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Female psychologists believed disclosures regardless of their personal trauma history, while male psychologists with a personal history of trauma believed disclosures significantly more than male psychologists without personal trauma history. Reported believability of the disclosure, while unrelated to treatment planning, was associated with a reported intention to validate the client\u0027s experience. The results support that, similar to community samples, gender and a personal trauma history impact psychologist believability of CSA disclosure. 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However, false positive results stigmatizing the patient seem to be more frequent than false negative results and make supplementary tests desirable. This multicenter approach studied the usefulness of an IVCT with 4-chloro-m-cresol (4-CmC), a ryanodine receptor-specific agonist for a better definition of MH susceptibility. Diagnosis made by the standard IVCT was compared with the results of this 4-CmC test on muscle specimens of 202 individuals from 6 European MH centers. In the 4-CmC test, the results of the MH susceptible group differed significantly from both the MH normal and the MH equivocal group. 4-CmC revealed a qualitatively dose response-curve similar to caffeine. A correlation index of r \u003d 0.79 for the concentration thresholds underlined the strong concordance of the caffeine and the 4-CmC effects. The optimal threshold concentration was determined to be 75 microM in the pooled data of all centers and is much lower than that of caffeine (2 mM), suggesting a more than 25-fold higher affinity of 4-CmC. The predictive value of 4-CmC is as high as that of caffeine and consequently higher than that of halothane. 4-CmC seems to be a suitable drug to refine diagnosis of MH susceptibility and could be used as an additional test substance.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3aea680e5eecf5326b9a320ffa962","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10625004","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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This applier tool is designed for ergonomic handling of delicate electro-mechanical devices such as the Iowa-Patch™ spinal cord stimulator implant, which is aimed at overcoming certain shortcomings in the performance of standard epidural stimulator devices. The applier is approximately 14 cm long, 6 mm in diameter, made of stainless steel components, and has simple and reliable mechanisms for the attachment and release of the implant from it. We describe the design of the device, details of its construction, and its performance during in vivo testing of somatosensory evoked potentials in an ovine model of intradural spinal cord stimulation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3aecd79e1cf51d739f7d5a0f67d34","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22339111","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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From these, the Cape Griffon vulture (Gyps corprotheres) is the most endangered species in the region. Although inadequate nutritional support has been blamed on the constant decline in populations, the process of vulture restaurants has failed to improve the population status over the last twenty years. One possible reason for the decline may be an underlying reproductive disorder as described in endocrine disruptive syndromes. Both DDT and p,p\u0027-DDE have been detected previously at very high concentrations in the mid 1980s, with lower concentrations still being detectable as late as 2001. To establish the effect of DDT and DDE, the vulture estrogen receptor alpha (ERalpha) was sequenced from two species using 5\u0027 and 3\u0027 rapid amplification cDNA ends (RACE). Using transient transfected mammalian cell assays, vulture ERalpha estrogen-dependent transcription activity was validated using various estrogens and DDT derivatives. The receptor assay was sensitive to p,p\u0027-DDT, o,p\u0027-DDT and p,p\u0027-DDE with EC(50) of 2.41x10(-6), 3.47x10(-7) and 3.81x10(-5)M. When compared to results obtained from human, zebrafish, chicken, salamander and turtle, the vulture ERalpha showed high sensitivity to o,p\u0027-DDT and intermediately responsive to p,p\u0027-DDE. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Mccarty, M. 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The fact that IL-6 is detectable in early stage diffuse plaques encourages the speculation that the acute-phase process is crucial to the pathogenesis of AD. The epidemiological association of AD with estrogen deficiency, as well as with various disorders characterized by vascular endotheliopathy, suggest a protective role for vascular nitric oxide (NO). NO has an autocrine anti-inflammatory impact on endothelium, owing in part to antagonism of NF-kappaB activity; since induction of IL-6 is dependent on NF-kappaB, this may explain recent evidence that NO inhibits macrophage IL-6 production. It is reasonable to postulate that, analogously, cerebrovascular NO decreases IL-6 production in the brain. Vascular NO may also have direct neuroprotective activity. Estrogen, in addition to promoting vascular NO synthesis, can block IL-6 production by a more direct mechanism in cells expressing estrogen receptors; since such receptors have been reported in brain glia and astrocytes, estrogen has the potential to limit brain IL-1 activity. Testosterone likewise can inhibit IL-6 induction in androgen-responsive cells, which may include brain glia and astrocytes. Since fish oil and gamma linolenic acid (GLA) suppress IL-1 production by stimulated monocytes, they conceivably could exert this effect in the brain as well; the comparatively low prevalence of AD in elderly Japanese is intriguing in this regard. These considerations suggest that a healthy cerebrovascular endothelium, sex hormone activity, and dietary fish oil/GLA may slow or prevent AD onset by dampening acute-phase mechanisms in the brain.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3c26961e31dd9a8afe727998cf016","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10616034","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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We tested whether or not human adipose-derived stem cells (ASCs) promote tissue formation in rats. ASCs were evaluated in vitro for mRNA expression of angiogenic factors, including the vascular endothelial growth factor, basic fibroblast growth factor, interleukin-8 (IL-8), and stromal cell-derived factor-1 (SDF-1) and proliferative activity on human microvascular endothelial cells. For in vivo analysis, CM-DiI-labeled ASCs were implanted with a rat cardiac extracellular matrix (ECM) extract-derived hydrogel into a chamber with a femoral arteriovenous loop in the groin of male nude rats for 7 days. Vascularization in newly generated tissue was estimated by histomorphometry after endothelial nitric oxide synthase (eNOS) immunostaining. ASCs expressed growth factor mRNA and produced an angiogenic activity in vitro. After implantation, ASCs survived, but remained suspended in the ECM and relatively few were incorporated into the newly formed tissue. The volume of newly generated tissue was significantly higher in chambers containing ASCs and it was enriched with vasculature when compared with the ECM alone. We conclude that human ASCs promote tissue growth and angiogenesis in the rat vascularized chamber, thereby showing promise for tissue-engineering applications for regenerative therapy.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3c4551ea00c3d2f579e9b2192631d","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23394225","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Robertson, Lynn C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Michael Esterman","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Fortenbaugh, Francesca C.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Changes in the distribution of sustained attention alter the perceived structure of visual space.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-02-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Visual spatial attention is a critical process that allows for the selection and enhanced processing of relevant objects and locations. While studies have shown attentional modulations of perceived location and the representation of distance information across multiple objects, there remains disagreement regarding what influence spatial attention has on the underlying structure of visual space. The present study utilized a method of magnitude estimation in which participants must judge the location of briefly presented targets within the boundaries of their individual visual fields in the absence of any other objects or boundaries. Spatial uncertainty of target locations was used to assess perceived locations across distributed and focused attention conditions without the use of external stimuli, such as visual cues. Across two experiments we tested locations along the cardinal and 45° oblique axes. We demonstrate that focusing attention within a region of space can expand the perceived size of visual space; even in cases where doing so makes performance less accurate. Moreover, the results of the present studies show that when fixation is actively maintained, focusing attention along a visual axis leads to an asymmetrical stretching of visual space that is predominantly focused across the central half of the visual field, consistent with an expansive gradient along the focus of voluntary attention. 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Because no differences were observed in the ALR-derived interval extending 0.41 mB proximal to H2-K in any of these congenic stocks, a component of what was originally designated \"Idd16\" was sited to an interval shorter than 7.33 mB, distinguishing D.R2 from D.R3. 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Since it was shown that 50-kHz calls can serve as indices of the animal\u0027s positive subjective state, they have received increasing experimental attention, and have successfully been used to study neurobiological mechanisms of positive affect. However, it is likely that such calls do not only reflect a positive affective state, but that they also serve a communicative purpose. Actually, rats emit the highest rates of 50-kHz calls typically during social interactions, like reproductive behavior, juvenile play and tickling. Furthermore, it was recently shown that rats emit 50-kHz calls after separation from conspecifics. The aim of the present study was to test the communicative value of such 50-kHz calls. In a first experiment, conducted in juvenile rats situated singly on a radial maze apparatus, we showed that 50-kHz calls can induce behavioral activation and approach responses, which were selective to 50-kHz signals, since presentation of 22-kHz calls, considered to be aversive or threat signals, led to behavioral inhibition. In two other experiments, we used either natural 50-kHz calls, which had been previously recorded from other rats, or artificial sine wave stimuli, which were identical to these calls with respect to peak frequency, call length and temporal appearance. These signals were presented to either juvenile (Exp. 2) or adult (Exp. 3) male rats. Our data clearly show that 50-kHz signals can induce approach behavior, an effect, which was more pronounced in juvenile rats and which was not selective to natural calls, especially in adult rats. The recipient rats also emitted some 50-kHz calls in response to call presentation, but this effect was observed only in adult subjects. Together, our data show that 50-kHz calls can serve communicative purposes, namely as a social signal, which increases the likelihood of approach in the recipient conspecific.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3d1d663853863885d3b211e82b5b2","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"18159248","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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We performed equilibrium force-distance measurements across the common ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([C4mim][NTf2]) using a surface forces apparatus with in situ electrochemical control and quantitatively modeled these measurements using the van der Waals and electrostatic double-layer forces of the Derjaguin-Landau-Verwey-Overbeek theory with an additive repulsive steric (entropic) ion-surface binding force. Our results indicate that ionic liquids screen charged surfaces through the formation of both bound (Stern) and diffuse electric double layers, where the diffuse double layer is comprised of effectively dissociated ionic liquid ions. Additionally, we used the energetics of thermally dissociating ions in a dielectric medium to quantitatively predict the equilibrium for the effective dissociation reaction of [C4mim][NTf2] ions, in excellent agreement with the measured Debye length. Our results clearly demonstrate that, outside of the bound double layer, most of the ions in [C4mim][NTf2] are not effectively dissociated and thus do not contribute to electrostatic screening. We also provide a general, molecular-scale framework for designing ionic liquids with significantly increased dissociated charge densities via judiciously balancing ion pair interactions with bulk dielectric properties. Our results clear up several inconsistencies that have hampered scientific progress in this important area and guide the rational design of unique, high-free-ion density ionic liquids and ionic liquid blends.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3d2ff2125eb5aa63e9f1dee38899d","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23716690","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018253089}
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Although N-methyl-d-aspartate receptor (NMDAR) antagonists potently attenuate neonatal brain damage in several animal models, they can also impact trophic functions in the developing brain. As a consequence, high-affinity NMDAR antagonists have been shown to trigger widespread apoptotic neurodegeneration in the newborn brain. Dextromethorphan (DM), a low-affinity NMDAR antagonist with anti-inflammatory properties, may be neuroprotective against excitotoxic and inflammation-enhanced excitotoxic brain injury, without the associated stimulation of apoptotic degeneration. Using an established newborn mouse model of excitotoxic brain damage, we determined whether systemic injection of DM significantly attenuates excitotoxic lesion size. We investigated several doses and time regimens; a dose of 5 microg/g DM given in a combination of both pre-injury and repetitive post-injury treatment proved most effective. DM treatment significantly reduced lesion size in gray and white matter by reducing cell death as shown by a decreased Fluoro-Jade B staining and caspase-3 activation. Pre-treatment with interleukin-1beta and lipopolysaccharide enhanced NMDAR-mediated excitotoxic brain injury and microglial cell activation. This sensitizing effect was abolished by DM treatment, as the effectiveness of DM in reducing lesion size and microglial cell activation was similar to phosphate-buffered saline-pre-treated controls. In all cases, no gender-specific differences were detected. DM treatment did not trigger any apoptotic neurodegeneration (caspase-3 cleavage, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, Fluoro-Jade B staining). Although functional parameters were not measured, our data corroborate reports that DM is neuroprotective and that it may therefore improve functional outcome following perinatal brain injury.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3dedbfa12eecf2c74c952dde478e6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"18279363","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Urbanization is the interplay between a city\u0027s physical growth and its socio-economic development, both of which consume a substantial amount of energy and resources. Knowledge of the underlying driver(s) of urban expansion facilitates not only academic research but, more importantly, bridges the gap between science, policy drafting, and practical urban management. An increasing number of researchers are recognizing the benefits of innovative remotely sensed datasets, such as nighttime lights data (NTL), as a proxy to map urbanization and subsequently examine the driving socio-economic variables in cities. We further these approaches, by taking a trans-pacific view, and examine how an array of socio-economic ind0icators of 25 culturally and economically important urban hubs relate to long term patterns in NTL for the past 21 years. We undertake a classic econometric approach-panel causality tests which allow analysis of the causal relationships between NTL and socio-economic development across the region. The panel causality test results show a contrasting effect of population and gross domestic product (GDP) on NTL in fast, and slowly, changing cities. Information derived from this study quantitatively chronicles urban activities in the pan-Pacific region and potentially offers data for studies that spatially track local progress of sustainable urban development goals.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3e05e74636fdcd699d29cc32fc2dd","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29995923","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Distinct Staphylococcus aureus associated microbial associated molecular patterns (MAMPs) binding to TLR2 heterodimers could be identified to initiate long-lasting cutaneous inflammation driven by T helper cells and consecutively local immune suppression by induction of myeloid-derived suppressor cells further favoring secondary skin infections as often seen in AD patients. Moreover dissecting cellular and molecular mechanisms in cutaneous innate immune sensing in AD pathogenesis paved the way for exploiting regulatory and anti-inflammatory pathways to attenuate skin inflammation. Activation of the innate immune system by MAMPs of non-pathogenic bacteria on AD skin alleviated cutaneous inflammation. The induction of tolerogenic dendritic cells, interleukin-10 expression and regulatory Tr1 cells were shown to mediate this beneficial effect. 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ChIP-reChIP results indicate that endogenous MEF2C associates with HDAC4 on the Mmp13 promoter; after PTH treatment, this association decreased. From gel shift, ChIP, and promoter-reporter assays, MEF2C was found to associate with the activator protein-1 (AP-1) site without directly binding to DNA and had its stimulatory effect through interaction with c-FOS. In conclusion, MEF2C is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 site in the Mmp13 promoter. The observation of MEF2C interacting with a member of the AP-1 transcription factor family provides knowledge of the functions of HDAC4, c-FOS, and MEF2C.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3eaf395daed7151db62403dad4825","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28973134","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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These mechanisms are orchestrated in part by transcriptional regulators. The key hematopoietic transcription factor stem cell leukemia (SCL)/TAL1 is required in early hematopoietic progenitors for specification of the megakaryocytic lineage. These early functions have, so far, prevented full investigation of its role in megakaryocyte development in loss-of-function studies. Here, we report that SCL critically controls terminal megakaryocyte maturation. In vivo deletion of Scl specifically in the megakaryocytic lineage affects all key attributes of megakaryocyte progenitors (MkPs), namely, proliferation, ploidization, cytoplasmic maturation, and platelet release. Genome-wide expression analysis reveals increased expression of the cell-cycle regulator p21 in Scl-deleted MkPs. Importantly, p21 knockdown-mediated rescue of Scl-mutant MkPs shows full restoration of cell-cycle progression and partial rescue of the nuclear and cytoplasmic maturation defects. 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Vitamin D deficiency is a recognized risk factor for all-cause mortality in normal individuals and in chronic kidney disease (CKD) patients. The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that maintain mineral homeostasis and skeletal integrity, and prevent secondary hyperparathyroidism, hypertension, immune disorders, and renal and cardiovascular (CV) damage. The kidney is the main site for the conversion of 25-hydroxyvitamin D (25D) to circulating calcitriol, and therefore essential for the health benefits of endocrine VDR activation. The kidney is also essential for the uptake of 25D from the glomerular ultrafiltrate for its recycling to the circulation to maintain serum 25D levels, extrarenal calcitriol synthesis, and the prosurvival benefits of autocrine/paracrine VDR activation. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Tate, R. B.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Cohen, M. M.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Macwilliam, L.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Kaufert, P. 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The possibility that allocation was not random was examined for NBSS participants in Manitoba, Canada, using health insurance data that were external to and independent of the NBSS. The study design consisted of a retrospective observation study using health insurance (claims) data to construct health histories of breast disease prior to NBSS entry. Self-reported breast disease from the NBSS entry questionnaires was compared to breast disease histories on the basis of health insurance claims. The setting consisted of one NBSS screening center in Winnipeg, Canada. The patient population consisted of 9477 women with at least one health insurance claim in the 24 months prior to NBSS entry. We determined the proportions of women within each study arm who had claims for breast disease, breast disease investigation, or xeromammograms in the 24 months prior to NBSS entry, and compared the proportion of women\u0027s self-reports of breast disease or xeromammography with the presence/absence of a claim prior to NBSS entry for breast disease or xeromammography. No significant differences in the proportion of women with prior histories of benign breast disease, investigation, or xeromammograms (p \u003e 0.05) were found across the study arms. Nine women in the mammography group versus one in the no mammography group had one prior health insurance claim for breast cancer, but eight of these women had no subsequent claims for breast cancer. There were no differences across the study arms in the proportion of women who reported a prior history of breast disease or a prior xeromammogram for whom an insurance claim was found. Using data external to the NBSS for Manitoba participants, the study found no definitive evidence to support a nonrandom allocation of women with prior breast disease to the mammography arms of the study. 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We performed an electronic search for articles that have assessed the diagnostic accuracy of MPV in patients admitted at the emergency department with a suspected diagnosis of ischemic heart disease, including articles in which the exact number of true-positive, false-positive, false-negative and true-negative test results could be either directly or indirectly extracted. Heterogeneity was assessed by I(2) test. The cumulative estimates and 95% confidence interval (95% CI) of sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), area under the receiver operator characteristic (ROC) curve (AUC) and diagnostic odds ratio (DOR) were calculated using a random effect model. Three studies were finally included in our analysis (mean quality score, 10.8) totaling 3577 participants (566 cases and 3011 controls). The between-study variation was high (I(2), 96.2%; P \u003c 0.001). The pooled estimates were 0.820 (95% CI 0.786-0.851) for sensitivity, 0.461 (95% CI 0.443-0.479) for specificity, 0.932 (95% CI 0.918-0.944) for NPV and 0.222 (95% CI 0.205-0.241) for PPV and 0.652 (95% CI 0.596-0.707) for AUC. The DOR was 3.9 (95% CI 2.3-6.5), with 0.52 diagnostic accuracy. The outcome of this meta-analysis suggests that MPV does not meet the requirements for efficient triage of patients in emergency department when used as stand-alone test, whereas its combination with high-sensitive troponin immunoassays merits further investigations.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb3ffc425d35f2a87b4fc71d8fa65ae","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23147473","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Trent, Jonathan C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Axel Le Cesne","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Baldini, Elizabeth H.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Neoadjuvant Chemotherapy, Concurrent Chemoradiation, and Adjuvant Chemotherapy for High-Risk Extremity Soft Tissue Sarcoma.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-27","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Standard treatment of large intermediate- and high-grade extremity soft tissue sarcoma (ESTS) typically includes wide excision and radiation therapy. Many patients do well with this approach, but for those with unfavorable features, risk for distant recurrence and, ultimately, mortality can exceed 50%. Unfortunately, universally accepted data elucidating effective treatments to prevent recurrences and improve survival for such high-risk patients are lacking. Accordingly, opinions about the appropriate role of systemic therapy for patients with high-risk localized ESTS vary. This article reviews the current literature pertaining to neoadjuvant chemotherapy, concurrent chemoradiation, and adjuvant chemotherapy for high-risk ESTS. All of these approaches are feasible and reasonable to consider. Ultimately, the decision to incorporate chemotherapy into the treatment regimen is best reached by discussion among an experienced multidisciplinary sarcoma team and should be tailored to the individual patient risk profile.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb400c7fdd68089eb33430d8677f6d6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"30231383","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Singh, D. K.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Dubey, R. K.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Kant, R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Dube, S. K.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Nasogastric tube insertion with LMA-Classic in situ.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2009-09-09","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb400eed3691a0c6d04db92514681ec","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19419378","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The incidence of adverse cardiovascular events is greater among patients with CID, though they may not have conventional atherosclerotic risk factors. Endothelial dysfunction is one of the underlying fundamental mechanisms that trigger development of atherosclerotic alterations in arteries, and flow-mediated dilatation (FMD) is a noninvasive method to determine endothelial dysfunction. Recent studies have shown a relationship between high triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio and coronary atherosclerosis. Many studies have demonstrated that patients with CID have lower FMD values compared to healthy population, indicating endothelial dysfunction. However TG/HDL ratio and its relationship to FMD in patients with CID has not been investigated. The present study investigated whether TG/HDL ratio in CID patients differs from that of healthy population, and its relationship to FMD in patients with CID.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb402d5cbae21bb4ebb857e443ce7a4","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28058384","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The role of corticotrophin-releasing hormone (CRH), the 41-amino acid peptide, which activates the HPA axis in response to stressful stimuli, remains controversial. In this study, we report that CRH in low physiological concentrations (2 pM), prevented glutamate-induced neurotoxicity via receptor-mediated mechanisms when administered to organotypic hippocampal cultures both during and after the glutamate-induced insult. Detailed investigations on the mechanisms mediating this neuroprotective effect showed that activation of the adenylate cyclase pathway and induction of MAP kinase phosphorylation mediate the CRH action. In addition we showed that CRH can inhibit the phosphorylation of JNK/SAPK by glutamate. Most importantly, we showed that CRH can afford neuroprotection against neurotoxicity up to 12 h following the insult, suggesting that CRH is acting at a late stage in the neuronal death cycle, and this might be important in the development of novel neuroprotective agents in order to improve neuronal survival following the insult.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb403ad2461092aa703f8e196a62a1e","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"11908464","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Renal biopsy revealed that he had focal and segmental glomerulosclerosis on light microscopy, dominant mesangial deposition of C1q by immunofluorescent staining, and electron dense deposits on electron microscopy, which are all compatible with C1q nephropathy. He had no clinical sign of any collagen diseases, including systemic lupus erythematodes. So, the diagnosis of C1q nephropathy was made. An intensive treatment by a combination of cyclosporine, prednisolone and methylprednisolone pulse therapy was successful in achieving remission and disappearance of proteinuria in this patient. Although he developed hypertension requiring calcium blocker and angiotensin converting enzyme inhibitor, his renal function stayed within normal limit for 3 years after the initiation of the treatment. The growth was well preserved during the 3 years of treatment with almost unchanged SD scores for height. 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By comparing published data in these areas, the review identifies several gaps in current knowledge that are crucial to the development of effective intraspinal neuroprostheses. Gaps can be categorized into a lack of systematic and reproducible details of: (a) Topography and threshold for ISMS across the segmental motor system, the topography of autonomic recruitment by ISMS, and the coupling relations between these two types of outputs in practice. (b) Compositional rules for ISMS motor responses tested across the full range of the target spinal topographies. (c) Rules for ISMS effects\u0027 dependence on spinal cord state and neural dynamics during naturally elicited or ISMS triggered behaviors. (d) Plasticity of the compositional rules for ISMS motor responses, and understanding plasticity of ISMS topography in different spinal cord lesion states, disease states, and following rehabilitation. All these knowledge gaps to a greater or lesser extent require novel electrode technology in order to allow high density chronic recording and stimulation. The current lack of this technology may explain why these prominent gaps in the ISMS literature currently exist. It is also argued that given the \"known unknowns\" in the current ISMS literature, it may be prudent to adopt and develop control schemes that can manage the current results with simple superposition and winner-take-all interactions, but can also incorporate the possible plastic and stochastic dynamic interactions that may emerge in fuller analyses over longer terms, and which have already been noted in some simpler model systems. 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This study was carried out to determine the facial index in the target population and compare it in both sexes and with result of other similar studies. The sample consisted of 600 youths aged 18-32 years. Data were collected through self-administered questionnaire to establish ethnic background. Facial length and facial breadth were measured using spreading calipers and facial index calculated according to standard formula. Statistical analysis was done using SPSS for windows version 20 (IBM Corporation, New York, USA). Statistical significance was considered at p ≤0.05. The mean facial length of \u003cem\u003eTiv\u003c/em\u003e was 10.3±0.63 cm and the mean facial breadth was 12.3±0.79 cm. The mean facial length of \u003cem\u003eIdoma\u003c/em\u003e was 10.6±0.60 cm and the mean facial breadth was 12.5±0.76 cm. There was statistically significant mean difference in facial length and facial index between the two ethnic groups with \u003cem\u003eIdoma\u003c/em\u003e having higher mean values (p\u0026lt;0.05). In addition, both ethnic groups exhibited sexual dimorphism with males having significantly higher mean values than females (p\u0026lt;0.05). The mean facial index of \u003cem\u003eTiv\u003c/em\u003e was 83.9±4.79 while that of \u003cem\u003eIdoma\u003c/em\u003e was 85.2±5.66. Based on facial index, it was concluded that the face type in \u003cem\u003eTiv\u003c/em\u003e was mesoproscopic while the face type in \u003cem\u003eIdoma\u003c/em\u003e was leptoproscopic.\u003c/strong\u003e","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Zenodo","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb42977196ba7ebeb9b39566db4a26b","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5281/zenodo.2592038","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The samples were obtained at autopsy from one woman and four men at the age of 47 and 66-83 years, respectively. PBDEs were found in all samples. The sum of nine PBDE congeners ranged 5-18 ng/g lipids and 4-8 ng/g lipids in liver and adipose tissue, respectively. In three paired samples the concentrations were similar in liver and adipose tissue, while in two of the pairs the concentrations were higher in liver than in adipose tissue. The PBDE congeners 2,2\u0027,4,4\u0027-tetraBDE (BDE-47), 2,2\u0027,4,4\u0027,5-pentaBDE (BDE-99), and 2,2\u0027,4,4\u0027,5,5\u0027-hexaBDE (BDE-153) occurred at highest levels and constituted together 87-96% and 84-94% of the total sum of PBDEs in liver and adipose tissue, respectively. The levels of PBDEs were compared to those of polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p\u0027-DDE), and hexachlorobenzene (HCB).","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb43fb0ce5084a8a0ff76a8e8c889db","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"11525501","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018255023}
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The factors that determine such differences are largely unknown. Here we targeted Aurora A to the localization of Aurora B and found that Aurora A phosphorylates the substrate of Aurora B and substitutes its function in spindle checkpoint. In return, the centrosome targeting of Aurora B substitutes the function of Aurora A in the mitotic entry. Expressing the chimera proteins of the Auroras with exchanged N termini in cells indicates that the divergent N termini are also important for their spatiotemporal localizations and functions. Collectively, we demonstrate that functional divergence of Aurora kinases is determined by spatial compartmentalization, and their divergent N termini also contribute to their spatial and functional differentiation. 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Previously we found that adenocarcinoma (A549.B2) cells favored wild-type (WT) mtDNA, whereas rhabdomyosarcoma (RD.Myo) cells favored mutant (m3243G) mtDNA. Mitochondrial quality control (mtQC) can purge the cells of dysfunctional mitochondria via mitochondrial dynamics and mitophagy and appears to offer the perfect solution to the human diseases caused by mutant mtDNA. In A549.B2 and RD.Myo cybrids, with various mutant mtDNA levels, mtQC was explored together with macroautophagy/autophagy and bioenergetic profile. The 2 types of tumor-derived cell lines differed in bioenergetic profile and mitophagy, but not in autophagy. A549.B2 cybrids displayed upregulation of mitophagy, increased mtDNA removal, mitochondrial fragmentation and mitochondrial depolarization on incubation with oligomycin, parameters that correlated with mutant load. Conversely, heteroplasmic RD.Myo lines had lower mitophagic markers that negatively correlated with mutant load, combined with a fully polarized and highly fused mitochondrial network. 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Previously, the in vitro mechanism of action has been determined, their activity has been demonstrated in cells, and some representatives of this class of MnSOD mimetics have entered clinical trials. However, MnPAM uptake, distribution, and metabolism in cells are largely unknown. Therefore, we have used X-ray fluorescence microscopy (XFM) and X-ray absorption spectroscopy (XAS) to study the cellular fate of a number of MnPAMs. We have also synthesized and characterized fluorescently labeled (pyrene and rhodamine) manganese(II) pyane [manganese(II) trans-2,13-dimethyl-3,6,9,12,18-pentaazabicyclo[12.3.1]octadeca-1(18),14,16-triene] derivatives and investigated their utility for cellular imaging of MnPAMs. Their SOD activity was determined via a direct stopped-flow technique. XFM experiments show that treatment with amine-based manganese(II) pyane type pentaazamacrocycles leads to a 10-100-fold increase in the overall cellular manganese levels compared to the physiological levels of manganese in control cells. In treated cells in general, manganese was distributed throughout the cell body, with a couple of notable exceptions. The lipophilicity of the MnPAMs, examined by partitioning in octanol-buffer system, was a good predictor of the relative cellular manganese levels. Analysis of the XAS data of treated cells revealed that some fraction of amine-based MnPAMs taken up by the cells remained intact, with the rest transformed into SOD-active manganese(II) phosphate. Higher phosphate binding constants, determined from the effect of the phosphate concentration on in vitro SOD activity, were associated with more extensive metabolism of the amine-based MnPAMs to manganese(II) phosphate. In contrast, the imine-based manganese(II) pydiene complex that is prone to hydrolysis was entirely decomposed after uptake and free manganese(II) was oxidized to a manganese(III) oxide type species, in cytosolic compartments, possibly mitochondria. Complex stability constants (determined for some of the MnPAMs) are less indicative of the cellular fate of the complexes than the corresponding phosphate binding constants.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb444eeadf9eed8fb1ff374bbbff770","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28492332","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Differentiation of MSCs under hypoxic conditions results in inhibited osteogenesis, while chondrogenesis is unaffected. The reasons for these results may be associated with the inherent metabolism of the cells. The present investigation measured the oxygen consumption, glucose consumption and lactate production of MSCs during proliferation and subsequent differentiation towards the osteogenic and chondrogenic lineages. MSCs expanded under normoxia had an oxygen consumption rate of ∼98 fmol/cell/h, 75% of which was azide-sensitive, suggesting that these cells derive a significant proportion of ATP from oxidative phosphorylation in addition to glycolysis. By contrast, MSCs differentiated towards the chondrogenic lineage using pellet culture had significantly reduced oxygen consumption after 24 h in culture, falling to ∼12 fmol/cell/h after 21 days, indicating a shift towards a predominantly glycolytic metabolism. By comparison, MSCs retained an oxygen consumption rate of ∼98 fmol/cell/h over 21 days of osteogenic culture conditions, indicating that these cells had a more oxidative energy metabolism than the chondrogenic cultures. In conclusion, osteogenic and chondrogenic MSC cultures appear to adopt the balance of oxidative phosphorylation and glycolysis reported for the respective mature cell phenotypes. The addition of TGF-β to chondrogenic pellet cultures significantly enhanced glycosaminoglycan accumulation, but caused no significant effect on cellular oxygen consumption. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Francisco Cervantes","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Francesco Passamonti","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ayalew Tefferi","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Sergio Siragusa","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Survival in young patients with intermediate- / high-risk myelofibrosis: estimates derived from databases for non transplant patients.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2010-11-18","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Recent studies have suggested that allogenic stem cell transplantation (allo-SCT) might be a better treatment option, compared to drug therapy, for young patients with high-/intermediate-risk primary myelofibrosis (PMF). However, there are no controlled studies that validate this contention and allo-SCT is associated with a substantial risk of procedure-related mortality and morbidity. In a retrospective analysis of nontransplant PMF patients, who were both young (age \u003c60 years) and with high-/intermediate-risk disease, 1- and 3-year survival estimates were 87% and 55%, 95% and 77%, 71% and 58%, respectively, involving patients seen at three different centers with expertise in PMF; these data did not appear to be inferior to those published in the context of either myeloablative or reduced-intensity conditioning allo-SCT. These observations underscore the need for controlled studies to accurately assess the value of allo-SCT in PMF.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb457f3077c036f7d6e8efbd3d46e45","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19123461","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"George Plitas","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Hebroon Obaid","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ocuin, Lee M.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Dematteo, Ronald P.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Balachandran, Vinod P.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Bamboat, Zubin M.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Endogenous ligands such as high-mobility group box 1 (HMGB1) and nucleic acids are released by dying cells and bind Toll-like receptors (TLRs). Because TLR9 sits at the interface of microbial and sterile inflammation by detecting both bacterial and endogenous DNA, we investigated its role in a model of segmental liver ischemia-reperfusion (I/R) injury. Mice were subjected to 1 hour of ischemia and 12 hours of reperfusion before assessment of liver injury, cytokines, and reactive oxygen species (ROS). Wild-type (WT) mice treated with an inhibitory cytosine-guanosine dinucleotide (iCpG) sequence and TLR9(-/-) mice had markedly reduced serum alanine aminotransferase (ALT) and inflammatory cytokines after liver I/R. Liver damage was mediated by bone marrow-derived cells because WT mice transplanted with TLR9(-/-) bone marrow were protected from hepatic I/R injury. Injury in WT mice partly depended on TLR9 signaling in neutrophils, which enhanced production of ROS, interleukin-6 (IL-6), and tumor necrosis factor (TNF). In vitro, DNA released from necrotic hepatocytes increased liver nonparenchymal cell (NPC) and neutrophil cytokine secretion through a TLR9-dependent mechanism. Inhibition of both TLR9 and HMGB1 caused maximal inflammatory cytokine suppression in neutrophil cultures and conferred even greater protection from I/R injury in vivo.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb458bc08b8fb469e7ed3f8a8895cf0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19902481","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Yun-Chuan Mu","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Kan-Kai Zhu","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ji-Ren Yu","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Jie Zhong","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Xiao-Sun Liu","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Qing Zhang","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Acute cholecystitis immediately after radical gastrectomy: a report of three cases.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Acute cholecystitis is not a common complication of gastrectomy. Its clinical presentations and management strategies in old patients have not been well described in available literature. This report describes the clinical features, management strategies, and treatment outcome of acute cholecystitis immediately after gastrectomy. Acute cholecystitis immediately after gastrectomy in old patients has different clinical presentations, such as fever and high plasma C-reaction protein level. Abdominal computed tomography (CT) scan and ultrasonography showed acute cholecystitis in our cases, which was treated with antibiotics and ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD). The results indicate that abdominal CT scan and ultrasonography can effectively diagnose acute cholecystitis after gastrectomy, which can be effectively treated with antibiotics and PTGD.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb458cf3fff7db3a14e4312135df207","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"20518096","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Arnold, Allison S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Dick, Taylor J. M.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Wakeling, James M.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Quantifying Achilles tendon force in vivo from ultrasound images.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-12-02","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This study evaluated a procedure for estimating in vivo Achilles tendon (AT) force from ultrasound images. Two aspects of the procedure were tested: (i) accounting for subject-specific AT stiffness and (ii) accounting for changes in the relative electromyographic (EMG) intensities of the three triceps surae muscles. Ten cyclists pedaled at 80rpm while a comprehensive set of kinematic, kinetic, EMG, and ultrasound data were collected. Subjects were tested at four crank loads, ranging from 14 to 44Nm (115 to 370W). AT forces during cycling were estimated from AT length changes and from AT stiffness, which we derived for each subject from ultrasound data and from plantar flexion torques measured during isometric tests. AT length changes were measured by tracking the muscle-tendon junction of the medial gastrocnemius (MG) relative to its insertion on the calcaneus. Because the relative EMG intensities of the triceps surae muscles varied with load during cycling, we divided subjects׳ measured AT length changes by a scale factor, defined as the square root of the relative EMG intensity of the MG, weighted by the fractional physiological cross-sectional areas of the three muscles, to estimate force. Subjects׳ estimated AT forces during cycling increased with load (p\u003c0.05). On average, peak forces ranged from 920±96N (14Nm, 115W) to 1510±129N (44Nm, 370W). 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Cells grown on nutrient agar in the presence of benzalkonium (800 mug/ml) grew in broth plus benzalkonium (10 mug/ml) without stripping of their external membrane, but replicate inocula into broth plus benzalkonium (10 mug/ml) and edetate disodium (50 mug/ml) produced cells with structural damage to the outer lavers of the cell envelope.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb45b483db8e0c3148619c1cd1a381a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"815540","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018242482}
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With 100 participants randomly selected at various stages of HIV-related immunosuppression, serum HCV RNA concentrations increased with age (P \u003d .007) and were higher in HIV-positive IDUs with 201-500 (P \u003d .026) and 51-200 (P \u003d .004) CD4 cells/mL than in HIV-negative participants. Among 27 HCV-infected IDUs who acquired HIV infection, serum HCV RNA concentrations varied between semiannual visits by a mean of 0.45 logs, increasing by 0.60 logs after HIV seroconversion (P \u003c .0001), by 0.12 logs each subsequent year (P \u003d .006), and by 0.36 logs per log increase in CD4 cells (P \u003d .01). Serum ALT levels were similar between HIV-positive (40.1 IU/mL) and HIV-negative (45.4 IU/mL) patients (P \u003e .10). 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By contrast, colon tumor-derived cell lines are usually resistant to induction of Fas-mediated apoptosis, and colon cancer cells frequently coexpress Fas and FasL. The mechanisms allowing resistance to Fas-mediated apoptosis are complex, and defects have been identified at several levels of Fas signal transduction. The \"Bcl-2 rheostat\" may be pitched against apoptosis in colon cancer, inasmuch as overexpression of Bcl-2, downregulation of Bak, and mutation of Bax are common defects in colon tumors. Caspase-1 is also downregulated in colon cancer. The high frequency of p53 mutations in late-stage cancers may also inhibit Fas signaling. 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A long open reading frame within the RAD2 transcribed region encodes a protein of 1,031 amino acids with a calculated molecular weight of 117,847. A disruption of the RAD2 gene that deletes the 78 carboxyl terminal codons results in loss of RAD2 function. The 5\u0027 ends of RAD2 mRNA show considerable heterogeneity, mapping 5 to 62 nucleotides upstream of the first ATG codon of the long RAD2 open reading frame. The longest RAD2 transcripts also contain a short open reading frame of 37 codons that precedes and overlaps the 5\u0027 end of the long RAD2 open reading frame. The RAD2 3\u0027 mRNA end maps 171 nucleotides downstream of the TAA termination codon and 20 nucleotides downstream from a 12-base-pair inverted repeat that might function in transcript termination. Northern blot analysis showed a ninefold increase in steady-state levels of RAD2 mRNA after treatment of yeast cells with UV light. The 5\u0027 flanking region of the RAD2 gene contains several direct and inverted repeats and a 44-nucleotide-long purine-rich tract. 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Most traditional analysis methods, designed to estimate relatively long-term brain dynamics, are not always appropriate to capture these patterns. Here we introduce a novel data-driven approach for detecting short-lived fMRI brain activity patterns. Exploiting Density Peak Clustering (Rodriguez and Laio [2014]), our approach reveals well localized clusters by identifying and grouping together voxels whose time-series are similar, irrespective of their brain location, even when very short time windows (∼10 volumes) are used. The method, which we call Coherence Density Peak Clustering (CDPC), is first tested on simulated data and compared with a standard unsupervised approach for fMRI analysis, independent component analysis (ICA). CDPC identifies activated voxels with essentially no false-positives and proves more reliable than ICA, which is troubled by a number of false positives comparable to that of true positives. The reliability of the method is demonstrated on real fMRI data from a simple motor task, containing brief iterations of the same movement. The clusters identified are found in regions expected to be involved in the task, and repeat synchronously with the paradigm. The methodology proposed is especially suitable for the study of short-time brain dynamics and single trial experiments, where the event or task of interest cannot be repeated for the same subject, as happens, for instance, in problem-solving, learning and decision-making. A GUI implementation of our method is available for download at https://github.com/micheleallegra/CDPC. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Saeland, E.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jónsdóttir, I.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Jakobsen, H.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Schulz, D.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Gizurarson, S.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Host defenses against Streptococcus pneumoniae depend largely on opsonophagocytosis mediated by antibodies and complement. Since pneumococcus is a respiratory pathogen, mucosal immune responses may play a significant role in the defense against pneumococcal infections. Thus, mucosal vaccination may be an alternative approach to current immunization strategies, but effective adjuvants are required. Protein antigens induce significant mucosal immunoglobulin A (IgA) and systemic IgG responses when administered intranasally (i. n.) with the glyceride-polysorbate based adjuvant RhinoVax (RV) both in experimental animals and humans. The immunogenicity and efficacy of pneumococcal polysaccharide conjugate vaccines (PNC) of serotypes 1 and 3 was studied in mice after i.n. immunization with RV. Antibodies were measured in serum (IgM, IgG, and IgA) and saliva (IgA) and compared to antibody titers induced by parenteral immunization. The PNCs induced significant systemic IgG and IgA antibodies after i.n. immunization only when given with RV and, for serotype 1, serum IgG titers were comparable to titers induced by subcutaneous immunization. In addition, i.n. immunization with PNC-1 in RV elicited detectable mucosal IgA. These results demonstrate that RV is a potent mucosal adjuvant for polysaccharides conjugated to proteins. A majority of the PNC-1-immunized mice were protected against both bacteremia and pneumonia after i.n. challenge with a lethal dose of serotype 1 pneumococci, and protection correlated significantly with the serum IgG titers. Similarly, the survival of mice immunized i.n. with PNC-3 in RV was significantly prolonged. These results indicate that mucosal vaccination with PNC and adjuvants may be an alternative strategy for prevention against pneumococcal infections.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb46541e2c615266a9750ff4cb349c6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10417183","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Moore, Michael P.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Cassandra Lis","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Martin, Ryan A.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Immune deployment increases larval vulnerability to predators and inhibits adult life-history traits in a dragonfly.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-09-05","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"While deploying immune defences early in ontogeny can trade-off with the production and maintenance of other important traits across the entire life cycle, it remains largely unexplored how features of the environment shape the magnitude or presence of these lifetime costs. Greater predation risk during the juvenile stage may particularly influence such costs by (1) magnifying the survival costs that arise from any handicap of juvenile avoidance traits and/or (2) intensifying allocation trade-offs with important adult traits. Here, we tested for predator-dependent costs of immune deployment within and across life stages using the dragonfly, Pachydiplax longipennis. We first examined how larval immune deployment affected two traits associated with larval vulnerability to predators: escape distance and foraging under predation risk. Larvae that were induced to mount an immune response had shorter escape distances but lower foraging activity in the presence of predator cues. We also induced immune responses in larvae and reared them through emergence in mesocosms that differed in the presence of large predatory dragonfly larvae (Aeshnidae spp.). Immune-challenged larvae had later emergence overall and lower survival in pools with predators. Immune-challenged males were also smaller at emergence and developed less sexually selected melanin wing coloration, but these effects were independent of predator treatment. Overall, these results highlight how mounting an immune defence early in ontogeny can have substantial ecological and physiological costs that manifest both within and across life stages.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb466b1e982b44aa369772c9002a9c4","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29927003","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Anselme Shyaka","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Akiko Kusumoto","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Hiroshi Asakura","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Keiko Kawamoto","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Whole-Genome Sequences of Eight Campylobacter jejuni Isolates from Wild Birds.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"We present here the draft genome sequences of 8 Campylobacter jejuni strains isolated from wild birds. The strains were initially isolated from swabs taken from resident wild birds in the Tokachi area of Japan. The genome sizes range from 1.65 to 1.77 Mbp. ","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb466bf59d25539f65e243ce74ef15b","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"25908133","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In mice fed a high-fat diet, human fibroblast growth factor 19 (FGF19) increased metabolic rate [1.53 +/- 0.06 liters O(2)/h.kg(0.75) (vehicle) vs. 1.93 +/- 0.05 liters O(2)/h.kg(0.75) (FGF19); P \u003c 0.001] and decreased respiratory quotient [0.82 +/- 0.01 (vehicle) vs. 0.80 +/- 0.01 (FGF19); P \u003c 0.05]. In contrast to the vehicle-treated mice that gained weight (0.14 +/- 0.05 g/mouse.d), FGF19-treated mice lost weight (-0.13 +/- 0.03 g/mouse.d; P \u003c 0.001) without a significant change in food intake. Furthermore, in addition to a reduction in weight gain, treatment with FGF19 prevented or reversed the diabetes that develops in mice made obese by genetic ablation of brown adipose tissue or genetic absence of leptin. To explore the mechanisms underlying the FGF19-mediated increase in metabolic rate, we profiled the FGF19-induced gene expression changes in the liver and brown fat. In brown adipose tissue, chronic exposure to FGF19 led to a gene expression profile that is consistent with activation of this tissue. We also found that FGF19 acutely increased liver expression of the leptin receptor (1.8-fold; P \u003c 0.05) and decreased the expression of acetyl coenzyme A carboxylase 2 (0.6-fold; P \u003c 0.05). The gene expression changes were consistent with the experimentally determined increase in fat oxidation and decrease in liver triglycerides. Thus, FGF19 is able to increase metabolic rate concurrently with an increase in fatty acid oxidation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4673b3f7002bc7760224ca8d9caa3","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"14976145","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Hajime Yaegashi","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Satoko Kanematsu","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Natural infection of the soil-borne fungus Rosellinia necatrix with novel mycoviruses under greenhouse conditions.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-03-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Fungi are an important component of the soil ecosystem. Mycoviruses have numerous potential impacts on soil fungi, including phytopathogenic fungal species. However, the diversity and ecology of mycoviruses in soil fungi is largely unexplored. Our previous work has shown that the soil-borne phytopathogenic fungus Rosellinia necatrix was infected with several novel mycoviruses after growing for 2-3 years in an apple orchard. In this study, we investigated whether natural infection of R. necatrix with mycoviruses occurs under limited conditions. Virus-free R. necatrix isolates were grown in a small bucket containing soil samples for a short time (1.5-4.5 months) under greenhouse conditions. Screening of dsRNA mycoviruses among 365 retrieved isolates showed that four, including 6-31, 6-33, 6-35, and 7-11, harbored virus-like dsRNAs. Molecular characterization of the dsRNAs revealed that three retrieved isolates, 6-31, 6-33, and 6-35 were infected with a novel endornavirus and isolate 7-11 is infected with a novel partitivirus belonging to the genus Alphapartitivirus. These novel mycoviruses had no overt biological impact on R. necatrix. Overall, this study indicates that natural infections of R. necatrix with new mycoviruses can occur under experimental soil conditions.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb469da79c2a976c93c17112557e531","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26555164","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Ito, N.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Fukushima, S.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Nakanowatari, J.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Hibino, T.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Arai, M.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Okuda, M.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"psychological phenomena and processes","qualifier":{"classid":"mesheuropmc","classname":"mesheuropmc","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":false,"inferenceprovenance":"iis::document_classes","provenanceaction":{"classid":"iis","classname":"iis","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}}}],"title":[{"value":"Differences in susceptibility to sodium saccharin among various strains of rats and other animal species.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2014-10-03","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Differences in the susceptibilities to sodium saccharin of the urinary bladder epithelium in various strains of rats and other animal species were examined. In Experiment 1, male ACI, Wistar, F344 and Sprague-Dawley rats were administered 5.0% sodium saccharin in the diet for 52 weeks. Rats were killed after weeks 12, 24, 36 and 52. In ACI rats, sodium saccharin induced not only preneoplastic lesions of the urinary bladder, but also tumors. However, in other strains it did not. The urinary bladder of ACI rats given sodium saccharin had the most marked lesions under scanning electron microscopy, with less marked changes in Wistar and F344 rats. Sprague-Dawley rats were resistant to sodium saccharin. In Experiment 2, male F344 rats, B6C3F1 mice, Syrian golden hamsters, and Hartley guinea pigs were given 5.0% sodium saccharin in the diet for 20 weeks. The animals were sacrificed sequentially. Rats developed urinary bladder lesions during the experiment, as detected by light microscopy and scanning electron microscopy. Increased DNA synthesis of the urinary bladder epithelium was detected in rats by autoradiography. However, mice, hamsters and guinea pigs were resistant to sodium saccharin. These results indicate that there are strain and species differences in the urinary bladder response to sodium saccharin.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb469e7e7b16059d70ca4c87e279945","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"6840440","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018257431}
