dhp-workflows/dhp-aggregation/src/test/resources/eu/dnetlib/dhp/actionmanager/project/prepared_projects.json

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 {"rcn":"229281","id":"896300","acronym":"STRETCH","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Smart Textiles for RETrofitting and Monitoring of  Cultural Heritage Buildings","startDate":"2020-09-01","endDate":"2022-08-31","projectUrl":"","objective":"This project aims to develop novel techniques using smart multifunctional materials for the combined seismic-plus-energy retrofitting, and Structural Health Monitoring (SHM) of the European cultural heritage buildings (CHB). The need for upgrading the existing old and CHB is becoming increasingly important for the EU countries, due to: (1) their poor structural performance during recent earthquakes (e.g. Italy, Greece) or other natural hazards (e.g. extreme weather conditions) that have resulted in significant economic losses, and loss of human lives; and (2) their low energy performance which increases significantly their energy consumption (buildings are responsible for 40% of EU energy consumption). Moreover, the SHM of the existing buildings is crucial for assessing continuously their structural integrity and thus to provide information for planning cost effective and sustainable maintenance decisions. Since replacing the old buildings with new is not financially feasible, and even it is not allowed for CHB, their lifetime extension requires considering simultaneously both structural and energy retrofitting. It is noted that the annual cost of repair and maintenance of existing European building stock is estimated to be about 50% of the total construction budget, currently standing at more than €300 billion. To achieve cost effectiveness, STRETCH explores a novel approach, which integrates technical textile reinforcement with thermal insulation systems and strain sensors to provide simultaneous structural-plus-energy retrofitting combined with SHM, tailored for masonry cultural heritage building envelopes. The effectiveness of the proposed retrofitting system will be validated experimentally and analytically. Moreover, draft guidelines and recommendations for determining future research on the use of smart composite materials for the concurrent retrofitting (structural-plus-energy) and SHM of the existing cultural heritage buildings envelopes will be proposed.","totalCost":"183473,28","ecMaxContribution":"183473,28","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION","coordinatorCountry":"BE","participants":"","participantCountries":"","subjects":""}
 {"rcn":"229265","id":"892890","acronym":"RhythmicPrediction","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Rhythmic prediction in speech perception: are our brain waves in sync with our native language?","startDate":"2021-01-01","endDate":"2022-12-31","projectUrl":"","objective":"Speech has rhythmic properties that widely differ across languages. When we listen to foreign languages, we may perceive them to be more musical, or rather more rap-like than our own. Even if we are unaware of it, the rhythm and melody of language, i.e. prosody, reflects its linguistic structure. On the one hand, prosody emphasizes content words and new information with stress and accents. On the other hand, it is aligned to phrase edges, marking them with boundary tones. Prosody hence helps the listener to focus on important words and to chunk sentences into phrases, and phrases into words. In fact, prosody is even used predictively, for instance to time the onset of the next word, the next piece of new information, or the total remaining length of the utterance, so the listener can seamlessly start their own speaking turn. \nSo, the listener, or rather their brain, is actively predicting when important speech events will happen, using prosody. How prosodic rhythms are exploited to predict speech timing, however, is unclear. No link between prosody and neural predictive processing has yet been empirically made. One hypothesis is that rhythm, such as the alternation of stressed and unstressed syllables, helps listeners time their attention. Similar behavior is best captured by the notion of an internal oscillator which can be set straight by attentional spikes. While neuroscientific evidence for the relation of neural oscillators to speech processing is starting to emerge, no link to the use of prosody nor predictive listening exists, yet. Furthermore, it is still unknown how native language knowledge affects cortical oscillations, and how oscillations are affected by cross-linguistic differences in rhythmic structure. The current project combines the standing knowledge of prosodic typology with the recent advances in neuroscience on cortical oscillations, to investigate the role of internal oscillators on native prosody perception, and active speech prediction.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"UNIVERSITE DE GENEVE","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}
