Otto",
        "year": "2018",
        "journal-title": "Microbiol Spectr"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref012",
        "doi-asserted-by": "crossref",
        "first-page": "9",
        "DOI": "10.1038/s41522-018-0053-6",
        "article-title": "Fighting biofilms with lantibiotics and other groups of bacteriocins",
        "volume": "4",
        "author": "H Mathur",
        "year": "2018",
        "journal-title": "NPJ Biofilms Microbiomes"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref013",
        "doi-asserted-by": "crossref",
        "first-page": "310",
        "DOI": "10.1128/MMBR.00041-08",
        "article-title": "Signals, regulatory networks, and materials that build and break bacterial biofilms",
        "volume": "73",
        "author": "E Karatan",
        "year": "2009",
        "journal-title": "Microbiol Mol Biol Rev"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref014",
        "doi-asserted-by": "crossref",
        "first-page": "147",
        "DOI": "10.1016/S1473-3099(01)00091-3",
        "article-title": "Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance",
        "volume": "1",
        "author": "K Hiramatsu",
        "year": "2001",
        "journal-title": "Lancet Infect Dis"
      },
      {
        "key": "pone.0233284.ref015",
        "doi-asserted-by": "crossref",
        "first-page": "339",
        "DOI": "10.1146/annurev.mi.38.100184.002011",
        "article-title": "The structure and mode of action of glycopeptide antibiotics of the vancomycin group",
        "volume": "38",
        "author": "JC Barna",
        "year": "1984",
        "journal-title": "Annu Rev Microbiol"
      },
      {
        "key": "pone.0233284.ref016",
        "unstructured": "Health Service Executive Mastitis Factsheet for Health Care Professionals. Available at: https://www.breastfeeding.ie/Uploads/Mastitis.pdf"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref017",
        "first-page": "136",
        "article-title": "Breast infection: a review of diagnosis and management practices",
        "volume": "14",
        "author": "E Boakes",
        "year": "2018",
        "journal-title": "Eur J Breast Health"
      },
      {
        "key": "pone.0233284.ref018",
        "doi-asserted-by": "crossref",
        "first-page": "1205",
        "DOI": "10.3389/fmicb.2017.01205",
        "article-title": "Bacteriocin-antimicrobial synergy: A medical and food perspective",
        "volume": "8",
        "author": "H Mathur",
        "year": "2017",
        "journal-title": "Front Microbiol"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref019",
        "doi-asserted-by": "crossref",
        "first-page": "223",
        "DOI": "10.1016/S0005-2736(99)00208-4",
        "article-title": "The lantibiotic nisin, a special case or not?",
        "volume": "1462",
        "author": "E Breukink",
        "year": "1999",
        "journal-title": "Biochim Biophys Acta"
      },
      {
        "issue": "10",
        "key": "pone.0233284.ref020",
        "doi-asserted-by": "crossref",
        "first-page": "963",
        "DOI": "10.1038/nsmb830",
        "article-title": "The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics",
        "volume": "11",
        "author": "ST Hsu",
        "year": "2004",
        "journal-title": "Nat Struct Mol Biol"
      },
      {
        "issue": "5793",
        "key": "pone.0233284.ref021",
        "doi-asserted-by": "crossref",
        "first-page": "1636",
        "DOI": "10.1126/science.1129818",
        "article-title": "An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II",
        "volume": "313",
        "author": "HE Hasper",
        "year": "2006",
        "journal-title": "Science"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref022",
        "doi-asserted-by": "crossref",
        "first-page": "1772",
        "DOI": "10.1074/jbc.M006770200",
        "article-title": "Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity",
        "volume": "276",
        "author": "I Wiedemann",
        "year": "2001",
        "journal-title": "J Biol Chem"
      },
      {
        "key": "pone.0233284.ref023",
        "doi-asserted-by": "crossref",
        "first-page": "104539",
        "DOI": "10.1016/j.idairyj.2019.104539",
        "article-title": "Bovine mastitis is a polymicrobial disease requiring a polydiagnostic approach",
        "volume": "99",
        "author": "A Angelopoulou",
        "year": "2019",
        "journal-title": "Int Dairy J"
      },
      {
        "issue": "4",
        "key": "pone.0233284.ref024",
        "doi-asserted-by": "crossref",
        "first-page": "493",
        "DOI": "10.1093/ajcp/45.4_ts.493",
        "article-title": "Antibiotic susceptibility testing by a standardized single disk method",
        "volume": "45",
        "author": "AW Bauer",
        "year": "1966",
        "journal-title": "Am Journal Clin Pathol"
      },
      {
        "key": "pone.0233284.ref025",
        "unstructured": "v_9.0_Breakpoint_Tables.pdf. Available at: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_9.0_Breakpoint_Tables.pdf (Accessed: 28th July 2019)."