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This novel agent, when administered until disease progression in combination with chemotherapy, extends the survival of women with HER2-positive metastatic breast cancer (MBC). However, the optimal duration of trastuzumab therapy remains to be confirmed. We conducted a retrospective case review study of women with HER2-positive MBC who continued to receive trastuzumab beyond disease progression. Objectives were to assess whether treatment beyond disease progression shows any evidence of efficacy and to evaluate the feasibility of this approach. One hundred five patients (median age, 47 years; range, 24-77 years) were identified in 13 centers. Women had received \u003c/\u003d6 chemotherapy regimens (median, 1) before trastuzumab therapy. Median survival from first trastuzumab dose was 29 months. The overall response rate to trastuzumab alone or with a taxane as the first regimen was 39%; a further 30% of patients had stable disease as the best response. These rates were 36% and 38% after a second regimen of trastuzumab alone or with paclitaxel or vinorelbine was administered. Some patients responded to both the first and second regimens; others responded to the second regimen after the first had failed. Twenty-two patients experienced cardiac events, of whom 18 received \u003e/\u003d1 more trastuzumab regimen. Trastuzumab treatment beyond progression appears to be of value, producing responses and clinical benefit, and is well tolerated without significant cardiac toxicity. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Kenny, A. D.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Role of carbonic anhydrase in bone: plasma acetazolamide concentrations associated with inhibition of bone loss.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-02-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Earlier reports from our laboratory have indicated that the carbonic anhydrase inhibitor acetazolamide blocks the hypercalcemic response to parathyroid hormone. In addition, we have reported that acetazolamide when administered by several routes partially prevents denervation-induced bone loss in a rat model of disuse osteoporosis. Continuous subcutaneous infusion required the least daily dose (8 mg/kg). The present study extends these earlier findings in several ways. It was found that in partially preventing denervation-induced bone loss: (1) incorporation of 1 M THAM [tris(hydroxymethyl)aminoethane] enhanced the potency of acetazolamide such that it was effective at daily doses of 0.6 mg/kg; (2) acetazolamide in the presence of 1 M THAM was effective at plasma concentrations as low as 50 ng/ml which are more than 500-fold less than peak plasma concentrations normally encountered in the human when acetazolamide is being used as a therapeutic agent; and (3) another inhibitor, benzolamide, was also effective by continuous subcutaneous infusion.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb46c4c78a2f7de11bca27e77c1c1b5","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"3927329","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Cendan, Juan C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jörg Peters","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Sukitti Punak","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Kurenov, Sergei N.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Minho Kim","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Simulation for training with the Autosuture Endo Stitch device.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2007-01-17","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The rapid development and deployment of novel laparoscopic instruments present the surgical educator and trainee with a significant challenge. Several useful instruments have been particularly difficult to teach the novice. We have developed a platform that allows the combination of the actual instrument handle with a virtual re-creation of the instrument tip. We chose the Autosuture Endo Stitch device as the prototypical instrument because it satisfies our subjective experience of \"useful, but hard to teach.\" A software package was developed to support the re-creation of the needle and suture that accompany the device. The apparatus has haptic capabilities and collision detection so that the needle driver is \"aware\" of suture and instrument contact. The developed virtual environment allows re-creation of the necessary motion to simulate the instrument, the trainee can use the actual instrument handle, and the system can be altered to accommodate other instruments.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb46d358b0480a7cd04038494c8f17b","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17227928","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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A clinical and genetic study.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-01-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Alzheimer\u0027s disease (AD) occurred in 37 individuals from two kindreds of Jewish ancestry with a mode of transmission suggesting an autosomal dominant genetic trait. Both kindreds originated from Byelorussia and spoke the Lithuanian dialect of Yiddish. In one of the two families one case of pathologically confirmed AD occurred with clinical and neuropathological signs of Parkinson\u0027s disease. In the other family one case of amyotrophic lateral sclerosis and one case of Down\u0027s syndrome occurred, both without clinical or pathological signs of AD. In the single kindred tested, a study of the chromosome 6 markers HLA, Bf and GLO failed to reveal a correlation between the transmission of AD and the segregation of these markers. The association of increased aneuploidy of peripheral blood chromosomes with AD was not confirmed in either of these families. Genetic differences between the familial and the sporadic form of AD are discussed.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb46fcbc4007974587eebc29f9d4f48","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"7205322","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In this article, we examine the activation-degradation role of the acidic TAD of EKLF and demonstrate that the first 40 residues (EKLFTAD1) within this region form a noncovalent interaction with UBI. Nuclear magnetic resonance (NMR) structural studies of an EKLFTAD1-UBI complex show that EKLFTAD1 adopts a 14-residue α helix that forms the recognition interface with UBI in a similar manner as the UBI-interacting helix of Rabex5. We also identify a similar interaction between UBI and the activation-degradation region of SREBP1a, but not with the activation-degradation regions of p53, GAL4, and VP16. These results suggest that select activation-degradation regions like the ones found in EKLF and SREBP1a function in part through their ability to form noncovalent interactions with UBI. 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The aims of the present investigation were (1) to provide reference data for selected dimensions of lips (linear distances and ratios, vermilion area, volume); (2) to quantify the relevant growth changes; and (3) to evaluate sex differences in growth patterns. The 3-dimensional coordinates of 6 soft-tissue landmarks on the lips were obtained by an optoelectronic instrument in a mixed longitudinal and cross-sectional study (2023 examinations in 1348 healthy subjects between 6 y of age and young adulthood). From the landmarks, several linear distances (mouth width, total vermilion height, total lip height, upper lip height), the vermilion height-to-mouth width ratio, some areas (vermilion of the upper lip, vermilion of the lower lip, total vermilion) and volumes (upper lip volume, lower lip volume, total lip volume) were calculated and averaged for age and sex. Male values were compared with female values by means of Student\u0027s t test. Within each age group all lip dimensions (distances, areas, volumes) were significantly larger in boys than in girls (P \u003c 0.05), with some exceptions in the first age groups and coinciding with the earlier female growth spurt, whereas the vermilion height-to-mouth width ratio did not show a corresponding sexual dimorphism. Linear distances in girls had almost reached adult dimensions in the 13-14 y age group, while in boys a large increase was still to occur. The attainment of adult dimensions was faster in the upper than in the lower lip, especially in girls. The method used in the present investigation allowed the noninvasive evaluation of a large sample of nonpatient subjects, leading to the definition of 3-dimensional normative data. 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Their clinical benefits are indisputable. Recently, unexpected long-term presence of Gd in the brain has been reported by numerous retrospective clinical studies and confirmed in preclinical models particularly after linear GBCA (L-GBCA) compared with macrocyclic GBCA (M-GBCA). Even if no clinical consequences of Gd presence in brain tissue has been demonstrated so far, in-depth investigations on potential toxicological consequences and the fate of Gd in the body remain crucial to potentially adapt the clinical use of GBCAs, as done during the nephrogenic systemic fibrosis crisis. Preclinical models are instrumental in the understanding of the mechanism of action as well as the potential safety consequences. However, such models may be associated with risks of biases, often related to the protocol design. Selection of adequate terminology is also crucial. 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There was no statistically significant difference in volume error for repeated CT scans or scans taken with techniques where only pitch, field of view, or tube current (mA) were changed. However, the slice thickness significantly (p \u003c 0.05) affected the volume error. Therefore, to evaluate nodule growth, consistent imaging conditions and high resolution should be used for acquisition of the serial CT scans, especially for smaller nodules. Understanding the effects of scanning and reconstruction parameters on volume measurements by 3DAC allows better interpretation of data and assessment of growth. 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Nursing faculty must prepare graduates for this challenge. However, nursing faculty are often removed from everyday practice and must rely on the perceptions of those entrenched in practice in order to ground teaching endeavors in authenticity. Nurse managers are well positioned to provide knowledgeable insights to nursing faculty regarding nurse relationships. The purpose of this qualitative, descriptive study was to explore nurse managers\u0027 perceptions regarding new graduates\u0027 relationships with more experienced nurses. Researcher-participant audiotaped interviews were conducted with 13 nurse managers. A content analysis revealed that all participants believed nurse relationships were significant, that factors such as perceived inequities and stressful occurrences triggered poor relationships, that new graduates were often targeted for negative relationships, and that reasons for targeting of new graduates included prolonged dependence on experienced nurses and either over or under confidence of the new graduate. Providing a supportive, protective environment and hiring practices that promote team unity were posed as strategies that could help to prevent targeting of new graduates. 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In conclusion, our findings show that mitochondria were the main target in T. castaneum in response to low oxygen. The beetles under hypoxia inhibited mitochondrial respiration and increased antioxidant activity after reoxygenation. 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The main features of ICMFF include: (a) parameterization for the dielectric constant relevant to the condensed state (ε \u003d 2) instead of vacuum, (b) an improved description of hydrogen-bond interactions using duplicate sets of van der Waals parameters for heavy atom-hydrogen interactions, and (c) improved backbone covalent geometry and energetics achieved using novel backbone torsional potentials and inclusion of the bond angles at the C(α) atoms into the internal variable set. The performance of ICMFF was evaluated through loop modeling simulations for 4-13 residue loops. ICMFF was combined with a solvent-accessible surface area solvation model optimized using a large set of loop decoys. Conformational sampling was carried out using the biased probability Monte Carlo method. Average/median backbone root-mean-square deviations of the lowest energy conformations from the native structures were 0.25/0.21 Å for four residues loops, 0.84/0.46 Å for eight residue loops, and 1.16/0.73 Å for 12 residue loops. To our knowledge, these results are significantly better than or comparable with those reported to date for any loop modeling method that does not take crystal packing into account. Moreover, the accuracy of our method is on par with the best previously reported results obtained considering the crystal environment. We attribute this success to the high accuracy of the new ICM force field achieved by meticulous parameterization, to the optimized solvent model, and the efficiency of the search method.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4831280241c3d89aae3fffb1f874a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21069716","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Patient-centered health outcomes are useful in monitoring and predicting recovery and evaluating treatments. An outcome questionnaire for young adult burn survivors was developed and tested. This 5-year (2003-2008) prospective, controlled, multicenter study included burned and nonburned adults ages 19 to 30 years. The Young Adult Burn Outcome Questionnaires were completed at initial contact, 10 days, and 6 and 12 months. Factor analysis established construct validity. Reliability assessments used Cronbach α and test-retest. Recovery patterns were investigated using generalized linear models, with generalized estimating equations using mixed models and random effects. Burned (n \u003d 153) and nonburned subjects (n \u003d 112) completed 620 questionnaires (47 items). Time from injury to first questionnaire administration was 157 ± 36 days (mean ± SEM). Factor analysis included 15 factors: Physical Function, Fine Motor Function, Pain, Itch, Social Function Limited by Physical Function, Perceived Appearance, Social Function Limited by Appearance, Sexual Function, Emotion, Family Function, Family Concern, Satisfaction With Symptom Relief, Satisfaction With Role, Work Reintegration, and Religion. Cronbach α ranged from 0.72 to 0.92, with 11 scales \u003e0.8. Test-retest reliability ranged from 0.29 to 0.94, suggesting changes in underlying health status after burns. Recovery curves in five domains, Itch, Perceived Appearance, Social Function Limited by Appearance, Family Concern, and Satisfaction with Symptom Relief, remained below the reference group at 24 months. The Young Adult Burn Outcome Questionnaire is a reliable and valid instrument for multidimensional functional outcomes assessment. 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In higher education context, only a few studies are available on satisfaction and loyalty of the main customers who are the students, which signifies the need to investigate the field more thoroughly. The aim of this research is to measure the strength of determinants of students\u0027 satisfaction and the importance of antecedents in students\u0027 satisfaction and loyalty in Denmark. Our research model is the modification of European Performance Satisfaction Index (EPSI), which takes the university\u0027s image direct effects on students\u0027 expectations into account from students\u0027 perspective. The structural equation model of student satisfaction and loyalty has been evaluated using partial least square path modelling. Our findings confirm that the EPSI framework is applicable on student satisfaction and loyalty among Danish universities. We show that all the relationships among variables of the research model are significant except the relationship between quality of software and students\u0027 loyalty. Results further verify the significance of antecedents in students\u0027 satisfaction and loyalty at Danish universities; the university image and student satisfaction are the antecedents of student loyalty with a significant direct effect, while perceived value, quality of hardware, quality of software, expectations, and university image are antecedents of student satisfaction. Eventually, our findings may be of an inspiration to maintain and improve students\u0027 experiences during their study at the university. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Lars Arendt-Nielsen","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"César Fernández-de-Las-Peñas","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Thomas Graven-Nielsen","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Basic aspects of musculoskeletal pain: from acute to chronic pain.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The transition from acute to chronic musculoskeletal pain is not well understood. To understand this transition, it is important to know how peripheral and central sensitization are manifested and how they can be assessed. A variety of human pain biomarkers have been developed to quantify localized and widespread musculoskeletal pain. In addition, human surrogate models may be used to induce sensitization in otherwise healthy volunteers. Pain can arise from different musculoskeletal structures (e.g. muscles, joints, ligaments, or tendons), and differentiating the origin of pain from those different structures is a challenge. Tissue specific pain biomarkers can be used to tease these different aspects. Chronic musculoskeletal pain patients in general show signs of local/central sensitization and spread of pain to degrees which correlate to pain intensity and duration. From a management perspective, it is therefore highly important to reduce pain intensity and try to minimize the duration of pain.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb493548d902ac8b03e4a685dcbb0d8","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23115471","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Wastewater compositions affect sulfide and methane production kinetics through both its short-term variation influencing the substrate availability to sewer biofilms, and its long-term variation affecting the sewer biofilm structure. While the short-term effect is well considered in existing sewer models with the use of Monod or half-order equations, the long-term effect has not been explicitly considered in current sewer models suitable for network modelling. In this study, the long-term effect of wastewater compositions on sulfide and methane production activities in rising main sewers was investigated. A detailed biofilm model was firstly developed, and then calibrated and validated using experimental data measured during the entire biofilm development period of a laboratory sewer reactor. 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Together this suggests deficits later in the auditory processing hierarchy in Sz. Here, MMN and ASP were elicited by deviations from a complex zig-zag pitch pattern that cannot be predicted by simple linear rules. Twenty-seven SZ and 26 matched healthy controls (HC) participated. Frequent groups of patterns contained eight tones that zig-zagged in a two-up one-down pitch-based paradigm. There were two deviant patterns: the final tone was either higher in pitch than expected (creating a jump in pitch) or was repeated. Simple MMN to pitch-deviants among repetitive tones was measured for comparison. Sz exhibited a smaller pitch MMN compared to HC as expected. HC produced a late MMN in response to the repeat and jump-deviant and a larger ASP to the standard group of tones, all of which were significantly blunted in SZ. In Sz, the amplitude of the late complex MMN was related to neuropsychological functioning, whereas ASP was not. ASP and late MMN did not significantly correlate in HC or in Sz, suggesting that they are not dependent on one another and may originate within distinct processing streams. Together this suggests multiple deficits later in the auditory sensory-perceptual hierarchy in Sz, with impairments evident in both segmentation and deviance detection abilities. This article is protected by copyright. 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Examination of the cross-linking conditions, the use of various mutated ribozymes, as well as the probing and characterization of the resulting ribozyme-substrate complexes, revealed several new features of the molecular mechanism: (1) the close proximity of several bases between nucleotides of the substrate and ribozyme; (2) the active ribozyme-substrate complex folds in a manner that docks the middle of the P1 stem on the P3 stem, while concomitantly the scissile phosphate is in close proximity to the catalytic cytosine; and, (3) some complexes appear to be compatible with being active intermediates along the folding pathway, while others seem to correspond to misfolded structures. 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Pramlintide is generally well tolerated, with the most frequent treatment-emergent adverse event being mild to moderate nausea, which decreases over time. Pramlintide treatment is also associated with improvements in markers of oxidative stress and cardiovascular risk and improved patient-reported treatment satisfaction. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Lianlin Li","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Fang Li","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Beating the Rayleigh limit: orbital-angular-momentum-based super-resolution diffraction tomography.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-10-15","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This paper reports a super-resolution imaging approach based on orbital-angular-momentum diffraction tomography (OAM-DT), which makes an important breakthrough on the Rayleigh limit associated with conventional diffraction tomography (DT) technique. It is well accepted that orbital-angular momentum (OAM) provides additional electromagnetic degrees of freedom. This concept has been widely applied in science and technology. In this paper we revisit the DT problem extended with OAM, and demonstrate theoretically and numerically that there is no physical limit on imaging resolution with OAM-DT. The physical mechanism behind it is that either the near field or superoscillation of the transmitter is employed to super-resolve probed objects. This super-resolution OAM-DT imaging paradigm does not require near-field measurement, a subtle focusing lens, or complicated postprocessing, etc., thus providing an approach to realize the wave-field imaging of universal objects with subwavelength resolution.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4a1e3846e87bd98bf54abe49c92e0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"24125378","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Therapeutic Concentrations of Heparin Augment Platelet Activation at the Time of Coronary Angiography.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-02-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Background: Besides its anticoagulant effects, heparin is known to alter platelet (PLT) function. We examined the effects of unfractionated heparin on PLT function in patients with stable coronary artery disease (CAD). Methods and Results: PLT function was evaluated by whole-blood flow cytometry to detect PLT CD62 expression and by impedance aggregometry to assess the platelet aggregation (PA) before and after bolus intravenous administration of low-dose heparin (2713 +/- 1231 U) in 16 patients undergoing coronary angiography (group 1) and high-dose heparin (7937 +/- 2414 U) in 16 patients undergoing coronary angioplasty (group 2). Activated clotting time (ACT) and plasma antifactor-Xa heparin levels also were measured. Heparin increased PLT CD62 expression, which was significantly more pronounced in group 1 patients with plasma heparin levels less than 0.7 U/mL and ACT of 222 +/- 52 seconds compared with group 2 patients with heparin levels greater than 0.7 U/mL and ACT of 365 +/- 86 seconds (8 +/- 9 v -1 +/- 4% change in resulting PLTs, P \u003d.01, and 11 +/- 12 v 1 +/- 6% increase in adenosine diphosphate (ADP) [5 µM]-stimulated PLTs, P \u003d.02). Heparin produced a slight increase in PA in group 1 patients (1.4 +/- 5.3 ohms) as compared with the group 2 patients, where it significantly suppressed PA (-3.0 +/- 5.3 ohms, P.05 v group 1). A strong and statistically significant negative correlation between change in platelet CD62 expression and heparin concentration was observed in group 1 patients (r \u003d -.5, P \u003d.05, -ADP; r \u003d -.65, P \u003d.006, +ADP), whereas this relationship was weak and did not reach statistical significance in group 2 patients (r \u003d -0.4, P \u003d.2, -ADP; r \u003d.11, P \u003d 0.9; +ADP). Conclusion: Bolus administration of intravenous heparin augmented PLT activation in patients at clinically relevant anticoagulant concentrations (\u003c0.7 U/mL). These findings may have implications for optimal dosing strategy for heparin as an antithrombotic agent in clinical situations characterized by platelet-dependent thrombotic events.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4a277847e707a9d19c0dbe5d8db56","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10684486","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The renoprotection of adiponectin is associated with improvement of the endothelial dysfunction, reduction of oxidative stress, and upregulation of endothelial nitric oxide synthase expression through activation of adenosine 5\u0027-monophosphate-activated protein kinase by AdipoR1 and activation of peroxisome proliferator-activated receptor (PPAR)-α signaling pathway by AdipoR2. Several single nucleotide polymorphisms in the AdipoQ gene, including the promoter, are associated with increased risk of the development of T2D and DKD. Renin-angiotensin-aldosterone system blockers, adiponectin receptor agonists, and PPAR agonists (e.g., tesaglitazar, thiazolidinediones, fenofibrate), which increase plasma adiponectin levels and adiponectin receptors expression, may be potential therapeutic drugs for the treatment of DKD.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4b1948ea0793661f3ff7539ad98e5","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28402446","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Clinical findings were nonspecific; tick exposure was documented in 2 of the dogs. Hematologic abnormalities included anemia (n\u003d2), neutrophilia (n\u003d2, including 1 with a left shift), lymphopenia (n\u003d3), eosinopenia (n\u003d3), and thrombocytopenia (n\u003d2). One anemic dog had a positive Coombs\u0027 test. In 1 dog, Western blot analysis of serum yielded multiple positive bands with B turicatae lysate, indicating the spirochetemia most likely was due to B turicatae infection. In 2 dogs, spirochetes were cultured from the blood and identified using DNA analysis as Borrelia turicatae; 1 of these dogs also was seropositive for Ehrlichia canis and B burgdorferi. In 2 cases, spirochetemia was more prominent in blood smears prepared immediately after sample collection than in smears prepared from EDTA blood. Two dogs recovered with doxycycline treatment; 1 dog declined clinically despite treatment and was euthanized. B turicatae is the agent of tick-borne (endemic) relapsing fever in humans and is distinct from B burgdorferi, the agent of Lyme disease; however, serologic cross-reactivity may occur. 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As multiple duplexes (CHA) or concatemers of increasing length (HCR) are generated, there are opportunities to couple these outputs to different analytical modalities, including transduction to fluorescent, electrochemical, and colorimetric signals. Because both amplification and transduction are at their root dependent on the programmability of Waston-Crick base pairing, nucleic acid circuits can be much more readily tuned and adapted to new applications than can many other biomolecular amplifiers. As an example, robust methods for real-time monitoring of isothermal amplification reactions have been developed recently. Beyond amplification, nucleic acid circuits can include logic gates and thresholding components that allow them to be used for analysis and decision making. Scalable and complex DNA circuits (seesaw gates) capable of carrying out operations such as taking square roots or implementing neural networks capable of learning have now been constructed. 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Collecting sites and distribution. Table S2. Best substitution models for the atpB-rbcL and ITS used in the Bayesian analyses. Table S3. T Statistical summary of asymmetric values for the among-lineage diversification rate variation in the phylogenetic topologies. Table S4. Testing for diversification rate variation models by ∆AICRC test statistic. Figure S1. The phylogenetic tree reconstructed by cpDNA atpB-rbcL spacer and nrITS under the Yule’s pure-birth speciation model. Samples that were identified as the same species but represented at different clades in the gene trees (supplementary) were separated to different OTUs. Bold lines indicate the lineages grouping with posterior probability \u0026gt; 80%; node labels are the splitting time (unit: mya); node bar is the 95% highest posterior density interval (HPD) of the splitting time. The nodes probably have diversification rate shift were labeled by nodes i and ii of cpDNA tree and nodes a and b of ntITS tree. The testing results of diversification-rate shift of descendents of nodes i, ii, a, and b inferred by delta-statistics were indicated in the inner table. Figure S2. Biogeographic inferences by cpDNA+nrITS (Fig. 2A). (A) Biogeographic inference under the DEC model. Lineages with bold and thin lines indicate the lineages derived from nodes (ancestral areas) with likelihood \u0026gt; 0.7 and \u0026gt; 0.5, respectively. Likelihood less than 0.5 are treated as unknown (black lineages). (B) Biogeographic inference under the S-DIVA model. The dispersal (d) or vicariance (v) events with a posterior probability \u0026gt; 0.5 are marked in the node. The yellow dots indicate the events of range transition inferred by both dispersal and vicariance events. The open dots indicate that thebiogeographic distribuion of deriving lineages were explained as consequences of dispersal events. Figure S3. Biogeographic inferences by cpDNA (Fig. 3). (A) Biogeographic inference under the DEC model. 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Cytokines increase both oxidant production and antioxidant defenses, thus minimizing damage to the host. While antioxidant defenses interact when a component is compromised, the nature and extent of the defenses are influenced by dietary intake of sulfur amino acids, for glutathione synthesis, and vitamins E and C. In animal studies, in vivo and in vitro responses to inflammatory stimuli are influenced by dietary intake of copper, zinc, selenium, N-acetylcysteine, cysteine, methionine, taurine, and vitamin E. Information from animal studies has yet to be fully translated into a clinical context. However, N-acetylcysteine, vitamin E, and a cocktail of antioxidant nutrients have reduced inflammatory symptoms in inflammatory joint disease, acute and chronic pancreatitis, and adult respiratory distress syndrome. Impaired antioxidant defenses may contribute to disease progression after infection with human immunodeficiency virus. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Zhixiang Wang","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Wei Zhang","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Hongxing Lei","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Chun Wu","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Yong Duan","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Dual binding modes of Congo red to amyloid protofibril surface observed in molecular dynamics simulations.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-11-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Congo red has been used to identify amyloid fibrils in tissues for more than 80 years and is also a weak inhibitor to both amyloid-beta fibril formation and toxicity. 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Because of the ubiquitous long grooves on the amyloid fibril surface, we propose that this binding interaction could be a general recognition mode of amyloid fibrils by Congo red, Thioflavin T, and other long flat molecules. In the secondary mode, Congo red bound parallel to the beta-strands on the edge or in the middle of a beta-sheet. The primary binding mode of Congo red and GNNQQNY protofibril was more stable than the secondary mode by -5.7 kcal/mol as estimated by the MM-GBSA method. Detailed analysis suggests that the hydrophobic interactions play important roles for burial of the hydrophobic part of the Congo red molecules. 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This approach enables us to achieve high sensitivity with experiments that bring the power of NMR to Giga-Pascal pressure condensed matter research. First applications, the detection of a topological electronic transition in ordinary aluminum metal and the closing of the pseudo-gap in high-temperature superconductivity, show the power of such an approach. Meanwhile, the range of achievable pressures was increased tremendously with a new generation of anvil cells (up to 10.1 GPa), that fit standard-bore NMR magnets. This approach might become a new, important tool for the investigation of many condensed matter systems, in chemistry, geochemistry, and in physics, since we can now watch structural changes with the eyes of a very versatile probe. 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The molecular machinery that translates the Ca(2+) signal into exocytosis is only beginning to emerge. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins syntaxin, SNAP-25, and synaptobrevin are central components of the fusion apparatus. Assembly of a membrane-bridging ternary SNARE complex is thought to initiate membrane merger, but the roles of other factors are less understood. Complexins are two highly conserved proteins that modulate the Ca(2+) responsiveness of neurotransmitter release. In vitro, they bind in a 1:1 stoichiometry to the assembled synaptic SNARE complex, making complexins attractive candidates for controlling the exocytotic fusion apparatus. We have now performed a detailed structural, kinetic, and thermodynamic analysis of complexin binding to the SNARE complex. 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Incremental cost-effectiveness ratios for the same screening intervals were higher for non-African Americans: $17,000, $23,000, $44,000, and $81,000 per quality-adjusted life year, respectively. In summary, these models suggest that screening African Americans for microalbuminuria at either 5- or 10-year intervals is highly cost-effective.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4e438766fc4cb9d394702336f7d53","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23204444","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018258027}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Sandra Bausch-Goldbohm","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Piet van den Brandt","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Michael Jerrett","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Rob Beelen","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Leo Schouten","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Bert Brunekreef","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Gerard Hoek","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Ben Armstrong","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Edward Hughes","name":"","surname":"","rank":9,"pid":[],"affiliation":[]},{"fullname":"Paul Fischer","name":"","surname":"","rank":10,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2009-06-26","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Evidence is increasing that long-term exposure to ambient air pollution is associated with deaths from cardiopulmonary diseases. In a 2002 pilot study, we reported clear indications that traffic-related air pollution, especially at the local scale, was related to cardiopulmonary mortality in a randomly selected subcohort of 5000 older adults participating in the ongoing Netherlands Cohort Study (NLCS) on diet and cancer. In the current study, referred to as NLCS-AIR, our objective was to obtain more precise estimates of the effects of traffic-related air pollution by analyzing associations with cause-specific mortality, as well as lung cancer incidence, in the full cohort of approximately 120,000 subjects. Cohort members were 55 to 69 years of age at enrollment in 1986. Follow-up was from 1987 through 1996 for mortality (17,674 deaths) and from late 1986 through 1997 for lung cancer incidence (2234 cases). Information about potential confounding variables and effect modifiers was available from the questionnaire that subjects completed at enrollment and from publicly available data (including neighborhood-scale information such as income distributions). The NLCS was designed for a case-cohort approach, which makes use of all the cases in the full cohort, while data for the random subcohort are used to estimate person-time experience in the study. Full information on confounders was available for the subjects in the random subcohort and for the emerging cases of mortality and lung cancer incidence during the follow-up period, and in NLCS-AIR we used the case-cohort approach to examine the relation between exposure to air pollution and cause-specific mortality and lung cancer. We also specified a standard Cox proportional hazards model within the full cohort, for which information on potential confounding variables was much more limited. Exposure to air pollution was estimated for the subjects\u0027 home addresses at baseline in 1986. Concentrations were estimated for black smoke (a simple marker for soot) and nitrogen dioxide (NO2) as indicators of traffic-related air pollution, as well as nitric oxide (NO), sulfur dioxide (SO2), and particulate matter with aerodynamic diameter \u003c or \u003d 2.5 microm (PM2.5), as estimated from measurements of particulate matter with aerodynamic diameter \u003c or \u003d 10 microm (PM10). Overall long-term exposure concentrations were considered to be a function of air pollution contributions at regional, urban, and local scales. We used interpolation from data obtained routinely at regional stations of the National Air Quality Monitoring Network (NAQMN) to estimate the regional component of exposure at the home address. Average pollutant concentrations were estimated from NAQMN measurements for the period 1976 through 1996. Land-use regression methods were used to estimate the urban exposure component. For the local exposure component, geographic information systems (GISs) were used to generate indicators of traffic exposure that included traffic intensity on and distance to nearby roads. A major effort was made to collect traffic intensity data from individual municipalities. The exposure variables were refined considerably from those used in the pilot study, but we also analyzed the data for the full cohort in the current study using the exposure indicators of the pilot study. We analyzed the data in models with the estimated overall pollutant concentration as a single variable and with the background concentration (the sum of regional and urban components) and the local exposure estimate from traffic indicators as separate variables. In the full-cohort analyses adjusted for the limited set of confounders, estimated overall exposure concentrations of black smoke, NO2, NO, and PM2.5 were associated with mortality. For a 10-microg/m3 increase in the black smoke concentration, the relative risk (RR) (95% confidence interval [CI]) was 1.05 (1.00-1.11) for natural-cause (nonaccidental) mortality, 1.04 (0.95-1.13) for cardiovascular mortality, 1.22 (0.99-1.50) for respiratory mortality, 1.03 (0.88-1.20) for lung cancer mortality, and 1.04 (0.97-1.12) for noncardiopulmonary, non-lung cancer mortality. Results were similar for NO2, NO, and PM2.5. For a 10-microg/m3 increase in PM2.5 concentration, the RR for natural-cause mortality was 1.06 (95% CI, 0.97-1.16), the same as in the results of the American Cancer Society Study reported by Pope and colleagues in 2002. The highest relative risks were found for respiratory mortality, though confidence intervals were wider for this less-frequent cause of death. No associations with mortality were found for SO2. Some of the associations between the traffic indicator variables used to assess traffic intensity near the home and mortality reached statistical significance in the full cohort. For an increase in traffic intensity of 10,000 motor vehicles in 24 hours (motor vehicles/day) on the road nearest a subject\u0027s residence, the RR was 1.03 (95% CI, 1.00-1.08) for natural-cause mortality, 1.05 (0.99-1.12) for cardiovascular mortality, 1.10 (0.95-1.26) for respiratory mortality, 1.07 (0.96-1.19) for lung cancer mortality, and 1.00 (0.94-1.06) for noncardiopulmonary, non-lung cancer mortality. Results were similar for traffic intensity in a 100-m buffer around the subject\u0027s residence and living near a major road (a road with more than 10,000 motor vehicles/day). Distance in meters to the nearest major road and traffic intensity on the nearest major road were not associated with any of the mortality outcomes. We did not find an association between cardiopulmonary mortality and living near a major road as defined using the methods of the pilot study. In the case-cohort analyses adjusted for all potential confounders, we found no associations between background air pollution and mortality. The associations between traffic intensity and mortality were weaker than in the full cohort, and confidence intervals were wider, consistent with the smaller number of subjects. The lower relative risks of mortality associated with traffic variables in the case-cohort study population could be related to the particular subcohort that was randomly selected from the full cohort, as the risks estimated with the actual subcohort were well below the average estimates obtained for 100 new case-cohort analyses with 100 alternative subcohorts of 5000 subjects each that we randomly selected from the full cohort. Differences in adjusted relative risks between the full-cohort and the case-cohort analyses could be explained by random error introduced by sampling from the full cohort and by a selection effect resulting from the relatively large number of missing data for variables in the extensive confounder model used in the case-cohort analyses. More complete control for confounding probably did not contribute much to the lower relative risks in the case-cohort analyses, especially for the traffic variables, as results were similar when the limited confounder model for the full cohort was used in analyses of the subjects in the case-cohort study population. In additional analyses using black smoke concentrations as the exposure variables, we found that the association between overall black smoke and cardiopulmonary mortality was somewhat stronger for case-cohort subjects who did not change residence during follow-up, and in the full cohort, there was a tendency for relative risks to be higher for subjects living in the three major cities included in the study. Adjustment for estimated exposure to traffic noise did not affect the associations of background black smoke and traffic intensity with cardiovascular mortality. There was some indication of an association between traffic noise and cardiovascular mortality only for the 1.6% of the subjects in the full cohort who were exposed to traffic noise in the highest category of \u003e 65 A-weighted decibels (dB(A); decibels with the sound pressure scale adjusted to conform with the frequency response of the human ear). Examination of sex, smoking status, educational level, and vegetable and fruit intake as possible effect modifiers showed that for overall black smoke concentrations, associations with mortality tended to be stronger in case-cohort subjects with lower levels of education and those with low fruit intake, but differences between strata were not statistically significant. For lung cancer incidence, we found essentially no relation to exposure to NO2, black smoke, PM2.5, SO2, or several traffic indicators. Associations of overall air pollution concentrations and traffic indicator variables with lung cancer incidence were, however, found in subjects who had never smoked, with an RR of 1.47 (95% CI, 1.01-2.16) for a 10-microg/m3 increase in overall black smoke concentration. In the current study, the mortality risks associated with both background air pollution and traffic exposure variables were much smaller than the estimate previously reported in the pilot study for risk of cardiopulmonary mortality associated with living near a major road (RR, 1.95; 95% CI, 1.09-3.51). The differences are most likely due to the extension of the follow-up period in the current study and to random error in the pilot study related to sampling from the full cohort. Though relative risks were generally small in the current study, long-term average concentrations of black smoke, NO2, and PM2.5 were related to mortality, and associations of black smoke and NO2 exposure with natural-cause and respiratory mortality were statistically significant. Traffic intensity near the home was also related to natural-cause mortality. The highest relative risks associated with background air pollution and traffic variables were for respiratory mortality, though the number of deaths was smaller than for the other mortality categories. (ABSTRACT TRUNCATED)","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4e44a4aa3d60aa1b7ae533a974b1a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19554969","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Yilong Shu","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Masami Takahashi","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Xin Liu","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Yan Yang","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Gillis, Kevin D.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Phosphorylation of SNAP-25 at Ser187 mediates enhancement of exocytosis by a phorbol ester in INS-1 cells.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-11-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Activation of diacylglycerol (DAG) signaling pathways with phorbol esters dramatically enhances Ca2+-triggered exocytosis from both endocrine cells and neurons, however the relevant targets of DAG are controversial. A possible effector mechanism for this signaling pathway is phosphorylation of SNAP-25 (25 kDa synaptosome-associated protein) at Ser187 by PKC. Here, we investigated the role of Ser187 in the enhancement of exocytosis by the phorbol ester PMA (phorbol 12-myristate 13-acetate). We used patch-clamp measurements of membrane capacitance together with photorelease of caged-Ca2+ and membrane depolarization to study exocytosis. Expression of the nonphosphorylatable S187C SNAP-25 mutant did not attenuate the enhancement of exocytosis by PMA in either bovine chromaffin cells or the INS-1 insulin-secreting cell line. To test the effects of Ser187 mutations under conditions in which the endogenous SNAP-25 is disabled, we expressed botulinum toxin serotype E to cleave SNAP-25 in INS-1 cells. Coexpression of a toxin-resistant mutant (TR), but not wild-type SNAP-25, was able to rescue PMA-modulated exocytosis. Coexpression of the toxin with the TR-S187C SNAP-25 mutant was able to completely block the enhancement of exocytosis by PMA in response to photoelevation of [Ca2+]i to low microM levels or to a depolarizing train. The phospho-mimetic S187E mutation enhanced the small, fast burst of exocytosis evoked by photelevation of Ca2+, but, like PMA, had smaller effects on exocytosis evoked by a depolarizing train. This work supports the hypothesis that phosphorylation of Ser187 of SNAP-25 by PKC is a key step in the enhancement of exocytosis by DAG.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4e4a25f6eeabe0156bbcca01955c0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"18171919","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Andres Gomez-Lievano","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Hyejin Youn","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bettencourt, Luís M. A.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The statistics of urban scaling and their connection to Zipf\u0027s law.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-12-01","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Urban scaling relations characterizing how diverse properties of cities vary on average with their population size have recently been shown to be a general quantitative property of many urban systems around the world. However, in previous studies the statistics of urban indicators were not analyzed in detail, raising important questions about the full characterization of urban properties and how scaling relations may emerge in these larger contexts. Here, we build a self-consistent statistical framework that characterizes the joint probability distributions of urban indicators and city population sizes across an urban system. To develop this framework empirically we use one of the most granular and stochastic urban indicators available, specifically measuring homicides in cities of Brazil, Colombia and Mexico, three nations with high and fast changing rates of violent crime. We use these data to derive the conditional probability of the number of homicides per year given the population size of a city. To do this we use Bayes\u0027 rule together with the estimated conditional probability of city size given their number of homicides and the distribution of total homicides. We then show that scaling laws emerge as expectation values of these conditional statistics. Knowledge of these distributions implies, in turn, a relationship between scaling and population size distribution exponents that can be used to predict Zipf\u0027s exponent from urban indicator statistics. Our results also suggest how a general statistical theory of urban indicators may be constructed from the stochastic dynamics of social interaction processes in cities.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4e5a808b1db07e8e18dcbed8384c1","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22815745","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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This protective effect has been considered to be mediated through mononuclear phagocytes. By using radioactive labelling, we localized the beta-1,3-D-polyglucose derivatized microbeads (GDM) during the period following injection. The GDM was recovered mainly in the milky spots of the omentum. In animals treated with GDM, the total white cell number was significantly increased in peritoneal fluid of mice before and after challenge with E. coli. Bacterial counts in peritoneal fluid of GDM treated animals declined to zero after 24 h. In untreated animals there was a slight increase in bacterial counts until the animals died after about 12 h. Mouse peritoneal macrophages stimulated with GDM released significant amounts of IL-1 and PGE2. There was no significant release of TNF. Levels of IL-1 and PGE2 in peritoneal fluid increased significantly during the first 48 h after treatment with GDM. There was no increase of levels of TNF. After challenge with E. coli, the levels of IL-1, TNF, and PGE2 were significantly lower compared with control animals. In untreated animals the levels of IL-1 and TNF remained elevated until the animals died after about 12 h. These studies demonstrate that the raised levels of arachidonic acid metabolites after pretreatment with GDM or AG seems to inhibit the otherwise lethal elevation of IL-1 and TNF in body fluids which is seen in untreated animals.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb4fa76b0c9ad6ca1e26438f83cbc1a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"1874801","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Ten patients with NES underwent preictal (on hospital admission) and postictal (\u003c or \u003d6 hours after seizure) ERP recordings of an auditory oddball paradigm. Additionally, 10 temporal lobe epilepsy (TLE) patients with partial seizures and secondary generalization underwent preictal, postictal (\u003c 6 hours after seizures), and interictal (7-48 hours after seizure) ERP recordings. We recently reported that ERPs recorded in TLE patients with partial epilepsy undergo a temporary change postictally, while returning to their preictal state during interictal recordings. In the current study intraclass correlations, transformed into z scores, are used to determine test-retest validity of repeated ERP recordings. An independent sample t test with z scores for the comparison of preictal and postictal recordings showed that ERP activation differed between NES and TLE patients (P\u003d0.009). More specifically, ERP recordings in the preictal and postictal states were similar in NES patients, but dissimilar in TLE patients. On the other hand, this dissimilarity in ERPs disappeared when comparing z scores for the preictal and postictal recordings in NES patients with z scores for the preictal and interictal recordings in TLE patients. This further supports the notion that identical waveforms during preictal and postictal recordings in NES patients reflect nonepileptic seizure activity. 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We develop and implement an algorithm to calculate the admittance of each vascular bed, using bifurcating structured trees and recursion. The structured-tree models take into account the geometry and material properties of the \u0027smaller\u0027 arteries and veins of radii ≥ 50 μm. We study the effects on flow and pressure associated with three classes of pulmonary hypertension expressed via stiffening of larger and smaller vessels, and vascular rarefaction. 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In the absence of red blood cells and in a dose-dependent manner, DETA-NONOate strongly inhibited platelet aggregation induced by several stimuli (ADP, epinephrine and collagen) whereas RRx-001 only slightly inhibited platelet aggregation under the same conditions in a dose-dependent manner; these antiaggregant effects were blocked when both DETA-NONOate and RRx-001 were co-incubated with carboxy-PTIO (CPTIO 0.01-100 micromol), a widely accepted NO scavenger. However, in the presence of red blood cells from healthy human donors, RRx-001, which binds covalently to haemoglobin (Hb) and catalyses the production of NO from endogenous nitrite, more strongly inhibited the aggregation of platelets than DETA-NONOate in a dose-dependent manner likely because haemoglobin avidly scavenges nitric oxide and reduces its half-life; the RRx-001-mediated platelet inhibitory effect was increased in the presence of nitrite. 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Psychosis frequently occurs subsequent to the onset of dementia. Published prevalence estimates of psychosis in patients with AD range from 10 to 73% with an overall median of 34% within clinic populations, and from 7 to 20% in community and clinical trials populations depending on definitions used. Among people with AD who have no psychotic symptoms there appears to be an annualized incidence of psychosis of about 20% in outpatients, and a much higher rate in nursing home patients. Female gender, somewhat greater cognitive impairment among outpatients, somewhat lesser cognitive impairment among nursing home patients, and physical aggression are more associated with psychotic signs and symptoms than not. Right frontal hypometabolism and greater frontal neuropsychological deficits occur in AD patients with psychosis in comparison to those without. Among nursing home patients with dementia who have clinically significant agitation, the substantial majority have delusions or hallucinations. Among patients in nursing homes with dementia and psychosis, nearly two-thirds have persistent symptoms over at least 12 weeks, and among outpatient studies, hallucinations and delusions may persist in approximately 40-50% over periods of 3 months to one year. There is some evidence that psychotic symptoms improve modestly with antipsychotic medication treatment. 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Our previous work has shown that DBS in the subthalamic nucleus (STN) can improve major motor deficits, and induce a variety of neural responses in rats with unilateral dopamine (DA) lesions. In the present study, we examined the effect of STN DBS on reaction time (RT) performance and parallel changes in neural activity in the cortico-basal ganglia regions of partially bilateral DA- lesioned rats. We recorded neural activity with a multiple-channel single-unit electrode system in the primary motor cortex (MI), the STN, and the substantia nigra pars reticulata (SNr) during RT test. RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum. In parallel with such behavioral impairments, the number of responsive neurons to different behavioral events was remarkably decreased after DA lesion. Bilateral STN DBS improved RT performance in 6-OHDA lesioned rats, and restored operational behavior-related neural responses in cortico-basal ganglia regions. These behavioral and electrophysiological effects of DBS lasted nearly an hour after DBS termination. These results demonstrate that a partial DA lesion-induced impairment of RT performance is associated with changes in neural activity in the cortico-basal ganglia circuit. Furthermore, STN DBS can reverse changes in behavior and neural activity caused by partial DA depletion. 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Using the Center for Cardiometabolic Risk Reduction in South Asia surveillance study (a population-based survey of Delhi and Chennai, India) we estimated overall, and age-, sex-, city-, and diabetes-specific prevalence of CKD, and defined the distribution of the study population by the Kidney Disease Improving Global Outcomes (KDIGO) classification scheme. The likelihood of cardiovascular events in participants with and without CKD was estimated by the Framingham and Interheart Modifiable Risk Scores. Of the 12,271 participants, 80% had complete data on serum creatinine and albuminuria. The prevalence of CKD and albuminuria, age standardized to the World Bank 2010 world population, was 8.7% (95% confidence interval: 7.9-9.4%) and 7.1% (6.4-7.7%), respectively. Nearly 80% of patients with CKD had an abnormally high hemoglobin A1c (5.7 and above). Based on KDIGO guidelines, 6.0, 1.0, and 0.5% of study participants are at moderate, high, or very high risk for experiencing CKD-associated adverse outcomes. The cardiovascular risk scores placed a greater proportion of patients with CKD in the high-risk categories for experiencing cardiovascular events when compared with participants without CKD. Thus, 1 in 12 individuals living in two of India\u0027s largest cities have evidence of CKD, with features that put them at high risk for adverse outcomes. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Stoof, T. J.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Raaij, L. 