<ArticleTitle>The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells.</ArticleTitle>
<ArticleTitle>The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP
concentration and on incorporation of 32Pi into ATP in rat fat cells.
<ArticleTitle>[Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)].</ArticleTitle>
<ArticleTitle>[Biochemical studies on camomile components/III. In vitro studies about the antipeptic
activity of (--)-alpha-bisabolol (author's transl)].
</ArticleTitle>
<Pagination>
<MedlinePgn>1352-4</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText>(--)-alpha-Bisabolol has a primary antipeptic action depending on dosage, which is not caused by an alteration of the pH-value. The proteolytic activity of pepsin is reduced by 50 percent through addition of bisabolol in the ratio of 1/0.5. The antipeptic action of bisabolol only occurs in case of direct contact. In case of a previous contact with the substrate, the inhibiting effect is lost.</AbstractText>
<AbstractText>(--)-alpha-Bisabolol has a primary antipeptic action depending on dosage, which is not
caused by an alteration of the pH-value. The proteolytic activity of pepsin is reduced by 50
percent through addition of bisabolol in the ratio of 1/0.5. The antipeptic action of bisabolol
only occurs in case of direct contact. In case of a previous contact with the substrate, the
<VernacularTitle>Biochemische Untersuchungen von Kamilleninhaltsstoffen. III. In-vitro-Versuche über die antipeptische Wirkung des (-)-alpha-Bisabolols</VernacularTitle>
<VernacularTitle>Biochemische Untersuchungen von Kamilleninhaltsstoffen. III. In-vitro-Versuche über die
<ArticleTitle>[Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a N-(2-cyanoethylene)-urea. Novel prophylactic possibilities].</ArticleTitle>
<ArticleTitle>[Demonstration of tumor inhibiting properties of a strongly immunostimulating
low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS
carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a
<AbstractText>A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent. (Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.) However this comparison is characterized by the fact that both substances exhibit two quite different (complementary) mechanisms of action. Leucocyte counts made after application of the said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with ifosfamide, the known suppression in the post-therapeutic interval usually found with standard cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow conclusions on the immunity status. Since IF can be taken as one of the most efficient cancerostatics--there is no other chemotherapeutic known up to now that has a more significant effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally, the total amount of leucocytes and lymphocytes as well as their time behaviour was determined from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising.</AbstractText>
<AbstractText>A report is given on the recent discovery of outstanding immunological properties in
BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS
carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent
LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40
percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under
otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development
of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent
LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent.
(Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.)
However this comparison is characterized by the fact that both substances exhibit two quite
different (complementary) mechanisms of action. Leucocyte counts made after application of the
said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with
ifosfamide, the known suppression in the post-therapeutic interval usually found with standard
cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow
conclusions on the immunity status. Since IF can be taken as one of the most efficient
cancerostatics--there is no other chemotherapeutic known up to now that has a more significant
effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally,
the total amount of leucocytes and lymphocytes as well as their time behaviour was determined
from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained
numerical values clearly show that further research work on the prophylactic use of this
substance seems to be necessary and very promising.
<VernacularTitle>Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung kleiner Molekülmasse. Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid. Stimulierung der körpereigenen Abwehr über etwa 20 Tage durch BA 1, einen N-(2-Cyanthylen)-harnstoff. Neue prophylaktische Möglichkeiten</VernacularTitle>
<VernacularTitle>Nachweis krebshemmender Eigenschaften einer stark immunstimulierenden Verbindung
kleiner Molekülmasse. Versuche am immunlabilen DS-Karzinosarkom im Vergleich mit Ifosfamid.
Stimulierung der körpereigenen Abwehr über etwa 20 Tage durch BA 1, einen
N-(2-Cyanthylen)-harnstoff. Neue prophylaktische Möglichkeiten
</VernacularTitle>
</Article>
<MedlineJournalInfo>
<Country>Germany</Country>
@ -5016,7 +5075,20 @@
<MedlinePgn>1400-3</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText>The distribution of blood flow to the subendocardial, medium and subepicardial layers of the left ventricular free wall was studied in anaesthetized dogs under normoxic (A), hypoxic (B) conditions and under pharmacologically induced (etafenone) coronary vasodilation (C). Regional myocardial blood flow was determined by means of the particle distribution method. In normoxia a transmural gradient of flow was observed, with the subendocardial layers receiving a significantly higher flow rate compared with the subepicardial layers. In hypoxia induced vasodilation this transmural gradient of flow was persistent. In contrast a marked redistribution of regional flow was observed under pharmacologically induced vasodilation. The transmural gradient decreased. In contrast to some findings these experiments demonstrate that a considerable vasodilatory capacity exists in all layers of the myocardium and can be utilized by drugs. The differences observed for the intramural distribution pattern of flow under hypoxia and drug induced vasodilation support the hypothesis that this pattern reflects corresponding gradients of regional myocardial metabolism.</AbstractText>
<AbstractText>The distribution of blood flow to the subendocardial, medium and subepicardial layers
of the left ventricular free wall was studied in anaesthetized dogs under normoxic (A), hypoxic
(B) conditions and under pharmacologically induced (etafenone) coronary vasodilation (C).
Regional myocardial blood flow was determined by means of the particle distribution method. In
normoxia a transmural gradient of flow was observed, with the subendocardial layers receiving a
significantly higher flow rate compared with the subepicardial layers. In hypoxia induced
vasodilation this transmural gradient of flow was persistent. In contrast a marked
redistribution of regional flow was observed under pharmacologically induced vasodilation. The
transmural gradient decreased. In contrast to some findings these experiments demonstrate that a
considerable vasodilatory capacity exists in all layers of the myocardium and can be utilized by
drugs. The differences observed for the intramural distribution pattern of flow under hypoxia
and drug induced vasodilation support the hypothesis that this pattern reflects corresponding
gradients of regional myocardial metabolism.
</AbstractText>
</Abstract>
<AuthorListCompleteYN="Y">
<AuthorValidYN="Y">
@ -5185,4 +5257,151 @@
</ReferenceList>
</PubmedData>
</PubmedArticle>
<PubmedArticle>
<MedlineCitationStatus="MEDLINE"Owner="NLM">
<PMIDVersion="1">4917185</PMID>
<DateCompleted>
<Year>1970</Year>
<Month>10</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised>
<Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<ArticlePubModel="Print">
<Journal>
<ISSNIssnType="Print">0003-6919</ISSN>
<JournalIssueCitedMedium="Print">
<Volume>19</Volume>
<Issue>6</Issue>
<PubDate>
<Year>1970</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Applied microbiology</Title>
<ISOAbbreviation>Appl Microbiol</ISOAbbreviation>
</Journal>
<ArticleTitle>Bactericidal activity of a broad-spectrum illumination source.</ArticleTitle>
<Pagination>
<MedlinePgn>1013-4</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText>Several hours of exposure to Vita-Lite lamps, which have a unique spectral
distribution, give significant killing of cells of Staphylococcus aureus.