      },
      {
        "issue": "1–2",
        "key": "pone.0233284.ref026",
        "doi-asserted-by": "crossref",
        "first-page": "67",
        "DOI": "10.1016/j.vetmic.2010.05.044",
        "article-title": "(GTG)5-PCR fingerprinting for the classification and identification of coagulase-negative Staphylococcus species from bovine milk and teat apices: a comparison of type strains and field isolates",
        "volume": "147",
        "author": "G Braem",
        "year": "2011",
        "journal-title": "Vet Microbiol"
      },
      {
        "key": "pone.0233284.ref027",
        "doi-asserted-by": "crossref",
        "first-page": "270",
        "DOI": "10.1186/s12859-015-0703-0",
        "article-title": "GelJ a tool for analyzing DNA fingerprint gel images",
        "volume": "16",
        "author": "J Heras",
        "year": "2015",
        "journal-title": "BMC bioinformatics"
      },
      {
        "issue": "4",
        "key": "pone.0233284.ref028",
        "doi-asserted-by": "crossref",
        "first-page": "473",
        "DOI": "10.1111/j.1751-7915.2010.00184.x",
        "article-title": "Studies with bioengineered nisin peptides highlight the broad-spectrum potency of nisin V",
        "volume": "3",
        "author": "D Field",
        "year": "2010",
        "journal-title": "Microb Biotechnol"
      },
      {
        "issue": "11",
        "key": "pone.0233284.ref029",
        "doi-asserted-by": "crossref",
        "first-page": "e79563",
        "DOI": "10.1371/journal.pone.0079563",
        "article-title": "Intensive mutagenesis of the nisin hinge leads to the rational design of enhanced derivatives",
        "volume": "8",
        "author": "B Healy",
        "year": "2013",
        "journal-title": "PLoS One"
      },
      {
        "issue": "10",
        "key": "pone.0233284.ref030",
        "doi-asserted-by": "crossref",
        "first-page": "e46884",
        "DOI": "10.1371/journal.pone.0046884",
        "article-title": "Bioengineered nisin A derivatives with enhanced activity against both Gram positive and Gram negative pathogens",
        "volume": "7",
        "author": "D Field",
        "year": "2012",
        "journal-title": "PLoS One"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref031",
        "doi-asserted-by": "crossref",
        "first-page": "e0119684",
        "DOI": "10.1371/journal.pone.0119684",
        "article-title": "A Bioengineered nisin derivative to control biofilms of Staphylococcus pseudintermedius",
        "volume": "10",
        "author": "D Field",
        "year": "2015a",
        "journal-title": "PLoS One"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref032",
        "doi-asserted-by": "crossref",
        "first-page": "207",
        "DOI": "10.1007/s13765-012-3253-4",
        "article-title": "Biofilm formation, attachment, and cell hydrophobicity of foodborne pathogens under varied environmental conditions",
        "volume": "56",
        "author": "NY Choi",
        "year": "2013",
        "journal-title": "J Korean Soc Appl Biol Chem"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref033",
        "doi-asserted-by": "crossref",
        "first-page": "175",
        "DOI": "10.1016/S0167-7012(00)00122-6",
        "article-title": "A modified microtiter-plate test for quantification of staphylococcal biofilm formation",
        "volume": "40",
        "author": "S Stepanović",
        "year": "2000",
        "journal-title": "J Microbiol Methods"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref034",
        "doi-asserted-by": "crossref",
        "first-page": "225",
        "DOI": "10.1111/j.1574-695X.2011.00806.x",
        "article-title": "Characterization of Staphylococcus aureus strains involved in human and bovine mastitis",
        "volume": "62",
        "author": "S Delgado",
        "year": "2011",
        "journal-title": "FEMS Immunol Med Microbiol"
      },
      {
        "key": "pone.0233284.ref035",
        "doi-asserted-by": "crossref",
        "first-page": "53",
        "DOI": "10.2174/1874285801711010053",
        "article-title": "Understanding the mechanism of bacterial biofilms resistance to antimicrobial agents",
        "volume": "11",
        "author": "S Singh",
        "year": "2017",
        "journal-title": "Open Microbiol J"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref036",
        "doi-asserted-by": "crossref",
        "first-page": "61",
        "DOI": "10.2174/1389203053027584",