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Pentoxifylline (PTX), a methylxanthine derivative widely used for the symptomatic treatment of various vascular disorders, was recently found to have anti-inflammatory effects. PTX can suppress tumor necrosis factor-alpha production and function, and inhibits leukocyte-endothelial cell adherence. The aim of the present study was to investigate whether PTX also interferes with T-cell/keratinocyte binding. Peripheral blood T cells were activated with phorbol myristate acetate and co-incubated with interferon-gamma- or tumor necrosis factor-alpha-stimulated keratinocytes (SVK 14 cells) in the presence or absence of PTX. Using an enzyme-linked immuno cell adhesion assay PTX was found to inhibit T-cell/keratinocyte adhesion in a dose-dependent manner. A similar inhibition was found when PTX was replaced by isobutylmethylxanthine, another methylxanthine derivative, or by a combination of two cyclic adenosine monophosphate analogues. No major effect on T-cell/keratinocyte adherence was observed when PTX was present during the pre-incubation of keratinocyte monolayers with tumor necrosis factor-alpha or interferon-gamma prior to the adhesion assay. In keratinocyte monolayers the interferon-gamma or tumor necrosis factor-alpha induced intercellular adhesion molecule-1 expression could not be inhibited by PTX. However, when PTX was added to short-term organ cultures of normal human skin biopsies, the lipopolysaccharide- and tumor necrosis factor-alpha-induced keratinocyte intercellular adhesion molecule-1 expression was blocked completely. The interferon-gamma-induced ICAM-1 expression was not blocked by PTX. The results presented herein suggest that impaired T-cell/keratinocyte binding may be one of the mechanisms by which PTX exerts a beneficial effect in certain inflammatory dermatoses.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb51275bad113d3d01789e3aedb1a76","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"7539468","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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This resource is composed of 10,459 T-DNA lines generated using the Arabidopsis thaliana ecotype Columbia. The flanking sequence tag for each T-DNA insertion has been deposited in public databases, and seed for each line is currently available from the Arabidopsis Biological Resource Center. The pDsLox vector used to create this new population contains a Ds transposon and Cre/Lox recombination sites. Each WiscDsLox line therefore has the potential to serve as a launch-pad for performing local saturation mutagenesis by mobilization of the Ds element. In addition, Cre-Lox recombination between the T-DNA and a transposed Ds element should enable targeted deletion of specific genomic regions. We generated the WiscDsLox collection using an improved high-throughput pipeline that streamlines analysis of large numbers of independent Arabidopsis thaliana (L.) Hyenh. lines. In this paper we describe the details of this novel method and also provide potential users of WiscDsLox T-DNA lines with useful background information about this collection. Experiments to characterize the utility of the Ds transposon and Cre/Lox elements present in the WiscDsLox lines are in progress and will be reported in the future.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb518225dc63e8760f5f3b2b134568d","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17186119","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In this review, the authors focused on the x-ray repair cross-complementing protein group 3 (XRCC3) and xeroderma pigmentosum group D (XPD)/excision repair cross-complementing rodent repair deficiency (ERCC2) genes, because they are among the most extensively studied but no final conclusion has yet been drawn about their role in cancer occurrence. XRCC3 participates in DNA double-strand break/recombinational repair through homologous recombination to maintain chromosome stability. XPD/ERCC2 is a helicase involved in the nucleotide excision repair pathway, which recognizes and repairs many structurally unrelated lesions, such as bulky adducts and thymidine dimers. The authors identified a sufficient number of epidemiologic studies on cancer to perform meta-analyses for XPD/ERCC2 variants in codons 156, 312, and 751 and XRCC3 variants in codon 241. 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A SEDENTEXCT dose index adult phantom and custom-built adolescent and pediatric PMMA dosimetry phantoms were used. Panoramic radiographs were performed using a Planmeca ProMax 2D and the panoramic mode on a Carestream 9300 CBCT and an i-CAT NG using the protocols used clinically. Point dose measurements were performed at the center, around the periphery and on the surface of each phantom using a thimble ionization chamber. Five repeat measurements were taken at each location. For each machine, single-factor ANOVA was conducted to determine dose differences between protocols in each phantom, as well as determine the differences in absorbed dose when the same protocol was used for different-sized phantoms. For any individual phantom, using protocols with lower kVp, mA, or acquisition times resulted in statistically significant dose savings, as expected. When the same protocol was used for different-sized phantoms, the smaller phantom had a higher radiation dose due to less attenuation of x-rays by the smaller phantom and differences in the positioning of the ion chamber relative to the focal trough. The panoramic-mode on the CBCT machines produce images suitable for clinical use with similar dose levels to the stand-alone panoramic device. 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The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes. Using anterograde viral tracing, we show that innervation of cerebellum by rubrospinal neuron collaterals is remarkably selective for the IN compared with the cerebellar cortex. Optogenetic activation of the pathway in acute mouse brain slices drove IN activity despite small amplitude synaptic currents, suggesting an active role in IN information processing. Monosynaptic transsynaptic rabies tracing indicated the pathway contacts multiple cell types within the IN. By contrast, IN inputs to the RNm targeted a region that lacked inhibitory neurons. 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The versatility of 2 as a synthon for Re(II) chemistry was demonstrated by substitution reactions of [Re(II)Br(4)(CO)(2)](2-) with different mono-, bi-, and tridentate ligands. The resulting Re(II) complexes form highly crystalline compounds, and the solid state structures of the neutral trans-cis-[Re(II)Br(2)(CO)(2)(X)(n)] species (where X \u003d imidazole, pyridine, or phenanthroline) could be determined. All complexes are stable under aerobic conditions, both as solids and in solution, and showed fully reversible one-electron Re(II) --\u003e Re(I) reductions between ca. -70 and -120 mV. Carbonyl stretching frequencies (nu(CO)) of this new family of Re(II) complexes are observed in the 1990 cm(-1) (A(1)) and 1830 (E(g)) cm(-1) regions. 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While the 30 Hz blue light septal stimulations only altered theta frequency in CA1 while the rat had limited mobility, it robustly increased the amplitude of hippocampal signals at 30 Hz in both regions in all three recording contexts. 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IBD-unclassified (IBD-U) is a diagnosis that covers the \"grey\" zone of diagnostic uncertainty between UC and CD. Current diagnosis of IBD relies on the clinical, endoscopic, radiological, histological and biochemical features, but this approach has shortcomings especially in cases of overlapping symptoms of CD and UC. The need for a diagnostic tool that would improve the conventional methods in IBD diagnosis directed the search towards potential immunological markers, since an aberrant immune response against microbial or endogenous antigens in a genetically susceptible host seems to be implicated in IBD pathogenesis. The spectrum of antibodies to different microbial antigens and autoantibodies associated with IBD is rapidly expanding. Most of these antibodies are associated with CD like anti-glycan antibodies: anti-Saccharomices cerevisiae (ASCA) and the recently described anti-laminaribioside (ALCA), anti-chitobioside (ACCA), anti-mannobioside (AMCA), anti-laminarin (anti-L) and anti-chitin (anti-C) antibodies; in addition to other antibodies that target microbial antigens: anti-outer membrane porin C (anti-OmpC), anti-Cbir1 flagellin and anti-12 antibody. Also, autoantibodies targeting the exocrine pancreas (PAB) were shown to be highly specific for CD. In contrast, UC has been associated with anti-neutrophil cytoplasmic autoantibodies (pANCA) and antibodies against goblet cells (GAB). Current evidence suggests that serologic panels of multiple antibodies are useful in differential diagnosis of CD versus UC and can be a valuable aid in stratifying patients according to disease phenotype and risk of complications.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb538d09e503f83c61d03e08272888c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23457764","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Ross, A. E.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"On Representation of Integers by Quadratic Forms.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2008-11-20","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb53bd92acbc90cb8688e2c6a57c210","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"16577482","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Koichi Noguchi","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Takashi Kondo","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Jun Sakurai","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Hiroto Miwa","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-11-16","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Afferent fibers innervating the gastrointestinal tract have major roles in consciously evoked sensations including pain. We reported previously that the activation of ERK1/2, a member of the mitogen-activated protein kinase (MAPK) family, in primary sensory neurons was involved in acute visceral pain. Moreover, we also revealed that this activation of ERK1/2 occurred through transient receptor potential (TRP) A1, a member of the TRP family of ion channels. In contrast, it is known that the activation of p38 MAPK (p38) contributes to the development and maintenance of inflammatory and neuropathic pain. On the basis of these results, the aim of this study was to investigate the involvement of p38 and TRPA1 in acute visceral pain. Male Sprague-Dawley rats were used. Electromyographic responses to gastric distension (GD) were recorded from the acromiotrapezius muscle. We then examined the phosphorylated-p38 (p-p38) labeling in the dorsal root ganglion (DRG) after GD using immunohistochemistry. Noxious GD induced p-p38 in DRG neurons with a peak at 2 min after GD. We also found a stimulus intensity-dependent increase in the number of p-p38-immunoreactive neurons in the DRG. Intrathecal administration of the p38 inhibitor, SB203580, attenuated the electromyographic response to noxious GD. Furthermore, intrathecal administration of TRPA1 antisense oligodeoxynucleotide decreased the p38 activation in DRG neurons. The activation of p38 pathways in DRG neurons by noxious GD may be correlated with the activation state of the primary afferent neurons through TRPA1, and further, involved in the development of visceral pain.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb53c38a6e97a79044ec19ef213823f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23222658","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Epstein, L.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Israel\u0027s prevention programs and screening policies for cardiovascular disease.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"For all four broad ethnic groups in Israel, mortality rates declined over the last decade for both ischemic heart disease (IHD) and cerebrovascular disease (CVD), the first and third most important causes of death in the country. The four broad ethnic groups consist of persons born in Israel, Asia, North Africa, and Europe. Mortality data also indicate a low male to female ratio in mortality from IHD, a definite female predominance in mortality from CVD, and high mortality rates for IHD and CVD in males and females born in North Africa. Morbidity data, especially incidence, are scarce for CVD in both sexes and IHD in females. The feasibility of preventive intervention needs to be tested under the specific conditions of Israel. Although a multiple risk factor trial in Jerusalem showed that such a program can be conducted in a primary care framework, it clearly still needs to be tested in clinics rather than in a model teaching institution. The best place for intervention would seem to be the primary health care system, which has almost complete access to the country\u0027s population. Kupat Holim (the Health Insurance Institute of the General Federation of Labour) is attempting systematically to identify and manage hypertension patients. To date, management of acute coronary disease has been emphasized in Israel. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Reisenbichler, Emily S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Omar Hameed","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Reporting the greatest linear extent of ductal carcinoma in situ on needle core biopsy.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-03-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Ductal carcinoma in situ (DCIS) of the breast is staged as pTis regardless of size; however, extent of DCIS correlates with local recurrence rates and likelihood of close or positive margins. 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Mean extent was greater on excision than on core biopsy (16.0 versus 5.7 mm; P \u003c .0001); however, the opposite was seen when only small tumors (≤ 10 mm final size) were considered (4.5 versus. 3.6 mm; P \u003d .0161). There was strong linear correlation (r \u003d 0.9761; P \u003c .0001) between the size change (excision size minus biopsy size) and final pathologic size. 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Although transgene RNA was expressed in both tissues, and mutant protein could be detected at high levels in the kidney and was appropriately localized to the nuclei of proximal tubules, no gross or microscopic lesions developed, even when mice were held as long as 75 weeks. When these mice were crossed with transgenic mice carrying HrasT24 (containing a codon 12 mutation) driven by the same promoter, the p53val135 transgene partially suppressed the mutant ras phenotype (proximal tubular hyperplasia and adenomas and carcinomas of the ciliary body and retinal pigment epithelium). The kidneys of double transgenic mice younger than 25 weeks showed less tubular hyperplasia and cystic change than littermates carrying gamma-glutamyltranspeptidase(I)rasT24 alone. By 33 weeks, there was no difference in the severity of the kidney lesions. The eye lesions were less aggressive, and no malignant lesions were identified. Our findings are consistent with the work of others, indicating that p53val135 is not tumorigenic under all conditions; in fact, in some circumstances, it retains some of the suppressing activity of wild-type p53.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb550b2e97380f5ab48dc96a771a56c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"8667605","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Recent studies have indicated that elevated serum GIP concentrations in type II diabetic patients might induce desensitization of the GIP-R, and this mechanism could contribute to impaired insulin secretion. The cellular and molecular mechanisms governing GIP desensitization are unknown. Here, we report the results of studies on a new family of proteins known as regulators of G protein signaling (RGS) that have been shown to mediate the desensitization process of other receptors. GIP-R and RGS1, -2, -3, and -4 complementary DNAs were cotransfected into human embryonic kidney cells (L293). GIP-stimulated cAMP generation in control cells and in those coexpressing RGS1, -3, and -4 displayed a dose-dependent increase 10 min after GIP treatment. In contrast, RGS2 expression inhibited the GIP-induced cAMP response by 50%, a response similar to that of cells desensitized by preincubation with 10(-7) M GIP. In betaTC3 cells, preincubation of GIP attenuated GIP-induced insulin release by 45% at 15 min and by 55% at 30 min. Expression of RGS2 in the betaTC3 cells significantly decreased GIP-stimulated insulin secretion, whereas glucose-induced insulin release was not affected. RGS2 messenger RNA was identified by Northern blot analysis to be expressed endogenously in betaTC3 and L293 cells, and its level was significantly induced by GIP treatment in betaTC3 cells. Moreover, RGS2 bound Gs alpha protein in an in vitro system, suggesting that RGS2 attenuated the Gs-adenylate cyclase signaling pathway. 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In biological systems, cooperativity is observed in protein-protein, protein-lipid and protein-molecule interactions. Synergistic effects are relevant in frustrated Lewis pairs, organic multispin systems, multimetallic clusters and also in nanoparticles. However, a general approach to determine cooperativity in the different chemical systems is currently not known. In the present concept paper it is suggested that, at least for simpler systems that can be described at the molecular level, cooperativity can be defined based on energy considerations. For systems in which no chemical transformation occurs, determination of interaction energies of the whole system with respect to the interaction energies between all individual component pairs (subsystems) will allow determination of cooperativity. For systems comprising of chemical transformations, cooperativity can be evaluated by determining the activation energy of the synergistic system and by comparing this with activation energies of the corresponding subsystems that lack an activating moiety. 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The complete cDNA sequence of AgeHex2 is comprised of 2,088 bp encoding 696 amino acid residues. The AgeHex2 had four potential N-glycosylation sites. The AgeHex2 contained the highly conserved two larval storage protein signature motifs. The deduced protein sequence of AgeHex2 showed high homology with A. germari hexamerin1 (51% amino acid identity), Tenebrio molitor hexamerin2 (49% amino acid identity), T. molitor early-staged encapsulation inducing protein (43% amino acid identity), and Leptinotarsa decemlineata diapause protein1 (43% amino acid identity). Phylogenetic analysis further confirmed the AgeHex2 is more closely related to coleopteran hexamerins than to the other insect storage proteins. Northern blot analysis confirmed that the AgeHex2 showed fat body-specific expression. The cDNA encoding AgeHex2 was expressed as a 75-kDa protein in the baculovirus-infected insect cells. Furthermore, N-glycosylation of the recombinant AgeHex2 was revealed by tunicamycin to the recombinant virus-infected Sf9 cells, demonstrating that the AgeHex2 is N-glycosylated. Western blot analysis using the polyclonal antiserum against recombinant AgeHex2 indicated that the AgeHex2 corresponds to a 75-kDa storage protein present in the A. germari larval hemolymph.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb55b02cdde696db9957972c3d65da6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15146541","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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One receptor that binds extracellular adenosine triphosphate released at sites of infection and injury is P2X(7), which is an ionotrophic receptor that can also lead to the formation of a non-specific pore, activate multiple mitogen-activated protein kinases (MAPKs), and stimulate the production of immune mediators including interleukin family members and reactive oxygen species (ROS). In the present report, we have investigated the signaling mechanisms by which P2X(7) promotes monocytic cell mediator production and induces transcription factor expression/phosphorylation, as well as how receptor-associated pore activity is regulated by intracellular trafficking. We report that P2X(7) stimulates ROS production in macrophages through the MAPKs ERK1/2 and the nicotinamide adenine dinucleotide phosphate oxidase complex, activates several transcription factors including cyclic-AMP response element-binding protein and components of the activating protein-1 complex, and contains specific sequences within its intracellular C-terminus that appear critical for its activity. 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We report here the complete genome sequence of a novel recombinant E-25 strain (E25/2010/CHN/BJ) isolated from a neonate with hand, foot, and mouth disease complicated by encephalitis in Beijing, China in 2010. The complete viral genome consists of 7429 nucleotides (nts), including a 6585-nt open reading frame. Phylogenetic dendrogram based on VP1 gene regions revealed that this strain belonged to subgroup D4, which contains the other E-25 strains isolated from China in recent years. The difference in the amino acid sites (P130S, K/T135I) of the VP1 region may affect its immunogenicity. SimPlot and Bootscan analyses suggested that E25/2010/CHN/BJ is a recombination result of E-25 and Coxsackievirus B3 (CVB-3) strains. Our results would facilitate the study of the origin, evolution, and molecular epidemiology of E-25. 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The rarer variant, bullous impetigo, is characterized by fragile fluid-filled vesicles and flaccid blisters and is invariably caused by pathogenic strains of Staphylococcus aureus. Bullous impetigo is at the mild end of a spectrum of blistering skin diseases caused by a staphylococcal exfoliative toxin that, at the other extreme, is represented by widespread painful blistering and superficial denudation (the staphylococcal scalded skin syndrome). In bullous impetigo, the exfoliative toxins are restricted to the area of infection, and bacteria can be cultured from the blister contents. In staphylococcal scalded skin syndrome the exfoliative toxins are spread hematogenously from a localized source causing widespread epidermal damage at distant sites. Both occur more commonly in children under 5 years of age and particularly in neonates. It is important to swab the skin for bacteriological confirmation and antibiotic sensitivities and, in the case of staphylococcal scalded skin syndrome, to identify the primary focus of infection. Topical therapy should constitute either fusidic acid (Fucidin, Leo Pharma Ltd) as a first-line treatment, or mupirocin (Bactroban, GlaxoSmithKline) in proven cases of bacterial resistance. First-line systemic therapy is oral or intravenous flucloxacillin (Floxapen, GlaxoSmithKline). Nasal swabs from the patient and immediate relatives should be performed to identify asymptomatic nasal carriers of Staphylococcus aureus. In the case of outbreaks on wards and in nurseries, healthcare professionals should also be swabbed.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5617029d32d43ef45c33bb98f9e0f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15482208","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The etiology of PD is probably a combination of environmental and genetic factors. Recent progress in molecular genetics has identified several genes causing PD, including alpha-synuclein, leucine-rich repeat kinase 2 (LRRK2), Parkin, DJ-1 and PTEN-induced kinase 1 (PINK1), many of them coding for proteins found in LBs and/or implicated in mitochondrial function. However, the mechanism(s) leading to the development of the disease have not been identified, despite intensive research. Animal models help us to obtain insights into the mechanisms of several symptoms of PD, allowing us to investigate new therapeutic strategies and, in addition, provide an indispensable tool for basic research. As PD does not arise spontaneously in animals, characteristic and specific functional changes have to be induced by administration of toxins or by genetic manipulations. This review will focus on the comparison of three types of rodent animal models used to study different aspects of PD: (a) animal models using neurotoxins; (b) genetically modified mouse models reproducing findings from PD linkage studies or based on ablation of genes necessary for the development and survival of dopamine neurons; and (c) tissue-specific knockouts in mice targeting dopamine neurons. 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Inactivation of ATP7B or related ATP7A leads to severe neurodegenerative disorders, whereas their overexpression contributes to cancer cell resistance to chemotherapeutics. Copper-transporting ATPases differ from other P-type ATPases in their topology and the sequence of their nucleotide-binding domain (N-domain). To gain insight into the structural basis of ATP7B function, we have solved the structure of the ATP7B N-domain in the presence of ATP by using heteronuclear multidimensional NMR spectroscopy. The N-domain consists of a six-stranded β-sheet with two adjacent α-helical hairpins and, unexpectedly, shows higher similarity to the bacterial K+-transporting ATPase KdpB than to the mammalian Ca2+-ATPase or Na+,K+-ATPase. The common core structure of P-type ATPases is retained in the 3D fold of the N-domain; however, the nucleotide coordination environment of ATP7B within this fold is different. The residues H1069, G1099, G1101, I1102, G1149, and N1150 conserved in the P1B-ATPase subfamily contribute to ATP binding. Analysis of the frequent disease mutation H1069Q demonstrates that this mutation does not significantly affect the structure of the N-domain but prevents tight binding of ATP. The structure of the N-domain accounts for the disruptive effects of \u003e30 known Wilson disease mutations. 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There were significantly more nymphs of the Chilean population on plants of Dn4 than on Dn6 plants at both 18 and 23 d postinfestation, and the Ethiopian population attained a significantly greater weight on Dn4 plants than on plants containing Dn5 or Dn6. 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Within the limits of the PCR methodology, no evidence for any alternative exon other than the previously identified VASE was obtained. The regulation of expression of this exon was found to be complex and tissue specific. Expression of the 30-bp exon in the heart and nervous system was found to be regulated independently; a significant proportion of embryonic day 15 heart NCAM mRNAs contain VASE while only a very small amount of day 15 nervous system mRNAs contain VASE. Some adult central nervous system regions, notably the olfactory bulb and the peripheral nervous system structures adrenal gland and dorsal root ganglia, express NCAM which contains very little VASE. VASE is undetectable in NCAM PCR products from the olfactory epithelium. Other nervous system regions express significant quantities of NCAM both with and without VASE. Clonal cell lines in culture generally expressed very little VASE. 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HRS is a functional renal failure that develops mainly as a consequence of a severe cardiovascular dysfunction which is characterized by an extreme splanchnic arterial vasodilation and a reduction of cardiac output. HRS may develop in two clinical types: as an acute and rapidly progressive renal failure (AKI-HRS) or as chronic and not progressive renal failure (CKD-HRS). Several small studies and some randomized control studies have been published on the use of terlipressin plus albumin in the treatment of HRS, mainly on AKI-HRS. Terlipressin plus albumin was shown to improve renal function in almost 35-45% of patients with AKI-HRS, as well as to improve short-term survival in these patients. Terlipressin was most commonly used by intravenous boluses moving from an initial dose of 0.5-1 mg every 4 h to 3 mg every 4 h in the case of a nonresponse. In other studies, terlipressin was also given by continuous intravenous infusion. Thus, the best way to administer terlipressin in the treatment of HRS has not yet been defined. α-Adrenergic drugs, such as intravenous norepinephrine or oral midodrine plus subcutaneous octreotide, administered with albumin have also been used in the treatment of AKI-HRS, with promising results. However, we need further studies in order to define whether they can represent a real therapeutic alternative. In conclusion, available data are sufficient to state that the use of terlipressin plus albumin has really changed the management of HRS. 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Compared with the Kirschner and bandage fixation, the fiberglass fixation reduced the relative movement of osteotomy fragments and obtained the maximum CS. We concluded that fiberglass fixation in HV treatment was helpful to the bone healing of distal fragment. 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A screen for upstream activators of NF-kappaB identified a novel serine-threonine kinase capable of activating NF-kappaB and inducing apoptosis. Based upon domain organization and sequence similarity, this novel kinase, named mRIP3 (mouse receptor interacting protein 3), appears to be a new RIP family member. RIP, RIP2, and mRIP3 contain an N-terminal kinase domain that share 30 to 40% homology. In contrast to the C-terminal death domain found in RIP or the C-terminal caspase-recruiting domain found in RIP2, the C-terminal tail of mRIP3 contains neither motif and is unique. Despite this feature, overexpression of the mRIP3 C terminus is sufficient to induce apoptosis, suggesting that mRIP3 uses a novel mechanism to induce death. mRIP3 also induced NF-kappaB activity which was inhibited by overexpression of either dominant-negative NIK or dominant-negative TRAF2. In vitro kinase assays demonstrate that mRIP3 is catalytically active and has autophosphorylation site(s) in the C-terminal domain, but the mRIP3 catalytic activity is not required for mRIP3 induced apoptosis and NF-kappaB activation. Unlike RIP and RIP2, mRIP3 mRNA is expressed in a subset of adult tissues and is thus likely to be a tissue-specific regulator of apoptosis and NF-kappaB activity. While the lack of a dominant-negative mutant precludes linking mRIP3 to a known upstream regulator, characterizing the expression pattern and the in vitro functions of mRIP3 provides insight into the mechanism(s) by which cells modulate the balance between survival and death in a cell-type-specific manner.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb574fcac93cc9ef32fd4bb2f9a0dcc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10490590","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Relying on Software-Defined Networking-enabled home gateways and the virtualization of network functions in the cloud, we achieve advanced networking security and automation through the definition of isolated, usage-oriented slices. 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The formation of MEH-PPV/Au NP complexes was confirmed through high-resolution transmission electron microscopy and Fourier transform infrared experiments. The laser confocal microscope photoluminescence (PL) efficiency of the complex MEH-PPV/Au single NP dramatically increased compared with that of the MEH-PPV single NP without Au NPs, which was directly confirmed through color charge-coupled device images. The enhanced PL efficiency of the MEH-PPV/Au NP complex might have originated from the energy transfer effect in a surface plasmon resonance coupling between a MEH-PPV NP and Au NPs. The strong local field enhancement due to nanogaps between Au NPs in the background of a light-emitting MEH-PPV NP might be another origin of the PL enhancement of the NP complex, as supported by finite difference time domain calculations. We also observed the blue shift of the PL peaks of the single MEH-PPV and MEH-PPV/Au NP, compared with the solution PL peaks of those NPs.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb57b241b32bd8a07f96f57b5dc9898","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19456168","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Puntis, M. C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jiang, W. G.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Lloyds, D.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Nakamura, T.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Hallett, M. B.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Hepatocyte growth factor (HGF), also known as scatter factor, regulates both cell motility and the growth of some cell types. We have determined the effects of HGF on the motility and growth of human colon cancer cell lines (HT115, HT29, HRT18 and HT55). Cell motility, as measured by dissociation from carrier beads or by scattering of cell colonies, was greatly increased in all cell lines. The effects were completely blocked by anti-HGF antibody. In contrast, cell growth of HT115, HT29 and HRT18 cells was inhibited by a wide range of concentrations of HGF. HT55 cell growth was also inhibited but needed a prolonged culture period (\u003e 5 days). The HGF receptor/Met protein is highly expressed in the membrane fraction of these cells as determined by Western blotting. It is concluded that HGF has an effect on both colon cancer cell motility and growth, which may be important in the control of the spread of colon cancer.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb57b726ea91000789bec3024428e2e","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"8386069","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Vanpool, Todd L.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Brien, Michael J. O.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Lee Lyman, R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Alex Mesoudi","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Cultural traits as units of analysis.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Cultural traits have long been used in anthropology as units of transmission that ostensibly reflect behavioural characteristics of the individuals or groups exhibiting the traits. After they are transmitted, cultural traits serve as units of replication in that they can be modified as part of an individual\u0027s cultural repertoire through processes such as recombination, loss or partial alteration within an individual\u0027s mind. Cultural traits are analogous to genes in that organisms replicate them, but they are also replicators in their own right. No one has ever seen a unit of transmission, either behavioural or genetic, although we can observe the effects of transmission. Fortunately, such units are manifest in artefacts, features and other components of the archaeological record, and they serve as proxies for studying the transmission (and modification) of cultural traits, provided there is analytical clarity over how to define and measure the units that underlie this inheritance process.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb57c0b1f57693c1070c48af3de81de","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21041205","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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While there is ample evidence that a dysfunction of the blood-brain barrier contributes to epileptogenesis, blood-brain barrier dysfunction as a consequence of single epileptic seizures has not been systematically investigated. We hypothesized that blood-brain barrier dysfunction is temporally and anatomically associated with epileptic seizures in patients and used a newly-established quantitative MRI protocol to test our hypothesis. Twenty-three patients with epilepsy undergoing inpatient monitoring as part of their presurgical evaluation were included in this study (10 females, mean age ± standard deviation: 28.78 ± 8.45). For each patient, we acquired quantitative T1 relaxation time maps (qT1) after both ictal and interictal injection of gadolinium-based contrast agent. The postictal enhancement of contrast agent was quantified by subtracting postictal qT1 from interictal qT1 and the resulting ΔqT1 was used as a surrogate imaging marker of peri-ictal blood-brain barrier dysfunction. Additionally, the serum concentrations of MMP9 and S100, both considered biomarkers of blood-brain barrier dysfunction, were assessed in serum samples obtained prior to and after the index seizure. Fifteen patients exhibited secondarily generalized tonic-clonic seizures and eight patients exhibited focal seizures at ictal injection of contrast agent. By comparing ΔqT1 of the generalized tonic-clonic seizures and focal seizures groups, the anatomical association between ictal epileptic activity and postictal enhancement of contrast agent could be probed. The generalized tonic-clonic seizures group showed significantly higher ΔqT1 in the whole brain as compared to the focal seizures group. Specific analysis of scans acquired later than 3 h after the onset of the seizure revealed higher ΔqT1 in the generalized tonic-clonic seizures group as compared to the focal seizures group, which was strictly lateralized to the hemisphere of seizure onset. Both MMP9 and S100 showed a significantly increased postictal concentration. The current study provides evidence for the occurrence of a blood-brain barrier dysfunction, which is temporally and anatomically associated with epileptic seizures. qT1 after ictal contrast agent injection is rendered as valuable imaging marker of seizure-associated blood-brain barrier dysfunction and may be measured hours after the seizure. The observation of the strong anatomical association of peri-ictal blood-brain barrier dysfunction may spark the development of new functional imaging modalities for the post hoc visualization of brain areas affected by the seizure.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb57c82b1452a6816eee59734a2508a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"30239618","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Parallel observations were made in humans, in that all T cell acute lymphoblastic leukemias examined showed expression of Notch3 and of the Notch target gene HES-1, as well as of pTalpha a and b transcripts, whereas the expression of all these genes was dramatically reduced or absent in remission. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Hong Zheng","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Yunong Gao","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Serum HE4 as a useful biomarker in discriminating ovarian cancer from benign pelvic disease.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-10-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"To evaluate the role of the novel tumor marker human epididymal secretory protein E4 (HE4) in discriminating ovarian cancer from benign pelvic disease in patients with a pelvic mass.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb58b067d0193873c2190ebdcfebaea","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22426406","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In several cell types, the stimulation of PI3K results in downstream activation of the mechanistic target of rapamycin (MTOR), a serine-threonine protein kinase that is a critical regulator of cellular metabolism, growth, and proliferation. MTOR activation is involved in the regulation of thyrocyte proliferation by TSH. Here, we show that MTOR inhibition by rapamycin increases iodide uptake in TSH-stimulated PCCL3 thyroid cell line, although the effect of rapamycin was less pronounced than PI3K inhibition. Thus, NIS inhibitory pathways stimulated by PI3K might also involve the activation of proteins other than MTOR. Insulin downregulates iodide uptake and NIS protein expression even in the presence of TSH, and both effects are counterbalanced by MTOR inhibition. NIS protein expression levels were correlated with iodide uptake ability, except in cells treated with TSH in the absence of insulin, in which rapamycin significantly increased iodide uptake, while NIS protein levels remained unchanged. Rapamycin avoids the activation of both p70 S6 and AKT kinases by TSH, suggesting the involvement of MTORC1 and MTORC2 in TSH effect. A synthetic analog of rapamycin (everolimus), which is clinically used as an anticancer agent, was able to increase rat thyroid iodide uptake in vivo. In conclusion, we show that MTOR kinase participates in the control of thyroid iodide uptake, demonstrating that MTOR not only regulates cell survival, but also normal thyroid cell function both in vitro and in vivo.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb58d2b3e7d98d0b28445c279ea68c7","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"20392814","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Peptide-specific CTL responses before vaccination were observed in only 3 of 42 patients, but they became detectable in 23 of 36 patients tested after vaccination. Peptide-specific IgG responses were also boosted in 19 of 36 patients. Peptide-specific IgG1 responses to both C-35 and TAA-derived peptides could be potentially prognostic for overall survival. Conclusion. Further clinical study of PPV would be warranted for HCV-positive advanced HCC, based on the safety and strong immune induction. 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En ellos no se evidencia una etiología infecciosa, neoplásica o autoinmune. Están causadas por alteraciones de la inmunidad innata, lo que ocasiona una desregulación del sistema inflamatorio a nivel del inflamosoma. Estos síndromes se subdividen en dos grandes grupos los síndromes hereditarios de fiebre periódica y las enfermedades autoinflamatorias persistentes, dentro de este último se ubican las enfermedades inflamatorias óseas donde se incluye la osteomielitis multifocal crónica recurrente. Presentamos un caso de una niña de 9 años que ingresa en nuestro hospital por un síndrome febril prolongado y después de múltiples investigaciones se concluye como una osteomielitis multifocal crónica recurrente. \u003cstrong\u003eABSTRACT\u003c/strong\u003e Autoinflammatory syndromes are a group of diseases characterized by spontaneous, recurrent or persistent episodes of multisystem inflammation. They do not show an infectious, neoplastic or autoimmune etiology. They are caused by alterations of the innate immunity, which causes a dysregulation of the inflammatory system at the level of the inflammasome. These syndromes are subdivided into two major groups, the hereditary syndromes of periodic fever and the persistent autoinflammatory diseases; within the latter are the inflammatory bone diseases which chronic recurrent multifocal osteomyelitis. 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Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain IMCC1412(T) was most closely related to Kordia algicida, with a sequence similarity of 96.7 %, but only distantly related to other species in the family Flavobacteriaceae (\u003c92 % similarity). The G+C content of the DNA was 37.3 mol%. The strain contained MK-6 as the major respiratory quinone and phosphatidylethanolamine, unidentified aminolipids and unidentified polar lipids as the major polar lipids. On the basis of phylogenetic distinctiveness and differential phenotypic characteristics, strain IMCC1412(T) ( \u003d KACC 14311(T) \u003d KCTC 22801(T) \u003d NBRC 106077(T)) should be assigned to the genus Kordia as the type strain of a novel species, for which the name Kordia periserrulae sp. nov. is proposed. 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Laboratory tests showed severe hyperparathyroidism [intact parathyroid hormone (iPTH) 69 pmol/L; reference range: 1.3-6.8 pmol/L], hypercalcaemia (2.79 mmol/L), hyperphosphataemia (1.6 mmol/L) and elevated serum total alkaline phosphatase (200 U/L). After developing a disturbed sensation and paraesthesia in both feet, epidural compression of the spinal cord was suspected. Magnetic resonance imaging showed a tumour that severely compressed the myelum of the thoracic spine. Histological investigation revealed a brown tumour or osteoclastoma, an erosive bony lesion caused by increased osteoclastic activity and peritrabecular fibrosis. A brown tumour is a benign tumour that is a rare complication of severe renal hyperparathyroidism. The brown tumour developed despite a 1-year treatment of the patient with cinacalcet, which, however, did not result in a major decrease in serum iPTH concentration (from 110 to 69 pmol/L: 37% reduction). 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Gregory Aird","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jenna Sitenga","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Silberstein, Peter T.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Aabra Ahmed","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Impact of siltuximab on patient-related outcomes in multicentric Castleman\u0027s disease.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Multicentric Castleman\u0027s disease (MCD) is a rare, widespread lymphoproliferative disorder and a life-threatening disease involving hyperactivity of the immune system, excessive proinflammatory cytokine release, immune cell proliferation, and organ system dysfunction. Interleukin-6 (IL-6) is a cytokine that plays a key role in the pathogenesis of MCD, as it is involved in the synthesis of acute-phase reactants and aids in the induction of B-cell proliferation. Siltuximab is an anti-IL-6 chimeric monoclonal antibody that acts as a novel treatment modality to bind to IL-6 with high affinity, thus neutralizing the cytokine bioactivity and inhibiting B-cell proliferation. Clinical trials with siltuximab have shown early clinical promise for patients with MCD for many years, leading to recent US Food and Drug Administration approval as a novel agent for the treatment of MCD. Here, a systematic review was conducted to include 171 cases of MCD patients treated with siltuximab. While traditional treatment methods were able to achieve a 5-year survival rate of only 55%-77%, results of siltuximab treatment demonstrated 5-year survival rates of nearly 96.4% (only 2 deaths reported out of 55 patients with follow-up data). Ultimately, the results from multiple clinical trials have demonstrated that siltuximab is extremely efficacious in alleviating disease symptoms (fatigue, pain, and lymphadenopathy) while simultaneously achieving disease remission, thus extending progression-free survival for years longer than the average 5-year survival rates for MCD.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5ab94c02c6116b94f3e046ba625cc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29391839","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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This estuarine anemone is an excellent model system for investigating the evolution of stress tolerance because it is easy to collect in its natural habitat and to culture in the laboratory, and it has a sequenced genome. Additionally, there is evidence of local adaptation to environmental stress in different N. vectensis populations, and abundant protein-coding polymorphisms have been identified, including polymorphisms in proteins that are implicated in stress responses. N. vectensis can tolerate a wide range of environmental parameters, and has recently been shown to have substantial intraspecific variation in temperature preference. We investigated whether different clonal lines of anemones also exhibit differential tolerance to oxidative stress. N. vectensis populations are continually exposed to reactive oxygen species (ROS) generated during cellular metabolism and by other environmental factors. Fifteen clonal lines of N. vectensis collected from four different estuaries were exposed to hydrogen peroxide. Pronounced differences in survival and regeneration were apparent between clonal lines collected from Meadowlands, NJ, Baruch, SC, and Kingsport, NS, as well as among 12 clonal lines collected from a single Cape Cod marsh. To our knowledge, this is the first example of intraspecific variability in oxidative stress resistance in cnidarians or in any marine animal. As oxidative stress often accompanies heat stress in marine organisms, resistance to oxidative stress could strongly influence survival in warming oceans. 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Most japonica-type glutinous rice was found to have a 23-bp duplication in the second exon, which causes loss of the function of granule-bound starch synthase (GBSS) encoded by the Wx gene. Without the 23-bp duplication, there was an insertion of 7,764 bp in the ninth exon of the wx allele of \u0027Oragamochi\u0027. Expression analysis of the wx allele using RT-PCR and Northern blot analysis revealed that transcripts of the \u0027Oragamochi\u0027 wx allele are about 1-kb shorter and that the deduced amino acid sequence of the transcript lacks a motif important for GBSS. Therefore, this insertion was considered to be the cause of the glutinous trait of \u0027Oragamochi\u0027. This 7,764-bp insertion had long terminal repeats, a primer binding site, and a polypurine tract, but no sequence homologous with gag and pol, suggesting that it is a non-autonomous element. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Ginestra Bianconi","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Superconductor-insulator transition on annealed complex networks.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2012-09-25","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Cuprates show multiphase and multiscale complexity that has hindered physicists search for the mechanism of high T{c} for many years. Recently the interest has been addressed to a possible optimum inhomogeneity of dopants, defects, and interstitials, and the structural scale invariance of dopants detected by scanning micro-x-ray diffraction has been reported to promote the critical temperature. In order to shed light on critical phenomena on granular materials, here we propose a stylized model capturing the essential characteristics of the superconducting-insulator transition of a highly dynamical, heterogeneous granular material: the random transverse Ising model (RTIM) on annealed complex network. We show that when the networks encode for high heterogeneity of the expected degrees described by a power-law distribution, the critical temperature for the onset of the superconducting phase diverges to infinity as the power-law exponent γ of the expected degree distribution is less than 3, i.e., γ\u003c3. Moreover we investigate the case in which the critical state of the electronic background is triggered by an external parameter g that determines an exponential cutoff in the power-law expected degree distribution characterized by an exponent γ. We find that for g\u003dg{c} the critical temperature for the superconducting-insulator transition has a maximum if γ\u003e3 and diverges if γ\u003c3.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5c1d3aeb9c19386bcd18e09ab26b2","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23005057","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Laura Näätsaari","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Michael Schubert","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Anton Glieder","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Thallinger, Gerhard G.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Krainer, Florian W.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Peroxidase gene discovery from the horseradish transcriptome.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of life sciences and suggested uses in medical applications, chemical synthesis and other industrial applications, the HRP isoenzymes, their substrate specificities and enzymatic properties are poorly characterized. Due to lacking sequence information of natural isoenzymes and the low levels of HRP expression in heterologous hosts, commercially available HRP is still extracted as a mixture of isoenzymes from the roots of A. rusticana.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5c4347df5c26866a9ceb1d41386fe","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"24666710","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In α-chloralose-anesthetized cats, pudendal nerve stimulation (PNS) at 3-5 Hz was used to inhibit bladder reflex activity while the sacral S1 or S2 dorsal root was stimulated at 15-30 Hz to mimic sacral neuromodulation and to block the bladder inhibition induced by PNS. The intensity threshold (T) for PNS or S1/S2 dorsal root stimulation (DRS) to induce muscle twitch of anal sphincter or toe was determined. PNS at 1.5-2T intensity inhibited the micturition reflex by significantly ( P \u003c 0.01) increasing bladder capacity to 150-170% of control capacity. S1 DRS alone at 1-1.5T intensity did not inhibit bladder activity but completely blocked PNS inhibition and restored bladder capacity to control level. At higher intensity (1.5-2T), S1 DRS alone inhibited the micturition reflex and significantly increased bladder capacity to 135.8 ± 6.6% of control capacity. However, the same higher intensity S1 DRS applied simultaneously with PNS, suppressed PNS inhibition and significantly ( P \u003c 0.01) reduced bladder capacity to 126.8 ± 9.7% of control capacity. S2 DRS at both low (1T) and high (1.5-2T) intensity failed to significantly reduce PNS inhibition. PNS and S1 DRS did not change the amplitude and duration of micturition reflex contractions, but S2 DRS at 1.5-2T intensity doubled the duration of the contractions and increased bladder capacity. 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We have recently shown that fertilized zygotes retain reprogramming activities, suggesting that such activities might also persist in cleavage-stage embryos. Here, we used chromosome transplantation techniques to investigate whether the blastomeres of two-cell-stage mouse embryos can reprogram more differentiated cells. When chromosomes from one of the two blastomeres were replaced with the chromosomes of an embryonic or CD4(+) T lymphocyte donor cell, we observed nuclear reprogramming and efficient contribution of the manipulated cell to the developing blastocyst. Embryos produced by this method could be used to derive stem cell lines and also developed to term, generating mosaic \"cloned\" animals. 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Thrombospondin 1 (TSP1) induces focal adhesion disassembly and cell migration through a sequence (hep I) in its heparin-binding domain signaling through the calreticulin-low density lipoprotein receptor-related protein receptor complex. This involves the Galphai-dependent activation of ERK and phosphoinositide (PI) 3-kinase, both of which are required for focal adhesion disassembly. Focal adhesion kinase (FAK) regulates adhesion dynamics, acting in part by modulating RhoA activity, and FAK is implicated in ERK and PI 3-kinase activation. In this work, we sought to determine the role of FAK in TSP1-induced focal adhesion disassembly. TSP1/hep I does not stimulate focal adhesion disassembly in FAK knockout fibroblasts, whereas re-expressing FAK rescues responsiveness. Inhibiting FAK signaling through FRNK or FAK Y397F expression in endothelial cells also abrogates this response. TSP1/hep I stimulates a transient increase in FAK phosphorylation that requires calreticulin and Galphai, but not ERK or PI 3-kinase. Hep I does not activate ERK or PI 3-kinase in FAK knockout fibroblasts, suggesting activation occurs downstream of FAK. TSP1/hep I stimulates RhoA inactivation with kinetics corresponding to focal adhesion disassembly in a FAK, ERK, and PI 3-kinase-dependent manner. Furthermore, hep I does not stimulate focal adhesion disassembly in cells expressing constitutively active RhoA, suggesting that RhoA inactivation is required for this response. This is the first work to illustrate a connection between FAK phosphorylation in response to a soluble factor and RhoA inactivation, as well as the first report of PI 3-kinase and ERK in FAK regulation of RhoA activity.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5ebba698dfc55fa699e190303d002","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15371459","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The aortic root dilatation is frequently associated with valve\u0027s pathology, rupture and dissection are two serious events that might occur; are linked with high mortality and are closely connected to aortic diameter and to wall\u0027s pathology, so that the elective indication is essential and it basically depends on those two factors. There are different technical alternatives, anatomical and functional, of the aortic root, the procedure\u0027s election is most specially based on patient\u0027s age, on pathological substract, on anticoagulation risk, and on possible infection, etc. We wish to report our experience performed from 1990 onto 2004 with 364 cases of aortic root surgery, of which 312 were elective interventions and 52 were emergencies, with a mortality of 4.8% and 19.2% respectively, and a global mortality of 6.8% using the different procedures. The choice of procedure is a multifactorial decision and it is necessary try offering the patient, the most idoneus individualized solution, according to personal characteristics. The different surgical techniques (valved conduits, remodelling procedures, biological grafts, etc.) can be carried out with low figures of morbid-mortality and excellent long term outcomes.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5ef5217155038ea3163298828dfd1","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17451098","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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To assess the effect of vitamin A supplementation on vaginal shedding of HIV-1, a randomized, double-blind, placebo-controlled trial of 6 weeks of daily oral vitamin A (10,000 IU of retinyl palmitate) was conducted among 400 HIV-1-infected women in Mombasa, Kenya. At follow-up, there was no statistically significant difference in the prevalence of HIV-1 DNA (18% vs. 21%, P\u003d.4) or the quantity of HIV-1 RNA (3.12 vs. 3.00 log(10) copies/swab, P\u003d1.0) in vaginal secretions of women receiving vitamin A, compared with women receiving placebo. No significant effect of supplementation on plasma HIV-1 load or CD4 or CD8 cell counts was observed, and no effect was seen among women who were vitamin A deficient at baseline. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Jing Zhang","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Zecheng Hu","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Zhongdong Chen","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"[Inhibitory effect of emodin on the growth of cervical cancer in tumor-transplanted mice and underlying mechanism].","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-03-06","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"To observe the effect of emodin on the growth of transplanted U14 cervical cancer cells in mice, and explore its mechanism of anti-tumor.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5f30a9725e613def0330bf5ec90df","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"25744842","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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DOI\u003c/strong\u003e\u003cstrong\u003e \u003c/strong\u003e\u003cstrong\u003ehttp://dx.doi.org/10.5281/zenodo.2639384\u003c/strong\u003e \u003cstrong\u003ehttp://ojs.ukw.edu.pl/index.php/johs/article/view/682\u003c/strong\u003e\u003cstrong\u003e7\u003c/strong\u003e \u003cstrong\u003ehttps://pbn.nauka.gov.pl/sedno-webapp/works/911077\u003c/strong\u003e \u003cstrong\u003eThe journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).\u003c/strong\u003e \u003cstrong\u003e1223 Journal of Education, Health and Sport eISSN 2391-8306 7\u003c/strong\u003e \u003cstrong\u003e© The Authors 2019;\u003c/strong\u003e \u003cstrong\u003eThis article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland\u003c/strong\u003e \u003cstrong\u003eOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.\u003c/strong\u003e \u003cstrong\u003e(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.\u003c/strong\u003e \u003cstrong\u003eThe authors declare that there is no conflict of interests regarding the publication of this paper.\u003c/strong\u003e \u003cstrong\u003eReceived: 28.03.2019. Revised: 30.03.2019. Accepted: 14.04.2019.\u003c/strong\u003e \u003cstrong\u003eRelationship between intestinal microbiota\u003c/strong\u003e \u003cstrong\u003eand thyroid homeostasis\u003c/strong\u003e \u003cbr\u003e \u003cstrong\u003eAnna Fabian-Danielewska\u003csup\u003e1\u003c/sup\u003e, Agata Wawryków\u003csup\u003e2\u003c/sup\u003e,\u003csup\u003e \u003c/sup\u003eKatarzyna Korabiusz\u003csup\u003e2\u003c/sup\u003e,\u003c/strong\u003e \u003cstrong\u003eMonika Stecko\u003csup\u003e2\u003c/sup\u003e, Magdalena Żukowska\u003csup\u003e2\u003c/sup\u003e\u003c/strong\u003e \u003cbr\u003e \u003csup\u003e1 \u003c/sup\u003ePomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Lekarskiego \u003csup\u003e2 \u003c/sup\u003ePomorski Uniwersytet Medyczny w Szczecinie, Studium Doktoranckie Wydziału Nauk o Zdrowiu \u003cbr\u003e \u003cbr\u003e \u003cstrong\u003elek. Anna Fabian-Danielewska\u003csup\u003e1\u003c/sup\u003e, mgr Agata Wawryków\u003csup\u003e2\u003c/sup\u003e,\u003csup\u003e \u003c/sup\u003emgr Katarzyna Korabiusz\u003csup\u003e2\u003c/sup\u003e,\u003c/strong\u003e \u003cstrong\u003emgr Monika Stecko\u003csup\u003e2\u003c/sup\u003e, lek. Magdalena Żukowska\u003csup\u003e2\u003c/sup\u003e\u003c/strong\u003e \u003cbr\u003e \u003cbr\u003e \u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eKey words: microbiota, thyroid\u003c/strong\u003e \u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eSummary\u003c/strong\u003e The human digestive tract is inhabited by hundreds of bacterial species, both aerobic and anaerobic, bacteriophages, viruses and fungi that collectively are referred to as intestinal microbiota. Microbiota has a significant impact on the production and maintenance of immunological, hormonal and metabolic homeostasis. Dysbiosis is present in inflammations, e.g. intestinal inflammation, autoimmune diseases, e.g. multiple sclerosis, type 1 diabetes, rheumatic diseases, metabolic disorders such as obesity or type 2 diabetes, and mental illness. Currently, numerous studies are underway on the effect of microbiota on thyroid autoimmune diseases. . It seems, that microbiota has a small, if any, effect on the metabolism of iodine and selenium - elements particularly responsible for thyroid homeostasis. However, the relationship between thyroid function and the gastrointestinal tract has been proven.