 {"rcn":"229235","id":"886828","acronym":"ASAP","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Advanced Solutions for Asphalt Pavements","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"The Advanced Solutions for Asphalt Pavements (ASAP) project involves the development of a unique road paving technology which will use a bio-bitumen rejuvenator to rejuvenate aged asphalt bitumen.  This technology will help to extend the lifespan of asphalt pavements (roads) and will reduce the environmental and economic impact of roads and road maintenance processes. Recycling and self-healing processes will replace fossil fuel dependent technology. Self-healing will involve rejuvenating aged asphalt bitumen using a bio-rejuvenator developed using microalgae oils (rejuvenating bio-oil). Microalgae has been selected because of its fast growth, versatility and ability to survive within hostile environments, such as wastewater.  \n\nASAP will utilise microalgae, cultivated within the wastewater treatment process, as a source of the rejuvenating bio-oil. The solvent (Soxhlet) processes will be used to extract the oil from the microalgae. To ensure the efficiency of the oil extraction process, an ultrasonication process will be used to pre-treat the microalgae. The suitability of rejuvenating bio-oil as a replacement for the bitumen rejuvenator (fossil fuel based) will be ascertained via a series of standard bituminous and accelerated tests. A rejuvenator-binder diffusion numerical model will be developed, based on the Delft Lattice concrete diffusion model, to determine the conditions required for rejuvenation to occur and to ascertain the healing rate of the asphalt binder. These parameters will facilitate the selection and optimisation of the asphalt self-healing systems (specifically the amount of bio-oil rejuvenator and time required) to achieve full rejuvenation. \n\nThis novel approach will benchmark the effectiveness of this intervention against existing asphalt design and maintenance processes and assess feasibility. The ASAP project presents an opportunity to revolutionise road design and maintenance processes and reduce its environmental and financial costs.","totalCost":"187572,48","ecMaxContribution":"187572,48","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO","coordinatorCountry":"NL","participants":"","participantCountries":"","subjects":""}
-{"rcn":null,"id":"886776","acronym":null,"status":null,"programme":"H2020-EU.2.1.4.","topics":null,"frameworkProgramme":"H2020","title":"BIO-Based pESTicides production for sustainable agriculture management plan","startDate":"2020-05-01","endDate":"2023-04-30","projectUrl":"","objective":"The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. \nBIOVITIS, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. \nBIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). \nThe BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.\nTo assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. \nA Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.\nThe adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.","totalCost":"4402772,5","ecMaxContribution":"3069653","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"BIOVITIS","coordinatorCountry":"FR","participants":"MERCIER FRERES SARL;FUNDACION TECNALIA RESEARCH & INNOVATION;LAMBERTI SPA;EURION CONSULTING;CIAOTECH Srl;STOWARZYSZENIE ZACHODNIOPOMORSKI KLASTER CHEMICZNY ZIELONA CHEMIA;NORDZUCKER AG;INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN","participantCountries":"FR;ES;IT;PL;DE","subjects":""}
+{"rcn":null,"id":"886776","acronym":null,"status":null,"programme":"H2020-EU.2.1.4.","topics":"BBI-2019-SO3-D4","frameworkProgramme":"H2020","title":"BIO-Based pESTicides production for sustainable agriculture management plan","startDate":"2020-05-01","endDate":"2023-04-30","projectUrl":"","objective":"The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. \nBIOVITIS, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. \nBIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). \nThe BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.\nTo assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. \nA Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.\nThe adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.","totalCost":"4402772,5","ecMaxContribution":"3069653","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"BIOVITIS","coordinatorCountry":"FR","participants":"MERCIER FRERES SARL;FUNDACION TECNALIA RESEARCH & INNOVATION;LAMBERTI SPA;EURION CONSULTING;CIAOTECH Srl;STOWARZYSZENIE ZACHODNIOPOMORSKI KLASTER CHEMICZNY ZIELONA CHEMIA;NORDZUCKER AG;INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN","participantCountries":"FR;ES;IT;PL;DE","subjects":""}
 {"rcn":null,"id":"886776","acronym":null,"status":null,"programme":"H2020-EU.3.2.6.","topics":"BBI-2019-SO3-D4","frameworkProgramme":"H2020","title":"BIO-Based pESTicides production for sustainable agriculture management plan","startDate":"2020-05-01","endDate":"2023-04-30","projectUrl":"","objective":"The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. \nBIOVITIS, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. \nBIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). \nThe BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.\nTo assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. \nA Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.\nThe adoption of the effective and cost-efficient biopesticide will have significant impacts with a potential ROI of 30 % in just 5 years and a total EBITDA of more than € 6,400,000.","totalCost":"4402772,5","ecMaxContribution":"3069653","call":"H2020-BBI-JTI-2019","fundingScheme":"BBI-IA-DEMO","coordinator":"BIOVITIS","coordinatorCountry":"FR","participants":"MERCIER FRERES SARL;FUNDACION TECNALIA RESEARCH & INNOVATION;LAMBERTI SPA;EURION CONSULTING;CIAOTECH Srl;STOWARZYSZENIE ZACHODNIOPOMORSKI KLASTER CHEMICZNY ZIELONA CHEMIA;NORDZUCKER AG;INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN","participantCountries":"FR;ES;IT;PL;DE","subjects":""}