        "article-title": "Bacterial lantibiotics: strategies to improve therapeutic potential",
        "volume": "6",
        "author": "PD Cotter",
        "year": "2005",
        "journal-title": "Curr Protein Pept Sci"
      },
      {
        "issue": "5",
        "key": "pone.0233284.ref037",
        "doi-asserted-by": "crossref",
        "first-page": "494",
        "DOI": "10.1016/j.ijantimicag.2015.07.011",
        "article-title": "Bacteriocins and their position in the next wave of conventional antibiotics",
        "volume": "46",
        "author": "VL Cavera",
        "year": "2015",
        "journal-title": "Int J Antimicrob Agents"
      },
      {
        "key": "pone.0233284.ref038",
        "doi-asserted-by": "crossref",
        "first-page": "1363",
        "DOI": "10.3389/fmicb.2015.01363",
        "article-title": "Bioengineering lantibiotics for therapeutic success",
        "volume": "6",
        "author": "D Field",
        "year": "2015b",
        "journal-title": "Front Microbiol"
      },
      {
        "issue": "11",
        "key": "pone.0233284.ref039",
        "doi-asserted-by": "crossref",
        "first-page": "5572",
        "DOI": "10.1128/AAC.00888-13",
        "article-title": "Effects of bacteriocins on methicillin-resistant Staphylococcus aureus biofilm",
        "volume": "57",
        "author": "K Okuda",
        "year": "2013",
        "journal-title": "Antimicrob Agents Chemother"
      },
      {
        "issue": "6",
        "key": "pone.0233284.ref040",
        "doi-asserted-by": "crossref",
        "first-page": "511",
        "DOI": "10.1159/000335598",
        "article-title": "In vitro activities of nisin alone or in combination with vancomycin and ciprofloxacin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains",
        "volume": "57",
        "author": "S Dosler",
        "year": "2011",
        "journal-title": "Chemotherapy"
      },
      {
        "issue": "18",
        "key": "pone.0233284.ref041",
        "doi-asserted-by": "crossref",
        "first-page": "5809",
        "DOI": "10.1128/AEM.01104-07",
        "article-title": "Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation",
        "volume": "73",
        "author": "R Rink",
        "year": "2007",
        "journal-title": "Appl Environ Microbiol"
      },
      {
        "issue": "6",
        "key": "pone.0233284.ref042",
        "doi-asserted-by": "crossref",
        "first-page": "806",
        "DOI": "10.1007/s00253-004-1599-1",
        "article-title": "Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants",
        "volume": "64",
        "author": "J Yuan",
        "year": "2004",
        "journal-title": "Appl Microbiol Biotechnol"
      },
      {
        "key": "pone.0233284.ref043",
        "doi-asserted-by": "crossref",
        "first-page": "508",
        "DOI": "10.3389/fmicb.2016.00508",
        "article-title": "In vitro activities of nisin and nisin derivatives alone and in combination with antibiotics against Staphylococcus biofilms",
        "volume": "7",
        "author": "D Field",
        "year": "2016",
        "journal-title": "Front Microbiol"
      },
      {
        "issue": "18",
        "key": "pone.0233284.ref044",
        "doi-asserted-by": "crossref",
        "first-page": "1573",
        "DOI": "10.2217/fmb-2019-0153",
        "article-title": "Nisin Z and lacticin 3147 improve efficacy of antibiotics against clinically significant bacteria",
        "volume": "14",
        "author": "JC Ellis",
        "year": "2020",
        "journal-title": "Future Microbiol"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref045",
        "doi-asserted-by": "crossref",
        "first-page": "311",
        "DOI": "10.1177/0890334408317435",
        "article-title": "The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation",
        "volume": "24",
        "author": "L Fernández",
        "year": "2008",
        "journal-title": "J Hum Lact"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref046",
        "doi-asserted-by": "crossref",
        "first-page": "33",
        "DOI": "10.1159/000272223",
        "article-title": "Inflammatory breast diseases during lactation: milk stasis, puerperal mastitis, abscesses of the breast, and malignant tumors–current and evidence-based strategies for diagnosis and therapy",
        "volume": "5",
        "author": "M Abou-Dakn",
        "year": "2010",
        "journal-title": "Breast Care"
      },
      {
        "issue": "6",
        "key": "pone.0233284.ref047",