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Zenodo","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb5f564b055b69c4ba4eab5d78cb80f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5281/zenodo.2639383","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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A mechanosensory-induced cough reflex conveys through branches of myelinated Aδ nerve fibers is not chemically reactive (i.e., capsaicin, bradykinin); possibly, its evolution is to prevent the harmful effects of aspiration of gastric or particulate contents into the lungs. This became necessary as the larynx moves closer to the opening of the esophagus as human ancestors adapt phonation over olfaction beginning less than 10 million years ago. The second type of cough reflex, a chemosensory type, is carried by unmyelinated C fibers. Supposedly, its origin dates back when prehistoric humans began living in close proximity to each other and were at risk for infectious respiratory diseases or irritant-induced lung injury. The mechanism for the latter type of cough is analogous to induced pain after tissue injury; and, it is controlled by the identical transient receptor potential vanilloid cation channel (TRPV1). The airways do not normally manifest nociceptive pain from a stimulus but the only consistent response that capsaicin and lung inflammation provoke in healthy human airways is cough. TRPA1, another excitatory ion channel, has been referred to as the \"irritant receptor\" and its activation also induces cough. 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This supervision strategy is seldom evaluated but often can be through routine use of a regression discontinuity design (RDD). This article argues that RDD provides a rigorous and cost-effective method for correctional agencies to evaluate and improve supervision strategies and advocates for using RDD routinely in corrections administration. The objective is to better employ correctional resources.Method:This article uses a Neyman–Pearson counterfactual framework to introduce readers to RDD, to provide intuition for why RDD should be used broadly, and to motivate a deeper reading into the methodology. The article also illustrates an application of RDD to evaluate an intensive supervision program for probationers.Result:Application of the RDD, which requires basic knowledge of regressions and some special diagnostic tools, is within the competencies of many criminal justice evaluators. RDD is shown to be an effective strategy to identify the treatment effect in a community corrections agency using supervision that meets the necessary conditions for RDD.Conclusion:The article concludes with a critical review of how RDD compares to experimental methods to answer policy questions. The article recommends using RDD to evaluate whether differing levels of control and correction reduce criminal recidivism. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Andrea Kübler","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Holz, Elisa M.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Tobias Kaufmann","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Comparison of tactile, auditory, and visual modality for brain-computer interface use: a case study with a patient in the locked-in state.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This paper describes a case study with a patient in the classic locked-in state, who currently has no means of independent communication. Following a user-centered approach, we investigated event-related potentials (ERP) elicited in different modalities for use in brain-computer interface (BCI) systems. Such systems could provide her with an alternative communication channel. To investigate the most viable modality for achieving BCI based communication, classic oddball paradigms (1 rare and 1 frequent stimulus, ratio 1:5) in the visual, auditory and tactile modality were conducted (2 runs per modality). Classifiers were built on one run and tested offline on another run (and vice versa). In these paradigms, the tactile modality was clearly superior to other modalities, displaying high offline accuracy even when classification was performed on single trials only. Consequently, we tested the tactile paradigm online and the patient successfully selected targets without any error. Furthermore, we investigated use of the visual or tactile modality for different BCI systems with more than two selection options. In the visual modality, several BCI paradigms were tested offline. Neither matrix-based nor so-called gaze-independent paradigms constituted a means of control. These results may thus question the gaze-independence of current gaze-independent approaches to BCI. A tactile four-choice BCI resulted in high offline classification accuracies. Yet, online use raised various issues. Although performance was clearly above chance, practical daily life use appeared unlikely when compared to other communication approaches (e.g., partner scanning). Our results emphasize the need for user-centered design in BCI development including identification of the best stimulus modality for a particular user. Finally, the paper discusses feasibility of EEG-based BCI systems for patients in classic locked-in state and compares BCI to other AT solutions that we also tested during the study. 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Home BP monitoring is the preferred method of the patients. Automated BP devices with remote data transmission have been repeatedly shown to be useful in improving hypertension control in the frame of clinical trials on telemedicine. Recently, new technologies have created a new context. Despite the important number of smartphone apps devoted to BP developed these last 10 years, only two BP monitoring apps refer to the European Society of Hypertension (ESH) Guidelines and have been published in peer-reviewed journals: Hy-Result and ESH CARE. At present, the absence of close collaboration between start-up engineers and healthcare professionals is a risk for patient safety. 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The mechanisms accounting for the increase in angptl4 expression are largely unknown. This study shows that human α1-antitrypsin (A1AT) upregulates expression and release of angplt4 in human blood adherent mononuclear cells and in primary human lung microvascular endothelial cells in a concentration- and time-dependent manner. Mononuclear cells treated for 1 h with A1AT (from 0.1 to 4 mg/ml) increased mRNA of angptl4 from 2- to 174-fold, respectively, relative to controls. In endothelial cells, the maximal effect on angptl4 expression was achieved at 8 h with 2 mg/ml A1AT (11-fold induction versus controls). In 10 emphysema patients receiving A1AT therapy (Prolastin), plasma angptl4 levels were higher relative to patients without therapy (nanograms per milliliter, mean [95% confidence interval] 127.1 [99.5-154.6] versus 76.8 [54.8-98.8], respectively, p \u003d 0.045) and correlated with A1AT levels. The effect of A1AT on angptl4 expression was significantly diminished in cells pretreated with a specific inhibitor of ERK1/2 activation (UO126), irreversible and selective PPARγ antagonist (GW9662), or genistein, a ligand for PPARγ. GW9662 did not alter the ability of A1AT to induce ERK1/2 phosphorylation, suggesting that PPARγ is a critical mediator in the A1AT-driven angptl4 expression. In contrast, the forced accumulation of HIF-1α, an upregulator of angptl4 expression, enhanced the effect of A1AT. Thus, acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. 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This selection manifests as phylogenetically acquired activities that depend on evolved nervous system circuitries. Lorenz and Tinbergen already postulated that heritable behaviours and their reliable performance are specified by genetically determined programs. Here we compare the functional anatomy of the insect central complex and vertebrate basal ganglia to illustrate their role in mediating selection and maintenance of adaptive behaviours. Comparative analyses reveal that central complex and basal ganglia circuitries share comparable lineage relationships within clusters of functionally integrated neurons. These clusters are specified by genetic mechanisms that link birth time and order to their neuronal identities and functions. Their subsequent connections and associated functions are characterized by similar mechanisms that implement dimensionality reduction and transition through attractor states, whereby spatially organized parallel-projecting loops integrate and convey sensorimotor representations that select and maintain behavioural activity. In both taxa, these neural systems are modulated by dopamine signalling that also mediates memory-like processes. The multiplicity of similarities between central complex and basal ganglia suggests evolutionarily conserved computational mechanisms for action selection. We speculate that these may have originated from ancestral ground pattern circuitries present in the brain of the last common ancestor of insects and vertebrates. 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The current 7-week inpatient study assessed oral oxycodone self-administration by patients with chronic pain who had a history of opioid abuse. Participants (n\u003d25) were transitioned from their preadmission prescribed opioid to Bup/Nx. All of the participants were tested under each of the sublingual Bup/Nx maintenance doses (2/0.5, 8/2 or 16/4 mg) in random order. During each maintenance period, participants could self-administer oxycodone orally (0, 10, 20, 40 or 60 mg prescription opioids) or receive money during laboratory sessions. Drug choice (percentage) was the primary dependent variable. Subjective ratings of clinical pain and withdrawal symptoms also were measured. Mann-Whitney tests compared percentage of drug choice for each active oxycodone dose to placebo. Logistic regression analyses identified correlates of oxycodone preference, defined as 60% or greater choice of oxycodone compared to money. Pain was significantly reduced while participants were maintained on Bup/Nx compared to preadmission ratings. No differences in percentage drug choice were observed between the active oxycodone doses and placebo under each Bup/Nx maintenance dose. However, factors associated with oxycodone preference were lower Bup/Nx maintenance dose, more withdrawal symptoms and more pain. These data suggest that Bup/Nx was effective in reducing pain and supplemental oxycodone use. 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A first-in-class HSP90 drug, the geldanamycin analog 17-AAG, has provided proof of concept for HSP90 inhibition in patients at well tolerated doses and therapeutic activity has been seen. Other inhibitors show promise in preclinical and clinical development. Opportunities and challenges for HSP90 inhibitors are discussed, including use in combination with other agents. Most of the current HSP90 inhibitors act by blocking the essential nucleotide binding and ATPase activity required for chaperone function. Potential new approaches are discussed, for example, interference with cochaperone binding and function in the superchaperone complex. Biomarkers for use with HSP90 inhibitors are described. 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Thirty-one full diagnosed cancer patients underwent the radiotherapy procedures. The interleukin-10 (IL-10) and interleukin-6 (IL-6) serum levels were measured before therapy and after 3, 6 and 12 months after therapy. The interleukins concentrations were evaluated using a solid phase sandwich Enzyme-Linked-Immuno-Sorbent-Assay (ELISA). In all patients the serum levels of IL-10 have been found elevated. Due to the treatment they progressively declined to almost normal ranges in responders, while they remained elevated in non-responders. Serum levels of interleukin-6 have been elevated in the majority of our patients. After 12 months observation they also decreased, mainly in patients responding to the treatment. No correlation between serum IL-10 and IL-6 level has been found. The importance of serum IL-6 determination in lung cancer patients monitoring has already been established. 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The effect was observed at drug concentrations that inhibited the protein phosphatase type 2A but not type 1. We investigated whether apoptosis was a consequence of the preceding mitosis arrest or was induced independently by okadaic acid. We found that (1) apoptosis, but not mitotic arrest, was inhibited in cells with constitutive expression of Bcl-2; (2) pretreatment of cells with the DNA synthesis inhibitor hydroxyurea blocked the mitotic arrest but not the apoptosis mediated by okadaic acid; (3) down-regulation of c-myc gene was associated with apoptosis, but not with mitotic arrest; and (4) inhibition of protein synthesis abrogated mitotic arrest, but not apoptosis. 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A flagellum-dependent bacteriophage of the Myoviridae, ΦTE, evolved rare mutants that \"escaped\" ToxIN-mediated abortive infection within Pectobacterium atrosepticum. Wild-type ΦTE encoded a short sequence similar to the repetitive nucleotide sequence of the RNA antitoxin, ToxI, from ToxIN. The ΦTE escape mutants had expanded the number of these \"pseudo-ToxI\" genetic repeats and, in one case, an escape phage had \"hijacked\" ToxI from the plasmid-borne toxIN locus, through recombination. Expression of the pseudo-ToxI repeats during ΦTE infection allowed the phage to replicate, unaffected by ToxIN, through RNA-based molecular mimicry. This is the first example of a non-coding RNA encoded by a phage that evolves by selective expansion and recombination to enable viral suppression of a defensive bacterial suicide system. 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The natural history of this disorder, characterized by marked clinical and radiographic variation in site of lesion, and the timing and severity of intracranial hemorrhage, make it a useful model for investigating contributing factors and consequences of intracranial hemorrhage in general. For at-risk and affected patients early and sequential CCTs are necessary. 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The goal of this systematic review was to summarize and evaluate the available literature on pre-bariatric surgery weight loss requirements and the relation between preoperative weight loss and postoperative outcome. Major databases, including Medline, PubMed and PsychINFO were searched for relevant articles. Case studies, studies\u003e20 years old and studies that utilized self-reported body weight data were excluded. Data on the effect of the following was summarized: (1) preoperative requirements on preoperative weight loss; (2) insurance-mandated preoperative requirements; (3) the contingency of receipt of surgery; (4) preoperative weight loss on postoperative weight loss and (5) preoperative weight loss on perioperative and postoperative complication and comorbidity rates. The majority of studies suggest that: (1) current preoperative requirements held by the majority of third party payer organizations in the United States are ineffective in fostering preoperative weight loss; (2) making receipt of surgery contingent upon achieving preoperative weight loss, and meal-replacement diets, may be particularly effective in fostering preoperative weight loss and (3) preoperative weight loss may lead to improvements in at least some relevant postoperative outcomes. However, a preoperative weight loss mandate may lead to the denial of surgery and subsequent health benefits to individuals who are unable to achieve a prespecified amount of weight. 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Carboxy- and hydroxybutyrfentanyl were identified as most abundant metabolites. Comparison of t1 and t2 showed a concentration increase of butyrfentanyl in femoral blood of 120%, in heart blood of 55% and a decrease in lung of 30% within 19h. No clear concentration changes could be observed in the other matrices. Postmortem concentration changes were also observed for the metabolites. In conclusion, butyrfentanyl seems to be prone to postmortem redistribution processes and concentrations in forensic death cases should be interpreted with caution. 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Thirty-six physical active men performed 1-repetition maximum in a bench press (1 RM (BP)) and half squat position (1 RM (HS)), and performed maximal power-output continuous repetition sets randomly every 10 days until failure with a submaximal load (60 %, 65 %, 70 %, and 75 % of 1RM, respectively) during bench press and parallel squat. Average velocity of each repetition was recorded by linking a rotary encoder to the end part of the bar. The values of 1 RM (BP) and 1 RM (HS) were 91 +/- 17 and 200 +/- 20 kg, respectively. The number of repetitions performed for a given percentage of 1RM was significantly higher (p \u003c 0.001) in half squat than in bench press performance. Average repetition velocity decreased at a greater rate in bench press than in parallel squat. The significant reductions observed in the average repetition velocity (expressed as a percentage of the average velocity achieved during the initial repetition) were observed at higher percentage of the total number of repetitions performed in parallel squat (48 - 69 %) than in bench press (34 - 40 %) actions. The major finding in this study was that, for a given muscle action (bench press or parallel squat), the pattern of reduction in the relative average velocity achieved during each repetition and the relative number of repetitions performed was the same for all percentages of 1RM tested. However, relative average velocity decreased at a greater rate in bench press than in parallel squat performance. This would indicate that in bench press the significant reductions observed in the average repetition velocity occurred when the number of repetitions was over one third (34 %) of the total number of repetitions performed, whereas in parallel squat it was nearly one half (48 %). Conceptually, this would indicate that for a given exercise (bench press or squat) and percentage of maximal dynamic strength (1RM), the pattern of velocity decrease can be predicted over a set of repetitions, so that a minimum repetition threshold to ensure maximal speed performance is determined.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6425f0af764b824372cbae08766cb","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"16944400","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Messi Zac","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Cyrille, Noa Ndoua Claude","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Damaris, Enyegue Mandob","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"Syndrome M?tabolique Pr?valence Facteurs de risque sociod?mographiques Yaound?-Cameroun.","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"title":[{"value":"Facteurs De Risques Sociodemographiques Du Syndrome Metabolique Dans Une Population De Yaounde-Cameroun.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-04-07","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Contexte: Le Syndrome M?tabolique est une constellation d?anomalies m?taboliques qui concourent ? l?augmentation du risque cardiovasculaire chez une personne. Au Cameroun, plusieurs ?tudes relatives au Syndrome M?tabolique existent d?j?, cependant, aucune d?elles ne s?est appesantie sur le syndrome ?tabolique et ses facteurs de risques sociod?mographiques. Notre ?tude se propose d??valuer la pr?valence du Syndrome M?tabolique en fonction des facteurs sociod?mographiques au sein de notre population d??tude puis d?identifier lesquels sont facteurs de risque du syndrome m?tabolique. Mat?riel et M?thodes: Dans le cadre de cette ?tude transversale, nos recherches ont port? sur l??valuation de la pr?valence du Syndrome m?tabolique selon la d?finition de National Cholesterol Education Programm 2001 en fonction des variables sociod?mographiques puis l?identification ses facteurs de risque par r?gression logistique dans une population pr?sum?e saine ayant vivant ? Yaound? recrut?s de Mars 2014 ? D?cembre 2017. R?sultats: A l?issue de notre ?tude, il se d?gage parmi les variables sociod?mographiques ?tudi?es du Syndrome M?tabolique, celles ? risque au sein de notre population sont le sexe f?minin, les tranches d??ge sup?rieures ? 45 ans, la dur?e de r?sidence ? Yaound? sup?rieure ? cinq ans. Les autres variables ? l?instar du statut matrimonial, la zone ?cologique, l?emploi et le niveau d?instruction ne sont pas associ?es au Syndrome M?tabolique. Conclusion: Dans la mise en place des programmes de pr?vention sp?cifiques au Syndrome M?tabolique au sein de nos populations, un accent particulier devra ?tre mis chez les femmes, chez les individus ayant une dur?e de r?sidence en ville de plus de cinq ans et chez les individus ?g?s de plus de 45 ans.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Zenodo","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb643984c5b21aac11b57fdddadcf3f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5281/zenodo.1219943","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Kawaguchi, T.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Hamasuna, R.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Kataoka, H.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Miyazawa, K.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Koono, M.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Shimomura, T.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Kitamura, N.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Itoh, H.","name":"","surname":"","rank":8,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-11-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Hepatocyte growth factor activator (HGFA) is responsible for proteolytic activation of the precursor form of hepatocyte growth factor in injured tissues. To date, two specific inhibitors of HGFA have been identified, namely HGFA inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin (PB). Both inhibitors are first synthesized as integral membrane proteins having two Kunitz domains and a transmembrane domain, and are subsequently released from cell surface by shedding. Here we show that an active form of HGFA is specifically complexed with membrane-form HAI-1, but not with HAI-2/PB, on the surface of epithelial cells expressing both inhibitors. This binding required the enzyme activity of HGFA. The selective binding of HGFA to the cell surface HAI-1 was further confirmed in an engineered system using Chinese hamster ovary cells, in which only the cells expressing HAI-1 retained exogenous HGFA. The binding of HGFA to HAI-1 was reversible, and no irreversible modifications affecting the enzyme activity occurred during the binding. Importantly, HAI-1 and the HGFA.HAI-1 complex were quickly released from the cell surface by treatment with phorbol 12-myristate 13-acetate or interleukin 1beta accompanying the generation of 58-kDa fragments of HAI-1, which are less potent against HGFA, as well as significant recovery of HGFA activity in the culture supernatant. This regulated shedding was completely inhibited by BB3103, a synthetic zinc-metalloproteinase inhibitor. We conclude that HAI-1 is not only an inhibitor but also a specific acceptor of active HGFA, acting as a reservoir of this enzyme on the cell surface. The latter property appears to ensure the concentrated pericellular HGFA activity in certain cellular conditions, such as tissue injury and inflammation, via the up-regulated shedding of HGFA.HAI-1 complex. These findings shed light on a novel function of the integral membrane Kunitz-type inhibitor in the regulation of pericellular proteinase activity.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb643c92e244d32b1d988e3927aaf68","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"11013244","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Priya Padmanabhan","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Katie Scott","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Dmochowski, Roger R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Delivery methods for drugs used in the treatment of overactive bladder.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-12-02","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It is likely that low adherence rates with the use of these drugs are due in some part to drug side effects. It is therefore important that alternate methods for drug delivery be explored to reduce side effect profiles and improve patient compliance.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6442e93994bd955703b460cb10f9d","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26654220","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Rajagopalan, K. V.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Temple, C. A.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Mechanism of assembly of the Bis(Molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2007-11-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"A fully defined in vitro system has been developed for studying the mechanism of assembly of the bis(molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase (DMSOR). R. sphaeroides DMSOR expressed in a mobA(-) Escherichia coli strain lacks molybdopterin and molybdenum but contains a full complement of guanine in the form of GMP and GDP. Escherichia coli MobA, molybdopterin-Mo, GTP, and MgCl(2) are required and sufficient for the in vitro activation of purified DMSOR expressed in the absence of MobA. High levels of MobA inhibit the in vitro activation. A chaperone is not required for the in vitro activation process. The reconstituted DMSOR can exhibit up to 73% of the activity observed in recombinant DMSOR purified from a wild-type strain. The use of radiolabeled GTP has demonstrated incorporation of the guanine moiety from the GTP into the activated DMSOR. No role was observed for E. coli MobB in the in vitro activation of apo-DMSOR. This work also represents the first time that the MobA-mediated conversion of molybdopterin to molybdopterin guanine dinucleotide has been demonstrated directly without using the activation of a molybdoenzyme as an indicator for cofactor formation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6449bf6893f832bb4a86d2a5a1f96","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10978348","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Consequently, uptake and intracellular storage of iron are tightly controlled. The filamentous fungus A. nidulans lacks the iron storage compound ferritin but possesses an intracellular siderophore, which is accumulated in a highly regulated manner as iron-free desferri-ferricrocin or iron-containing ferricrocin via transcriptional regulation of the nonribosomal peptide synthetase SidC. Biosynthesis of desferri-ferricrocin was low during iron-replete conditions but up-regulated by both iron starvation and intracellular iron excess, the latter caused by either a shift from iron-depleted to high-iron conditions or deregulation of iron uptake. Consequently, ferricrocin constituted only about 5% of the total iron content under iron-replete conditions but up to 64% during conditions of intracellular excess. In contrast, during iron starvation, desferri-ferricrocin was accumulated, which appears to represent a proactive strategy to prevent iron toxicity. Accumulation of the intracellular siderophore was also up-regulated by oxidative stress, which underscores the intertwining of iron metabolism and oxidative stress. Lack of the intracellular siderophore causes pleiotropic effects, as SidC deficiency results in (i) less-efficient utilization of iron, indicated by reduced growth under iron-depleted conditions and a higher iron demand under iron-replete conditions, (ii) delayed germination under iron-depleted conditions, (iii) increased sensitivity of conidia to oxidative stress, and (iv) elimination of cleistothecia formation in homothallic conditions.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6451170db4bf6414adfaaf8c8c78f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17030991","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Kwong, Yok L.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Raymond Liang","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Chim, Chor S.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Gene hypermethylation in multiple myeloma: lessons from a cancer pathway approach.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2008-12-09","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Multiple myeloma (MM) is an incurable plasma cell neoplasm. Pathogenesis involves upregulation of D-type cyclins and activation of oncogenes, but little is known about the role of tumor suppressor genes. Gene hypermethylation is an alternative mechanism of tumor suppressor gene inactivation. Various approaches have been used to elucidate the role of gene hypermethylation in MM, including a candidate gene approach, microarray approach for genes upregulated by hypomethylating agents, and a cancer pathway approach, which enables a comprehensive picture of the involvement of multiple tumor suppressor genes in MM. Based on the cancer pathway approach, the following data on the involvement of cell cycle control, intrinsic tumor suppressor, and cell signaling were derived. First, among the INK4 and CIP/KIP families of cyclin-dependent kinase inhibitors, only CDKN2B and CDKN2A are frequently hypermethylated. Second, methylation of SHP1 and soluble Wnt inhibitors is associated with constitutive activation of JAK/STAT and Wnt signaling. Importantly, downregulation of the signaling pathways can be restored by demethylation and re-expression of SHP1 and soluble Wnt inhibitors, which is potentially important therapeutically. Third, of the tumor suppressor genes involved in the DAPK/P14/HDM2/P53/Apaf-1 pathway, only DAPK is frequently methylated, which appeared to be an adverse prognostic factor to survival. Lastly, apart from being implicated in the progression from monoclonal gammopathy of unknown significance to MM, aberrant gene promoter methylation might also account for late disease progression in MM. Future studies are needed to delineate the biologic consequence of gene hypermethylation, the prognostic effect of gene methylation, and the possibility of hypomethylation therapy.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb645d35744f75854efc269c9fe5085","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19064397","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In this paper, we present a framework for promoting quality measurement as a tool for improving quality of mental health care. We identify key barriers to this effort, including lack of standardized information technology-based data sources, limited scientific evidence for mental health quality measures, lack of provider training and support, and cultural barriers to integrating mental health care within general health environments. We describe several innovations that are underway worldwide which can mitigate these barriers. Based on these experiences, we offer several recommendations for improving quality of mental health care. Health care payers and providers will need a portfolio of validated measures of patient-centered outcomes across a spectrum of conditions. Common data elements will have to be developed and embedded within existing electronic health records and other information technology tools. Mental health outcomes will need to be assessed more routinely, and measurement-based care should become part of the overall culture of the mental health care system. Health care systems will need a valid way to stratify quality measures, in order to address potential gaps among subpopulations and identify groups in most need of quality improvement. Much more attention should be devoted to workforce training in and capacity for quality improvement. The field of mental health quality improvement is a team sport, requiring coordination across different providers, involvement of consumer advocates, and leveraging of resources and incentives from health care payers and systems.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb649297edd387e0f39aa0dd66409f1","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29352529","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The potential mechanism, however, remains unknown. We recently reported that diabetes depresses AMP-activated protein kinase (AMPK) activity, inhibits MAPK8/JNK1-BCL2 signaling, and promotes the interaction between BECN1 and BCL2. Concomitantly, diabetes induces cardiomyocyte apoptosis and suppresses cardiac autophagy. Activation of AMPK directly phosphorylates MAPK8, which mediates BCL2 phosphorylation and subsequent BECN1-BCL2 dissociation, leading to restoration of cardiac autophagy, protection against cardiac apoptosis, and ultimately improvement in cardiac structure and function. 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In order to fully utilize the potential of a genetic screen of this magnitude, in which exploration for genes responsible for genomic instability and radiation sensitivity is to occur, it is necessary to establish a simple assay system that is amenable to automation. Hence, we are using the single-cell gel electrophoresis (comet assay) to detect mouse mutants that display a genetic susceptibility to ionizing radiation. We have established the analysis parameters in the comet assay which are currently used to detect radiation-sensitive mouse mutants and to control the variance within the mouse population in the ENU screen. 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Mucocutaneous immunity to C. albicans requires T helper 17 (Th17) cell differentiation that is thought to depend on recognition of filamentous C. albicans. Systemic immunity is considered T cell independent. Using a murine skin infection model, we compared T helper cell responses to yeast and filamentous C. albicans. We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells. Filamentous forms induced Th1 without Th17 cell responses due to the absence of Dectin-1 ligation. Notably, Th17 cell responses provided protection against cutaneous infection while Th1 cell responses provided protection against systemic infection. Thus, C. albicans morphology drives distinct T helper cell responses that provide tissue-specific protection. 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Monotropic CCR5-using variants are found early in the infection while CXCR4-using variants may appear after progression to AIDS. CXCR4 use may consist of both monotropic and dualtropic viruses. The viral phenotype is important in evaluating the response to CCR5 inhibitors, a new class of antiviral drugs. The coreceptor use of HIV-1 was investigated using population sequencing in 24 patients from Botswana, carrying HIV-1 subtype C and failing antiretroviral treatment, while 26 treatment-naive patients acted as controls. Single genome sequencing was used to discern minor HIV-1 populations in the treatment-experienced group. The Geno2Pheno method was employed to predict the coreceptor use phenotype from HIV-1 env gp120 V3 DNA sequences. The glycan-charge model adjusted for subtype C was also used for phenotype prediction. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Cabral, J. R.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Galendo, D.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Carcinogenicity study of the pesticide fenvalerate in mice.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2012-11-15","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Fenvalerate is a widely used pesticide, which has been shown recently to be nonmutagenic. We studied its carcinogenicity in a long-term experiment in inbred C57Bl/6 mice given 0, 40 and 80 mg/kg body weight fenvalerate (99% pure) by gavage on 5 days/week for 104 weeks. Survival was decreased especially among females receiving the high dose. Exposure to fenvalerate resulted in a slight increase in the incidence of liver-cell tumours over that in controls only in male mice receiving the high dose. No significant difference in the incidence of other types of tumours was observed in treated groups when compared with controls. Fenvalerate-induced microgranulomas occurred concomitantly in the liver, spleen and lymph nodes of male and female mice, but their overall incidence did not increase with dose. In a separate experiment, groups of SJL/ola female mice were administered two different samples of fenvalerate (92% and 99% pure) once per week for 12 weeks. In animals that received 92% pure compound, the latent period for induction of lymphomas was shortened and their incidence increased, when compared with the group receiving 99% pure fenvalerate and with controls.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6759a4ea191f4d6cdbac660e7248f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"2302693","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The bacteria were distinguished from Corynebacterium species with validly published names by biochemical tests, fatty acid content and whole-cell protein analysis. Comparative 16S rRNA gene sequence analysis demonstrated unambiguously that the nine strains were related phylogenetically to the species \u0027Corynebacterium tuberculostearicum\u0027 and represented a distinct subline within the genus Corynebacterium. On the basis of both phenotypic and phylogenetic evidence, the formal description of Corynebacterium tuberculostearicum sp. nov. is proposed. 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The proximal promoter region along with the major intronic enhancer at approximately 87 kb, at which the GR binding peaked, had elevated levels of histone 3 acetylation and H3K4 trimethylation, whereas H3K36 trimethylation more generally marked the gene body and reflected the occupancy of RNA polymerase II. The occurrence of these active chromatin marks within the FKBP51 locus before glucocorticoid exposure suggests that it is poised for transcription in A549 cells. 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This monthly review \"d\u0027au moins 80 pages\" was called L\u0027Ecole Lyonnaise, and so to say, l\u0027Ecole Francaise d\u0027Anthropologie Criminelle, which defends against l\u0027Ecole Italienne of Lombroso, the culturalist theory of the birth of the criminal; according to this école du milieu social: \"La Société a les criminels qu\u0027elle merite\" (The society has criminals it deserves). 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Twenty in-depth interviews were conducted with men participating in a larger quantitative study where the median age of the men was 28.7 years and almost 56% had some high-school education, 17.2% were unemployed and 94.7% were not married. A Thematic Question Guide with open-ended questions was used for the interviews. A thematic content analysis was conducted to explore the characteristics and dynamics of social and sexual relationships among these men. A high number of temporary and stable concurrent female sexual partners, geographic mobility and high levels of unprotected sex were common. Increased status as a man and lack of trust in women\u0027s fidelity were given as important reasons for concurrent female sexual relationships. Strong social networks within male core groups provided economic and social support for the pursuit and maintenance of this behaviour. Concurrent sexual relationships in combination with high viral loads among newly infected individuals unaware of their HIV status create an extremely high-risk environment for the spread of HIV in this population. Interventions targeting men at high risk of HIV need to challenge current societal norms of masculinity to help promote individual sexual risk reduction strategies. 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Specifically, our results suggest that although SLN and PLN may preferentially regulate SERCA1a, and SERCA2a, respectively, physiologically they both may regulate either SERCA isoform. Furthermore, we show that SLN and PLN co-immunoprecipitate in human vastus lateralis homogenate and are simultaneously expressed in 81% of the fibers analyzed with Western blotting which implies that super-inhibition of SERCA may exist in human skeletal muscle. Finally, we demonstrate unequivocally that mouse soleus contains PLN protein suggesting that super-inhibition of SERCA may also be important physiologically in rodent skeletal muscle. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Paulina Papier","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Filip Szten","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Zygmunt Zdrojewicz","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Radosław Konieczny","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-10-23","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS)--specific to male germ cells and voltage-gated cation channel (CatSper). Both are responsible for sperm motility. Drugs such as thioridazine used in schizophrenia treatment and phenoxybenzamine (antihypertensive activity) exhibit a contraceptive effect. Similar action exhibits an analogue of lonidamine--adjudin and an antagonist of retinoic acid receptors (BMS-189453). Researchers are working on a contraceptive vaccine, whose active ingredient is epididymal protease inhibitor (Eppin). Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis. JQ1-the Brdt inhibitor causes reversible infertility without affecting the endocrine signaling pathways. A recent discovery of Juno as the binding partner for Izumo1 identifies these proteins as the cell-surface receptor pair, essential for gamete recognition and this interaction can be inhibited by an anti-Juno monoclonal antibody. Our review shows that the situation of men can change and investigators are close to the optimal solution. In the near future men will be able to choose the best contraceptive suited to their needs.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6a9b21bcd3b94020b02833039fe65","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26469117","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Davorka Zavrsnik","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Samija Muratović","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Marica Medić-Sarić","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Selma Spirtović","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Dzenita Softić","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The synthesis and antimicrobial activity of some 4-hydroxycoumarin derivatives.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Due to exceptional reactivity of 4-hydroxycoumarin, the synthesis of new coumarin derivatives of dimer and tetramer type has been carried out. The synthesis was carried out from 4-hydroxycoumarin and various aromatic aldehydes. In this way, compounds of the dimer 3,3\u0027-(benzilidene)bis (4-hydroxycoumarin) type, as well as of the tetramer 3,3\u0027,3\u0027\u0027,3\u0027\u0027\u0027-(1,4-dimethylenphenyl)tetra (4-hydroxycoumarin) type were prepared. The newly synthesized derivatives contain different functional groups, and as such they could exhibit microbiological activity. Therefore, we tested the microbiological activity of these derivatives on various species of bacteria and fungi. The tested compounds have shown different activity in terms of growth inhibition of microorganisms. Newly synthesized derivatives exhibit antibacterial activities, manifested as growth inhibition on Gram-positive bacteria types (Bacillus, Staphylococcus), while the activity against Candida was much weaker. The same compound did not show any antimicrobial activity against two Gram-negative bacteria types (Escherichia coli, Pseudomonas aeruginosa). The compound 1 showed the best microbiological activity. The obtained results confirmed its good antibacterial and antimycotic activities against different microorganisms.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6aabec3e1a7cacc93175513293a1b","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"18816263","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Its impact in the swine industry is well documented. However, in Chile, the current epidemiological status of rotavirus on porcine farms is unknown. This study evaluated the current epidemiologic status of rotavirus A infection in Chile using on-farm detection techniques, electrophoretic confirmation, genotyping and phylogenetic clustering by analysis of partial sequences of VP4 and VP7 genes. Rotavirus A was detected in four out of five farms with an overall prevalence of 17.7 % in diarrhoeic pigs. The average age of diarrhoea onset was at 32±6.2 days, corresponding to weaning pigs, and rotavirus was not detected in lactating piglets. Molecular characterization indicated that genotypes G5, G3, P[7] and P[13] are currently the most widely represented on these pigs farms. The phylogenetic analysis showed that farms shared similar G types (VP7), which might denote a common origin. Meanwhile, [P] types (VP4) showed considerable genetic diversity, and this might represent a high rate of reassortment of this genetic segment in rotavirus circulating in the researched area. These findings demonstrate the importance of considering both the geographical and production factors to accurately determine rotavirus prevalence status at the national level, and have relevant implications in determining effective strategies for rotavirus infection control on porcine farms.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6ad946d38a177112910c6a210639b","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"27902360","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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D.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Capillary electrophoresis/mass spectrometry determination of inorganic ions using an ion spray-sheath flow interface.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2006-11-15","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The determination of inorganic cations and anions by capillary electrophoresis/mass spectrometry (CE/MS) is reported using an ion spray-sheath flow interface coupling. A twelve-component synthetic mixture of cations which included the positive ions of K, Ba, Ca, Mn, Cd, Co, Pb, Cr, Ni, Zn, Ag, and Cu was loaded into the capillary column at levels ranging from 30 to 300 pg, separated by CE, and detected by indirect UV and in the full-scan (m/z 35-450) positive ion CE/MS mode using an aqueous buffer containing 30 mM creatinine and 8 mM alpha-hydroxyisobutyric acid, pH 4.8. Creatinine forms adducts with the cations which are observed in the gas phase and requires rather high (120 electron volts) declustering energy to dissociate. This produces a reduction in charge state to form the free, singly charged, inorganic cations which are observed in the mass spectra. CE/MS analysis of an aqueous acidic extract of used aircraft engine oil revealed high levels of lead as well as lower levels of chromium and nickel. CE-indirect UV analysis of a synthetic mixture containing 300 pg each of 11 inorganic ions, which included the anions of Br, Cl, NO2, NO3, S2O3, N3, SCN, SO4, SeO4, oxalate, and MoO4, is shown. The running buffer which affected this separation contained 5 mM ammonium dichromate, 10 mM ammonium acetate, and 20 mM diethylenetriamine at pH 9.3. Although indirect UV detection revealed good separation of these anions, CE/MS analysis of this mixture was complicated by interfering ion current signals from the cluster ions formed by the interaction between the additives and the analytes.(ABSTRACT TRUNCATED AT 250 WORDS)","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6b3048ca4360ee7a7d158dcb2c2e6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"8354239","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Maurice Finn","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Skye McDonald","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Repetition-lag training to improve recollection memory in older people with amnestic mild cognitive impairment. A randomized controlled trial.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-11-25","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The results of a randomized controlled trial of repetition-lag training in older adults with amnestic mild cognitive impairment (aMCI) are reported. A modified repetition-lag training procedure with extended encoding time and strategy choice was used. The training required discriminating studied words from non-studied lures that were repeated at varying intervals during the test phase. Participants were assessed pre/post using untrained measures of cognition and self-report questionnaires. Primary outcome measures were recall of unrelated word pairs both immediately following presentation and following a delay. Secondary outcomes were a measure of attention, cognitive flexibility, and visual working memory. Participants were also asked to report on the frequency of cognitive failures and mood before and after training. Participants (N \u003d 31) were randomized into either the treatment or a no-contact control group and attended the clinic twice per week over a four week period. Twenty-four participants completed the study (twelve in each group). Results indicated that the training group improved at recalling unrelated word pairs after a delay. There were no significant effects of training on other outcomes, self-reported cognitive failures or mood. 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NK cells activated by IL-12 have been reported to recognize and kill tumor cells in perforin-mediated apoptosis. We have reported that D-Fraction, a polysaccharide extracted from the maitake mushroom (Grifola frondosa), activates macrophages, dendritic cells, and T cells and inhibits the growth of tumor cells. However, the effects of D-Fraction on NK cell function in the innate immune response are not well known. In the present study, we administered D-Fraction to MM-46 mammary tumor-bearing C3H/HeJ mice intraperitoneally for 3 consecutive days and investigated its effects on the activation and cytotoxicity of NK cells. D-Fraction significantly enhanced the cytotoxicity against NK-sensitive YAC-1 cells and the expression of CD223 on NK cells. D-Fraction also increased the expression of CD86 on macrophages. In addition, the levels of IL-12 in the culture supernatant of whole spleen cells and in serum increased, compared with the control corresponding to an increase in expression of IL-12 receptor betaI on NK cells. These results suggest that D-Fraction enhances the cytotoxicity of NK cells through the production of IL-12 by macrophages activated by D-Fraction.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6b4dec535ff3b782bc31a2367d45c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15706424","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The genetic disorder, alpha1-AT deficiency, is well known as a cause of hereditary pulmonary emphysema and liver cirrhosis. To create an animal model of human alpha1-AT deficiency, we disrupted the major murine isoform PI2, which is similar to human alpha1-AT and is one of 7 alpha1-AT isoforms found in the mouse. The ability of the serum to inhibit the activities of human leukocyte elastase (HLE) and human chymotrypsin (CYT) was significantly lower in heterozygous mice (alpha1-AT/PI2 -/+) than wild-type (alpha1-AT/PI2 +/+) mice (73.2% vs. 100% for HLE and 67.8% vs.100% for CYT, respectively; P\u003c0.05). The distribution of genotypes among F(2) progeny was not in accordance with Mendelian distribution (P\u003c0.01), as the percentages of wild-type, heterozygotes and homozygotes were 47.8%, 37.3% and 14.9%, respectively. Thus, it is likely that impairment of the protease inhibitor had a critical effect on fetus development. The alpha1-AT/PI2 deficient mouse will be a useful animal model for elucidating the function of alpha1-AT in fetal development, studying the mechanisms of chronic inflammatory disease and evaluating therapeutic candidates for the treatment of inflammatory disease.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6b79eac5bb08fc43f1df2e4853026","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15516792","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Xin\u0027an Li","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Xia Zhao","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Lijun Ding","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Jianwu Dai","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Yali Hu","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Haixiang Sun","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Tianran Song","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Nacheng Lin","name":"","surname":"","rank":8,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"A variety of diseases may lead to hysterectomies or uterine injuries, which may form a scar and lead to infertility. Due to the limitation of native materials, there are a few effective methods to treat such damages. Tissue engineering combines cell and molecular biology with materials and mechanical engineering to replace or repair damaged organs and tissues. The use of human embryonic stem cells (hESCs) as a donor cell source for the replacement therapy will require the development of simple and reliable cell differentiation protocols. This study aimed at efficiently generating endometrium-like cells from the hESCs and at using these cells with collagen scaffold to repair uterine damage. The hESCs were induced by co-culturing with endometrial stromal cells, and simultaneously added cytokines: epidermal growth factor (EGF), platelet-derived growth factor-b (PDGF-b), and E2. Expression of cell specific markers was analyzed by immunofluorescence and reverse trascription-polymerase chain reaction to monitor the progression toward an endometrium-like cell fate. After differentiation, the majority of cells (\u003e80%) were positive for cytokeratin-7, and the expression of key transcription factors related to endometrial development, such as Wnt4, Wnt7a, Wnt5a, Hoxa11, and factors associated with endometrial epithelial cell function: Hoxa10, Intergrinβ3, LIF, ER, and PR were also detected. Then, we established the uterine full-thickness-injury rat models to test cell function in vivo. hESC-derived cells were dropped onto collagen scaffolds and transplanted into the animal model. Twelve weeks after transplantation, we discovered that the hESC-derived cells could survive and recover the structure and function of uterine horns in a rat model of severe uterine damage. The experimental system presented here provides a reliable protocol to produce endometrium-like cells from hESCs. Our results encourage the use of hESCs in cell-replacement therapy for severe uterine damage in future. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Wilhelmsen, E. C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Hawkes, W. C.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Tappel, A. 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Equilibration of the animals to a constant specific activity of 75Se allowed the measurement of 75Se to be used as a specific elemental assay for Se. Skeletal muscle, liver and blood accounted for 73% of the whole-body Se and 95% of the total Se-dependent glutathione peroxidase activity. Over 80% of the whole-body Se was in protein in the form of the selenoamino acid, selenocysteine. All other forms of Se that were measured accounted for less than 3% of the whole-body Se. The Se in protein was distributed in seven subunit sizes and nine chromatographic forms. The Se in glutathione peroxidase accounted for one-third of the whole-body Se. These results show that the main use of dietary Se, as selenite, in rats is for the synthesis of selenocysteine-containing proteins. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Tapert, Susan F.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Joanna Jacobus","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Effects of cannabis on the adolescent brain.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This article reviews neuroimaging, neurocognitive, and preclinical findings on the effects of cannabis on the adolescent brain. Marijuana is the second most widely used intoxicant in adolescence, and teens who engage in heavy marijuana use often show disadvantages in neurocognitive performance, macrostructural and microstructural brain development, and alterations in brain functioning. It remains unclear whether such disadvantages reflect pre-existing differences that lead to increased substances use and further changes in brain architecture and behavioral outcomes. Future work should focus on prospective investigations to help disentangle dose-dependent effects from pre-existing effects, and to better understand the interactive relationships with other commonly abused substances (e.g., alcohol) to better understand the role of regular cannabis use on neurodevelopmental trajectories. ","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6bd5a40c2916969399f7b44e0dbcd","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23829363","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Bmp activates early steps for both fates during late blastula stage. Low Bmp activates expression of transcription factors Tfap2a and Tfap2c in the lateral neural plate, thereby specifying neural crest fate. Elevated Bmp establishes preplacodal competence throughout the ventral ectoderm by coinducing Tfap2a, Tfap2c, Foxi1 and Gata3. PPE specification occurs later at the end of gastrulation and requires complete attenuation of Bmp, yet expression of PPE competence factors continues well past gastrulation. Here we show that competence factors positively regulate each other\u0027s expression during gastrulation, forming a self-sustaining network that operates independently of Bmp. Misexpression of Tfap2a in embryos blocked for Bmp from late blastula stage can restore development of both PPE and NC. However, Tfap2a alone is not sufficient to activate any other competence factors nor does it rescue individual placodes. On the other hand, misexpression of any two competence factors in Bmp-blocked embryos can activate the entire transcription factor network and support the development of NC, PPE and some individual placodes. We also show that while these factors are partially redundant with respect to PPE specification, they later provide non-redundant functions needed for development of specific placodes. 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Although the most common toxicities of these drugs have been extensively studied, robust data and comprehensive characterization still lack concerning fluoropyrimidine-induced cardiotoxicity (FIC), an infrequent but potentially life-threatening toxicity. This review summarizes the current state of knowledge of FIC with special regard to proposed pathogenetic models (coronary vasospasm, endothelium and cardiomyocytes damage, toxic metabolites, dihydropyrimidine dehydrogenase deficiency); risk and predictive factors; efficacy and usefulness in detection of laboratory markers, electrocardiographic changes and cardiac imaging; and specific treatment, including a novel agent, uridine triacetate. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Anton Fojtik","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Arnim Henglein","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Surface chemistry of luminescent colloidal silicon nanoparticles.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2007-03-23","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Luminescent colloidal silicon particles are obtained by burning silane and slowly etching the product with hydrogen fluoride. Depending on their size, the particles emit red-orange or blue-green light with decay times between 28 micros and \u003c0.1 micros, respectively. The quantum yield of the red luminescence is found to be 35%, i.e., much higher than the 7% previously reported, and the yield of the blue-green luminescence is 18%. The luminescence of the colloidal particles is quenched upon the attack of their surface by free radicals, oxygen-centered radicals being more efficient than carbon-centered ones. It is concluded from the dependence of the luminescence wavelength on the etching time and the dependence of the luminescence lifetime on the wavelength that the mechanism of the photoluminescence undergoes a change with decreasing particle size. The red luminescent particles exhibit amphiphilic properties, such as unusual wetting phenomena. This effect is understood in terms of the existence of few polar groups on the otherwise nonpolar surface of the particles, possibly Si-OH groups, which also act as centers of the red luminescence.