 {"rcn":"229276","id":"895426","acronym":"DisMoBoH","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Dissecting the molecular building principles of locally formed transcriptional hubs","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"Numerous DNA variants have already been identified that modulate inter-individual molecular traits – most prominently gene expression. However, since finding mechanistic interpretations relating genotype to phenotype has proven challenging, the focus has shifted to higher-order regulatory features, i.e. chromatin accessibility, transcription factor (TF) binding and 3D chromatin interactions. This revealed at least two enhancer types: “lead” enhancers in which the presence of genetic variants modulates the activity of entire chromatin domains, and “dependent” ones in which variants induce subtle changes, affecting DNA accessibility, but not transcription. Although cell type-specific TFs are likely important, it remains unclear which sequence features are required to establish such enhancer hierarchies, and under which circumstances genetic variation results in altered enhancer-promoter contacts and differential gene expression.  Here, we propose to investigate the molecular mechanisms that link DNA variation to TF binding, chromatin topology, and gene expression response. We will leverage data on enhancer hierarchy and sequence-specific TF binding to identify the sequence signatures that define “lead” enhancers. The results will guide the design of a synthetic locus that serves as an in vivo platform to systematically vary the building blocks of local transcriptional units: i) DNA sequence – including variations in TF binding site affinity and syntax, ii) molecular interactions between TFs, and iii) chromatin conformation. To validate our findings, we will perform optical reconstruction of chromatin architecture for a select number of DNA variants.  By simultaneously perturbing co-dependent features, this proposal will provide novel mechanistic insights into the formation of local transcriptional hubs.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-RI","coordinator":"ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}
 {"rcn":"229288","id":"898218","acronym":"devUTRs","status":"SIGNED","programme":"H2020-EU.1.3.2.","topics":"MSCA-IF-2019","frameworkProgramme":"H2020","title":"Uncovering the roles of 5′UTRs in translational control during early zebrafish development","startDate":"2021-09-01","endDate":"2023-08-31","projectUrl":"","objective":"Following fertilisation, metazoan embryos are transcriptionally silent, and embryogenesis is controlled by maternally deposited factors. Developmental progression requires the synthesis of new mRNAs and proteins in a coordinated fashion. Many posttranscriptional mechanisms regulate the fate of maternal mRNAs, but it is less understood how translational control shapes early embryogenesis. In eukaryotes, translation starts at the mRNA 5′ end, consisting of the 5′ cap and 5′ untranslated region (UTR). Protein synthesis is primarily regulated at the translation initiation step by elements within the 5′UTR. However, the role of 5′UTRs in regulating the dynamics of mRNA translation during vertebrate embryogenesis remains unexplored. For example, all vertebrate ribosomal protein (RP) mRNAs harbor a conserved terminal oligopyrimidine tract (TOP) in their 5′UTR. RP levels must be tightly controlled to ensure proper organismal development, but if and how the TOP motif mediates RP mRNA translational regulation during embryogenesis is unclear. Overall, we lack a systematic understanding of the regulatory information contained in 5′UTRs. In this work, I aim to uncover the 5′UTR in vivo rules for mRNA translational regulation during zebrafish embryogenesis. I propose to apply imaging and biochemical approaches to characterise the role of the TOP motif in RP mRNA translational regulation during embryogenesis and identify the trans-acting factor(s) that bind(s) to it (Aim 1). To systematically assess the contribution of 5′UTRs to mRNA translational regulation during zebrafish embryogenesis, I will couple a massively parallel reporter assay of 5′UTRs to polysome profiling (Aim 2). By integrating the translational behaviour of 5′UTR reporters throughout embryogenesis with sequence-based regression models, I anticipate to uncover novel cis-regulatory elements in 5′UTRs with developmental roles.","totalCost":"191149,44","ecMaxContribution":"191149,44","call":"H2020-MSCA-IF-2019","fundingScheme":"MSCA-IF-EF-ST","coordinator":"UNIVERSITAT BASEL","coordinatorCountry":"CH","participants":"","participantCountries":"","subjects":""}