        "doi-asserted-by": "crossref",
        "first-page": "430",
        "DOI": "10.1007/s12262-012-0776-1",
        "article-title": "Management of lactational mastitis and breast abscesses: review of current knowledge and practice",
        "volume": "75",
        "author": "K Kataria",
        "year": "2013",
        "journal-title": "Indian J Surg"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref048",
        "doi-asserted-by": "crossref",
        "first-page": "77",
        "DOI": "10.1016/j.micres.2012.09.004",
        "article-title": "Genotypic diversity and virulent factors of Staphylococcus epidermidis isolated from human breast milk",
        "volume": "168",
        "author": "J Begović",
        "year": "2013",
        "journal-title": "Microbiol Res"
      },
      {
        "issue": "Pt 8",
        "key": "pone.0233284.ref049",
        "doi-asserted-by": "crossref",
        "first-page": "761",
        "DOI": "10.1099/jmm.0.05453-0",
        "article-title": "Antimicrobial-resistance and enterotoxin-encoding genes among staphylococci isolated from expressed human breast milk",
        "volume": "53",
        "author": "LA Carneiro",
        "year": "2004",
        "journal-title": "J Med Microbiol"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref050",
        "doi-asserted-by": "crossref",
        "first-page": "113",
        "DOI": "10.1007/s00284-015-0925-4",
        "article-title": "Antibiotic susceptibility of commensal bacteria from human milk",
        "volume": "72",
        "author": "PW Chen",
        "year": "2016",
        "journal-title": "Curr Microbiol"
      },
      {
        "key": "pone.0233284.ref051",
        "doi-asserted-by": "crossref",
        "first-page": "2512",
        "DOI": "10.3389/fmicb.2018.02512",
        "article-title": "Microbial community dynamics in mother's milk and infant's mouth and gut in moderately preterm infants",
        "volume": "9",
        "author": "E Biagi",
        "year": "2018",
        "journal-title": "Front Microbiol"
      },
      {
        "key": "pone.0233284.ref052",
        "doi-asserted-by": "crossref",
        "first-page": "4",
        "DOI": "10.3410/M4-4",
        "article-title": "Reduced vancomycin susceptibility among clinical Staphylococcus aureus isolates ('the MIC Creep'): implications for therapy",
        "volume": "4",
        "author": "A Dhand",
        "year": "2012",
        "journal-title": "F1000 Med Rep"
      },
      {
        "issue": "12",
        "key": "pone.0233284.ref053",
        "doi-asserted-by": "crossref",
        "first-page": "1112",
        "DOI": "10.1136/jcp.2009.069021",
        "article-title": "Low concentrations of vancomycin stimulate biofilm formation in some clinical isolates of Staphylococcus epidermidis",
        "volume": "62",
        "author": "JS Cargill",
        "year": "2009",
        "journal-title": "J Clin Pathol"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref054",
        "doi-asserted-by": "crossref",
        "first-page": "191",
        "DOI": "10.1002/jobm.201000221",
        "article-title": "Effect of sub-lethal doses of vancomycin and oxacillin on biofilm formation by vancomycin intermediate resistant Staphylococcus aureus",
        "volume": "51",
        "author": "ZA Mirani",
        "year": "2011",
        "journal-title": "J Basic Microbiol"
      },
      {
        "key": "pone.0233284.ref055",
        "doi-asserted-by": "crossref",
        "first-page": "225",
        "DOI": "10.1016/j.micpath.2017.07.004",
        "article-title": "Vancomycin-induced biofilm formation by methicillin-resistant Staphylococcus aureus is associated with the secretion of membrane vesicles",
        "volume": "110",
        "author": "X He",
        "year": "2017",
        "journal-title": "Microb Pathog"
      },
      {
        "issue": "9",
        "key": "pone.0233284.ref056",
        "doi-asserted-by": "crossref",
        "first-page": "1627",
        "DOI": "10.4315/0362-028X.JFP-12-001",
        "article-title": "Effects of nisin and lysozyme on growth inhibition and biofilm formation capacity of Staphylococcus aureus strains isolated from raw milk and cheese samples",
        "volume": "75",
        "author": "M Sudagidan",
        "year": "2012",
        "journal-title": "J Food Prot"
      },
      {
        "issue": "3",
        "key": "pone.0233284.ref057",
        "doi-asserted-by": "crossref",
        "first-page": "253",
        "DOI": "10.1016/j.ijfoodmicro.2008.01.011",