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6c66736a27ce57cf21139c0d57ebd","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"16471774","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Sevin Turcan","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Vetter, Douglas E.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Slonim, Donna K.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Lack of nAChR activity depresses cochlear maturation and up-regulates GABA system components: temporal profiling of gene expression in alpha9 null mice.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"It has previously been shown that deletion of chrna9, the gene encoding the alpha9 nicotinic acetylcholine receptor (nAChR) subunit, results in abnormal synaptic terminal structure. Additionally, all nAChR-mediated cochlear activity is lost, as characterized by a failure of the descending efferent system to suppress cochlear responses to sound. In an effort to characterize the molecular mechanisms underlying the structural and functional consequences following loss of alpha9 subunit expression, we performed whole-transcriptome gene expression analyses on cochleae of wild type and alpha9 knockout (alpha9(-/-)) mice during postnatal days spanning critical periods of synapse formation and maturation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6c9cd1c634fb17b643bb92a98e0dc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"20140217","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Liliane da Rocha Siriano","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Neusa Leal Marra","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Juliana Boaventura Avelar","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Alejandro Ostermayer Luquetti","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Ana Maria de Castro","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Chagas disease: increased parasitemia during pregnancy detected by hemoculture.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"One hundred fifty-two Trypanosoma cruzi seropositive women were submitted to a single hemoculture; 101 were pregnant, and 51 were not pregnant. Seven tubes from each individual were harvested with liver infusion tryptose (LIT) medium and observed monthly until the fifth month. Hemocultures were positive in 50% (76 of 152) of the women. Results showed that the positivity was 29.4% (15 of 51) among non-pregnant women and 60.4% (61 of 101) in pregnant women (P \u003c 0.05). In relation to gestational age, there were significant differences in positivity, with a higher proportion of women with positive hemocultures (20 of 25) before 21 weeks and lower after 30 weeks (10 of 21; P \u003d 0.02). We conclude that pregnancy enhances the parasitemia in Chagas disease, with a higher effect early in pregnancy.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6cc947d5fcd94128210af4a077be4","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21460012","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Since VSV and DI-T particles display similar surface densities of the same attachment glycoprotein, we conclude that the physical properties of the particle dictate whether a virus-containing clathrin pit engages the actin system. We suggest that the elongated shape of a VSV particle prevents full enclosure by the clathrin coat and that stalling of coat assembly triggers recruitment of the actin machinery to finish the internalization process. Since some enveloped viruses have pleomorphic particle shapes and sizes, our work suggests that they may use altered modes of endocytic uptake. 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There were assessed level of CA-50 and CA-242 glycoprotein associated antigens. Results were compared with CEA-for digestive tract cancer and Tg levels in thyroid neoplasm respectively. In large bowel cancer (22 cases) there were in 10 patients (45%) with elevated level of CEA, 14 patients with elevated CA-50 (63%) and the same number for CA-242 (14 patients-63%). In cancer of pancreas (total 11 patients) there were CEA elevated level in 3 (27%) patients, CA-50 in 7 (64%) patients and CA-242 in 6 (55%) patients. Patients with well differentiated thyroid cancer (30 cases) revealed elevated level of Tg in 24 (80%) patients, CA-50 in 4 (13%), and CA-242 in 4 (13%) ones. The patients with follicular adenomas (21) had elevated Tg level in 17 (80%) cases, CA-50 in 3 (14%) cases and CA-242 in one patient (4.7%).","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6d2c427eff65da9e2969c5adf3b83","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9446350","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018234357}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Lindsay Whitton, J.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Nicole Silvestri","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Hassett, Daniel E.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Jie Zhang","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Neonates are thought to mount less vigorous adaptive immune responses than adults to antigens and infectious agents. This concept has led to a delay in the administration of many currently available vaccines until late infancy or early childhood. It has recently been shown that vaccines composed of plasmid DNA can induce both humoral and cell-mediated antimicrobial immunity when administered within hours of birth. In most of these studies, immune responses were measured weeks or months after the initial vaccination, and it is therefore questionable whether the observed responses were actually the result of priming of splenocytes within the neonatal period. Here we show that DNA vaccination at birth results in the rapid induction of antigen-specific CD8(+) T cells within neonatal life. Analyses of T-cell effector functions critical for the resolution of many viral infections revealed that neonatal and adult CD8(+) T cells produce similar arrays of cytokines. Furthermore, the avidities of neonatal and adult CD8(+) T cells for peptide and the rapidity with which they upregulate cytokine production after recall encounters with antigen are similar. Protective immunity against the arenavirus lymphocytic choriomeningitis virus, which is mediated by CD8(+) cytotoxic T cells, is also rapidly acquired within the neonatal period. Collectively these data imply that, at least in the case of CD8(+) T cells, neonates are not as immunodeficient as previously supposed and that DNA vaccines may be an effective and safe means of providing critical cell-mediated antiviral immunity extremely early in life.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6d54bf2a9e3ac9e7e71b3ecd37f62","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"12414933","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Nagase H.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"-H, Lim N.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Jozic D.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Bourenkov G.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Maskos K.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Visse R.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Bode W.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"X-ray Structure of Human proMMP-1: NEW INSIGHTS INTO PROCOLLAGENASE ACTIVATION AND COLLAGEN BINDING","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[],"description":[{"value":"Abstract Vertebrate collagenases, members of the matrix metalloproteinase (MMP) family, initiate interstitial fibrillar collagen breakdown. It is essential in many biological processes, and unbalanced collagenolysis is associated with diseases such as arthritis, cancer, atherosclerosis, aneurysm, and fibrosis. These metalloproteinases are secreted from the cell as inactive precursors, procollagenases (proMMPs). To gain insights into the structural basis of their activation mechanisms and collagen binding, we have crystallized recombinant human proMMP-1 and determined its structure to 2.2 A resolution. The catalytic metalloproteinase domain and the C-terminal hemopexin (Hpx) domain show the classical MMP-fold, but the structure has revealed new features in surface loops and domain interaction. The prodomain is formed by a three-helix bundle and gives insight into the stepwise activation mechanism of proMMP-1. The prodomain interacts with the Hpx domain, which affects the position of the Hpx domain relative to the catalytic domain. This interaction results in a “closed” configuration of proMMP-1 in contrast to the “open” configuration observed previously for the structure of active MMP-1. This is the first evidence of mobility of the Hpx domain in relation to the catalytic domain, providing an important clue toward the understanding of the collagenase-collagen interaction and subsequent collagenolysis.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"American Society for Biochemistry \u0026 Molecular Biology (ASBMB)","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6d67a93130033784bbaebaecb8865","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.1074/jbc.m411084200","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In particular, low- and middle-income countries (LMICs) should ensure adequate resource planning with regards to stock consumption and service delivery for new vaccines, whereas global suppliers must produce enough vaccines to meet demand. If a country underestimates the number of children seeking vaccination, a stock-out of commodities will create missed opportunities for saving lives. We describe the post-launch demand for the first dose of pneumococcal conjugate vaccine (PCV1) in Ethiopia and Malawi and the first dose of rotavirus vaccine (Rota1) in Malawi, with focus on the new birth cohort and the \u0027backlog cohort\u0027, comprised of older children who are still eligible for vaccination at the time of launch. PCV1 and Rota1 uptake were compared with the demand for the first dose of pentavalent vaccine (Penta1), a routine immunization that targets the same age group and immunization schedule. In the first year, the total demand for PCV1 was 37% greater than that of Penta1 in Ethiopia and 59% greater in Malawi. In the first 6 months, the demand of Rota1 was only 5.9% greater than Penta1 demand in Malawi. Over the first three post-introduction months, 70.7% of PCV1 demand in Ethiopia and 71.5% of demand in Malawi came from children in the backlog cohort, whereas only 28.0% of Rota1 demand in Malawi was from the backlog cohort. The composition of demand was impacted by time elapsed since vaccine introduction and age restrictions. Evidence suggests that countries\u0027 plans should account for the impact of backlog demand, especially in the first 3 months post-introduction. LMICs should request for higher stock volumes when compared with routine needs, plan social mobilization activities to reach the backlog cohort and allocate human resources and cold chain capacity to accommodate high demand following vaccine introduction. 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However, earlier laboratory evolution strategies for increasing acetic acid tolerance of Saccharomyces cerevisiae, based on prolonged cultivation in the presence of acetic acid, selected for inducible rather than constitutive tolerance to this inhibitor.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6daa490bdc64f0751167997148b74","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"27525042","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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In this study, we analyzed the efficacy and tolerability of crizotinib in the treatment of 72 Chinese patients with ALK-positive, advanced NSCLC. All patients received oral crizotinib 250 mg twice daily in 28-day cycles during the period June 1, 2013, to October 15, 2014. The tumor response was assessed after the first cycle of crizotinib and then after every two cycles using the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.0. Tolerability was assessed at least twice per cycle until crizotinib was discontinued. The patients tended to be young (mean age 55 years, range 31-83 years), never or light smokers (smoking index \u003c400), and to have an adenocarcinoma histology. Most (49/72; 68.1 %) had received previous anticancer treatment before crizotinib therapy. Sixty-seven patients (93 %) were able to be assessed for efficacy. The objective response rate and disease control rate were 52.2 % (95 % CI 40.5-63.9 %) and 64.2 % (95 % CI 52.75-75.7 %), respectively. The estimated median progression-free survival for all 67 patients was 10.3 months (95 % CI 8.6-12.0 months). Mild visual disturbances, nausea, vomiting, diarrhea and constipation were the most commonly reported adverse effects. Thus, crizotinib was well tolerated and showed promising efficacy in Chinese patients with ALK-positive, advanced NSCLC. Further prospective, multicenter studies with a larger sample size are needed to confirm these findings.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6de0d25ddc6909603227aad24c8e3","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"25966792","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Varela, Z.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Aboal, J. R.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Carballeira, A.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Fernández, J. 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Cluster analysis revealed that there were no common patterns of emission associated with the industrial sectors, probably because of differences in production processes and in the types of fuel and raw materials. However, when these variables were shared by different factories, the concentrations of the elements in moss tissues enabled the factories to be grouped according to their emissions. We compiled a list of the metals and metalloids emitted by the factories under study and found that the DSSP method was satisfactory for this purpose in most cases (53 of 56). The method appears to be a useful tool for compiling contaminant inventories; it may also be useful for determining the efficacy of technical improvements aimed at reducing the industrial emission of contaminants and could be incorporated in environmental monitoring and control programmes. 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Muscle biopsies were obtained from the vastus lateralis of eight young healthy sedentary men [23 +/- 2 yr (mean +/- SD), 93 +/- 17 kg, 183 +/- 6 cm] before and 4 and 24 h after 3 x 10 repetitions of bilateral knee extensions at 65% of one repetition maximum. The mRNA levels of TNF-alpha, calpains 1 and 2, muscle RING (really interesting novel gene) finger-1 (MuRF-1), atrogin-1, caspase-3, B-cell leukemia/lymphoma (Bcl)-2, and Bcl-2-associated X protein (Bax) were quantified using real-time RT-PCR. Generally, MHC I fibers had higher (1.6- to 5.0-fold, P \u003c 0.05) mRNA expression pre- and post-RE. One exception was a higher (1.6- to 3.9-fold, P \u003c 0.05) Bax-to-Bcl-2 mRNA ratio in MHC IIa fibers pre- and post-RE. RE increased (1.4- to 4.8-fold, P \u003c 0.05) MuRF-1 and caspase-3 mRNA levels 4-24 h post-RE in both fiber types, whereas Bax-to-Bcl-2 mRNA ratio increased 2.2-fold (P \u003c 0.05) at 4 h post-RE only in MHC I fibers. These results suggest that MHC I fibers have a greater proteolytic mRNA expression pre- and post-RE compared with MHC IIa fibers. The greatest mRNA induction following RE was in MuRF-1 and caspase-3 in both fiber types. This altered and specific proteolytic mRNA expression among slow- and fast-twitch muscle fibers indicates that the ubiquitin/proteasomal and caspase pathways may play an important role in muscle remodeling with RE.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6e467ec9d6a5b81489f6624bf5c26","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"16840578","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The identification of cognitive processes that are either robustly sensitive or robustly insensitive to the same experimental sleep deprivation procedure, will allow us to better focus on the specific effects of sleep on cognition, and increase understanding of the mechanisms involved. In the present study we investigate whether sleep deprivation differentially affects the two separate cognitive processes of acquisition and consolidation of a spatial reversal task. After training on a spatial discrimination between two levers in a Skinner box, male Wistar rats were exposed to a reversal of the previously learned stimulus-response contingency. We first evaluated the effect of sleep deprivation on the acquisition of reversal learning. Performance on reversal learning after 12h of sleep deprivation (n\u003d12) was compared to performance after control conditions (n\u003d12). The second experiment evaluated the effect of sleep deprivation on the consolidation of reversal learning; the first session of reversal learning was followed by 3h of nap prevention (n\u003d8) or undisturbed control conditions (n\u003d8). The experiments had sufficient statistical power (0.90 and 0.81, respectively) to detect differences with medium effect sizes. Neither the acquisition, nor the consolidation, of reversal learning was affected by acute sleep deprivation. 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Security is one of the safety aspects in VANET. To be secure, network availability must be obtained at all times since availability of the network is critically needed when a node sends any life critical information to other nodes. However, it can be expected that security attacks are likely to increase in the coming future due to more and more wireless applications being developed and deployed onto the well-known expose nature of the wireless medium. In this respect, the network availability is exposed to many types of attacks. In this paper, Denial of Service (DOS) attack on network availability is presented and its severity level in VANET environment is elaborated. 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Intranasal transmucosal delivery of benzodiazepines is useful in reducing time to drug administration and cessation of seizures in the pre-hospital setting, when actively seizing patients arrive in the emergency room, and at home where caregivers treat their dependents. This review summarizes factors to consider when choosing a benzodiazepine for intranasal administration, including formulation and device considerations, pharmacology and pharmacokinetic/pharmacodynamic profiles. A review of the most relevant clinical studies in epilepsy patients will provide context for the relative success of this technique with a number of benzodiazepines and relatively less sophisticated nasal preparations. Neuropeptides delivered intranasally, crossing the blood-brain barrier via the olfactory system, may increase the availability of medications for treatment of epilepsy. 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We found a surprisingly large contribution of brain leptin release to the plasma leptin pool, 529 +/- 175 ng/min (\u003e 40% whole body leptin release), with greater leptin release in obese than in lean men, 935 +/- 321 vs. 160 +/- 59 ng/min (P \u003d 0.045). In parallel with leptin measurements, we also quantified brain serotonin turnover and jugular overflow of neuropeptide Y (NPY). Brain serotonin turnover was higher in obese than in lean men, 227 +/- 112 vs. 21 +/- 14 ng/min (P \u003d 0.019), as was overflow of NPY from the brain, 12.9 +/- 1.4 vs. 5.3 +/- 2.2 ng/min (P \u003d 0.042). 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The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamental cellular process. Detailed searches were carried out both for components of the protein import system and for related peptidases. Comparative and phylogenetic analyses were used to investigate the evolution of mitochondrial proteins during eukaryote diversification. Key observations include phylogenetic evidence for very ancient origins for many protein import components (Tim21, Tim50, for example) and indications of differences between the outer membrane receptors that recognize the mitochondrial targeting signals, suggesting replacement, rearrangement and/or emergence of new components across the major eukaryotic lineages. Overall, the mitochondrial protein import components analysed in this study confirmed a high level of conservation during evolution, indicating that most are derived from very ancient, ancestral proteins. Several of the protein import components identified in Ectocarpus, such as Tim21, Tim50 and metaxin, have also been found in other stramenopiles and this study suggests an early origin during the evolution of the eukaryotes.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6f95a889d9bede16628fd6ac95e33","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21611166","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Because of the difference in species specificity between human GM-CSF and murine GM-CSF, there is no immune competent animal model on which the effect and metabolism of 6B11GM as a vaccine could be observed. In this study, 6B11mGM fusion gene was constructed by the fusing murine GM-CSF cDNA gene with 6B11ScFv. The fusion gene was cloned and expressed. The product of this gene is a fusion protein. It could specifically interact with the primary anti-ovarian carcinoma monoclonal antibody (COC166-9) and rat anti-mouse GM-CSF monoclonal antibody, respectively, and stimulate the growth of NFS-60 cells (a murine GM-CSF-dependent cell line). The specific anti-tumor immune response could be induced in BALB/c mice after immunized with anti-idiotypic fusion protein instead of ovarian carcinoma antigen without carrier proteins and adjuvant. Ab(3) could be detected in the sera of immunized mice with 6B11mGM by enzyme-linked immunoadsorbent assay test. Moreover, the fusion protein stimulated proliferation of CD4+ T cell from the spleen of BALB/c mice and proliferation of CD8+ T cell to a lesser degree. Therefore, 6B11mGM probably induces both humoral and cellular immunity against ovarian carcinoma in vivo.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6faa13d0ee250c4cfd8062a8f246e","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15086722","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Although these responses are well studied in Arabidopsis, little is known about the role of PHYs and the transcriptional responses to shade in the woody perennial Populus. Tissue expression and subcellular localization of Populus PHYs was studied by quantitative real-time PCR (qRT-PCR) and protoplast transient assay. Transgenic lines with altered PHYB1 and/or PHYB2 expression were used in phenotypic assays and transcript profiling with qRT-PCR. RNA-Seq was used to identify transcriptional responses to enriched FR light. All three PHYs were differentially expressed among tissue types and PHYBs were targeted to the nucleus under white light. Populus PHYB1 rescued Arabidopsis phyB mutant phenotypes. Phenotypes of Populus transgenic lines and the expression of candidate shade response genes suggested that PHYB1 and PHYB2 have distinct yet overlapping functions. RNA-Seq analysis indicated that genes associated with cell wall modification and brassinosteroid signaling were induced under enriched FR light in Populus. This study is an initial attempt at deciphering the role of Populus PHYs by evaluating transcriptional reprogramming to enriched FR and demonstrates functional diversity and overlap of the Populus PHYB1 and PHYB2 in regulating shade responses.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb6fb5ec8149227538c113ccfc3abac","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22943289","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018249555}
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Here, we report that pnk1pku70 and pnk1rhp51 double mutants are more sensitive to γ-radiation than single mutants, from which we infer that Pnk1\u0027s primary role is independent of either homologous recombination or non-homologous end joining mechanisms. We also report that pnk1 cells are more sensitive than wild-type cells to oxidizing and alkylating agents, suggesting that Pnk1 is involved in base excision repair. Mutational analysis of Pnk1 revealed that the DNA 3\u0027-phosphatase activity is necessary for repair of DNA damage, whereas the 5\u0027-kinase activity is dispensable. A role for Pnk1 in base excision repair is supported by genetic analyses which revealed that pnk1apn2 is synthetically lethal, suggesting that Pnk1 and Apn2 may function in parallel pathways essential for the repair of endogenous DNA damage. 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The aggregation of α-synuclein is a central feature of the disease pathogenesis. Among the different α-synuclein species, large oligomers/protofibrils have particular neurotoxic properties and should therefore be suitable as both therapeutic and diagnostic targets. Two monoclonal antibodies, mAb38F and mAb38E2, with high affinity and strong selectivity for large α-synuclein oligomers were generated. These antibodies, which do not bind amyloid-beta or tau, recognize Lewy body pathology in brains from patients with Parkinson\u0027s disease and dementia with Lewy bodies and detect pathology earlier in α-synuclein transgenic mice than linear epitope antibodies. An oligomer-selective sandwich ELISA, based on mAb38F, was set up to analyze brain extracts of the transgenic mice. The overall levels of α-synuclein oligomers/protofibrils were found to increase with age in these mice, although the levels displayed a large interindividual variation. Upon subcellular fractionation, higher levels of α-synuclein oligomers/protofibrils could be detected in the endoplasmic reticulum around the age when behavioral disturbances develop. In summary, our novel oligomer-selective α-synuclein antibodies recognize relevant pathology and should be important tools to further explore the pathogenic mechanisms in Lewy body disorders. 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In particular, the sterile inflammatory response in stroke has been intensively investigated in the last decade, and numerous experimental studies demonstrated the neuroprotective potential of a targeted modulation of the immune system. Among the investigated immunomodulatory agents, intravenous immunoglobulin (IVIg) stand out due to their beneficial therapeutic potential in experimental stroke as well as several other experimental models of acute brain injuries, which are characterized by a rapidly evolving sterile inflammatory response, e.g., trauma, subarachnoid hemorrhage. IVIg are therapeutic preparations of polyclonal immunoglobulin G, extracted from the plasma of thousands of donors. In clinical practice, IVIg are the treatment of choice for diverse autoimmune diseases and various mechanisms of action have been proposed. Only recently, several experimental studies implicated a therapeutic potential of IVIg even in models of acute CNS injury, and suggested that the immune system as well as neuronal cells can directly be targeted by IVIg. 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In addition, we studied the feasibility of using these tracers following a period of awake tracer uptake, during which the animal may perform a behavioral task. Male Sprague-Dawley rats were imaged with [¹⁸F]fallypride and with [¹⁸F]DMFP in four different studies using microPET. All scans were performed under isoflurane anesthesia. The first (test) and second (retest) study were 150-min baseline scans. No retest scans were performed with [¹⁸F]DMFP. A third study was a 60-min awake uptake of radiotracer followed by a 90-min scan. A fourth study was a 150-min competition scan with haloperidol (0.2 mg/kg) administered via tail vein at 90-min post-[¹⁸F]fallypride injection and 60-min post-[¹⁸F]DMFP. For the test-retest studies, BP(ND) was measured using both Logan noninvasive (LNI) method and the interval ratios (ITR) method. Cerebellum was used as a reference region. For the third study, the binding was measured only with the ITR method, and the results were compared to the baseline results. Studies showed that the average transient equilibrium time in the dorsal striatum (DSTR) was at 90 min for [¹⁸F]fallypride and 30 min for [¹⁸F]DMFP. The average BP(ND) for [¹⁸F]fallypride was 14.4 in DSTR, 6.8 in ventral striatum (VSTR), 1.3 in substantia nigra/ventral tegmental area (SN/VTA), 1.4 in colliculi (COL), and 1.5 in central gray area. In the case of [¹⁸F]DMFP, the average BP(ND) values were 2.2 in DSTR, 2.7 in VSTR, and 0.8 in SN/VTA. The haloperidol blockade showed detectable decrease in binding of both tracers in striatal regions with a faster displacement of [¹⁸F]DMFP. No significant changes in BP(ND) of [¹⁸F]fallypride due to the initial awake state of the animal were found, whereas BP(ND) of [¹⁸F]DMFP was significantly higher in the awake state compared to baseline. We were able to demonstrate that dynamic PET using MicroPET Inveon allows quantification of both striatal and extrastriatal [¹⁸F]fallypride binding in rats in vivo. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Barbagallo, Federica","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Gimmelli, Roberto","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Dolci, Susanna","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Nori, S.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Di Siena, Sara","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Pellegrini, Manuela","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Lenzi, Andrea","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Naro, Fabio","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Isidori, Andrea","name":"","surname":"","rank":9,"pid":[],"affiliation":[]},{"fullname":"Campolo, Federica","name":"","surname":"","rank":10,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"C-kit; cardiac regeneration; stem cells; transgenic mice","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"title":[{"value":"Characterization of c-Kit receptor function in cardiac regeneration by using transgenic mouse models","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-01-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Background. Cardiac stem cells expressing the tyrosine kinase receptor c-kit have been recently used in in vivo and in vitro cardiac regenerative studies. However, it remains to be clarified whether the c-kit receptor itself plays a critical role in the process of cardiac regeneration. In order to clarify this point, we will explore whether c-Kit receptor affects cardiac stem cells proliferation, survival, migration and differentiation after heart injury. Methods and Results. We have generated transgenic mice in which an activatory point mutation (c-KitD814Y mice) has been introduced in the kinase domain of the c-kit gene. Initially, we have analyzed c-kit expression in tissues and organs at different stages of embryonal and post-natal development through immunohystochemical and biochemical analyses. We have found that in two transgenic lines the receptor is highly expressed and activated in heart, testis and cerebellum, compared to wild type mice. In order to follow the fate of the c-Kit transgenic stem cells we crossed c-KitD814Y mice with mice expressing GFP under c-Kit regulative sequences control. By cytofluorimetric and fluorescence microscopy analyses, we observed a 2 fold of increase in the number of c-kit positive cells on heart samples from double transgenic mice at different ages. To verify the c-kit role in cardiac regeneration we performed a necrotic heart damage in vivo and monitored cardiac repair in transgenic mice versus wild-type mice. After 9 days the wounded hearts of transgenic mice presented a larger connectival tissue area compared to wild-type mice. On the contrary, after 45 days a consistent reduction of fibrotic area was observed in transgenic mice. These preliminary results suggest a faster repair of damaged heart area that contain stem cells with an activated c-kit receptor. Further in vitro and in vivo experiments will be performed to assess whether transgenic c-kit cells directly transdifferentiate into cardiomyocytes or whether they act in a paracrine manner. In summary, the generation of transgenic mice carrying a constitutively activated c-kit in cardiac stem cells, will allow to investigate the role of the receptor and to highlight the molecular mechanism underlying heart regeneration.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Italian Journal of Anatomy and Embryology","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb71b98d3c772310cd83260aa9e1180","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.13128/ijae-12012","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Thellamurege, Nandun M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Pratanphorn Chuanprasit","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Kai Xu","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Hajime Hirao","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugs.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The metabolism of amine-containing drugs by cytochrome P450 enzymes (P450s) is prone to form a nitrosoalkane metabolic intermediate (MI), which subsequently coordinates to the heme iron of a P450, to produce a metabolic-intermediate complex (MIC). This type of P450 inhibition, referred to as mechanism-based inactivation (MBI), presents a serious concern in drug discovery processes. We applied density functional theory (DFT) to the reaction between N-methylhydroxylamine (NMH) and the compound I reactive species of P450, in an effort to elucidate the mechanism of the putative final step of the MI formation in the alkylamine metabolism. Our DFT calculations show that H-abstraction from the hydroxyl group of NMH is the most favorable pathway via which the nitrosoalkane intermediate is produced spontaneously. H-abstraction from the N-H bond was slightly less favorable. In contrast, N-oxidation and H-abstraction from the C-H bond of the methyl group had much higher energy barriers. Hence, if the conversion of NMH to nitrosoalkane is catalyzed by a P450, the reaction should proceed preferentially via H-abstraction, either from the O-H bond or from the N-H bond. Our theoretical analysis of the interaction between the MI and pentacoordinate heme moieties provided further insights into the coordination bond in the MIC. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Elisa Venturi","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Toshihiko Ogura","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Miyuki Nishi","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Toshio Moriya","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Kazuhiro Mio","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Pitt, Samantha J.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Rebecca Sitsapesan","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Sho Kakizawa","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Chikara Sato","name":"","surname":"","rank":9,"pid":[],"affiliation":[]},{"fullname":"Hiroshi Takeshima","name":"","surname":"","rank":10,"pid":[],"affiliation":[]},{"fullname":"Kazutaka Okuda","name":"","surname":"","rank":11,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Mitsugumin 23 (MG23) is a 23 kDa transmembrane protein localized to the sarcoplasmic/endoplasmic reticulum and nuclear membranes in a wide variety of cells. Although the characteristics imply the participation in a fundamental function in intracellular membrane systems, the physiological role of MG23 is unknown. Here we report the biochemical and biophysical characterization of MG23. Hydropathicity profile and limited proteolytic analysis proposed three transmembrane segments in the MG23 primary structure. Chemical cross-linking analysis suggested a homo-oligomeric assembly of MG23. Ultrastructural observations detected a large symmetrical particle as the predominant component and a small asymmetric assembly as the second major component in highly purified MG23 preparations. Single-particle three-dimensional reconstruction revealed that MG23 forms a large bowl-shaped complex equipped with a putative central pore, which is considered an assembly of the small asymmetric subunit. After reconstitution into planar phospholipid bilayers, purified MG23 behaved as a voltage-dependent, cation-conducting channel, permeable to both K(+) and Ca(2+). A feature of MG23 gating was that multiple channels always appeared to be gating together in the bilayer. Our observations suggest that the bowl-shaped MG23 can transiently assemble and disassemble. 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Cys34, the only free Cys residue, is the predominant plasma thiol and a relevant sacrificial antioxidant. Both in vivo circulating HSA and pharmaceutical preparations are heterogeneous with respect to the oxidation state of Cys34. In this work, we developed an external pH gradient chromatofocusing procedure that allows the analysis of the oxidation status of HSA in human plasma and biopharmaceutical products based on the different apparent isoelectric points and chemical properties of the redox isoforms. Specifically, reduced-mercury blocked HSA (HSA-SHg(+)), HSA with Cys34 oxidized to sulfenic acid (HSA-SOH) and HSA oxidized to sulfinate anion (HSA-SO2(-)) can be separated with resolutions of 1.4 and 3.1 (first and last pair) and hence quantified and purified. In addition, an N-terminally degraded isoform (HSA3-585) in different redox states can be resolved as well. Confirmation of the identity of the chromatofocusing isolated isoforms was achieved by high resolution whole protein MS. It is proposed that the chromatofocusing procedure can be used to produce more exact and complete descriptions of the redox status of HSA in vivo and in vitro. Finally, the scalability capabilities of the chromatofocusing procedure allow for the preparation of highly pure standards of several redox isoforms of HSA. 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In the studies of coumestrol and zearalanol, the rats were allocated to a control group, a phytoestrogen-treated group (1.5 micromol coumestrol or 3.1 mmol zearalanol twice per week, intramuscular) or, in the coumestrol study, an estrogen-treated group (28.1 nmol, intramuscular). In the isoflavone study, the rats were allocated to a control group, an estrogen treated group or a treatment group that received 131.25 mg of phytoestrogens per week incorporated into the nonpurified rat diet. Bone mineral density was measured globally and at the spine and femur at base line and 6 wk post-oophorectomy. In the coumestrol study, blood and urine samples were collected. Compared with the control group, rats receiving coumestrol and zearalanol had significantly reduced bone loss at all sites measured. The estrogen-treated group had significantly greater bone density than the control and the coumestrol-treated groups in the spine and global measurements. Coumestrol reduced urine calcium excretion and the bone resorption markers pyridinoline and deoxypyridinoline after 1 wk of treatment. Oral isoflavone phytoestrogens had no effect on oophorectomized rats including bone loss at the dose used. 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Further examination of 39 cyanobacteria and algae species revealed that 32 species could produce RAs and 4-oxo-RAs (1.6-1.4 × 10(3) ng/g dry weight), and the dominant cyanobacteria species in Taihu Lake, Microcystis flos-aquae and Microcystis aeruginosa, produced high amounts of RAs and 4-oxo-RAs with concentrations of 1.4 × 10(3) and 3.7 × 10(2) ng/g dry weight, respectively. Most genera of cyanobacteria that could produce RAs and 4-oxo-RAs, such as Microcystis, Anabaena, and Aphanizomenon, often occur dominantly in blooms. Production of RAs and 4-oxo-RAs by cyanobacteria was associated with species, origin location, and growth stage. These results represent a conclusive demonstration of endogenous production of RAs in freshwater cyanobacteria blooms. The observation of teratogenic RAs in cyanobacteria is evolutionarily and ecologically significant because RAs are vertebrate-specific hormones, and cyanobacteria form extensive and highly visible blooms in many aquatic ecosystems.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb734f7f9526ff1cd66522f65a8da56","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22645328","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Joseph Firth","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jack Cotter","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Rebekah Carney","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Yung, Alison R.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The pro-cognitive mechanisms of physical exercise in people with schizophrenia.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-12-02","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Schizophrenia is associated with pervasive cognitive deficits which are unresponsive to antipsychotic medications. 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Imaging studies collectively indicated that exercise can increase brain volume in people with schizophrenia, although the regions which responded to exercise varied across studies. Most biomarker studies assessed the effects of exercise on serum levels of BDNF. Several studies found significant increases from exercise along with positive correlations between BDNF and cognitive enhancements (indicating a mechanistic link), although other studies did not observe this relationship. In conclusion, the cognitive benefits of exercise in schizophrenia may be due to exercise stimulating neurogenesis, perhaps by up-regulating BDNF, although current evidence is insufficient to draw definitive conclusions. Further exploration of the pro-cognitive mechanisms of exercise in schizophrenia would inform the development of optimal interventions for reducing cognitive impairments in this population. 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While the area defined by the cell bodies of the LC was found not to differ between gabrb3(-/-) mice and controls, the pericoerulear dendritic zone of the LC was found to be significantly enlarged in gabrb3(-/-) mice. Relative to controls, gabrb3(-/-) mice were also found to be hypotonic, as was indicated by poor performance on the wire hanging task. Gabrb3(-/-) mice also exhibited a significant increase in stretch-attend posturing, a form of risk assessment behavior associated with anxiety. However, in the plus maze, a commonly used behavioral test for assessing anxiety, no significant difference was observed between gabrb3(-/-) and control mice. Lastly, relative to controls, gabrb3(-/-) mice exhibited significantly less marble burying behavior, a method commonly used to assess obsessive-compulsive behavior. However, the poor marble burying performance of the gabrb3(-/-) mice could be associated with the hypotonic condition exhibited by these mice. 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We report three new CD3gamma-deficient siblings from a consanguineous family with a combined T-B+NK+ immunodeficiency and their variable clinical and cellular phenotypes despite the same homozygous mutation of the CD3G gene (c.80-1G\u003eC). We also re-evaluate a previously reported non-consanguineous family with two CD3gamma-deficient siblings with the same mutation. The median age at diagnosis was 11 years (14 months-20 years). We found all five patients to display autoimmunity: autoimmune thyroiditis (n \u003d 5), autoimmune haemolytic anaemia (n \u003d 2), immune thrombocytopenia (n \u003d 1), autoimmune hepatitis (n \u003d 1), minimal change nephrotic syndrome (n \u003d 1), vitiligo (n \u003d 1) and positive antinuclear antibodies (n \u003d 3) as well as high IgE (n \u003d 2) and atopic eczema (n \u003d 2). While CD3(+) TCRαβ+T cell percentages were low in all patients, only one had lymphopenia and 3 had CD3(+) T cell lymphopenia. Strikingly, we report frequent and multiple autoimmunity in tested heterozygous carriers in both families (n \u003d 6; in 67%), and frequent autoimmunity in family members not available for testing (n \u003d 5, in 80%). The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations. 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It is tempting to criticize a method with which one is unfamiliar for its apparent complexity. Yet, many methods are quite elegant; neural computation uses nature\u0027s own best biological classifier, for example, and genetic algorithms apply rules of natural selection. Computer scientists will likely find no one single best inference engine to solve all classification problems. Rather, the modeler should choose the most appropriate computational tool based on the specific nature of a problem. If the problem can be separated into obvious components, a Markov chain may be useful. If the andrologist would like to encode a well-known clinical algorithm into the computer, the programmer may use an expert system. Once a modeler builds an inference engine, that engine is not truly useful until other andrologists use it to make inferences with their own data. Because a wide variety of computer hardware and software exists, it is a significant endeavor to translate, or \"port,\" software designed and built on one machine to many other different computers. Fortunately, the World Wide Web offers a means by which computational tools may be made directly available to multiple users on many different systems, or \"platforms.\" The World Wide Web refers to a standardization of information traffic on the global computer network, the Internet. The Internet is simply the linkage of many computers worldwide by computer operators who have chosen to allow other users access to their systems. Because many different types of computers exist, until recently only communication in very rudimentary form, such as text, or between select compatible machines, was available. Within the last half-decade, computer scientists and operators began to use standard means of communication between computers. Interpreters of these standard languages, such as Mosaic and Netscape, are now widely available, and they allow the casual user to access the most sophisticated multimedia aspects of computer information on a variety of different systems. Andrologists may thus use the World Wide Web to make inference engines that they have programmed available to other clinicians and researchers. For example, we programmed a World Wide Web interface to the neural networks that we trained in order to solve a number of andrology classification problems. Interested users connect to our address (at this writing http:@godot.urol.uic.edu), and they may fill out electronic forms with their own patient data, press a \"predict\" button, and nearly immediately view the results of our neural networks\u0027 prediction on their own computers. With the explosion in computer hardware technology, mathematics and computer science that once seemed esoteric can now be investigated on computers available to nearly all andrologists. Rapid advances in computer network technology now render a tool developed by one andrologist immediately available to many. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Yang, C. Q.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"He, G. W.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Comparison of nitroprusside and nitroglycerin in inhibition of angiotensin II and other vasoconstrictor-mediated contraction in human coronary bypass conduits.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2014-11-20","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"To compare the effect of nitroprusside (SNP) and nitroglycerin (NTG) on angiotensin II (ANGII), endothelin-1 (ET-1), and alpha1-adrenoceptor (phenylephrine, PE)-mediated contraction in internal mammary artery (IMA).","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb74da690fcef4c796aba158a6f6d69","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9354311","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Real-time qPCR analysis revealed upregulation of the genes related to cholesterol biosynthesis and downregulation of the genes related to cholesterol efflux, suggesting a feedback response to the inhibition. Furthermore, an oxidative metabolite of 7-DHC that was previously identified as a biomarker in vivo was also found in cells exposed to BACs by liquid chromatography-mass spectrometry. 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The expression of both inducible beta-defensins was enhanced in the state of inflammation. Expression of HBD-2 showed a weak correlation with interleukin 8 only in inflamed CD biopsies but not with tumor necrosis factor alpha. 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We prepared such a serum collection from 26 apparently immune Nigerian adults who failed to develop patent parasitemia for at least 20 weeks following a documented increase in antibodies to the circumsporozoite protein (CSP) from Plasmodium falciparum. Volunteers were evaluated five times per week for malaria symptoms and bimonthly for parasites by examining thick blood smears. The incidence rate over 13 months for the cohort was 42% (47 malaria-confirmed volunteers) and the risk of infection was 1.3 infections/year. Responses to CSP did not correlate with protection. Because antibody responses to antigens other than CSP may be associated with protection, the sera from these immune individuals may be useful for identifying and characterizing other potential malaria vaccine candidates.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb75be5429bdd630cd9952011af4407","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9598461","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018238819}
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Systems science techniques can be used to uncover the key dynamic features of hRBC metabolism. Herein, we have studied a full dynamic hRBC metabolic model and developed several approaches to identify metabolic pools of metabolites. In particular, we have used phase planes, temporal decomposition, and statistical analysis to show hRBC metabolism is characterized by the formation of pseudoequilibrium concentration states. Such equilibria identify metabolic \"pools\" or aggregates of concentration variables. We proceed to define physiologically meaningful pools, characterize them within the hRBC, and compare them with those derived from systems engineering techniques. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Viroj Wiwanitkit","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Endothelin-1 and protein kinase C co-expression in the pathogenesis of diabetic retinopathy.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2007-10-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Diabetic retinopathy (DR) is becoming one of the most important complications of diabetes at present. Endothelin-1 (ET-1) and protein kinase C (PKC) are the two important proteins involved in the pathogenesis of DR. A clarification on the interaction between ET-1 and PKC has not yet been made. Here, the author used a new gene ontology technology to predict the molecular function of ET-1 and PKC in an episode of co-expression. With the use of the GoFigure server, the molecular function of ET-1 and PKC is predicted. According to this study, different pathways can be derived from ET-1 and PKC; however, ET-1-PKC produces the same pathway as PKC. This could mean that the interaction between ET-1 and PKC results in increased activity of the PKC pathway but does not generate any new pathway. This finding can be a good explanation for the co-expression between ET-1 and PKC in the pathogenesis of DR.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7637d32bbf817ac013ff413a823c6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17967707","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Third, we present empirical evidence of how scientists conceptualize \"the public\" and link this to attitudes toward the deficit model. We find that perceiving a knowledge deficit in the public is closely tied to scientists\u0027 perceptions of the individuals who comprise the public. Finally, we argue that the knowledge deficit model is perpetuated because it can easily influence public policy for science issues. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Thijs Van Kolfschoten","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Elfi Buhrs","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ivo Verheijen","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The larger mammal fauna from the Lower Paleolithic Schöningen Spear site and its contribution to hominin subsistence.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-12-26","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The locality Schöningen (Germany) is an important source of knowledge about Lower Paleolithic hominin subsistence. 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Evidence of hominin interference presents itself as either marks on skeletal remains related to the use of bones as knapping tools or hammers, or as marks that indicate butchering activities such as skinning, dismembering, defleshing, filleting, and marrow extraction. The humerus of the saber-toothed cat clearly shows that the bone has been used as a knapping tool. The fossil remains of the other larger carnivores do not show any signs of hominin interference or exploitation. This also applies to the limited number of elephant and rhinoceros remains found at the site. The large horse Equus mosbachensis dominates the larger mammal record and played a major role in hominin subsistence. Marks on the horse bones indicate that a large number of carcasses have been butchered. 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The descriptive screening model was used in the study. The survey provided a total of 407 participants, including men (f \u003d 229) and women (f \u003d 178) who use Istanbul Sports Centers in European part of Istanbul. The survey form, prepared for this research, consists of two parts. In the first part, there are closed-ended questions to measure the demographic characteristics of the participants. In the second part, the Brand Loyalty Scale (BLS) developed by Özdemir and Koçak (2012) is employed. Frequency, percentage, arithmetic mean and standard deviation are used in assessing the demographic characteristics. Independent sample t test for binary comparisons and one way ANOVA for independent multiple comparisons are also utilized. In addition, Post-Hoc tests are applied to determine the groups differences involved in the variance analysis. Moreover, Cronbach Alpha reliability coefficient of Brand Loyalty Scale is found to be 0,934. We find that there are statistically significant differences amongst the brand loyalty levels of age groups. In addition, we also see that there are statistically significant differences amongst the brand loyalty levels of income groups of the participants. As a result, brand loyalty of individuals varies according to their age and income levels. 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Male cyp2e1-/- and wild-type (cyp2e1+/+) mice were given a single i.p. injection of 1 ml/kg (\u003d 1.59 g/kg) CCl4 and 24 h later liver injury was assessed by elevations of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and histopathology. No significant increases in serum ALT and AST activities were observed in cyp2e1-/- mice when compared to wild-type counterparts after CCl4 exposure. No detectable abnormality in liver histology was found in cyp2e1-/- mice after CCl4 exposure. In contrast, CCl4 treatment resulted in 442- and 125-fold increases in serum ALT and AST activities, respectively, in wild-type mice. Consistent with the results of serum ALT and AST activities, severe hepatic damage was noted in livers of wild-type mice, indicating the importance of CYP2E1 in mediating the hepatic damage following CCl4 exposure in these mice. In addition, a dramatic decrease in CYP2E1-catalyzed p-nitrophenol activity and complete loss of immunoreactive CYP2E1 were observed in wild-type mice after CCl4 treatment, suggesting that CYP2E1 was degraded during the process of CCl4-induced hepatotoxicity. These studies conclusively demonstrate that CYP2E1 is the major factor involved in the CCl4-induced hepatotoxicity in mice.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7b95f9cf65e409bcdcf78f555d763","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9875305","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018234443}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Edwards, Patrick J. 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Pro* represents the following prolines: l-proline (Pro), l-trans-4-hydroxyproline (Hyp), l-cis-4-hydroxyproline (hyp), l-cis-4-methoxyproline (hyp[OMe]), l-trans-3-hydroxyproline (3-Hyp), l-cis-3-hydroxyproline (3-hyp), l-2,3-trans-3,4-cis-3,4-dihydroxyproline (DHP), and l-2,3-cis-3,4-trans-3,4-dihydroxyproline (dhp). The conformation of the pyrrolidine ring in each case is discussed in light of previous structural studies, analysis of potential stereoelectronic effects, and NMR data. Hydroxy substituents at C-4 have a greater impact on cis --\u003e trans isomerization than analogous substituents at C-3 as a result of the intervening bond distances and bridging groups. The position of the equilibrium and its dependence on temperature are a reflection of both enthalpic and entropic factors, the latter being complicated in this study by an Ar-Pro interaction in the cis conformation. 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However, PLANT DEFENSIN1.2 expression was unaltered, indicating a repressor role for LBD20 in a branch of the JA-signaling pathway. Plants overexpressing LBD20 (LBD20-OX) had reduced Thi2.1 and VSP2 expression. There was a significant correlation between increased LBD20 expression in the LBD20-OX lines with both Thi2.1 and VSP2 repression, and reduced survival following F. oxysporum infection. Chlorosis resulting from application of F. oxysporum culture filtrate was also reduced in lbd20 leaves relative to the wild type. Taken together, LBD20 is a F. oxysporum susceptibility gene that appears to regulate components of JA signaling downstream of COI1 and MYC2 that are required for full elicitation of F. oxysporum- and JA-dependent responses. 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Contact with these molecules via dermal exposure represent a significant concern for chemical manufacturers. Recent legislation in the EU has created the need to develop non-animal alternative methods for many routine safety studies including sensitization. Although most of the alternative research has focused on pure chemicals that possess reasonable solubility properties, it is important for any successful in vitro method to have the ability to test compounds with low aqueous solubility. This is especially true for the medical device industry where device extracts must be prepared in both polar and non-polar vehicles in order to evaluate chemical sensitization. The aim of this research was to demonstrate the functionality and applicability of the human reconstituted skin models (MatTek Epiderm(®) and SkinEthic RHE) as a test system for the evaluation of chemical sensitization and its potential use for medical device testing. In addition, the development of the human 3D skin model should allow the in vitro sensitization assay to be used for finished product testing in the personal care, cosmetics, and pharmaceutical industries. This approach combines solubility, chemical reactivity, cytotoxicity, and activation of the Nrf2/ARE expression pathway to identify and categorize chemical sensitizers. Known chemical sensitizers representing extreme/strong-, moderate-, weak-, and non-sensitizing potency categories were first evaluated in the skin models at six exposure concentrations ranging from 0.1 to 2500 µM for 24 h. The expression of eight Nrf2/ARE, one AhR/XRE and two Nrf1/MRE controlled gene were measured by qRT-PCR. The fold-induction at each exposure concentration was combined with reactivity and cytotoxicity data to determine the sensitization potential. The results demonstrated that both the MatTek and SkinEthic models performed in a manner consistent with data previously reported with the human keratinocyte (HaCaT) cell line. The system was tested further by evaluating chemicals known to be associated with the manufacture of medical devices. In all cases, the human skin models performed as well or better than the HaCaT cell model previously evaluated. In addition, this study identifies a clear unifying trigger that controls both the Nrf2/ARE pathway and essential biochemical events required for the development of ACD. 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However, currently available PEMS can only be used a single time or must be completely stripped and refunctionalized prior to subsequent uses. Here we report the successful use of an alternative regeneration protocol employing high salt concentrations to remove the target, leaving the functional probe immobilized on the microcantilever surface. Our model system employed the extracellular domain (ECD) of recombinant human Epidermal Growth Factor Receptor (EGFR) as the probe and anti-human EGFR polyclonal antibodies as the target. We report that high concentrations of MgCl2 dissociated polyclonal antibodies specifically bound to EGFR ECD immobilized on the sensor surface without affecting its bioactivity. This simple regeneration protocol both minimized the time required to re-conjugate the probe and preserved the density of probe immobilized on PEMS surface, yielding identical biosensor sensitivity over a series of assays.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7c447fbeb5919d0db4f46c83d2f15","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22413149","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Berkman, L.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Datta, G. D.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Lang, T.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Delpierre, C.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Lauwers-Cances, V.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Using self-rated health for analysing social inequalities in health: a risk for underestimating the gap between socioeconomic groups?","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2009-05-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The use of self-rated health (SRH) for measuring health inequalities could present some limits. The impact of the same disease on SRH could be different according to health expectations people have which are associated with social characteristics. The aim of this study was to analyse the link between physical health status and SRH, according to level of education.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7c729404ef2db0bb7c142a569d9f7","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19218251","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Moyer, Bruce A.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Bonnesen, Peter V.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Levitskaia, Tatiana G.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Kevin Chambliss, C.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Synergistic pseudo-hydroxide extraction: synergism and anion selectivity in sodium extraction using a crown ether and a series of weak lipophilic acids.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2003-11-04","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The nature of the weak lipophilic acid used in synergistic combination with a model crown ether cation host was shown to have a strong effect on the strength and selectivity of sodium hydroxide separation from alkaline aqueous salt solutions. Sodium ion-pair extraction employing only cis-syn-cis-dicyclohexano-18-crown-6 (1) in nitrobenzene (NB) was correlated with the standard Gibbs energy (deltaG(p)o) of anion partitioning into NB and was notably weak and nonselective for the hydroxide ion, in accord with Hofmeister bias. The Hofmeister order can be selectively overcome for NaOH by utilization of acid-base chemistry coupled with complexation of sodium ion in the NB phase. Upon addition of a lipophilic organic acid into the solution of 1 in NB, sodium extraction was selectively enhanced due to the initiation of an exchange reaction between the aqueous sodium ion and the ionizable proton of the organic acid. A series of weak lipophilic hydroxy acids (HA) including fluorinated alcohols and phenols was tested. The resulting synergistic pseudo-hydroxide extraction correlates with the pKa of the employed HA; the most acidic cation exchangers provide the greatest synergism. The synergistic factor obtained using a fluorinated benzyl alcohol 7 was as high as 256. Ion-pair extraction of neutral sodium salts was not changed or only mildly enhanced by addition of HA into the NB solution of 1. This enhancement was explained by hydrogen bonding of HA with the anion as related to the hardness of the anion and the acidity of HA. In comparison with the synergism observed for NaOH, this enhancement was weak and unable to overcome the Hofmeister effect. Examination of extraction selectivity revealed that the combination of 1 and 7 preferentially extracted NaOH over all other sodium salts, including the normally preferred nitrate and perchlorate salts. Quantitative recovery of NaOH from the NB phase was demonstrated via hydrolysis of the organic acid upon a single contact of the loaded solvent with water.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7c731d77794f3ff6747d33b9804ef","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"12585464","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Michelle Kloc","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Arianna Maffei","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Target-specific properties of thalamocortical synapses onto layer 4 of mouse primary visual cortex.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2014-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"In primary sensory cortices, thalamocortical (TC) inputs can directly activate excitatory and inhibitory neurons. In vivo experiments in the main input layer (L4) of primary visual cortex (V1) have shown that excitatory and inhibitory neurons have different tuning properties. The different functional properties may arise from distinct intrinsic properties of L4 neurons, but could also depend on cell type-specific properties of the synaptic inputs from the lateral geniculate nucleus of the thalamus (LGN) onto L4 neurons. While anatomical studies identified LGN inputs onto both excitatory and inhibitory neurons in V1, their synaptic properties have not been investigated. Here we used an optogenetic approach to selectively activate LGN terminal fields in acute coronal slices containing V1, and recorded monosynaptic currents from excitatory and inhibitory neurons in L4. LGN afferents made monosynaptic connections with pyramidal (Pyr) and fast-spiking (FS) neurons. TC EPSCs on FS neurons were larger and showed steeper short-term depression in response to repetitive stimulation than those on Pyr neurons. LGN inputs onto Pyr and FS neurons also differed in postsynaptic receptor composition and organization of presynaptic release sites. Together, our results demonstrate that LGN input onto L4 neurons in mouse V1 have target-specific presynaptic and postsynaptic properties. Distinct mechanisms of activation of feedforward excitatory and inhibitory neurons in the main input layer of V1 are likely to endow neurons with different response properties to incoming visual stimuli. 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Interestingly, this group includes a number of housekeeping and repair proteins such as DNA polymerase III, nudix hydrolase and rotamase. Here, we focus on a member of the nudix hydrolase family from D. radiodurans possessing low-complexity N- and C-terminal tails, which exhibit sequence signatures of intrinsic disorder and have unknown function. The enzyme catalyzes the hydrolysis of oxidatively damaged and mutagenic nucleotides, and it is thought to play an important role in D. radiodurans during the recovery phase after exposure to ionizing radiation or desiccation. We use molecular dynamics simulations to study the dynamics of the protein, and study its hydration free energy using the GB/SA formalism. We show that the presence of disordered tails significantly decreases the hydration free energy of the whole protein. We hypothesize that the tails increase the chances of the protein to be located in the remaining water patches in the desiccated cell, where it is protected from the desiccation effects and can function normally. We extrapolate this to other intrinsically disordered regions in proteins, and propose a novel function for them: intrinsically disordered regions increase the \"surface-properties\" of the folded domains they are attached to, making them on the whole more hydrophilic and potentially influencing, in this way, their localization and cellular activity.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb7cca4d987143487d269532be4068a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"20657662","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Therefore, an HPLC-ESI-MS method for simultaneous determination of both drugs, and their metabolites was developed for purpose of pharmacokinetic study. To determine as many metabolites as possible, the influence of parameters such as column, flow rate and pH value of mobile phase, ionization polarity and fragmentation voltage were optimized. Fourteen target analytes were well separated and all of them could be identified and determined in plasma after administration of promethazine and caffeine. The LODs and LOQs were 0.9-6.0 and 2.50-16.0 ng/ml, respectively; the recoveries of three levels of quality control samples were from 86.7% to 102%; the intra-day and inter-day precisions were less than 3% and 9%, separately; and the RSDs of compound stability were all lower than 10% within 24h after sample preparation. As a pharmacokinetic study of the combination therapy in 30 healthy volunteers, concentration-time curves of the drugs and metabolites were studied. 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A group of 2,154 students from 20 different institutions of public high school education answered a survey designed as an evaluation tool for a career path or technology area of interest. The survey results show that students have a low preference for engineering careers. Moreover, these results were augmented with an additional study on the high attrition of students in engineering schools in the city of Mexicali, Baja California, also conducted by the authors. 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We present this case to report the occurrence of postoperative cervical hematoma complicated by ipsilateral carotid thrombosis and aphasia after an uncomplicated C4-6 ACDF. This is a case of a 65-year-old woman who underwent revision fusions of the C4-5 and C6-7 levels complicated by postoperative cervical hematoma and carotid thrombosis. The patient\u0027s history, clinical examination, imaging findings, and treatment are reported. The revision fusions were performed and deemed routine. Approximately eight hours later 200 mL of blood was evacuated from a postoperative cervical hematoma. The patient became unresponsive and disoriented a few hours after evacuating the hematoma. Computed tomography and magnetic resonance imaging of the brain were normal, but magnetic resonance angiography demonstrated total occlusion of the left carotid artery. Thrombectomy was performed and the patient was discharged without residual deficits. 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The sequence of events following the binding of the AhR/AhR nuclear translocator protein (ARNT) heterodimer to dioxin response elements has yet to be completely understood. The role of coactivator, RIP140, in the modulation of transcriptional activity of AhR/ARNT heterodimer was examined. RIP140 enhanced TCDD-mediated, dioxin response element-driven reporter gene activity in three cell lines. Co-immunoprecipitation and co-localization assays revealed that RIP140 interacted with AhR, but not with ARNT, both in vitro and in cells. Mapping of the interaction sites revealed that RIP140 was recruited by the AhR transactivation domain via the Q-rich subdomain. The RIP140 domain that interacts with the AhR was mapped to a location between amino acid residues 154 and 350, which is distinct from those involved in estrogen receptor binding. The signature motif, LXXLL, which is responsible for binding of several coactivators to nuclear receptors, is not required for RIP140 binding to AhR. 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Initial studies have shown that BRAF mutations occur at a high frequency in melanocytic nevi and metastatic lesions, but recent data have revealed much lower incidence of these mutations in early-stage melanoma, implying that other factors may contribute to melanoma pathogenesis in a wild-type (WT) BRAF context. To identify such contributing factors, we used microarray gene expression profiling to screen for differences in gene expression between a panel of melanocytic and melanoma cell lines with WT BRAF and a group of melanoma cell lines with the V599E BRAF mutation. We found that SPRY2, an inhibitor homologous to SPRY4, which was previously shown to suppress Ras/ERK signaling via direct binding to Raf-1, had reduced expression in WT BRAF cells. Using small interfering RNA-mediated SPRY2 knockdown, we showed that SPRY2 acts as an inhibitor of ERK signaling in melanocytes and WT BRAF melanoma cells, but not in cell lines with the V599E mutation. We also show that SPRY2 and SPRY4 directly bind WT BRAF but not the V599E and other exon 15 BRAF mutants. 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Previous studies have shown that sirt6 exerts potent anti-senescent and anti-apoptotic effects in models of age-related degenerative disease. However, it is not known whether sirt6 protects against IDD. Here, we explored whether sirt6 influenced IDD. The sirt6 level was reduced in senescent human NP cells. Sirt6 overexpression protected against apoptosis and both replicative and stress-induced premature senescence. Sirt6 also activated NP cell autophagy both in vivo and in vitro. 3-methyladenine (3-MA) and chloroquine (CQ)-mediated inhibition of autophagy partially reversed the anti-senescent and anti-apoptotic effects of sirt6, which regulated the expression of degeneration-associated proteins. In vivo, sirt6 overexpression attenuated IDD. Together, the data showed that sirt6 attenuated cell senescence, and reduced apoptosis, by triggering autophagy that ultimately ameliorated IDD. 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This study examines HRQoL of breast cancer (BC) survivors compared with female survivors of other cancers, and to understand which subgroups of BC survivors were particularly at risk of reduced HRQoL. We placed emphasis on young (\u003c50 years) and recently diagnosed (≤5 years) survivors, where the deficits in HRQoL were most pronounced. The cross-sectional study consisted of 2,224 BC survivors, 8,504 non-cancer controls and 2,205 other cancer survivors in the Karma study. We examined HRQoL differences using linear regression analyses in the whole cohort and in a subset of young and recently diagnosed BC survivors (n \u003d 242) and female survivors of other cancers (n \u003d 140) with comparable ages at diagnosis (43.6 vs 43.6, p \u003d 0.917) and time since diagnosis (2.3 vs 2.8 years, p \u003c 0.001). HRQoL was assessed using the EORTC QLQ-C30 questionnaire. While only cognitive functioning was significantly compromised in BC survivors compared with survivors of other cancers when women of all ages were included, young BC survivors reported significantly lower HRQoL on multiple functional scales (global quality of life, emotional, role, social and cognitive functioning) and experienced more fatigue and insomnia. BC survivors with any prior medical history of mental disorders reported poorer HRQoL than those without such a history. We also observed a close-knit relationship between tumor and treatment characteristics. BC survivors perform poorly in HRQoL in comparison with female survivors of other cancers. 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They are present in all living cells, and their levels are generally increased in tumor cells. Progesterone receptor is a gene-regulatory protein that plays a major role in gestation and in hormonal responsiveness of breast cancer. We studied the effects of putrescine, spermidine, 2 lower homologues of spermidine, N1- and N8-acetyl spermidines, spermine, and N1-acetyl spermine on the sedimentation profile and DNA binding of progesterone receptor from rabbit uterus. Progesterone receptor, prepared in hypotonic buffer, sedimented at the 7S region of sucrose gradients. In the presence of 1 mM putrescine, a part of the receptor was converted to a 5S form. In the presence of 1 mM spermidine or 0.25 mM spermine, the receptor was completely transformed to the 5S form. The DNA binding of the 7S form of progesterone receptor was 7 +/- 3%. After incubating this receptor with 1 mM putrescine, 1 mM spermidine, or 0.25 mM spermine, its DNA binding increased to 16 +/- 4, 37 +/- 3, and 44 +/- 5%, respectively. The structural specificity of polyamines in facilitating the DNA binding of progesterone receptor was examined by using two spermidine homologues. The first homologue with one methylene group less than that of spermidine was as effective as spermidine in transforming progesterone receptor. Removal of two methylene groups, however, had a dramatic effect in reducing the efficacy of the resulting molecule to the level of putrescine. Taken together, our results show that natural polyamines are capable of modulating the binding of progesterone receptor to DNA. Since progesterone receptor is associated with the hormonal responsiveness of human breast cancer, polyamine levels in tumor cells might play an important role in the gene-regulatory function of progesterone receptor.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb80a57e03a00af2410549bb832b9dc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"3342402","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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We discuss the protein kinase signal cascades stimulated by Galphaq and Galphas coupled GPCRs and describe how control of NMDAR activity shifts the threshold for the induction of LTP.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb80c753abbeacc772437047d2124d0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17261268","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018260921}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"María Moreno-Morcillo","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Taylor, Nicholas M. I.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Carlos Fernández-Tornero","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Rashid, Umar J.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Pierre Legrand","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Müller, Christoph W.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Tim Gruene","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Ruiz, Federico M.","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Ulrich Steuerwald","name":"","surname":"","rank":9,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Solving the RNA polymerase I structural puzzle.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Knowing the structure of multi-subunit complexes is critical to understand basic cellular functions. However, when crystals of these complexes can be obtained they rarely diffract beyond 3 Å resolution, which complicates X-ray structure determination and refinement. The crystal structure of RNA polymerase I, an essential cellular machine that synthesizes the precursor of ribosomal RNA in the nucleolus of eukaryotic cells, has recently been solved. Here, the crucial steps that were undertaken to build the atomic model of this multi-subunit enzyme are reported, emphasizing how simple crystallographic experiments can be used to extract relevant biological information. In particular, this report discusses the combination of poor molecular replacement and experimental phases, the application of multi-crystal averaging and the use of anomalous scatterers as sequence markers to guide tracing and to locate the active site. The methods outlined here will likely serve as a reference for future structural determination of large complexes at low resolution.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb80eacfc572ed12192d8717c73f463","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"25286842","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The synthesized adsorbent was characterized by FT-IR, XRD, XPS, SEM and AFM measurements. The effects of variables such as pH solution, initial ion concentrations, adsorbent dosage and sonicating time were investigated on adsorption efficiency by rotatable central composite design. The optimum conditions, specified as 8mg of adsorbent, 20mgL(-1) of each ion at pH 5 and short time of 4min led to the achievement of a high adsorption capacities. Ultrasonic power had important role in shortening the adsorption time of ions by enhancing the dispersion of adsorbent in solution. The adsorption kinetic studies and equilibrium isotherms for evaluating the mechanism of adsorption process showed a good fit to the pseudo-second order and Langmuir model, respectively. The maximum adsorption capacities (Qm) of this adsorbent were 369.749, 257.201, 180.893 and 358.824mgg(-1) for lead, cadmium, nickel and copper ions, respectively. The removal performance of adsorbent on the real wastewater samples also showed the feasibility of adsorbent for applying in industrial purposes.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb80fc7a287101612f8f03f3996a7c8","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"27150770","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The aim of this study was to noninvasively visualize acute liver damage using positron emission tomography (PET) with N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[(18)F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]acetamide ([(18)F]FEDAC), a radiotracer specific for translocator protein (18 kDa, TSPO) as a biomarker for inflammation, and to determine cellular sources enriching TSPO expression in the liver. A mild acute liver damage model was prepared by a single intraperitoneal injection of cycloheximide (CHX) into rats. Treatment with CHX induced apoptosis and necrotic changes in hepatocytes with slight neutrophil infiltration. The uptake of radioactivity in the rat livers was measured with PET after injection of [(18)F]FEDAC. The uptake of [(18)F]FEDAC increased in livers damaged from treatment with CHX compared to the controls. Presence of TSPO was examined in the liver tissue using quantitative reverse transcriptase-polymerase chain reaction and immunohistochemical assays. mRNA expression of TSPO was elevated in the damaged livers compared to the controls, and the level was correlated with the [(18)F]FEDAC uptake and severity of damage. TSPO expression in the damaged liver sections was mainly found in macrophages (Kupffer cells) and neutrophils, but not in hepatocytes. The elevation of TSPO mRNA expression was derived from the increase of the number of macrophages with TSPO and neutrophils with TSPO in damaged livers. From this study we considered that PET imaging with [(18)F]FEDAC represented the mild liver damage through the enhanced TSPO signal in inflammatory cells. We conclude that this method may be a useful tool for diagnosis in early stage of acute liver damage. 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All tumors produce and secret various amines and peptides, which can be used as tissue and circulating markers. Chromogranin A (CgA) is a general tumor marker stored in secretory granules within the tumor cell and released upon stimulation. CgA is the best general tumor marker at the moment, expressed in 80-90% in all patients with GEP-NETs. CgA and NSE are used as tissue markers for the delineation of the neuroendocrine features of the tumors, but recently also the proliferation marker Ki-67 has been included in the standard procedure for evaluation of the proliferation. GEP-NETs are classified into well differentiated neuroendocrine tumors (Ki-67\u003c2%), well-differentiated neuroendocrine carcinoma (Ki-67 2-20%), poorly differentiated neuroendocrine carcinoma (Ki-67\u003e20%). The molecular imaging of NETs is based on the ability of these tumor cells to express somatostatin receptors as well as the APUD features. Octreoscan has been applied for imaging and staging of the disease for more than 2 decades and will nowadays be replaced by 68Ga-DOTA-Octreotate, with higher specificity and sensitivity. 18Fluoro-DOPA and 11C-5HTP are specific tracers for NETs with high specificity and selectivity. A new potential biomarker is auto-antibodies to paraneoplastic antigen MA2, which might indicate early recurrence of carcinoids after surgery with a curative intent. Circulating tumor cells (CTC) have been applied in GEP-NETs quite recently. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Shin, C.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Fahs, M.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Markowitz, S. B.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Leigh, J. P.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Landrigan, P. J.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Occupational injury and illness in the United States. Estimates of costs, morbidity, and mortality.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2012-10-23","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"To estimate the annual incidence, the mortality and the direct and indirect costs associated with occupational injuries and illnesses in the United States in 1992.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8167b3172dc01db05b8abdf7e1936","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9236557","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Corridors intended to facilitate the movement of multiple species could increase persistence of entire communities, but at the likely cost of being less efficient for any given species than a corridor intended specifically for that species. There have been few tests of the trade-offs between single- and multispecies corridor approaches. We assessed single-species and multispecies habitat corridors for 5 threatened mammal species in tropical forests of Borneo. We generated maps of the cost of movement across the landscape for each species based on the species\u0027 local abundance as estimated through hierarchical modeling of camera-trap data with biophysical and anthropogenic covariates. Elevation influenced local abundance of banded civets (Hemigalus derbyanus) and sun bears (Helarctos malayanus). Increased road density was associated with lower local abundance of Sunda clouded leopards (Neofelis diardi) and higher local abundance of sambar deer (Rusa unicolor). Pig-tailed macaque (Macaca nemestrina) local abundance was lower in recently logged areas. An all-species-combined connectivity scenario with least-cost paths and 1 km buffers generated total movement costs that were 27% and 23% higher for banded civets and clouded leopards, respectively, than the connectivity scenarios for those species individually. A carnivore multispecies connectivity scenario, however, increased movement cost by 2% for banded civets and clouded leopards. Likewise, an herbivore multispecies scenario provided more effective connectivity than the all-species-combined scenario for sambar and macaques. 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Both individual enzymes and transcriptional networks are controlled to meet changing needs of the many sterol pathway products. Regulation is tailored by evolution to match regulatory constraints, which can be very different in distinct species. Nevertheless, a broadly conserved feature of many aspects of sterol regulation is employment of proteostasis mechanisms to bring about control of individual proteins. Proteostasis is the set of processes that maintain homeostasis of a dynamic proteome. Proteostasis includes protein quality control pathways for the detection, and then the correction or destruction, of the many misfolded proteins that arise as an unavoidable feature of protein-based life. Protein quality control displays not only the remarkable breadth needed to manage the wide variety of client molecules, but also extreme specificity toward the misfolded variants of a given protein. These features are amenable to evolutionary usurpation as a means to regulate proteins, and this approach has been used in sterol regulation. We describe both well-trod and less familiar versions of the interface between proteostasis and sterol regulation and suggest some underlying ideas with broad biological and clinical applicability.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb81a2cf10a71d74147988e66c2befa","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28992438","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Thanh Doan","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Sharon Weiss","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bernstein, Kenneth E.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Nathan Dascal","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-11-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"L-type dihydropyridine-sensitive voltage dependent Ca(2+) channels (L-VDCCs; alpha(1C)) are crucial in cardiovascular physiology. Currents via L-VDCCs are enhanced by hormones and transmitters operating via G(q), such as angiotensin II (AngII) and acetylcholine (ACh). It has been proposed that these modulations are mediated by protein kinase C (PKC). However, reports on effects of PKC activators on L-type channels are contradictory; inhibitory and/or enhancing effects have been observed. Attempts to reproduce the enhancing effect of AngII in heterologous expression systems failed. We previously found that PKC modulation of the channel depends on alpha(1C) isoform used; only a long N-terminal (NT) isoform was up-regulated. Here we report the reconstitution of the AngII- and ACh-induced enhancement of the long-NT isoform of L-VDCC expressed in Xenopus oocytes. The current initially increased over several minutes but later declined to below baseline levels. Using different NT deletion mutants and human short- and long-NT isoforms of the channel, we found the initial segment of the NT to be crucial for the enhancing, but not for the inhibitory, effect. Using blockers of PKC and of phospholipase C (PLC) and a mutated AngII receptor lacking G(q) coupling, we demonstrate that the signaling pathway of the enhancing effect includes the activation of G(q), PLC, and PKC. The inhibitory modulation, present in both alpha(1C) isoforms, was G(q)- and PLC-independent and Ca(2+)-dependent, but not Ca(2+)-mediated, as only basal levels of Ca(2+) were essential. Reconstitution of AngII and ACh effects in Xenopus oocytes will advance the study of molecular mechanisms of these physiologically important modulations.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb81c8c6871a5448574d3d50006adbe","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"14722109","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Rongfei Wang","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Shengyuan Yu","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ran Ao","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Mo Yang","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Xuehui Shi","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Shihui Wei","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Altered Retinal Nerve Fiber Layer Thickness and Choroid Thickness in Patients with Migraine.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Migraine is a chronic neurological disorder. However, its pathogenesis is still unclear. This study aimed to measure the posterior ocular structure in patients with migraine using enhanced depth imaging (EDI)-optical coherence tomography (OCT) and explore the probable pathogenesis of migraine.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8204c7a732daa8dc0fefdd0590615","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"30423582","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"George, Steven Z.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Werneke, Mark W.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Mioduski, Jerome E.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Daniel Deutscher","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Hart, Dennis L.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Stratford, Paul W.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Using intake and change in multiple psychosocial measures to predict functional status outcomes in people with lumbar spine syndromes: a preliminary analysis.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-11-19","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Managing patients with lumbar spine syndromes who are seeking outpatient physical therapy represents a complex problem where psychosocial constructs such as fear-avoidance beliefs regarding physical activities or work activities, somatization, and depressive symptoms may affect functional status (FS) outcomes.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb828c05a966388b6549718638a2ef0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22003164","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Aurelie Coudert","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Francis Turjman","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Eric Truy","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Hung Thai-Van","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Pierre Reynard","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Aicha Ltaief-Boudrigua","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Ionescu, Eugen C.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Stenting the Superior Petrosal Sinus in a Patient With Symptomatic Superior Semicircular Canal Dehiscence.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Patients presenting superior semicircular canal dehiscence (SSCD) can experience symptoms such as conductive hearing loss, pulsatile tinnitus, autophony, and pressure-induced vertigo. Decreased cervical vestibular-evoked myogenic potentials (cVEMPs) thresholds and high-resolution computed tomography (HRCT) of the petrous bone are essential for diagnosis of SSCD syndrome. We report the case of a 43-year-old man suffering from constant right pulsatile tinnitus, intermittent autophony, and unsteadiness induced by physical exercise. An SSCD by the superior petrosal sinus (SPS) was confirmed on the right side by axial HRCT of the temporal bone reformatted in the plane of Pöschl and ipsilateral abnormally low elicited cVEMPs. Treatment options were discussed with the patient since the pulsatile tinnitus progressively became debilitating. Two options were considered: surgery or a new endovascular treatment; the patient chose the latter option. After stenting the right SPS, the intensity of the pulsatile tinnitus dramatically decreased. As there was no complication the patient was discharged at Day 1. The other symptoms improved progressively. By the 60-day follow-up visit the patient only reported a slight tinnitus worsened by physical exercise. Angiographic follow-up at 5 months confirmed the patency of the SPS. Stenting the SPS in patients with SSCD by the SPS appears to be an alternative to the existing surgical treatments.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8295e174696d528244d995cc473a3","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"30177909","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Yoshiaki Furukawa","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Meyer, Jeffrey H.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Oleh Hornykiewicz","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Kish, Stephen J.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Isabelle Boileau","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Mark Guttman","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Lee-Cyn Ang","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Junchao Tong","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Gausiha Rathitharan","name":"","surname":"","rank":9,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Brain monoamine oxidase B and A in human parkinsonian dopamine deficiency disorders.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-10-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"See Jellinger (doi:10.1093/awx190) for a scientific commentary on this article. The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson\u0027s disease. Inhibitors of MAOB are used clinically in Parkinson\u0027s disease for symptomatic purposes whereas the potential disease-modifying effect of monoamine oxidase inhibitors is debated. As astroglial cells express high levels of MAOB, the enzyme has been proposed as a brain imaging marker of astrogliosis, a cellular process possibly involved in Parkinson\u0027s disease pathogenesis as elevation of MAOB in astrocytes might be harmful. Since brain monoamine oxidase status in Parkinson\u0027s disease is uncertain, our objective was to measure, by quantitative immunoblotting in autopsied brain homogenates, protein levels of both monoamine oxidases in three different degenerative parkinsonian disorders: Parkinson\u0027s disease (n \u003d 11), multiple system atrophy (n \u003d 11), and progressive supranuclear palsy (n \u003d 16) and in matched controls (n \u003d 16). We hypothesized that if MAOB is \u0027substantially\u0027 localized to astroglial cells, MAOB levels should be generally associated with standard astroglial protein measures (e.g. glial fibrillary acidic protein). MAOB levels were increased in degenerating putamen (+83%) and substantia nigra (+10%, non-significant) in multiple system atrophy; in caudate (+26%), putamen (+27%), frontal cortex (+31%) and substantia nigra (+23%) of progressive supranuclear palsy; and in frontal cortex (+33%), but not in substantia nigra of Parkinson\u0027s disease, a region we previously reported no increase in astrocyte protein markers. Although the magnitude of MAOB increase was less than those of standard astrocytic markers, significant positive correlations were observed amongst the astrocyte proteins and MAOB. Despite suggestions that MAOA (versus MAOB) is primarily responsible for metabolism of dopamine in dopamine neurons, there was no loss of the enzyme in the parkinsonian substantia nigra; instead, increased nigral levels of a MAOA fragment and \u0027turnover\u0027 of the enzyme were observed in the conditions. Our findings provide support that MAOB might serve as a biochemical imaging marker, albeit not entirely specific, for astrocyte activation in human brain. The observation that MAOB protein concentration is generally increased in degenerating brain areas in multiple system atrophy (especially putamen) and in progressive supranuclear palsy, but not in the nigra in Parkinson\u0027s disease, also distinguishes astrocyte behaviour in Parkinson\u0027s disease from that in the two \u0027Parkinson-plus\u0027 conditions. The question remains whether suppression of either MAOB in astrocytes or MAOA in dopamine neurons might influence progression of the parkinsonian disorders.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb82b4d042ac01961480820a006f621","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29050386","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This study represents an initial attempt to analyze the humoral immune reactions of patients with malignant melanoma by hybridoma methodology. Using lymphocytes from regional lymph nodes, peripheral blood and tumor infiltrates, 158 fusions were performed with SKO-007 (human myeloma line), LICR-LON-HMy2 (LICR-2), GM 4672 (human lymphoblastoid lines), or NS-1 (mouse myeloma line). Fusion of lymph node lymphocytes with NS-1 resulted in a 3-4 times higher frequency of clones than fusion with LICR-2, and a 10 times higher frequency than fusion with SKO-007 or GM 4672. In the case of peripheral blood lymphocytes, fusion with NS-1 gave greater than 25 times higher frequency of clones than fusion with LICR-2 or SKO-007. Production of human mu, gamma, or alpha heavy chains was detected in 50-80% of wells containing growing clones, and the levels of immunoglobulin ranged from 0.3 micrograms to 40 micrograms/ml. NS-1-derived clones could be easily subcultured, while LICR-2 and SKO-007 clones grew more slowly on subculturing. In this study, Ig secretion appeared to be a more stable property of LICR-2-derived clones than NS-1-derived clones. A panel of 20 human cancer cell lines was used to screen 771 Ig-secreting cultures for antibody to cell surface or intracellular antigens. Reactivity with cell surface antigens was found infrequently (6 cultures), whereas reactivity with intracellular antigens was more common (27 cultures). A new cell surface antigen with properties of a glycolipid was defined with an IgM monoclonal antibody secreted by a tetraploid cell derived from a fusion of LICR-2 with lymphocytes from the axillary lymph node of a patient with melanoma. The hybrid cell line has been subcloned four times and secretes 5 micrograms IgM/ml. The antigen detected by this IgM antibody was found on 5 of 23 melanoma cell lines and 12 of 30 epithelial cancer cell lines. No reactions were found with 11 cultures derived from normal cells. Stable cell lines secreting human antibody that detected nuclei, nucleoli, cytoskeletal elements, Golgi complex, or other cytoplasmic components were also isolated in this study. One of these antibodies detected an intracellular antigen that is restricted to cells of neuroectodermal derivation, and a second antibody reacted primarily with cells of epithelial origin. Using these methods to isolate and analyze human monoclonal antibody, it should now be possible to define the repertoire of the humoral immune response to melanoma.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb82ee80d32278acf43dde6d2dd100f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"6864164","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The agents were the prostaglandin E(1) analogue misoprostol (30 mug/kg, s.c., b.i.d.), the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 100 mug/ml in drinking water) and the leumedin, N-(fluorenyl-9-methoxycarbonyl)-L-leucine (NPC 15199, 10 mg/kg, s.c.). Ileitis was induced by a transmural injection of trinitrobenzene sulphonic acid (TNBS 30 mg/kg in 50% ethanol) into the distal ileum of guinea-pigs. All anti-inflammatory therapies were introduced after TNBS administration and continued until day 7, when guinea-pigs were killed. Ileal substance P levels were measured by radioimmunoassay, and granulocyte infiltration was quantified by myeloperoxidase (MPO) activity. Protein and nitrite (an index of nitric oxide formation) levels in a luminal saline lavage were quantified in all groups. TNBS ileitis caused a marked reduction in ileal substance P content and increased MPO activity, protein and nitrite secretion. The nitric oxide synthase inhibitor, L-NAME, completely restored all parameters to baseline. Misoprostol attenuated the granulocyte infiltration and exacerbated protein leak but had no effect on substance P levels. In contrast, NPC 15199 had no effect on granulocyte infiltration but normalized substance P levels and protein leak. Only L-NAME and NPC 15199 blocked the TNBS induced increase in nitrite levels. These results suggest that the regulation of granulocyte infiltration in this model is unrelated to changes in substance P levels. 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Emerging evidences indicate that dysregulated microRNAs are implicated in the process of metastasis. In the present study, we investigated whether miR-9, miR-10b, miR-21 and miR-146b levels are predictive of papillary thyroid carcinoma recurrence. Using macro-dissection followed by quantitative real-time PCR, we measured miR-9, miR-10b, miR-21 and miR-146b expression levels in formalin-fixed, paraffin-embedded samples of 66 patients with papillary thyroid carcinoma categorized into two groups: the recurrent group (n \u003d 19) and the non-recurrent group (n \u003d 47). All patients underwent total thyroidectomy and were followed for at least 120 months after surgery to be considered recurrence-free. Univariate and multivariate analysis were performed using the Cox proportional hazard model in order to identify associations between multiple clinical variables and microRNA expression levels and papillary thyroid carcinoma recurrence. MiR-9 and miR-21 expression levels were found to be significant prognostic factors for recurrence in patients with papillary thyroid carcinoma (HR \u003d 1.48; 95 % CI 1.24-1.77, p \u003c 0.001; and HR \u003d 1.52; 95 % CI 1.18-1.94, p \u003d 0.001; respectively). Multivariate analysis involving the expression level of miR-9 and miR-21 and various clinical parameters identified the expression of these microRNAs as independent prognostic factors for papillary thyroid cancer patients. 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Trial-by-trial analysis showed that over the course of acquisition, activity in the amygdala attenuated. Interestingly, activity in the dACC and insula also declined. Representational similarity analysis (RSA) corroborated these results, indicating that the voxel patterns evoked by CS+ and CS- in these brain regions became less distinguishable over time. 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Therefore, in this article we discuss the evaluation of Host Defence Potentiators (HDP). IL-2 or TNF should not be included as HDP because their action is local and not selective to cancer cells, similar to the case of cancer chemotherapeutics. IL-2 is not useful without the presence of IL-2-responsive cells in the host. The most important facet of the action of HDP is to increase the response of the host to cytokines or other bioactive substances according to the degree of maturation, differentiation or proliferation of responsive cells in the host defence mechanism. Lentinan appears to represent a unique class of HDP, markedly potentiating host resistance to cancer and bacterial, viral and parasitic infections, and shows prominent antitumor activity in syngeneic and autochthonous hosts, suppressing chemical and viral oncogenesis. The most important target of HDP is complete prevention of recurrence after \"curative\" surgery fundamentally through growth inhibition and regression of a small number of autochthonous tumor cells scattered in the host. Considering the excellent end-point results for phase III advanced and recurrent gastrointestinal and breast cancer, lentinan seems to be the most hopeful drug against cancer recurrence. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Clare Stawski","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Gerhard Körtner","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Julia Nowack","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Fritz Geiser","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Phenotypic plasticity of post-fire activity and thermal biology of a free-ranging small mammal.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-12-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Ecosystems can change rapidly and sometimes irreversibly due to a number of anthropogenic and natural factors, such as deforestation and fire. How individual animals exposed to such changes respond behaviourally and physiologically is poorly understood. We quantified the phenotypic plasticity of activity patterns and torpor use - a highly efficient energy conservation mechanism - in brown antechinus (Antechinus stuartii), a small Australian marsupial mammal. We compared groups in densely vegetated forest areas (pre-fire and control) with a group in a burned, open habitat (post-fire). Activity and torpor patterns differed among groups and sexes. Females in the post-fire group spent significantly less time active than the other groups, both during the day and night. However, in males only daytime activity declined in the post-fire group, although overall activity was also reduced on cold days in males for all groups. The reduction in total or diurnal activity in the post-fire group was made energetically possible by a ~3.4-fold and ~2.2-fold increase in the proportion of time females and males, respectively, used torpor in comparison to that in the pre-fire and control groups. Overall, likely due to reproductive needs, torpor was more pronounced in females than in males, but low ambient temperatures increased torpor bout duration in both sexes. Importantly, for both male and female antechinus and likely other small mammals, predator avoidance and energy conservation - achieved by reduced activity and increased torpor use - appear to be vital for post-fire survival where ground cover and refuges have been obliterated. 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An expressive feature of his creative manner is the combination of elements of different types in a single syntactic construction, different in character of expressive influence and expressiveness, which realize expressive potential the best way; exert influence of each other; create a vivid, original expressive-aesthetic text, and therefore a powerful means of influencing the reader’s consciousness and contribute to the release of the author’s plan. The repeats of different positions in the sentence and different structures activate the reader’s attention, form a strong contact with the narrator, rhythmize the presentation of information, increase the intensity of the narrative. The partitioned structures show the intention of the author to reinforce the important part of the message, to make a powerful influence on the emotional and intellectual spheres of the reader. The rows of homogeneous components in their lexical content are not necessarily synonymous. However, in the context of each subsequent component undergoes specific connotations and acquires a gradual significance. The formation of syntactic structures with the homogeneous components reflects the intention of the author to focus the attention of the addressee on the meaning of those components of expression. The insert elements in the form of quasi-sentences of defrageologized nature expressly demonstrate the emotional state of the narrator or character, attesting his assessment of events. The tiled constructions cause increased interest in communication, activate the thinking of the reader, create an intrigue in the narrative.\u003c/em\u003e","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Zenodo","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb853d8eb0c2749b45f2fcc5796650f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5281/zenodo.2480268","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Since loss of MT expression is associated with a worse prognosis, in the present study we investigated the effects of overexpression of the most significantly downregulated isoform in CRC, namely MT1G, on the HT-29 cell line. Overexpression of MT1G resulted in xenograft tumors with an aberrant morphology, characterized by an evident increase in mucin-containing cells that were identified as goblet cells under electron microscopy. Immunohistochemical detection of CDX2 and cytokeratin 20 was also increased, as were goblet‑cell and enterocyte-specific genes by qRT-PCR. Microarray analysis of gene expression confirmed the alteration of several differentiation signaling pathways, including the Notch pathway. Using sodium butyrate and post-confluent growth as inducers of differentiation, we demonstrated that MT1G does indeed play a functional role in promoting goblet over enterocyte differentiation in vitro. Labile zinc is also induced upon differentiation of CRC cells, functionally contributing to enterocyte over goblet differentiation, as revealed using zinc‑specific chelating agents. Overall, our results uncover a new tumor-suppressor activity of MT1G in promoting the differentiation of at least some CRC tumors, and implicate MTs and zinc signaling as new players in colorectal differentiation. 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They are responsible for considerable morbidity and socioeconomic burden. Existing treatments are usually only partially successful and there is an urgent need to understand the aetiological factors and neurobiological bases of the disorders in order to develop new and more effective strategies for prevention, early detection and effective treatment. Emerging data from the neurosciences supports the reconceptualisation of obsessive-compulsive disorder as a spectrum disorder, related to but different from the anxiety disorders and closely aligned with other less well understood psychiatric disorders characterised by compulsive acts such as body dysmorphic disorder, trichotillomania, skin-picking disorder, hoarding disorder; and possibly extending to tic disorders and other neurodevelopmental disorders such as autism. A new, O-CRDs research network, supported by the Networks Initiative of the European College of Neuropsychopharmacology and comprising leading figures in preclinical and clinical research, has been established. It aims to provide a European perspective on the current debate around internationally-accepted diagnostic criteria and treatment strategies for O-CRDs. Its objectives include; (1) identifying the key outstanding research questions that depend upon cross-centre collaborative investigation, (2) setting a research agenda that is likely to produce an impact on health-outcomes, and (3) strengthening existing projects and collaborative enterprises with these objectives in mind. This paper reviews some of these critical research priorities. 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Heparin, a negatively charged glycosaminoglycan (GAG) is known to play an important role in sequestration of positively charged growth factors and, when incorporated within cellular aggregates, could be used to promote local availability of growth factors. We have developed a heparin-based cell coating and we believe that the electrostatic interaction between native heparin and the positively charged growth factors will result in (1) higher cell number in response to fibroblast growth factor-2 (FGF-2) and 2) greater chondrogenic differentiation in response to transforming growth factor-β1 (TGF-β1), compared to a desulfated heparin coating. Results revealed that in the presence of FGF-2, by day 14, heparin-coated MSC aggregates increased in DNA content 8.5 ± 1.6 fold compared to day 1, which was greater than noncoated and desulfated heparin-coated aggregates. In contrast, when cultured in the presence of TGF-β1, by day 21, desulfated heparin-coated aggregates upregulated gene expression of collagen II by 86.5 ± 7.5 fold and collagen X by 37.1 ± 4.7 fold, which was higher than that recorded in the noncoated and heparin-coated aggregates. These observations indicate that this coating technology represents a versatile platform to design MSC culture systems with pairings of GAGs and growth factors that can be tailored to overcome specific challenges in scale-up and culture for MSC-based therapeutics. © 2016 Wiley Periodicals, Inc. 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The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. 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These data point to a direct role of Dnmt1 in the restoration of epigenetic information during DNA repair.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb87645f6837106c6947ced7c0d7152","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15956212","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Synthesis, anti-inflammatory evaluation","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-01-01","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb87673e0da331d54b789ecb5a489ad","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.1016/j.molstruc.2017.09.092","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Leuschner Hanns Hubert","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Eckstein Jan","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bauerochse Andreas","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Birkholz Bernhard","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Achterberg Inke Elisabeth Maike","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Dendrochronologically dated pine stumps document phase wise bog\\nexpansion at a northwest German site between c. 6700 BC and c.\\n3400 BC","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[],"description":[{"value":"\u003cjats:p\u003eThis is a dendrochronological investigation of a mire site densely covered by peat-preserved pine stumps (\u0026lt;i\u0026gt;Pinus sylvestris\u0026lt;/i\u0026gt;). The site in the northwest German \u0026lt;i\u0026gt;Tote Moor\u0026lt;/i\u0026gt; revealed to feature trees from various Holocene millennia. The dendrochronologically dated site chronology covers 2345 years between 6703 BC and 3403 BC, containing 5 gaps between 6 and 550 years in length. It consists of 477 trees. A floating chronology segment of 309 years, containing 30 trees, was radiocarbon dated to the beginning of the 7th millennium cal. BC. The tree ring data from the site documents environmental changes over a larger period of time. Furthermore, the site is covered densely with in situ tree stumps from the fen-bog transition. This facilitates the spatio-temporal reconstruction of mire development, which is based on 212 in situ tree stumps in the case study presented here. Peat-stratigraphical survey was carried out additionally, and elevations a.s.l. were determined at several locations. \u0026lt;br\u0026gt;\u0026lt;br\u0026gt; Tree die-off phases, which indicate the local water level rise, mostly in context of the local fen-bog transition, are evident for c. 6600\u0026amp;amp;ndash;6450 BC, c. 6350\u0026amp;amp;ndash;5750 BC, c. 5300\u0026amp;amp;ndash;4900 BC, c. 4700\u0026amp;amp;ndash;4550 BC, c. 3900\u0026amp;amp;ndash;3850 BC, 3700\u0026amp;amp;ndash;3600 BC, c. 3500\u0026amp;amp;ndash;3450 BC and c. 3400 BC.\n \u003c/jats:p\u003e","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Copernicus GmbH","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb877be935f16b0aa4532d5d33897df","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5194/cp-2017-4","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Kathleen Myers","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Comer, Jonathan S.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The Case for Telemental Health for Improving the Accessibility and Quality of Children\u0027s Mental Health Services.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-05-12","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Children\u0027s mental health problems collectively impose a staggering public health burden. However, the quality of regionally accessible children\u0027s mental healthcare varies greatly, with youth in rural and other remote communities particularly underserved. Promoting knowledge and skill in telemental health (TMH) is critical to meaningfully overcoming traditional geographic barriers to children\u0027s mental healthcare.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb87a187177e5e2b2ceff79305f946e","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26859537","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Chun-Yu Liu","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Hsin-Yu Kuo","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Cheng-Hwai Tzeng","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Chung-Wai Shiau","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Hsiang-Po Huang","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Kuen-Feng Chen","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Ming-Huang Chen","name":"","surname":"","rank":7,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies. Here, we examined the antitumor activity and drug targets of bortezomib in leukemia cells. Human leukemia cell lines were used for in vitro studies. Drug efficacy was evaluated by apoptosis assays and associated molecular events assessed by Western Blot. Gene silencing was performed by small interference RNA. Drug was tested in vivo in xenograft models of human leukemia cell lines and in primary leukemia cells. Clinical samples were assessed by immunohistochemical staining. Bortezomib differentially induced apoptosis in leukemia cells that was independent of its proteasome inhibition. Cancerous inhibitor of protein phosphatase 2A, a cellular inhibitor of protein phosphatase 2A, mediated the apoptotic effect of bortezomib. Bortezomib increased protein phosphatase 2A activity in sensitive leukemia cells (HL-60 and KG-1), but not in resistant cells (MOLT-3 and K562). Bortezomib\u0027s downregulation of cancerous inhibitor of protein phosphatase 2A and phospho-Akt correlated with its drug sensitivity. Furthermore, cancerous inhibitor of protein phosphatase 2A negatively regulated protein phosphatase 2A activity. Ectopic expression of CIP2A up-regulated phospho-Akt and protected HL-60 cells from bortezomib-induced apoptosis, whereas silencing CIP2A overcame the resistance to bortezomib-induced apoptosis in MOLT3 and K562 cells. Importantly, bortezomib exerted in vivo antitumor activity in HL-60 xenografted tumors and induced cell death in some primary leukemic cells. Cancerous inhibitor of protein phosphatase 2A was expressed in leukemic blasts from bone marrow samples. 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This paper describes the systematic CT evaluation methodology that was devised during the Portico trial investigation and U.S. Food and Drug Administration submission; it also highlights the need for an ongoing discussion among experts to enable, with the help of the Valve Academic Research Consortium, standardization of reporting of this imaging finding to cater to the present and future needs of clinical trials.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb87f7d1df4817fc48b3cd60e4991ee","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28385256","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The hydrophilicity is enhanced upon UV laser irradiation since the embedded nonpolar spiropyran molecules convert to their polar merocyanine isomers. The process is reversed upon green laser irradiation. Structuring of the photochromic polymeric surfaces with soft lithography enhances significantly the hydrophobicity of the system, indicating that the water droplets on the patterned features interact with air that is trapped in the microcavities, thus creating superhydrophobic air-water contact areas. Furthermore, the light-induced wettability variations of the structured surfaces are enhanced by a factor of 3 compared to those on the flat surfaces. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Nicolle Bristow","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Burton, Teralee R.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Coleen Ong-Justiniano","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Michelle Brown","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Henson, Elizabeth S.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Gibson, Spencer B.