        "article-title": "Nisin-bacteriophage cross-resistance in Staphylococcus aureus",
        "volume": "122",
        "author": "B Martinez",
        "year": "2008",
        "journal-title": "Int J Food Microbiol"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref058",
        "doi-asserted-by": "crossref",
        "first-page": "82",
        "DOI": "10.2146/ajhp080434",
        "article-title": "Therapeutic monitoring of vancomycin in adult patients: a consensus review of the american society of health-system pharmacists, the infectious diseases society of america, and the society of infectious diseases pharmacists",
        "volume": "66",
        "author": "M Rybak",
        "year": "2009",
        "journal-title": "Am J Health Syst Pharm"
      },
      {
        "issue": "2",
        "key": "pone.0233284.ref059",
        "doi-asserted-by": "crossref",
        "first-page": "277",
        "DOI": "10.1111/j.1574-695X.2007.00300.x",
        "article-title": "Increased tolerance of Staphylococcus aureus to vancomycin in viscous media",
        "volume": "51",
        "author": "V Kostenko",
        "year": "2007",
        "journal-title": "FEMS Immunol Med Microbiol"
      },
      {
        "key": "pone.0233284.ref060",
        "first-page": "107",
        "article-title": "Multidrug tolerance of biofilms and persister cells",
        "volume": "322",
        "author": "K. Lewis",
        "year": "2008",
        "journal-title": "Curr Top Microbiol Immunol"
      },
      {
        "issue": "6",
        "key": "pone.0233284.ref061",
        "doi-asserted-by": "crossref",
        "first-page": "ftw056",
        "DOI": "10.1093/femspd/ftw056",
        "article-title": "Penetration barrier contributes to bacterial biofilm-associated resistance against only select antibiotics, and exhibits genus-, strain- and antibiotic-specific differences",
        "volume": "74",
        "author": "R Singh",
        "year": "2016",
        "journal-title": "Pathog Dis"
      },
      {
        "issue": "12",
        "key": "pone.0233284.ref062",
        "doi-asserted-by": "crossref",
        "first-page": "7273",
        "DOI": "10.1128/AAC.03132-14",
        "article-title": "Extracellular DNA impedes the transport of vancomycin in Staphylococcus epidermidis biofilms preexposed to subinhibitory concentrations of vancomycin",
        "volume": "58",
        "author": "N Doroshenko",
        "year": "2014",
        "journal-title": "Antimicrob Agents Chemotherapy"
      },
      {
        "issue": "1",
        "key": "pone.0233284.ref063",
        "doi-asserted-by": "crossref",
        "first-page": "46",
        "DOI": "10.1007/s00776-005-0968-7",
        "article-title": "Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases",
        "volume": "11",
        "author": "S Nishimura",
        "year": "2006",
        "journal-title": "J Orthop Sci"
      }
    ],
    "container-title": [
      "PLOS ONE"
    ],
    "original-title": [

    ],
    "language": "en",
    "link": [
      {
        "URL": "https://dx.plos.org/10.1371/journal.pone.0233284",
        "content-type": "unspecified",
        "content-version": "vor",
        "intended-application": "similarity-checking"
      }
    ],
    "deposited": {
      "date-parts": [
        [
          2020,
          5,
          29
        ]
      ],
      "date-time": "2020-05-29T17:54:37Z",
      "timestamp": 1590774877000
    },
    "score": 1,
    "resource": {
      "primary": {
        "URL": "https://dx.plos.org/10.1371/journal.pone.0233284"
      }
    },
    "subtitle": [

    ],
    "editor": [
      {
        "given": "Rita G.",
        "family": "Sobral",
        "sequence": "first",
        "affiliation": [

        ]
      }
    ],
    "short-title": [

    ],
    "issued": {
      "date-parts": [
        [
          2020,
          5,
          29
        ]
      ]
    },
    "references-count": 63,
    "journal-issue": {
      "issue": "5",
      "published-online": {
        "date-parts": [
          [
            2020,
            5,
            29
          ]
        ]
      }
    },
    "URL": "http://dx.doi.org/10.1371/journal.pone.0233284",
    "relation": {

    },
    "ISSN": [
      "1932-6203"
    ],
    "issn-type": [
      {
        "value": "1932-6203",
        "type": "electronic"
      }
    ],
    "subject": [
      "Multidisciplinary"
    ],
    "published": {
      "date-parts": [
        [
          2020,
          5,
          29
        ]
      ]
    }

}