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"BNIP3 (Bcl-2/adenovirus E1B Nineteen Kilodalton Interacting Protein) is a pro-cell death member of the Bcl-2 family of proteins. Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (hypoxia) and is found over expressed in hypoxic regions of many tumors. When over expressed, BNIP3 induces cell death through induction of mitochondrial dysfunction that is dependent on the presence of BNIP3\u0027s TM domain. Herein, we have determined that the SkOv3 ovarian cancer cell line expresses a truncated BNIP3 protein, which results in the elimination of the transmembrane domain. Truncation that eliminates all four domains of BNIP3 protein also inhibits hypoxia-induced cell death in SkOv3, HEK293, U251 and MCF-7 cells. Three different mutations in a BNIP3 expression vector that lead to a truncated BNIP3 protein, lacking TM domain only, or lacking CD, BH3, and TM domains resulted in inhibition of hypoxia-induced cell death when transfected into HEK293 cells. We found that truncated BNIP3 failed to associate with the mitochondria and the truncated BNIP3 lacking all four domains can bind to wild type BNIP3. Taken together, truncation of BNIP3 could be a novel mechanism for cancer cells to avoid hypoxia-induced cell death mediated by BNIP3 over expression.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb883fbecd275368877327214800629","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21138765","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Eva Nordberg Karlsson","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Sindhu Mathew","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Patrick Adlercreutz","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Extraction of soluble arabinoxylan from enzymatically pretreated wheat bran and production of short xylo-oligosaccharides and arabinoxylo-oligosaccharides from arabinoxylan by glycoside hydrolase family 10 and 11 endoxylanases.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-05-18","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The enzymatic, ecofriendly pretreatment of wheat bran with α-amylase from Bacillus amyloliquifaciens or B. licheniformis at 90°C for 1.5h followed by Neutrase at 50°C for 4h, aqueous liquefaction at 121°C for 15h and ethanol precipitation enabled the production of soluble arabinoxylan (AX) with purity of 70.9% and 68.4% (w/w) respectively. Process alternatives tried, to simplify the process and curtail the cost resulted in AX products with different purities, yields and arabinose to xylose ratio (A/X). Among the two glycoside hydrolase (GH) family endoxylanases evaluated, GH10 family hydrolysed soluble AX more efficiently with xylanase from Geobacillus stearothermophilus T-6 (GsXyn10A) producing maximum amount of quantifiable short xylo-oligosaccharides (XOS) and arabinoxylo-oligosaccharides (AXOS) (53% w/w) followed by the catalytic module of Rhodothermus marinus Xyn10A (RmXyn10A-CM) with 37% (w/w) conversion. The GH11 family endoxylanases, from Thermomyces lanuginosus (Pentopan Mono BG™) and Neocallimastix patriciarum (NpXyn11A) gave conversions of 21% and 22% (w/w) of the soluble AX, respectively (major AXOS products were not quantified). In addition to the XOS formed such as X","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb884c31bf47581731f74731aac33bc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28917931","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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J.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Methylation similarities of two CpG sites within exon 5 of human H19 between normal tissues and testicular germ cell tumours of adolescents and adults, without correlation with allelic and total level of expression.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Testicular germ cell tumours (TGCTs) of adolescents and adults morphologically mimic different stages of embryogenesis. Established cell lines of these cancers are used as informative models to study early development. We found that, in contrast to normal development, TGCTs show a consistent biallelic expression of imprinted genes, including H19, irrespective of histology. Methylation of particular cytosine residues of H19 correlates with inhibition of expression, which has not been studied in TGCTs thus far. We investigated the methylation status of two CpG sites within the 3\u0027 region of H19 (exon 5: positions 3321 and 3324) both in normal tissues as well as in TGCTs. To obtain quantitative data of these specific sites, the ligation-mediated polymerase chain reaction technique, instead of Southern blot analysis, was applied. The results were compared with the allelic status and the total level of expression of this gene. Additionally, the undifferentiated cells and differentiated derivatives of the TGCT-derived cell line NT2-D1 were analysed. While peripheral blood showed no H19 expression and complete methylation, a heterogeneous but consistent pattern of methylation and level of expression was found in the other normal tissues, without a correlation between the two. The separate histological entities of TGCTs resembled the pattern of their nonmalignant tissues. While the CpG sites remained completely methylated in NT2-D1, H19 expression was induced upon differentiation. These data indicate that methylation of the CpG sites within exon 5 of H19 is tissue dependent, without regulating allelic status and/or total level of expression. Of special note is the finding that, also regarding methylation of these particular sites of H19, TGCTs mimic their non-malignant counterparts, in spite of their consistent biallelic expression.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb886cf309a832e5a652ef7949ecdcc","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9310237","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Mice with a null mutation in the gene for the beta common (beta c) chain of the receptors for GM-CSF, interleukin(IL)-3 and IL-5 (beta c-null mice) display normal steady state hemopoiesis and develop lung disease similar to the human condition, alveolar proteinosis, due to a lack of signaling by GM-CSF. We therefore expected to observe a heightened sensitivity to Leishmania major in the beta c-null mice. Surprisingly, the beta c-null mice were more resistant to cutaneous infection than wild-type (wt) mice. Upon intradermal injection of L. major promastigotes, fewer beta c-null mice developed cutaneous lesions than wt mice and these lesions were smaller and healed more rapidly than in wt mice. This resistance to disease was associated with a reduced percentage of in vitro infected beta c-null macrophages. Macrophages from beta c-null mice displayed a more activated phenotype and produced increased amounts of nitric oxide following infection with L. major, both in vivo and in vitro. Paradoxically, however, the parasite burden in the draining lymph nodes was similar in both beta c-null and wt mice, suggesting that at least a subpopulation of cells was susceptible to the parasite. 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Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a small-molecule approach, we show significant expansion (\u003e2,000-fold) of cochlear supporting cells expressing and maintaining Lgr5, an epithelial stem cell marker, in response to stimulation of Wnt signaling by a GSK3β inhibitor and transcriptional activation by a histone deacetylase inhibitor. The Lgr5-expressing cells differentiate into hair cells in high yield. From a single mouse cochlea, we obtained over 11,500 hair cells, compared to less than 200 in the absence of induction. The newly generated hair cells have bundles and molecular machinery for transduction, synapse formation, and specialized hair cell activity. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"White, Danny K.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Alan Allchorn","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Neil Maxwell","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Mauger, Alexis R.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Castle, Paul C.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Deception of ambient and body core temperature improves self paced cycling in hot, humid conditions.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"We used incorrect visual feedback of ambient and core temperature in the heat to test the hypothesis that deception would alleviate the decrement in cycling performance compared to a no deception trial. Seven males completed three 30 min cycling time trials in a randomised order on a Kingcycle ergometer. One time trial was in temperate, control conditions (CON: 21.8 ± 0.6°C; 43.3 ± 4.3%rh), the others in hot, humid conditions (HOT: 31.4 ± 0.3°C; 63.9 ± 4.5%rh). In one of the hot, humid conditions (31.6 ± 0.5°C; 65.4 ± 4.3%rh), participants were deceived (DEC) into thinking the ambient conditions were 26.0°C; 60.0%rh and their core temperature was 0.3°C lower than it really was. Compared to CON (16.63 ± 2.43 km) distance covered was lower in HOT (15.88 ± 2.75 km; P \u003c 0.05), but DEC ameliorated this (16.74 ± 2.87 km; P \u003c 0.05). Mean power output was greater in DEC (184.4 ± 60.4 W) than HOT (168.1 ± 54.1 W; P \u003c 0.05) and no difference was observed between CON and DEC. Rectal temperature and iEMG of the vastus lateralis were not different, but RPE in the third minute was lower in DEC than HOT (P \u003c 0.05). Deception improved performance in the heat by creating a lower RPE, evidence of a subtle mismatch between the subconscious expectation and conscious perception of the task demands.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb893e1b2ccc248f55660cc6f0b8262","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21573777","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Patrick Shipman","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Liling Chen","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Thwaites, John J.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Darshan Roy","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Mendelson, Neil H.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"Quantitative Biology::Biomolecules","qualifier":{"classid":"arxiv","classname":"arxiv","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":false,"inferenceprovenance":"iis::document_classes","provenanceaction":{"classid":"iis","classname":"iis","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}}},{"value":"Physics::Biological Physics","qualifier":{"classid":"arxiv","classname":"arxiv","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":false,"inferenceprovenance":"iis::document_classes","provenanceaction":{"classid":"iis","classname":"iis","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}}}],"title":[{"value":"The dynamic behavior of bacterial macrofibers growing with one end prevented from rotating: variation in shaft rotation along the fiber\u0027s length, and supercoil movement on a solid surface toward the constrained end.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Bacterial macrofibers twist as they grow, writhe, supercoil and wind up into plectonemic structures (helical forms the individual filaments of which cannot be taken apart without unwinding) that eventually carry loops at both of their ends. Terminal loops rotate about the axis of a fiber\u0027s shaft in contrary directions at increasing rate as the shaft elongates. Theory suggests that rotation rates should vary linearly along the length of a fiber ranging from maxima at the loop ends to zero at an intermediate point. Blocking rotation at one end of a fiber should lead to a single gradient: zero at the blocked end to maximum at the free end. We tested this conclusion by measuring directly the rotation at various distances along fiber length from the blocked end. The movement of supercoils over a solid surface was also measured in tethered macrofibers.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8943db041315e7ea2578e36e35fac","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"12921542","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018262586}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Mahdieh Khodaie","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Azam Askari","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Kambiz Bahaadinbeigy","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"\"Evaluation of a very low-cost and simple teleradiology technique\".","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This paper describes and analyzes a proposed solution of fundamental limitative factor of teleradiology to overcome the teleradiology usages problems in underdeveloped and developing countries. The goal is to achieve a very simple and cost-efficient way to take advantage of teleradiology in anywhere even in remote and rural areas. To meet the goal of this study, the following methodology which is consists of two main procedures was done: (1) Using a digital camera in order to provide a digital image from radiographs. (2) Using an image compression tool in order to compress digital images. The results showed that there is no significant difference between digital images (non-compress and compress images) and radiographic films. Also, there was a logic relationship between the diagnostic quality and diagnostic accuracy. Since the maximum percent of diagnostic accuracy can be seen among \"Good\" quality images and the minimum to was related \"Poor\". The results of our study indicate that a digital camera could be utilized to capture digital images from radiographic films of chest x-ray. To reduce the size of digital images, a lossy compression technique could be applied at compression percent of 50 or less without any significant differences. The compressed images can be sent easily by email to other places for consultation and also they can be stored with a smaller size. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Keiko Gondou","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Chiaki Hasegawa","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Yuko Yoshimura","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Manabu Oi","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Tomoko Matsui","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Yoko Kamio","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Naotake Tsukidate","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Mitsuru Kikuchi","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Hiroshi Fujino","name":"","surname":"","rank":9,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Quantitative Aspects of Communicative Impairment Ascertained in a Large National Survey of Japanese Children.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-12-02","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The Japanese version of the Children\u0027s Communication Checklist-2 (CCC-2) was rated by caregivers in a large national population sample of 22,871 children aged 3-15 years. The General Communication Composite (GCC) of the CCC-2 exhibited a distribution with a single-factor structure. The GCC distribution between autism spectrum disorders (ASD) and language impairment (LI) groups in the general population fit inside a bell curve with significant overlap with the general population, and a continuum was evident between groups. No evidence of a natural cutoff that would differentiate categorically affected from unaffected children was seen. The Social Interaction Deviance Composite (SIDC) supported the notion that ASD and LI are on the opposite endpoints of a SIDC continuum of communication impairment.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb895ec32df43044ed7974a915e0b08","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28695437","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Fenn, D. S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Franklin, J.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Stanton, A. K.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Lewinsohn, P. M.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Relation of age at onset to duration of episode in unipolar depression.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2007-11-14","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The purpose of this study was to test the hypothesis that the duration of episodes of unipolar depression increases with age at onset. On the basis of elevated scores on a self-report depression measure, 2,020 persons were selected from a larger community sample to be interviewed and diagnosed using the Schedule for Affective Disorders and Schizophrenia-Research Diagnostic Criteria procedures. Of the 2,020 persons, 865 had a history of one or more episodes of unipolar depression. The potential effects of the following variables (singly and in interaction) on duration of episode were assessed by means of multiway frequency table analysis and chi-square: age at onset, sex of subject, interval since occurrence of the episode, and type of disorder (major vs. minor depressive disorder). The hypothesis that duration of episodes of depression increases with age at onset was not supported. Women were more likely to have multiple episodes, but did not have longer lasting episodes.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8961cecce86d683f738049ad45011","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"3267381","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Their measurements, however, are rarely performed in clinical practice. In the present study, we analyzed 30 varieties of eicosanoid mediators that were detectable in human plasma and serum collected from healthy donors, using liquid chromatography-tandem mass spectrometry from the viewpoint of the clinical application of the multiplex quantitation of eicosanoid mediators. Wider variety of eicosanoid mediators were detected in serum (27 out of 30) than in plasma (14 out of 30), since the serum was thought to contain lipid mediators released from activated platelets. Larger inter-individual variations were observed in the plasma and serum eicosanoid levels. On the other hand, the concentrations of eicosanoids were not affected by the platelet count but were affected by the concentration of arachidonic acid (AA) within the reference interval (17.4-40.5×10","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8984d8f581284413ea79a56088b93","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29032044","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Robert Root-Bernstein","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jessica Vonck","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Insulin activity is sensitive to glucose concentration but the mechanisms are still unclear. An unexamined possibility is that the insulin receptor (IR) is sensitive to glucose concentration. We demonstrate here that insulin-like peptides derived from the IR bind glucose at low millimolar, and cytochalasin B at low micromolar, concentrations; several insulin-like IR peptides bind insulin at nanomolar Kd; and this binding is antagonized by increasing glucose concentrations. In addition, glucose and cytochalasin B bind to IR isolated from rat liver and increasing glucose decreases insulin binding to this IR preparation. The presence of GLUT 1 in our IR preparation suggests the possibility of additional glucose-mediated allosteric control. We propose a model in which glucose binds to insulin, the IR, and GLUT; insulin binds to the IR; and the IR binds to GLUT. This set of interactions produces an integrated system of insulin-dependent interactions that is highly sensitive to glucose concentration.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb89a74d6a6868c7b004c398d1ee7e6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19554259","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The distinction between balanced and unbalanced spermatozoa on morphological criteria is still unfeasible. However, we previously showed that: i) spermatozoa with an unbalanced content have a higher rate of DNA fragmentation; and ii) that density gradient centrifugation partially separates balanced from unbalanced sperm cells. We hypothesized that a chromosomal imbalance could alter the fine spermatic nuclear architecture and consequently the condensation of DNA, thus modifying normal sperm density. Spermatic nuclear volumes in four translocation carriers were analyzed using confocal microscopy. Secondarily, FISH analysis was used to establish the segregation mode of each spermatozoon. We found the average spermatic nuclei size to be higher among unbalanced spermatozoa in all patients but one. All the unbalanced modes were associated with larger nuclei in two patients, while this was the case for the 3:1 mode only in the other two, suggesting an abnormal condensation. This could be the first step in elaborating a procedure to completely eliminate unbalanced spermatozoa from semen prior to in vitro fertilization. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Monika Adamczyk-Poplawska","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Andrzej Piekarowicz","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Michal Lower","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Deletion of one nucleotide within the homonucleotide tract present in the hsdS gene alters the DNA sequence specificity of type I restriction-modification system NgoAV.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"As a result of a frameshift mutation, the hsdS locus of the NgoAV type IC restriction and modification (RM) system comprises two genes, hsdS(NgoAV1) and hsdS(NgoAV2). The specificity subunit, HsdS(NgoAV), the product of the hsdS(NgoAV1) gene, is a naturally truncated form of an archetypal specificity subunit (208 N-terminal amino acids instead of 410). The presence of a homonucleotide tract of seven guanines (poly[G]) at the 3\u0027 end of the hsdS(NgoAV1) gene makes the NgoAV system a strong candidate for phase variation, i.e., stochastic addition or reduction in the guanine number. We have constructed mutants with 6 guanines instead of 7 and demonstrated that the deletion of a single nucleotide within the 3\u0027 end of the hsdS(NgoAV1) gene restored the fusion between the hsdS(NgoAV1) and hsdS(NgoAV2) genes. We have demonstrated that such a contraction of the homonucleotide tract may occur in vivo: in a Neisseria gonorrhoeae population, a minor subpopulation of cells appeared to have only 6 guanines at the 3\u0027 end of the hsdS(NgoAV1) gene. Escherichia coli cells carrying the fused gene and expressing the NgoAVΔ RM system were able to restrict λ phage at a level comparable to that for the wild-type NgoAV system. NgoAV recognizes the quasipalindromic interrupted sequence 5\u0027-GCA(N(8))TGC-3\u0027 and methylates both strands. NgoAVΔ recognizes DNA sequences 5\u0027-GCA(N(7))GTCA-3\u0027 and 5\u0027-GCA(N(7))CTCA-3\u0027, although the latter sequence is methylated only on the complementary strand within the 5\u0027-CTCA-3\u0027 region of the second recognition target sequence.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb89c4f47d9745b30191eddfeabc4c9","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21984785","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"So Young Lee","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Ane Fullaondo","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Regulation of Drosophila-virus interaction.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2011-11-08","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Drosophila melanogaster is a useful model system for deciphering mammalian biological processes including development, innate immunity and cancer. Most genetic studies conducted in Drosophila have focused on the immune response against microbial infection and the results obtained have been extrapolated to other organisms. During the last decade the issue of the antiviral response attracted a great deal of interest. In this review we highlight recent discoveries in the role of RNA interference pathway in antiviral response in Drosophila with a focus on the role of miRNAs as both host defense elements and helpers of viral replication.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb89ec8ddc9754ba165b6ade67bc6e6","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21925207","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Penny, Michelle A.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Duncan McHale","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Pharmacogenomics and the drug discovery pipeline: when should it be implemented?","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2009-11-03","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"One of the key factors in developing improved medicines lies in understanding the molecular basis of the complex diseases we treat. Investigation of genetic associations with disease utilizing advances in linkage disequilibrium-based whole genome association strategies will provide novel targets for therapy and define relevant pathways contributing to disease pathogenesis. Genetic studies in conjunction with gene expression, proteomic, and metabonomic analyses provide a powerful tool to identify molecular subtypes of disease. Using these molecular data, pharmacogenomics has the potential to impact on the drug discovery and development process at many stages of the pipeline, contributing to both target identification and increased confidence in the therapeutic rationale. This is exemplified by the identified association of 5-lipoxygenase-activating protein (ALOX5AP/FLAP) with increased risk of myocardial infarction, and of the chemokine receptor 5 (CCR5) with HIV infection and therapy. Pharmacogenomics has already been used in oncology to demonstrate that molecular data facilitates assessment of disease heterogeneity, and thus identification of molecular markers of response to drugs such as imatinib mesylate (Gleevec) and trastuzumab (Herceptin). Knowledge of genetic variation in a target allows early assessment of the clinical significance of polymorphism through the appropriate design of preclinical studies and use of relevant animal models. A focussed pharmacogenomic strategy at the preclinical phase of drug development will produce data to inform the pharmacogenomic plan for exploratory and full development of compounds. Opportunities post-approval show the value of large well-characterized data sets for a systematic assessment of the contribution of genetic determinants to adverse drug reactions and efficacy. The availability of genomic samples in large phase IV trials also provides a valuable resource for further understanding the molecular basis of disease heterogeneity, providing data that feeds back into the drug discovery process in target identification and validation for the next generation of improved medicines.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb89f34d82f092c0e698a5b533233f5","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15727489","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Wood, Alex M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Stephen Joseph","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The absence of positive psychological (eudemonic) well-being as a risk factor for depression: a ten year cohort study.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-11-25","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Previous research in psychiatry has focused on how negative personality traits and impaired well-being form risk factors for depression. This study presents the first longitudinal test of whether the absence of positive well-being forms an additional unique risk factor for depression.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8a188ded8e198fa088df9d780e977","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19706357","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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From 104 isolates, two rod-shaped and five coccal-shaped LAB were able to produce EPS from sucrose on solid media. However, only the cocci were capable of producing EPS in liquid media and these were identified as Pediococcus pentosaceus. Pediococcus pentosaceus strains AP-1 and AP-3 produced EPS in high yield. In liquid media containing sucrose as carbon source, the amount of EPS produced by AP-1 and AP-3 strains was 6.0 and 2.5 g/L, respectively. The isolated and purified EPSs were chemically characterized. On the basis of sugar composition, methylation analysis and nuclear magnetic resonance spectroscopy, both the EPSs were shown to belong to the same dextran class. In particular, both EPSs differed from linear dextran by branching through 3,6-di-Osubstituted alpha-D-glucopyranosyl residues. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Rose, J. E.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Levin, E. D.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Behm, F.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Development of a citric acid aerosol as a smoking cessation aid.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-06-02","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The satisfaction derived from smoking depends not only on the pharmacological effects of nicotine but also the sensory stimulation from smoke inhalation, particularly the tracheal \u0027scratch\u0027. In a previous study, we found that a citric acid aerosol produces a tracheal \u0027scratch\u0027 and provides some of the same satisfaction as cigarette smoke. In the present study, we evaluated a new pocket-sized device for delivering a citric acid aerosol and examined some of the important variables for providing a satisfying substitute for cigarettes. In the first experiment, volunteers who smoked at least 10 cigarettes per day compared a citric acid aerosol (either alone or with flavor additives) to a cigarette and a placebo. The addition of cigarette smoke flavor was found to best enhance the satisfaction provided by the citric acid aerosol. In the second experiment, smokers were given compact citric acid inhalers to use throughout 8 h of cigarette deprivation. The degree of satisfaction was highly correlated with the intensity of throat sensation provided by the aerosol. This citric acid aerosol inhaler may provide a useful tool for smokers while trying to quit smoking.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8a3660dfd1da4cfd6ddd27bd7fe76","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"2189719","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Sarnoff, Deborah S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Gotkin, Robert H.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"A preliminary study on the safety and efficacy of a novel fractional CO₂ laser with synchronous radiofrequency delivery.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2014-03-05","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Building upon the fractional CO₂ technology incorporated into the first generation SmartXide DOT (DEKA / ElEn, SpA, Calenzano, Italy) introduced in the U.S. in 2008, a second generation SmartXide Quadro has recently been introduced. This is a versatile device that has the ability to combine fractional CO₂ laser output for skin resurfacing with the synchronous delivery of bipolar radiofrequency (RF) energy for deeper, more diffuse heating. A pilot study was undertaken to demonstrate the safety and efficacy of the SmartXide Quadro, employing both fractional CO₂ laser output combined with the synchronous delivery of radiofrequency energy for the treatment of facial rhytides and acne scars. Ten patients, all women, six with facial rhytides and four with acne scarring, were treated with the SmartXide Quadro, a variably pulsed CO₂ laser with Pulse Shape Design® technology, a microablative DOT scanner and synchronized bipolar RF emission. Each patient was treated with a single fractional CO₂ laser-RF treatment; laser and RF parameters varied according to the severity of the rhytides or acne scars and were based upon both manufacturer-recommended settings and surgeon experience. Follow-up was at three days, one week, 2 weeks, and one month, three months, and six months after treatment. Results were judged by comparison of preoperative and post-operative photos evaluated by independent physicians, preoperative and post-operative grading by treating physicians, subjective evaluation of results by the patients themselves, and tabulation and categorization of adverse events (AEs). The SmartXide Quadro variably pulsed CO₂ laser with a microablative DOT scanner, with synchronous delivery of bipolar RF energy emission, proved to be both safe and effective in the treatment of facial rhytides and acne scars. The single treatment protocol was well tolerated and recovery was similar to fractional CO₂ laser skin resurfacing alone. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Eskin, B.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Szucs, P.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Ritter, A.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Allegra, J.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Nashed, A. 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Thirty-seven patients were treated (84% female), with an ED diagnosis of acute migraine with droperidol during the study period. The mean age was 36 +/- 12 years. Analgesics had been used within 24 hours before ED presentation by 62% of patients. At t30, 30 (81%) patients had symptomatic relief, 2 (5%) felt partial relief but required rescue medication, and 5 (14%) had no relief of symptoms. Drowsiness (14%) and mild akathisia (8%) were the only adverse reactions observed following drug administration. Droperidol 2.5 mg intramuscular may be a safe and effective therapy for the ED management of acute migraine headache. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Jwu-E Chen","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Lu-Ting Ko","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Tze-Yun Sung","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Hsi-Chin Hsin","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Ying-Shen Juang","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Optimization and implementation of scaling-free CORDIC-based direct digital frequency synthesizer for body care area network systems.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Coordinate rotation digital computer (CORDIC) is an efficient algorithm for computations of trigonometric functions. Scaling-free-CORDIC is one of the famous CORDIC implementations with advantages of speed and area. In this paper, a novel direct digital frequency synthesizer (DDFS) based on scaling-free CORDIC is presented. The proposed multiplier-less architecture with small ROM and pipeline data path has advantages of high data rate, high precision, high performance, and less hardware cost. The design procedure with performance and hardware analysis for optimization has also been given. It is verified by Matlab simulations and then implemented with field programmable gate array (FPGA) by Verilog. The spurious-free dynamic range (SFDR) is over 86.85 dBc, and the signal-to-noise ratio (SNR) is more than 81.12 dB. The scaling-free CORDIC-based architecture is suitable for VLSI implementations for the DDFS applications in terms of hardware cost, power consumption, SNR, and SFDR. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Tom Kiger","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Kuncel, Nathan R.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Goldberg, Lewis R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"A Plea for Process in Personality Prevarication.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"We make a series recommendations for focusing research on personality test faking. Overall we suggest that a focus on the response process test takers go through will accelerate our understanding of faking behavior. We argue that the decision making process for faking must be simple and dependent on a modest set of decision rules or heuristics. The set of heuristics used by any given test taker will, in turn, be the result of test taker goals and situational press. By focusing in on what the test taker is doing we will avoid adopting the wrong frame of reference and, hopefully, make ever more rapid progress.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8a8df2512c5d86bd0fbcdb6bb29bf","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21966260","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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To determine the transcriptional response to Salmonella enterica serovar Choleraesuis (SC) infection, a 13,297-oligonucleotide swine array was used to analyze RNA from control, 24-h postinoculation (hpi), and 48-hpi porcine lung tissue from pigs infected with SC. In total, 57 genes showed differential expression (p \u003c 0.001; false discovery rate \u003d 12%). Quantitative real-time PCR (qRT-PCR) of 61 genes was used to confirm the microarray results and to identify pathways responding to infection. Of the 33 genes identified by microarray analysis as differentially expressed, 23 were confirmed by qRT-PCR results. A novel finding was that two transglutaminase family genes (TGM1 and TGM3) showed dramatic increases in expression postinoculation; combined with several other apoptotic genes, they indicated the induction of apoptotic pathways during SC infection. A predominant T helper 1-type immune response occurred during infection, with interferon gamma (IFNG) significantly increased at 48 hpi. Genes induced by IFNs (GBP1, GBP2, C1S, C1R, MHC2TA, PSMB8, TAP1, TAP2) showed increased expression during porcine lung infection. 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Patterns of contrasting stripes that purportedly degrade an observer\u0027s ability to judge the speed and direction of moving prey (\u0027motion dazzle\u0027) are, however, rarely investigated. This is despite motion dazzle having been fundamental to the appearance of warships in both world wars and often postulated as the selective agent leading to repeated patterns on many animals (such as zebra and many fish, snake, and invertebrate species). Such patterns often appear conspicuous, suggesting that protection while moving by motion dazzle might impair camouflage when stationary. However, the relationship between motion dazzle and camouflage is unclear because disruptive camouflage relies on high-contrast markings. 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Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditionally dependent on the protein synthesis machinery resident within their cellular hosts to translate viral messenger RNAs (mRNAs). A complex signaling network responsive to physiological stress, including infection, regulates host translation factors and ribosome availability. Furthermore, access to the translation apparatus is patrolled by powerful host immune defenses programmed to restrict viral invaders. Here, we review the tactics and mechanisms used by viruses to appropriate control over host ribosomes, subvert host defenses, and dominate the infected cell translational landscape. 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In particular, we asked whether neural responses related to language processing depend on one\u0027s experience with the action-based content of this language. Ice-hockey players and novices passively listened to sentences about ice-hockey and everyday situations during functional magnetic resonance imaging (fMRI). When listening to action-related sentences, neural activation in left inferior frontal gyrus (IFG) and left dorsal premotor cortex (PMd) depended on one\u0027s actual (physical) experience with the action described in the sentence: hockey experts showed greater activity in these regions than novices for hockey sentences, but not for everyday-action sentences. Thus, personal experience with linguistic content modulated activity both in regions associated with language comprehension (IFG) and in those related to complex action planning (PMd). Moreover, hockey experts (who have extensive experience with both hockey and everyday situations) showed greater activity in left IFG regions for hockey relative to everyday sentences. This suggests that the degree to which one finds information personally relevant (i.e., over and above one\u0027s direct experience with it) also modulates processing in brain regions related to semantic-level processing.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8d7faad2bae7d3a76dfdc7bbf47c1","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19628276","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Obligate PTT dimer obtained by PTT SH cross-linking and PTTs with serially truncated linkers between pharmacophore isoleucine-ferrocenyltriazole-proline-tryptophan and cysteine-SH were synthesized. PTT variants showed loss of lytic activity but not binding and infection inhibition upon SH blockade. A disproportionate loss of lysis activity vs binding and infection inhibition was observed upon linker truncation. Molecular docking of PTT onto gp120 argued that, with sufficient linker length, the peptide SH could approach and disrupt several alternative gp120 disulfides. Inhibition of lysis by gp120 mAb 2G12, which binds at the base of the V3 loop, as well as disulfide mutational effects, argued that PTT-induced disruption of the gp120 disulfide cluster at the base of the V3 loop is an important step in lytic inactivation of HIV-1. Further, PTT-induced lysis was enhanced after treating virus with reducing agents dithiothreitol and tris (2-carboxyethyl)phosphine. Overall, the results are consistent with the view that the binding of PTT positions the peptide SH group to interfere with conserved disulfides clustered proximal to the CD4 binding site in gp120, leading to disulfide exchange in gp120 and possibly gp41, rearrangement of the Env spike, and ultimately disruption of the viral membrane. The dependence of lysis activity on thiol-disulfide interaction may be related to intrinsic disulfide exchange susceptibility in gp120 that has been reported previously to play a role in HIV-1 cell infection. 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Eudragit RS100 (X(1)) and ethyl cellulose (X(2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in first hour (Y (1)) and the time required for 50% drug transport (Y(2)) were selected as dependent variables. Eutectic blend of camphor and menthol was used as permeation enhancer cum solvent for film-forming polymers. The pH, viscosity, volume of solution delivered upon each actuation, spray angle, ex-in vivo physical evaluation and in vitro drug transport of the formulated products were evaluated. The optimized batch B16 containing 5.25% w/w ethyl cellulose and 10.6% w/w Eudragit RS100 was formulated by overlapping the contour plots of Y(1) and Y(2). The pH, viscosity, volume of solution sprayed upon each actuation and spray angle of the batch B16 was 6.3, 52.9 cPs, 0.24 ml and 82.6 degrees respectively. The film of optimized batch was flexible and dermal-adhesive. The responses Y(1) and Y(2) of batch B16 were 7.91 microg/ml and 347 min respectively. The kinetics of drug transport was best explained by the Korsmeyer and Peppas model. The eutectic mixture consisting of equal parts of camphor and menthol showed improved drug permeation through shed snake skin. Short-term stability study demonstrated insignificant changes in performance characteristics.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8e1888d44ac47bf8bfe9e6d545f56","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19462250","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Jae-Joon Lee","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Yang-Il Choi","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Jung-Seok Choi","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Sang-Keun Jin","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Effects of Duroc Breeding Lines on Carcass Composition and Meat Quality.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"This study was performed to investigate the carcass composition and pork quality of Duroc breeding lines in Korea. A total of 200 Duroc pigs were used, and those were originated from four different great-grandparent (GGP) breeding stock farms (L1: N farm, L2: W farm, L3: S farm, L4: R farm). The carcasses of pigs from these farms were collected, and meat quality traits were evaluated. L1 and L2 had smaller carcass weights and thin backfat, whereas L3 and L4 had heavy carcass weights and thick backfat. L3 and L4 had higher contents of fat and protein than L1 and L2. For the meat quality characteristics, L1, L2, and L4 had higher pH values than L3. In addition, L4 had higher water holding capacity than the other lines. L4 had the highest sensory evaluation scores with regard to both juiciness and flavor. Consequently, the study results indicate that pork quality information from domestic Duroc breeding stock lines could be used to effectively improve pork quality in Korea. ","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8e2899e253c1728cdff3b3ad9f1cb","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26761803","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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TGF alpha-immunoreactivity was detected in 7 (25.9%) of the 27 early carcinomas and in 110 (74.8%) of the 147 advanced carcinomas, the incidence being significantly different between the two (P less than 0.01). Out of the 67 c-Ha-ras p21 positive carcinomas, 59 (88.1%) showed TGF alpha-immunoreactivity synchronously. A significant positive correlation was observed between the grade of TGF alpha and incidence of c-Ha-ras p21-immunoreactivity in tumor cells (P less than 0.01). Furthermore, a good correlation was demonstrated between synchronous expression of TGF alpha and c-Ha-ras p21 and depth of tumor invasion (P less than 0.01). The incidence of synchronous expression of TGF alpha and c-Ha-ras p21 in metastatic tumors was significantly higher than that in primary tumors showing no lymphatic metastasis (P less than 0.01). Patients with carcinomas showing synchronous expression of TGF alpha and c-Ha-ras p21 had an extremely poorer prognosis than those without TGF alpha and c-Ha-ras p21. These results indicate that the synchronous expression of TGF alpha and c-Ha-ras p21 plays an important role in high malignancy of gastric carcinomas.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8e8a991e53ebc993432cfbb4dac32","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"3065747","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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We report on the use of double-sided adhesive conductive carbon tape during whole adult rat tissue sectioning of carboxymethyl cellulose (CMC) embedded animals, with samples mounted onto large format conductive glass and conductive plastic MALDI targets, enabling MSI analysis to be performed on both TOF and FT-ICR MALDI mass spectrometers. We show that mounting does not unduly affect small molecule MSI detection by analyzing tiotropium abundance and distribution in rat lung tissues, with direct on-tissue quantitation achieved. Significantly, we use the adhesive tape to provide support to embedded delicate heat-stabilized tissues, enabling sectioning and mounting to be performed that maintained tissue integrity on samples that had previously been impossible to adequately prepare section for MSI analysis. 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Interleukin-17 was induced in all three subsets by PMA + ionomycin, but γδT lymphocytes exhibited the largest increase in expression. We then established a mouse model to further investigate the role of IL-17 in granulomatous and fibrosing inflammation against parasite eggs. Reducing IL-17 activity using anti-IL-17A antibodies decreased infiltration of inflammatory cells and collagen deposition in the livers of infected C57BL/6 mice. The serum levels of soluble egg antigen (IL)-specific IgGs were enhanced by anti-IL-17A monoclonal antibody blockade, suggesting that IL-17 normally serves to suppress this humoral response. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Xing-Chang Wei","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Amin Kherani","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bello-Espinosa, Luis E.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Allan Micheil Innes","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Myers, Kenneth A.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"TUBA1A Mutation Associated With Eye Abnormalities in Addition to Brain Malformation.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-10-18","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"We describe the case of a boy with a TUBA1A mutation presenting with microphthalmia and congenital cataracts in addition to microcephaly and severe brain malformation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8f052d9b9f43babde9d80cd5a52ec","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26294046","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Smiley, James R.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Barr, Stephen D.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bushman, Frederic D.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The interferon response inhibits HIV particle production by induction of TRIM22.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2008-02-29","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatment and identified TRIM22 as one of the most strongly up-regulated genes. We confirmed, as in previous studies, that TRIM22 over-expression inhibited HIV replication. To assess the role of TRIM22 expressed under natural inducing conditions, we compared the effects of interferon in cells depleted for TRIM22 using RNAi and found that HIV particle release was significantly increased in the knockdown, implying that TRIM22 acts as a natural antiviral effector. Further studies showed that TRIM22 inhibited budding of virus-like particles containing Gag only, indicating that Gag was the target of TRIM22. TRIM22 did not block the release of MLV or EIAV Gag particles. Inhibition was associated with diffuse cytoplasmic staining of HIV Gag rather than accumulation at the plasma membrane, suggesting TRIM22 disrupts proper trafficking. Mutational analyses of TRIM22 showed that the catalytic amino acids Cys15 and Cys18 of the RING domain are required for TRIM22 antiviral activity. These data disclose a pathway by which Type 1 interferons obstruct HIV replication.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8f44eb6a75adb4d336ffa26c667c9","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"18389079","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Rourke, D. M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Tan, W.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Abdulagatov, A. I.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Bertness, K. A.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Lee, Y. C.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Guo, D. J.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"George, S. M.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"GaN nanowire functionalized with atomic layer deposition techniques for enhanced immobilization of biomolecules.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-11-25","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"We report the use of atomic layer deposition (ALD) coating as a nanobiosensor functionalization strategy for enhanced surface immobilization that may enable higher detection sensitivity. Three kinds of ALD coating films, Al(2)O(3), TiO(2), and SiO(2), were grown on the gallium nitride nanowire (GaN NW) surfaces and characterized with high-resolution transmission electron microscopy (HRTEM) and vacuum Fourier transform infrared spectroscopy (FTIR). Results from HRTEM showed that the thicknesses of ALD-Al(2)O(3), ALD-TiO(2) and ALD-SiO(2) coatings were 4-5 nm, 5-6 nm, and 12-14 nm, respectively. Results from FTIR showed that the OH contents of these coatings were, respectively, ∼6.9, ∼7.4, and ∼9.3 times that of piranha-treated GaN NW. Furthermore, to compare protein attachments on the different surfaces, poly(ethylene glycol) (PEG)-biotin was grafted on the OH-functionalized GaN NW surfaces through active Si-Cl functional groups. Streptavidin protein molecules were then attached to the biotin ends via specific binding. The immobilized streptavidin molecules were examined with scanning electron microscopy, HRTEM, and fluorescent imaging. Results from HRTEM and energy-dispersive X-ray revealed that the nitrogen concentrations on the three ALD coatings were significantly higher than that on the piranha-treated surface. Results from fluorescent imaging further showed that the protein attachments on the Al(2)O(3), TiO(2), and SiO(2) ALD coatings were, respectively, 6.4, 7.8, and 9.8 times that of piranha-treated surface. This study demonstrates that ALD coating can be used as a functionalization strategy for nanobiosensors because it is capable of creating functional groups with much higher density compared to widely used acid modifications, and among the three ALD coatings, ALD-SiO(2) yielded the most promising results in OH content and protein attachment.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb8f581f0894d4d3cc4fd810cfc42ec","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"21033757","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Rafi, Mohammad A.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Wenger, David A.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Han Zhi Rao","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Paola Luzi","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Curtis, Mark T.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Extended normal life after AAVrh10-mediated gene therapy in the mouse model of Krabbe disease.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder caused by the deficiency of the lysosomal enzyme galactocerebrosidase (GALC). This deficiency results in accumulation of certain galactolipids including psychosine which is cytotoxic for myelin-producing cells. Treatment of human patients at this time is limited to hematopoietic stem cell transplantation (HSCT) that appears to slow the progression of the disease when performed in presymptomatic patients. In this study, adeno-associated virus (AAV) serotype rh10-(AAVrh10) expressing mouse GALC was used in treating twitcher (twi) mice, the mouse model of GLD. The combination of intracerebroventricular, intracerebellar, and intravenous (iv) injection of viral particles in neonate twi mice resulted in high GALC activity in brain and cerebellum and moderate to high GALC activity in spinal cord, sciatic nerve, and some peripheral organs. Successfully treated mice maintained their weight with no or very little twitching, living up to 8 months. The physical activities of the long-lived treated mice were comparable to wild type for most of their lives. 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This article summarizes current studies on the extent, role, and context of methamphetamine use among gay men and its relationship to high risk sexual behaviors related to HIV transmission. Methamphetamine is often used by gay men to initiate, enhance, and prolong sexual encounters. Use of the drug is, therefore, associated with particular environments where sexual contact among gay men is promoted, such as sex clubs and large \"circuit\" parties. Research with gay and bisexual men indicates that methamphetamine use is strongly associated with risky sexual behaviors that may transmit HIV. This relationship, coupled with emerging evidence that methamphetamine use is on the rise among gay men, suggests that the drug could exacerbate the HIV/AIDS epidemic among this community. The article offers recommendations for further research and suggestions for prevention programs regarding methamphetamine use by gay men.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb90702a5215bd4e5a3eebbe6c2f7c3","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"11482426","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018256057}
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Emulsified [U-13C]ALNA was administered orally with a mixed meal to six subjects consuming their habitual diet. Approximately 33 % of administered [13C]ALNA was recovered as 13CO2 on breath over the first 24 h. [13C]ALNA was mobilised from enterocytes primarily as chylomicron triacylglycerol (TAG), while [13C]ALNA incorporation into plasma phosphatidylcholine (PC) occurred later, probably by the liver. The time scale of conversion of [13C]ALNA to eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) suggested that the liver was the principal site of ALNA desaturation and elongation, although there was some indication of EPA and DPA synthesis by enterocytes. [13C]EPA and [13C]DPA concentrations were greater in plasma PC than TAG, and were present in the circulation for up to 7 and 14 d, respectively. There was no apparent 13C enrichment of docosahexaenoic acid (DHA) in plasma PC, TAG or non-esterified fatty acids at any time point measured up to 21 d. This pattern of 13C n-3 fatty acid labelling suggests inhibition or restriction of DHA synthesis downstream of DPA. [13C]ALNA, [13C]EPA and [13C]DPA were incorporated into erythrocyte PC, but not phosphatidylethanolamine, suggesting uptake of intact plasma PC molecules from lipoproteins into erythrocyte membranes. Since the capacity of adult males to convert ALNA to DHA was either very low or absent, uptake of pre-formed DHA from the diet may be critical for maintaining adequate membrane DHA concentrations in these individuals.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb908edeb5536a0f687992b0ee6a9b4","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"12323085","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018251565}
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The Ca(v)beta(1d) isoform encodes a putative protein composed of the amino-terminal half of the full-length Ca(v)beta(1) isoform and thus lacks the known high-affinity binding site that recognizes the Ca2+ channel alpha1-subunit, the alpha-binding pocket. The present study investigated whether the Ca(v)beta(1d) subunit is expressed at the protein level in heart, and whether it exhibits any of the functional properties typical of full-length Ca(v)beta subunits. On Western blots, an antibody directed against the unique carboxyl terminus of Ca(v)beta(1d) identified a protein of the predicted molecular mass of 23 kDa from canine and human hearts. Immunocytochemistry and surface-membrane biotinylation experiments in transfected HEK-293 cells revealed that the full-length Ca(v)beta(1b) subunit promoted membrane trafficking of the pore-forming alpha1C (Ca(v)1.2)-subunit to the surface membrane, whereas the Ca(v)beta(1d) subunit did not. Whole cell patch-clamp analysis of transfected HEK-293 cells demonstrated no effect of coexpression of the Ca(v)beta(1d) with the alpha1C-subunit compared with the 15-fold larger currents and leftward shift in voltage-dependent activation induced by full-length Ca(v)beta(1b) coexpression. In contrast, cell-attached patch single-channel studies demonstrated that coexpression of either Ca(v)beta(1b) or Ca(v)beta(1d) significantly increased mean open probability four- to fivefold relative to the alpha1C-channels alone, but only Ca(v)beta(1b) coexpression increased the number of channels observed per patch. In conclusion, the Ca(v)beta(1d) isoform is expressed in heart and can modulate the gating of L-type Ca2+ channels, but it does not promote membrane trafficking of the channel complex.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb90c26ee797f2a49e0ae8b7710877f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"15615847","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Both sequences contained three introns and four exons with identical coding sequences predicting 537 amino acids. Two of the three introns in these two clones were different both in sequence and in length. Sequences of both 4CL clones were found in all nine megagametophyte DNAs tested, providing genetic evidence that these two 4CL genomic sequences are nonallelic genes. Our analyses suggest that there are at least two distinct, intron-containing 4CL genes, at least one of which is transcribed into 4CL mRNA in developing xylem tissue of loblolly pine. The levels of 4CL gene transcription in xylem were influenced by compressional stress, resulting in an elevated 4CL enzyme activity with 4-coumaric acid. 4CL enzyme activity with ferulic acid remained unchanged, whereas with caffeic acid it was significantly inhibited. Exogenously applied trans-cinnamic acid in the protein extracts from normal wood xylem caused inhibition of 4CL activity toward caffeic acid similar to that under compressional stress. 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The concept of health promotion-the overall enhancement of well being--is contrasted with primary or disease prevention, the specific protection from a health threat. The conceptual parameters of health promotion were used to search the nursing research journals for studies of health promotion in the family. The four major nursing research journals were reviewed and yielded five articles in 105 issues which addressed this phenomenon. The findings from these studies as well as other research literature are used to develop future directives. The directives are presented for both the internal environment of the family and its external environment. Areas for study related to the internal environment include definitions of health and health promotion, descriptions of current health promotion behaviours and those practised over time, decision making, fathering, and methods of intervention. Research of the external environment includes the societal norms, societal interventions, and the effects of societal institutions. This discussion of health promotion in the family describes an agenda for nursing research which is necessary to support nursing practice with families if \u0027health for all\u0027 is to be reached by the year 2000.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb93131d986d0b1a68a8842dad17b80","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"3372877","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Available data are mostly based on ancillary findings of mortality data or obtained from studies evaluating frequency of neoplasms in AD patients independently if they occurred before or after AD. Moreover, some studies estimated frequencies of neoplasms in demented individuals, who were not necessarily AD patients. We estimated frequency of tumors preceding the onset of AD in AD patients and compared it to that of age- and gender-matched AD-free individuals. Occurrence of tumors preceding AD onset was assessed through a semi-structured questionnaire. Tumors were categorized as benign, malignant, or of uncertain classification and as endocrine-related or not. Odds ratios (OR), used as measure of the association between the two diseases, were adjusted for tumor categories and known risk factors for AD and tumors. We included 126 AD patients and 252 matched controls. Tumor frequency before AD onset was 18.2% among cases and 24.2% among controls. There was a suggestive trend of an overall inverse association between the two diseases (adjusted OR 0.6; 95% CI 0.4-1.1; p \u003d 0.11). Risk for neoplasms was significantly reduced only for women (adjusted OR, 0.5; 95% CI 0.3-0.9; p \u003d 0.03) and for endocrine related tumors (adjusted OR, 0.5; 95% CI 0.2-1; p \u003d 0.04). Our study confirms the inverse association reported in previous epidemiological studies. Though our findings might be explained by processes playing an opposite role in tumors development and neurodegeneration, they are also suggestive for a possible role of estrogen.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9380be2931d918d3140f9c75c39bd","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22531415","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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A household survey was conducted with 1950 young-adults randomly drawn from the city\u0027s general population. The validated 92-item Portuguese version of the Prodromal Questionnaire (PQ) was used for face-to-face interviews. Latent class analysis was conducted. Mean age was of 24 years; 51.1% of the sample was of women. Mean total score on the PQ was 22.06 (SD\u003d17.16). Considering a suggested cut-off of 14 in the positive subscale, 30.8% of individuals were above the threshold for ultra-high risk for psychosis detection. Latent class analysis resulted in a three classes clusterization. Class 1 (20%; n\u003d390) had the highest overall PQ scores (mean\u003d49.31,SD\u003d10.783), class 2 (43%; n\u003d835) had intermediate scores (mean\u003d23.37,SD\u003d6.56), and class 3 (37%; n\u003d721) had the lowest scores (mean\u003d5.81,SD\u003d3.74). Class 1 had significantly more individuals with less education and significantly more individuals with lower socioeconomic class. 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RACE PCR was carried out to obtain the full-length sequences of HLFPV-BR which is 6453 nucleotides and has more than 99.15 % of complete genomic RNA nucleotide sequence identity with that of HLFPV Japanese isolate. The genomic structure of HLFPV-BR is similar to other tobamoviruses. It includes a 5\u0027 untranslated region (UTR), followed by open reading frames encoding for a 128-kDa protein and a 188-kDa readthrough protein, a 38-kDa movement protein, 18-kDa coat protein, and a 3\u0027 UTR. Interestingly, the unique feature of poly(A) tract is also found within its 3\u0027-UTR. Furthermore, from the total RNA extracted from the local lesions of HLFPV-BR-infected Chenopodium quinoa leaves, a biologically active, full-length cDNA clone encompassing the genome of HLFPV-BR was amplified and placed adjacent to a T7 RNA polymerase promoter. The capped in vitro transcripts from the cloned cDNA were infectious when mechanically inoculated into C. quinoa and Nicotiana benthamiana plants. 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The capsule polysaccharide (CPS) of Mmm is one of the few identified virulence determinants. In a previous study, immunization of mice against CPS generated antibodies, but they were not able to prevent multiplication of Mmm in this model animal. However, mice cannot be considered as a suitable animal model, as Mmm does not induce pathology in this species. Our aim was to induce antibody responses to CPS in cattle, and challenge them when they had specific CPS antibody titres similar or higher than those from cattle vaccinated with the live vaccine. The CPS was linked to the carrier protein ovalbumin via a carbodiimide-mediated condensation with 1-ethyl-3(3-imethylaminopropyl) carbodiimide (EDC). Ten animals were immunized twice and challenged three weeks after the booster inoculation, and compared to a group of challenged non-immunized cattle. When administered subcutaneously to adult cattle, the vaccine elicited CPS-specific antibody responses with the same or a higher titre than animals vaccinated with the live vaccine. Pathology in the group of immunized animals was significantly reduced (57%) after challenge with Mmm strain Afadé compared to the non-immunized group, a figure in the range of the protection provided by the live vaccine. 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Dialysis patients with diabetes mellitus (DM) have more complications and shorter survival duration than non-DM dialysis patients, requiring more clinical attention and difficult management. The registry committee of the Korean Society of Nephrology has collected data about dialysis therapy in Korea through an on-line registry program and analyzed the characteristics of patients. A survey of dialysis patients in 2016 showed that 50.2% of new dialysis patients had DM nephropathy as the cause of end-stage renal disease. The proportion of patients receiving hemodialysis (HD) for more than 5 years was 38% in DM patients and 51% in non-DM patients. The mean pulse pressure in DM HD patients was 71.5 mmHg, compared with 62.6 mmHg in non-DM patients. The proportion of DM patients with native vessel arteriovenous fistula as vascular access for HD was lower than that of non-DM patients (73% vs. 78%). Mean serum creatinine of DM and non-DM dialysis patients was 8.4 mg/dL and 9.5 mg/dL respectively. As vascular access of the DM HD patients was poor, the dialysis adequacy of DM patients was slightly lower than that of non-DM patients. The 5-year survival rate for DM HD patients was 53.9%, which was much lower than that of chronic glomerulonephritis patients (78.2%). The proportion of patients with a full-time job was 17% for DM patients and 28% for non-DM patients.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb93fc796161c6c0cca3df9f9517b24","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"29629274","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Wu, J. H.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jia, Q.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The heterogeneous energy landscape expression of KWW relaxation.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Here we show a heterogeneous energy landscape approach to describing the Kohlrausch-Williams-Watts (KWW) relaxation function. For a homogeneous dynamic process, the distribution of free energy landscape is first proposed, revealing the significance of rugged fluctuations. In view of the heterogeneous relaxation given in two dynamic phases and the transmission coefficient in a rate process, we obtain a general characteristic relaxation time distribution equation for the KWW function in a closed, analytic form. Analyses of numerical computation show excellent accuracy, both in time and frequency domains, in the convergent performance of the heterogeneous energy landscape expression and shunning the catastrophic truncations reported in the previous work. The stretched exponential β, closely associated to temperature and apparent correlation with one dynamic phase, reveals a threshold value of 1/2 defining different behavior of the probability density functions. Our work may contribute, for example, to in-depth comprehension of the dynamic mechanism of glass transition, which cannot be provided by existing approaches. ","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb94062c2b4721a16d5bb801ccc9d4c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26879824","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Witt, M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jółkowska, J.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"[Molecular study of bone marrow chimerism and expression of EVI-1 gene as manifestations of minimal residual disease after bone marrow transplantation (BMT)].","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-11-16","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Leukaemias are the most frequent tumour diseases in children. Bone marrow transplantation (BMT) is the most effective therapy for many patients with leukaemia. Highly polymorphic microsatellite markers provide useful genetic markers for detection of complete or mixed chimerism in patients after (BMT). Chimerism can be monitored successfully using several polymerase chain reaction (PCR) techniques and cytogenetic analysis, especially fluorescent in situ hybridization (FISH). It is still unclear whether individuals with mixed chimerism after bone marrow transplantation have an increased risk of developing leukaemic relapse or graft rejection. EVI-1 gene was mapped in human chromosome 3q26. It encodes zinc finger, DNA binding protein detected only in the nucleus. The EVI-1 function is unknown. It is not expressed in normal human haematopoietic cells, but is expressed in leukaemias especially with 3q26 abnormalities. Expression of the EVI-1 may play a significant role in pathogenesis of human leukaemias. Molecular study of chimerism and expression of EVI-1 gene may be useful for monitoring residual disease after bone marrow transplantation.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb940c83462506ef7acd7afc6e1257f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10910646","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Louis, W. J.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Doyle, A. E.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Harrap, S. B.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Failure of psychosocial stress to induce chronic hypertension in the rat.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2013-11-21","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The effect of psychosocial stress produced by aggregation in a special cage designed by Henry was investigated in three separate experiments using Wistar-Kyoto (WKY), Sprague-Dawley (SD) and F1 hybrids of the Japanese spontaneously hypertensive and Wistar-Kyoto (SHR-WKY F1) rats. Each aggregated group displayed typical \u0027stressed\u0027 behavioural disturbances. Adrenal hypertrophy, elevation of plasma renin activity and gastric erosions were noted in male aggregated SD rats; while adrenal enlargement, elevation of plasma noradrenaline and gastric erosions were found in male aggregated SHR-WKY F1 rats. Sustained hypertension, however, did not develop in any strain nor in any subgroup within each strain. Gastric erosions were also noted in isolated SD and SHR-SKY F1 rats suggesting that long term isolation of rats also induces stress. Isolated rats also remained normotensive throughout. Reduced haematocrit was found in both aggregated and isolated male SHR-WKY F1 rats suggesting increased plasma volume. We conclude that neither stress due to psychosocial disturbances nor that due to isolation produces chronic hypertension in the three strains of rat studied.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb941c5f300e478faf33c0f7a2538df","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"6543222","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Yong Wang","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"[New materia medica project: synthetic biology based bioactive metabolites research in medicinal plant].","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-06","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"In the last decade, synthetic biology research has been gradually transited from monocellular parts or devices toward more complex multicellular systems. The emerging plant synthetic biology is regarded as the \"next chapter\" of synthetic biology. The complex and diverse plant metabolism as the entry point, plant synthetic biology research not only helps us understand how real life is working, but also facilitates us to learn how to design and construct more complex artificial life. Bioactive compounds innovation and large-scale production are expected to be breakthrough with the redesigned plant metabolism as well. In this review, we discuss the research progress in plant synthetic biology and propose the new materia medica project to lift the level of traditional Chinese herbal medicine research.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb94413c9f85362f70e33a295556ba7","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"28941345","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Tumor characterization can identify cancer-driving mutations as treatment targets. One of the most successful examples of cancer targeted therapy is inhibition of mutated epidermal growth factor receptor (EGFR), which occurs in ~10-30% of NSCLC patients. While this treatment has benefited many patients with activating EGFR mutations, almost all who initially benefited will eventually acquire resistance. Approximately 50% of cases of acquired resistance (AR) are due to a secondary T790M mutation in exon 20 of the EGFR gene; however, many of the remaining mechanisms of resistance are still unknown. Much work has been done to elucidate the remaining mechanisms of resistance. This review aims to highlight both the mechanisms of resistance that have already been identified in patients and potential novel mechanisms identified in preclinical models which have yet to be validated in the patient settings. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Ludwig Brand","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jianhua Xu","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Olga Tcherkasskaya","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Jiejin Chen","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Patrik Callis","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Jonathan King","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Dmitri Toptygin","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Knutson, Jay R.","name":"","surname":"","rank":8,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"eye diseases","qualifier":{"classid":"mesheuropmc","classname":"mesheuropmc","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":false,"inferenceprovenance":"iis::document_classes","provenanceaction":{"classid":"iis","classname":"iis","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}}}],"title":[{"value":"Femtosecond fluorescence spectra of tryptophan in human gamma-crystallin mutants: site-dependent ultrafast quenching.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The eye lens Crystallin proteins are subject to UV irradiation throughout life, and the photochemistry of damage proceeds through the excited state; thus, their tryptophan (Trp) fluorescence lifetimes are physiologically important properties. The time-resolved fluorescence spectra of single Trps in human gammaD- and gammaS-Crystallins have been measured with both an upconversion spectrophotofluorometer on the 300 fs to 100 ps time scale, and a time correlated single photon counting apparatus on the 100 ps to 10 ns time scale, respectively. Three Trps in each wild type protein were replaced by phenylalanine, leading to single-Trp mutants: W68-only and W156-only of HgammaD- and W72-only and W162-only of HgammaS-Crystallin. These proteins exhibit similar ultrafast signatures: positive definite decay associated spectra (DAS) for 50-65 ps decay constants that indicate dominance of fast, heterogeneous quenching. The quenched population (judged by amplitude) of this DAS differs among mutants. Trps 68, 156 in human gammaD- and Trp72 in human gammaS-Crystallin are buried, but water can reach amide oxygen and ring HE1 atoms through narrow channels. QM-MM simulations of quenching by electron transfer predict heterogeneous decay times from 50-500 ps that agree with our experimental results. Further analysis of apparent radiative lifetimes allow us to deduce that substantial subpopulations of Trp are fully quenched in even faster (sub-300 fs) processes for several of the mutants. The quenching of Trp fluorescence of human gammaD- and gammaS-Crystallin may protect them from ambient light induced photo damage.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb951a84c1a90eb2cfd9dc041519f63","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"19919143","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018233791}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Stattin, P.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Prognostic factors in prostate cancer.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-11-19","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"The clinical course of prostate cancer (PCa), the most common cancer in Swedish men, is highly variable and difficult to predict. Consequently, there is an urgent need to distinguish tumours with a high risk of progression from those with a low risk. To investigate the prognostic implications of proliferation and apoptosis, two important processes in tumor biology, immunoreactivity for biomarkers associated with these processes was assessed, quantified in indexes, and related to cause-specific survival (CSS). A consecutive series of 186 men presenting with voiding symptoms and PCa were treated with transurethral resection and deferred endocrine therapy. After 13-21 years follow-up, 43% of these men had died of prostate cancer. In a subgroup of men with localised disease at the time of diagnosis, 27% succumbed to the disease. Immunoreactivity for p53 protein, indicative of a defective p53 function, predicted shorter CSS in univariate (52 vs 123 months, p \u003c 0.0001), but not in multivariate analysis. Mean index for the apoptosis blocking bcl-2 protein was higher in foci of prostatic intraepithelial neoplasia, a putative precursor to PCa, than in manifest cancer areas (79 vs 12, p \u003c 0.0001). This indicates that bcl-2 may be involved in early tumourigenesis. No prognostic value was found for the bcl-2 index. A high index for the proliferation marker Ki-67 predicted shorter CSS in univariate (53 vs 132 months p \u003c 0.0001) and in multivariate analysis. To test if p53 is predictive for clinical radioresistance, as suggested by experimental models, p53 immunoreactivity was investigated in biopsies obtained before radical radiotherapy in an unrelated series of 60 PCa patients. Patients with p53 reactive tumours had longer CSS, indicating that p53 is not treatment-predictive for radiotherapy in Pca. Core biopsies were obtained before and a week after castration therapy in patients with advanced PCa. According to the serum prostate specific antigen (PSA) level 3 months after therapy, 15 responding tumours and 13 non-responding tumours were selected. Regressive morphology was seen in 14/15 responders after castration therapy, compared with 4/13 non-responders. Median apoptotic index increased significantly after castration therapy for responders (from 2.6 to 3.5, p \u003c 0.05) whereas it was 2.8 before and after therapy in non-responders. This indicates that subsequent clinical response can be predicted by the induction of regressive morphology and an increase in apoptotic index. In conclusion, immunoreactivity for Ki-67 appeared to be a putative prognostic factor in PCa, whereas the prognostic value of p53 and bcl-2 was dubious. p53 immunoreactivity did not appear to be predictive of radioresistance in PCa. Cellular response in biopsies shortly after castration therapy might be treatment-predictive.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb951fb4940adeb6a4f1eb5ace4625e","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9249905","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Claudia Del Turco","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Riccardo Sacconi","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Maurizio Battaglia Parodi","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Francesco Bandello","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Pierluigi Iacono","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"CHOROIDAL THICKNESS IN BEST VITELLIFORM MACULAR DYSTROPHY.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-03-26","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"To assess the changes in choroidal thickness in different stages of Best vitelliform macular dystrophy (VMD).","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb95489652bcac5f0441b18d7a0da4c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26447398","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Łukasz Szeleszczuk","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Monika Zielińska-Pisklak","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Iwona Wawer","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Dariusz Maciej Pisklak","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"¹³C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug formulations Part II: CP kinetics and relaxation analysis.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2016-12-30","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Excipients used in the solid drug formulations differ in their NMR relaxation and (13)C cross-polarization (CP) kinetics parameters. Therefore, experimental parameters like contact time of cross-polarization and repetition time have a major impact on the registered solid state NMR spectra and in consequence on the results of the NMR analysis. In this work the CP kinetics and relaxation of the most common pharmaceutical excipients: anhydrous α-lactose, α-lactose monohydrate, mannitol, sucrose, sorbitol, sodium starch glycolate type A and B, starch of different origin, microcrystalline cellulose, hypromellose, ethylcellulose, methylcellulose, hydroxyethylcellulose, sodium alginate, magnesium stearate, sodium laurilsulfate and Kollidon(®) were analyzed. The studied excipients differ significantly in their optimum repetition time (from 5 s to 1200 s) and T(1ρ)(I) parameters (from 2 ms to 73 ms). The practical use of those differences in the excipients composition analysis was demonstrated on the example of commercially available tablets containing indapamide as an API. The information presented in this article will help to choose the correct acquisition parameters and also will save the time and effort needed for their optimization in the NMR analysis of the solid drug formulations.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb95510315e62dc68a02f7f91288b0a","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"26836362","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Botana, L. M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Alonso, E.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Leirós, M.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Ebel, R.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Alfonso, A.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Rateb, M. E.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Jaspars, M.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Houssen, W. E.","name":"","surname":"","rank":8,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Bromoalkaloids protect primary cortical neurons from induced oxidative stress.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-11-16","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Bromoalkaloids are secondary metabolites with a demonstrated high activity in several therapeutic areas. In this research, we probe the neuroprotective and antioxidant activities of hymenialdisine and hymenin. Both structures were tested in an oxidative stress cellular model, consisting of cortical neurons that are incubated with the oxidative stress inducer hydrogen peroxide and the tested compound. Several oxidation biomarkers were analyzed, and the results of the oxidative stress induced neurons in the presence and absence of bromoalkaloids were compared. Both compounds demonstrated significant neuroprotective ability under stress conditions at low nanomolar concentrations, with hymenialdisine highlighted for demonstrating a more complete protection. Also, the activity of hymenialdisine and hymenin was studied in the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, and, for the first time, these halogenated metabolites are described as Nrf2 inducers, reinforcing the antioxidant capacity observed and therefore opening a new path of investigation. These results, added to the previously described effect of this compound family in negatively modulating several kinases and proinflammatory cytokines, position hymenialdisine and hymenin as good candidates for the development of new drugs for neurodegenerative diseases. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Xinshu Zhao","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Yu-Leung Ng","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"200199 Communication and Media Studies not elsewhere classified","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"title":[{"value":"online_supplemental_materials – Supplemental material for The Human Alarm System for Sensational News, Online News Headlines, and Associated Generic Digital Footprints: A Uses and Gratifications Approach","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-08-23","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Supplemental material, online_supplemental_materials for The Human Alarm System for Sensational News, Online News Headlines, and Associated Generic Digital Footprints: A Uses and Gratifications Approach by Yu-Leung Ng and Xinshu Zhao in Communication Research","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Figshare","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9589d468d0cb4ec2ac03cd1a29ce0","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.25384/sage.7000643.v1","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Hixson, James E.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jaquish, Cashell E.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Kelly, Tanika N.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Shimmin, Lawrence C.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Dongfeng Gu","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Gu, Charles C.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"De-Pei Liu","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Jiang He","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Maria Daniela Defagó","name":"","surname":"","rank":9,"pid":[],"affiliation":[]},{"fullname":"Rice, Treva K.","name":"","surname":"","rank":10,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Common genetic variants in the endothelial system predict blood pressure response to sodium intake: the GenSalt study.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"BACKGROUND We examined the association between 14 endothelial system genes and salt-sensitivity of blood pressure (BP). METHODS After a 3-day baseline examination, during which time the usual diet was consumed, 1,906 Chinese participants received a 7-day low-sodium diet (51.3 mmol of sodium/day) followed by a 7-day high-sodium diet (307.8 mmol of sodium/day). BP measurements were obtained at baseline and at the end of each intervention using a random-zero sphygmomanometer. RESULTS The DDAH1 rs11161637 variant was associated with reduced BP salt sensitivity, conferring attenuated systolic BP (SBP) and mean arterial pressure (MAP) decreases from baseline to the low-sodium intervention (both P \u003d 2×10(-4)). Examination of genotype-sex interactions revealed that this relation was driven by the strong associations observed in men (P for interactions \u003d 1.10×10(-4) and 0.008, respectively). When switching from the low- to high-sodium intervention, increases in diastolic BP (DBP) and MAP were attenuated by the COL18A1 rs2838944 minor A allele (P \u003d 1.41×10(-4) and 1.55×10(-4), respectively). Conversely, the VWF rs2239153 C variant was associated with increased salt sensitivity, conferring larger DBP and MAP reductions during low-sodium intervention (P \u003d 1.22×10(-4) and 4.44×10(-5), respectively). Ten variants from 3 independent SELE loci displayed significant genotype-sex interactions on DBP and MAP responses to low-sodium (P for interaction \u003d 1.56×10(-3) to 1.00×10(-4)). Among men, minor alleles of 4 correlated markers attenuated BP responses to low-sodium intake, whereas minor alleles of another 4 correlated markers increased BP responses. No associations were observed in women for these variants. Further, qualitative interactions were shown for 2 correlated SELE markers. CONCLUSIONS These data support a role for the endothelial system genes in salt sensitivity.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9591f56a8fe6390b03e5badff5e37","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23443727","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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PDI-V protein contains two conserved thioredoxin (TRX) active domains (a and a\u0027) and an inactive domain (b). PDI-V interacted with E3 ligase CMPG1-V protein, which is a positive regulator of powdery mildew response. PDI-V was mono-ubiquitinated by CMPG1-V without degradation being detected. PDI-V was located on H. villosa chromosome 5V and encoded for a protein located in the endoplasmic reticulum. Bgt infection in leaves of H. villosa induced PDI-V expression. Virus induced gene silencing of PDIs in a T. durum-H. villosa amphiploid compromised the resistance. Single cell transient over-expression of PDI-V or a truncated version containing the active TXR domain a decreased the haustorial index in moderately susceptible wheat cultivar Yangmai 158. Stable transgenic lines over-expressing PDI-V in Yangmai 158 displayed improved powdery mildew resistance at both the seedling and adult stages. By contrast over-expression of point-mutated PDI-V(C57A) did not increase the level of resistance in Yangmai 158. 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Finally, animal experiments further confirmed that TIKI2 restoration was able to inhibit the growth of osteosarcoma in vivo. Taken together, we provided evidence that reduced expression of TIKI family protein in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Zhang N.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Wang Mengcheng","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Xia Guangmin","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Xia G.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Ai X.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Dong Wei","name":"","surname":"","rank":6,"pid":[],"affiliation":[]},{"fullname":"Zhao Y.","name":"","surname":"","rank":7,"pid":[],"affiliation":[]},{"fullname":"Zhang Naibo","name":"","surname":"","rank":8,"pid":[],"affiliation":[]},{"fullname":"Xiao Langtao","name":"","surname":"","rank":9,"pid":[],"affiliation":[]},{"fullname":"Huang Zhigang","name":"","surname":"","rank":10,"pid":[],"affiliation":[]},{"fullname":"Ai Xinghui","name":"","surname":"","rank":11,"pid":[],"affiliation":[]},{"fullname":"Huang Z.","name":"","surname":"","rank":12,"pid":[],"affiliation":[]},{"fullname":"Xiao L.","name":"","surname":"","rank":13,"pid":[],"affiliation":[]},{"fullname":"Zhao Yang","name":"","surname":"","rank":14,"pid":[],"affiliation":[]},{"fullname":"Dong W.","name":"","surname":"","rank":15,"pid":[],"affiliation":[]},{"fullname":"Wang M.","name":"","surname":"","rank":16,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"food and beverages","qualifier":{"classid":"mesheuropmc","classname":"mesheuropmc","schemeid":"dnet:subject_classification_typologies","schemename":"dnet:subject_classification_typologies"},"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":false,"inferenceprovenance":"iis::document_classes","provenanceaction":{"classid":"iis","classname":"iis","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}}}],"title":[{"value":"A Wheat Allene Oxide Cyclase Gene Enhances Salinity Tolerance via Jasmonate Signaling","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[],"description":[{"value":"None: One of the two branches of the α-linolenic acid metabolism pathway is catalyzed by 12-oxo-phytodienoic acid reductase I, and the other is involved in jasmonic acid (JA) synthesis. The former is known to be active in the response to salinity tolerance in wheat (Triticum aestivum), but the participation of the latter in this response has not been established as yet. Here, the salinity-responsive bread wheat gene TaAOC1, which encodes an allene oxide cyclase involved in the α-linolenic acid metabolism pathway, was constitutively expressed in both bread wheat and Arabidopsis (Arabidopsis thaliana). In both species, transgenic lines exhibited an enhanced level of tolerance to salinity. The transgenic plants accumulated a higher content of JA and developed shorter roots. Both the shortened roots and the salinity tolerance were abolished in a background lacking a functional AtMYC2, a key component of the JA and abscisic acid signaling pathway, but were still expressed in a background deficient with respect to abscisic acid synthesis. We provide the first evidence, to our knowledge, suggesting that JA is also involved in the plant salinity response and that the α-linolenic acid metabolism pathway has a regulatory role over this response.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"American Society of Plant Biologists (ASPB)","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb96b40901502d2ab8e9fefbdd1ae66","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.1104/pp.113.227595","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},{"value":"24326670","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":1572018241546}
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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Stein, Jeffrey S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Johnson, Patrick S.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Smits, Rochelle R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Liston, Kennan J.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Madden, Gregory J.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Effects of reward bundling on male rats\u0027 preference for larger-later food rewards.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"In both humans and nonhumans, prior research demonstrates increased preference for larger-later over smaller-sooner rewards when rewards are bundled together in a series (i.e., when an operant choice produces multiple discrete reward deliveries, as opposed to only a single delivery). These findings can be predicted using a traditional hyperbolic delay-discounting model. The present study was designed to examine the parametric effects of the size of the reward bundle on larger-later reward preference in male rats. During a reward-bundling phase, rats were exposed to bundle-sizes of either 1 (i.e., no bundling), 3, or 9 rewards. Rats in the Bundle-size 9 group showed significantly greater larger-later reward preference across a range of delays (0-17.5 s) than rats in any other group, but no other significant differences in choice were observed between groups. In addition, when choice for unbundled rewards was assessed following the reward-bundling phase, rats in the Bundle-size 9 group showed a significant increase in larger-later reward preference (compared to a pre-test). Obtained data from the reward-bundling phase are compared to model-predicted data, and potential mechanisms of the observed increase in self-control for unbundled rewards are discussed.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb96fcf1fafac546bf439e149f1cb6c","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23319442","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Kostenko, S.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Potapov, V.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[{"value":"simulation modeling","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},{"value":"infrared frying","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},{"value":"temperature kinetics","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},{"value":"meat semi-finished product","qualifier":{"classid":"keyword","classname":"keyword","schemeid":"dnet:subject","schemename":"dnet:subject"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"title":[{"value":"Simulation Modeling Of Temperature Kinetics Of Infrared Frying Of Meat Semi-Finished Products","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-07-06","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"\u003cem\u003eInfrared frying of meat semi-finished products is a complex mass-exchange process, qualitative research and optimization of that are possible only through system-dynamic modeling, which is based on analytical connections of the system and physical experiment. The aim of the study was to create a simulation model for the temperature of meat semi-finished products during the infrared frying using the Vensim software package and determining the influence of the type of meat raw material and the power of the emitter of the apparatus on the temperature of inner layers of the product. In previous studies, the authors obtained an equation describing kinetics of temperature of the inner layers of the product, what became analytical basis of the simulation model. The heat receiver is a meat semi-finished product, normal cut of which is a semi-ellipse. To verify the results, real frying was carried out in the apparatus ARJM-0.07-1 that became physical basis of the simulation model. Using the software complex Vensim, a computer experiment was conducted: the temperature of inner layers of meat semi-finished from pork and beef was determined for their identical form and identical power of the emitter, as well as the temperature of inner layers of beef semi-finished products at different emitter power. Comparison of the obtained results of the simulation model of temperature kinetics and real frying proves the adequacy of the created model. Use of the simulation model allows optimize the process of foods products based on the selected reactions through a computer experiment with change and combination of criteria values, providing a quality product.\u003c/em\u003e \u003cem\u003eInfrared frying of meat semi-finished products is a complex mass-exchange process, qualitative research and optimization of that are possible only through system-dynamic modeling, which is based on analytical connections of the system and physical experiment. The aim of the study was to create a simulation model for the temperature of meat semi-finished products during the infrared frying using the Vensim software package and determining the influence of the type of meat raw material and the power of the emitter of the apparatus on the temperature of inner layers of the product. In previous studies, the authors obtained an equation describing kinetics of temperature of the inner layers of the product, what became analytical basis of the simulation model. The heat receiver is a meat semi-finished product, normal cut of which is a semi-ellipse. To verify the results, real frying was carried out in the apparatus ARJM-0.07-1 that became physical basis of the simulation model. Using the software complex Vensim, a computer experiment was conducted: the temperature of inner layers of meat semi-finished from pork and beef was determined for their identical form and identical power of the emitter, as well as the temperature of inner layers of beef semi-finished products at different emitter power. Comparison of the obtained results of the simulation model of temperature kinetics and real frying proves the adequacy of the created model. Use of the simulation model allows optimize the process of foods products based on the selected reactions through a computer experiment with change and combination of criteria values, providing a quality product.\u003c/em\u003e","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"Zenodo","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9706764c48923be02b830bde60d71","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"10.5281/zenodo.1306615","qualifier":{"classid":"doi","classname":"doi","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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They also sense gradients of attractants extending over five orders of magnitude in concentration (up to 1 mM aspartate). Here we consider the possibility that this combination of sensitivity and range of response depends on the clustering of chemotactic receptors on the surface of the bacterium. We examine what will happen if ligand binding changes the activity of a receptor, propagating this change in activity to neighbouring receptors in a cluster. Calculations based on these assumptions show that sensitivity to extracellular ligands increases with the extent of spread of activity through an array of receptors, but that the range of concentrations over which the array works is severely diminished. However, a combination of low threshold of response and wide dynamic range can be attained if the cell has both clusters and single receptors on its surface, particularly if the extent of activity spread can adapt to external conditions. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Mallory, Grant W.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Clarke, Michelle J.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Halasz, Sasha R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Advances in the treatment of cervical rheumatoid: Less surgery and less morbidity.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Rheumatoid arthritis is a chronic systemic inflammatory disease that often affects the cervical spine. While it was initially thought that cervical involvement was innocuous, natural history studies have substantiated the progressive nature of untreated disease. Over the past 50 years, there has been further elucidation in the pathophysiology of the disease, as well as significant advancements in medical and surgical therapy. The introduction of disease modifying drugs and biologic agents has reduced the amount of patients with advanced stages of the disease needing surgery. Advancement in instrumentation techniques has improved patient outcomes and fusion rates. The introduction of endoscopic approaches for ventral decompression may further lower surgical morbidity. In this review, we give a brief overview of the pertinent positives of the disease. A discussion of historical techniques and the evolution of surgical therapy into the modern era is provided. With improved medical therapies and less invasive approaches, we will likely continue to see less advanced cases of disease and less surgical morbidity. Nonetheless, a thorough understanding of the disease is crucial, as its systemic involvement and need for continued medical therapy have tremendous impact on overall complications and outcomes even in patients being seen for standard degenerative disease with comorbid rheumatoid. 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Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases; epidemictyphus, trench fever, and relapsing fever. In order to gain insights into the molecular bases for these differences, we analyzed alternative splicing (AS) using next-generation sequencing data for one strain of head lice and one strain of body lice. We identified a total of 3,598 AS events which were head or body lice specific. Exon skipping AS events were overrepresented among both head and body lice, whereas intron retention events were underrepresented in both. However, both the enrichment of exon skipping and the underrepresentation of intron retention are significantly stronger in body lice compared with head lice. Genes containing body louse-specific AS events were found to be significantly enriched for functions associated with development of the nervous system, salivary gland, trachea, and ovarian follicle cells, as well as regulation of transcription. In contrast, no functional categories were overrepresented among genes with head louse-specific AS events. Together, our results constitute the first evidence for transcript pool differences in head and body lice, providing insights into molecular adaptations that enabled human lice to adapt to clothing, and representing a powerful illustration of the pivotal role AS can play in functional adaptation. 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M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Randall, Matthew J.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Bouwman, Freek G.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Albert van der Vliet","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Aalt Bast","name":"","surname":"","rank":5,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Chronic obstructive pulmonary disease (COPD) is the leading cause of cigarette smoke-related death worldwide. Acrolein, a crucial reactive electrophile found in cigarette smoke mimics many of the toxic effects of cigarette smoke-exposure in the lung. In macrophages, cigarette smoke is known to hinder histone deacetylases (HDACs), glucocorticoid-regulated enzymes that play an important role in the pathogenesis of glucocorticoid resistant inflammation, a common feature of COPD. Thus, we hypothesize that acrolein plays a role in COPD-associated glucocorticoid resistance. To examine the role of acrolein on glucocorticoid resistance, U937 monocytes, differentiated with PMA to macrophage-like cells were treated with acrolein for 0.5h followed by stimulation with hydrocortisone for 8h, or treated simultaneously with LPS and hydrocortisone for 8h without acrolein. GSH and nuclear HDAC activity were measured, or gene expression was analyzed by qPCR. Acrolein-mediated TNFα gene expression was not suppressed by hydrocortisone whereas LPS-induced TNFα expression was suppressed. Acrolein also significantly inhibited nuclear HDAC activity in macrophage-like cells. Incubation of recombinant HDAC2 with acrolein led to the formation of an HDAC2-acrolein adduct identified by mass spectrometry. Therefore, these results suggest that acrolein-induced inflammatory gene expression is resistant to suppression by the endogenous glucocorticoid, hydrocortisone. 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After each walk, dogs were examined and the number and species of ticks present were recorded. The dogs were then returned to outdoor kennels to allow the infestations and subsequent transmission of any pathogens to proceed. Serum samples and whole blood were collected from each dog twice weekly for 121 days and evaluated via indirect fluorescence antibody (IFA) for antibodies reactive to Rickettsia rickettsii, R. montanensis, and \"R. amblyommii,\" and by PCR for evidence of Rickettsia spp. Dogs became infested with a total of 57-108 ticks over the entire 8-week infestation period (weekly average tick infestation\u003d12.0±4.1). The great majority of the ticks present were Amblyomma americanum (90.5%), with a small number of Dermacentor variabilis and A. maculatum also identified. All (10/10) dogs seroconverted to R. rickettsii, R. montanensis, and \"R. amblyommii,\" with mean maximum inverse titers of 1176, 1448, and 6654, respectively, for all dogs in the study. Maximum inverse titers to \"R. amblyommii\" ranged from 4096 to 16,384 and were higher in 9/10 dogs than maximum inverse titers to R. rickettsii or R. montanensis. Sequence-confirmed SFG Rickettsia spp. (R. montanensis and \"R. amblyommii\") were occasionally, but not consistently, identified from whole blood by PCR. Taken together, our data suggest that, in areas where A. americanum is common, antibodies reactive to R. rickettsii in dogs may be due instead to infection with \"R. amblyommii\" or other, closely related SFG Rickettsia spp.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb97975bcb63f66c22f4d993382a2d8","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"24359419","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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Subjects showed significant increases in strength, measured isometrically (p \u003c .01) and isokinetically (p \u003c .01 at four of five speeds). They also demonstrated improved endurance and rated their functional ability higher. 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We analyzed patients with AA (N \u003d 93) and hypocellular MDS (hMDS, N \u003d 24) using single nucleotide polymorphism arrays (SNP-A) complementing routine cytogenetics. We hypothesized that clinically important cryptic clonal aberrations may exist in some patients with BM failure. Combined metaphase and SNP-A karyotyping improved detection of chromosomal lesions: 19% and 54% of AA and hMDS cases harbored clonal abnormalities including copy-neutral loss of heterozygosity (UPD, 7%). Remarkably, lesions involving the HLA locus suggestive of clonal immune escape were found in 3 of 93 patients with AA. In hMDS, additional clonal lesions were detected in 5 (36%) of 14 patients with normal/noninformative routine cytogenetics. In a subset of AA patients studied at presentation, persistent chromosomal genomic lesions were found in 10 of 33, suggesting that the initial diagnosis may have been hMDS. Similarly, using SNP-A, earlier clonal evolution was found in 4 of 7 AA patients followed serially. 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First, whole brain voxel-based analysis revealed several clusters in the frontal projections of the corpus callosum, where higher FA was associated with worse inhibitory performance, as well as several clusters in posterior brain regions and one in the brainstem where higher FA was associated with better cognitive flexibility (in the Switching task), suggesting a dichotomous relationship between FA and these two aspects of cognitive control. Tractography through these clusters identified several white matter tracts, which were then manual traced in native space. Pearson\u0027s correlations confirmed associations between higher FA of frontal projections of the corpus callosum with poorer inhibitory performance (independent of age), though associations with Switching were not significant. Post-hoc evaluation suggested that FA of orbital and anterior frontal projections of the corpus callosum also mediated performance differences across conditions, which may reflect differences in self-monitoring or strategy use. These findings suggest a link between the development of inhibition and cognitive control with that of the underlying white matter, and may help to identify deviations of neurobiology in adolescent psychopathology. 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Fibrillar and nonfibrillar collagens are major constituents of the ECM that modulate cell shape and proliferative responses and thereby contribute to the pathogenesis of intimal hyperplasia. Halofuginone, an anticoccidial quinoazolinone derivative, inhibits collagen type I gene expression. We investigated the effect of halofuginone on (1) proliferation of bovine aortic endothelial cells and SMCs derived from the same specimen and maintained in vitro, (2) ECM deposition and collagen type I synthesis and gene expression, and (3) injury-induced intimal hyperplasia in vivo. DNA synthesis and proliferation of vascular SMCs in response to serum or basic fibroblast growth factor were abrogated in the presence of as little as 0.1 microgram/mL halofuginone; this inhibition was reversible upon removal of the compound. Under the same conditions, halofuginone exerted a relatively small antiproliferative effect on the respective vascular endothelial cells. Halofuginone also inhibited the synthesis and deposition of ECM components by vascular SMCs as indicated both by a substantial reduction in the amount of sulfated proteoglycans and collagen type I synthesis and gene expression. Local administration of halofuginone in the rabbit ear model of crush injury-induced arterial intimal hyperplasia resulted in a 50% reduction in intimal thickening as measured by a morphometric analysis of the neointima/media ratio. The differential inhibitory effect of halofuginone on vascular SMCs versus endothelial cells, its inhibition of ECM deposition and collagen type I synthesis, and its ability to attenuate injury-induced intimal hyperplasia may place halofuginone alone or in combination with other antiproliferative compounds as a potential candidate for prevention of arterial stenosis and accelerated atherosclerosis.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9b0d7202c133bf643883146d0aaed","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"9012656","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The cytotoxic T-lymphocyte antigen-4 gene (CTLA-4) is an important candidate gene for influencing the development of OS. This study aimed to investigate the potential association of CTLA-4 genetic polymorphisms with OS risk in Chinese Han population. A total of 415 OS patients and 431 healthy controls were enrolled in this study. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were used to detect the genotyping of CTLA-4 c.75G[C and c.326G[A genetic polymorphisms. We observed that the genotypes/alleles of c.75G[C and c.326G[A genetic polymorphisms were statistically associated with the increased risk of OS (for c.75G[C, CC versus (vs.) GG: OR 1.72, 95% CI 1.09–2.74; C vs. G: OR 1.30, 95% CI 1.06–1.60; for c.326G[A, AA vs. GG: OR 2.12, 95% CI 1.31–3.42; A vs. G: OR 1.31, 95% CI 1.07–1.61). The allele-C/genotype-CC of c.75G[C and allele-A/genotype-AA of c.326G[A may contribute to OS susceptibility. These data indicate that CTLA-4 genetic polymorphisms are potentially related to OS risk in Chinese Han population, and might be used as molecular markers for evaluating the risk of OS.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9c0a65a5555018c97a9dec1b7b3f1","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"24078408","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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The diagnosis and treatment are reported with the clinical course so far. A 20-year-old man underwent surgical resection of a tumor on the left side of the chest in 1990, and a diagnosis of Askin tumor was made. In 1993, the disease recurred in the left axilla and was surgically resected. The surgical specimen was investigated histologically, and a diagnosis of MPNST was made instead of Askin tumor. Recently, a tumor began to grow in the left pleural cavity and was surgical resected. The tumor tissue contained both cells with oval and long spindle nuclei, which were intermingled with each other. Immunohistochemically, the tumor cells were positive for vimentin and some of them were positive for S100 protein. Because electron microscopy showed cytoplasmic processes on the tumor cell and basal lamina-like structures, a diagnosis of recurrent MPNST was made. Because this lesion resembled Askin tumor in its clinical manifestations and histological characteristics, differential diagnosis from Askin tumor was necessary. When a malignant soft tissue tumor arising from the mediastinum or chest walls is detected, immunohistochemical and electron microscopic studies should be performed. 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{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Motoshi Ichikawa","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Takashi Kobayashi","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Mineo Kurokawa","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Yasuhiko Kamikubo","name":"","surname":"","rank":4,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Acute myeloid leukemia with cryptic CBFB-MYH11 type D.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2012-11-20","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"A 77 year-old female was found with FAB M4Eo acute myeloid leukemia. Although CBFB-MYH11 mRNA was detected in RT-PCR, the conventional cytogenetic analysis failed to reveal inv(16). Fluorescence in situ hybridization (FISH) and the sequence analysis revealed a fusion between the exon 5 of CBFB and the exon 8 of MYH11, resulting in a minor variant fusion product previously reported as type D. In order to detect the cryptic inv(16) type D, both FISH and RT-PCR are required, and furthermore, the primers for the sequence analysis needs to be selected for the proper diagnosis.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9c61e4886ab4d8cae0cf375b201c7","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"23236551","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Ning Yan","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Rittmann, Bruce E.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Hua Xu","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Yongming Zhang","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Qi Bai","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Lihui Yang","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Intimately coupling of photolysis accelerates nitrobenzene biodegradation, but sequential coupling slows biodegradation.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2015-04-03","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Photo(cata)lysis coupled with biodegradation is superior to photo(cata)lysis or biodegradation alone for removal of recalcitrant organic compounds. The two steps can be carried out sequentially or simultaneously via intimate coupling. We studied nitrobenzene (NB) removal and mineralization to evaluate why intimate coupling of photolysis with biodegradation was superior to sequential coupling. Employing an internal circulation baffled biofilm reactor, we compared direct biodegradation (B), biodegradation after photolysis (P+B), simultaneous photolysis and biodegradation (P\u0026B), and biodegradation with nitrophenol (NP) and oxalic acid (OA) added individually and simultaneously (B+NP, B+OA, and B+NP+OA); NP and OA were NB\u0027s main UV-photolysis products. Compared with B, the biodegradation rate P+B was lower by 13-29%, but intimately coupling (P\u0026B) had a removal rate that was 10-13% higher; mineralization showed similar trends. B+OA gave results similar to P\u0026B, B+NP gave results similar to P+B, and B+OA+NP gave results between P+B and P\u0026B, depending on the amount of OA and NP added. The photolysis product OA accelerated NB biodegradation through a co-substrate effect, but NP was inhibitory. Although decreasing the UV photolysis time could minimize the inhibition impact of NP in P+B, P\u0026B gave the fastest removal of NB by accentuating the co-substrate effect of OA.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9c82164177af8c332713e6f40062f","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"25661172","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Teiji Sota","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Motoyoshi Mogi","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Origin of pitcher plant mosquitoes in Aedes (Stegomyia): a molecular phylogenetic analysis using mitochondrial and nuclear gene sequences.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2017-11-16","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Two mosquito species of the subgenus Stegomyia (genus Aedes) (Diptera: Culicidae) on the islands of Palau and Yap (Aedes dybasi Bohart and Aedes maehleri Bohart) are adapted to aquatic habitats occupied by Nepenthes pitcher plants. To reveal the origin of these pitcher plant mosquitoes, we attempted a molecular phylogenetic analysis with 11 Stegomyia species by using sequence data from mitochondrial cytochrome oxidase subunit I and 16SrRNA genes as well as the nuclear 28SrRNA gene. Ae. dybasi, a pitcher plant specialist, was sister to Aedes palauensis Bohart within the scutellaris group from the same islands. Ae. maehleri, an opportunistic pitcher plant mosquito, was in a distinct lineage related to the scutellaris group. The adaptation to pitcher plants could have occurred independently in these two species, and recent differentiation of the pitcher plant mosquito Ae. dybasi from the nonpitcher plant mosquito Ae. palauensis was suggested by a relatively small sequence divergence between these species. We also discuss the implications of this analysis for the phylogeny of some other Stegomyia species.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9c99b59cfba4e5e8d05d08f287145","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17017211","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Jackson, Richard J.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Marottoli, Richard A.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]},{"fullname":"Prohaska, Thomas R.","name":"","surname":"","rank":3,"pid":[],"affiliation":[]},{"fullname":"Phelan, Elizabeth A.","name":"","surname":"","rank":4,"pid":[],"affiliation":[]},{"fullname":"Satariano, William A.","name":"","surname":"","rank":5,"pid":[],"affiliation":[]},{"fullname":"Guralnik, Jack M.","name":"","surname":"","rank":6,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Mobility and aging: new directions for public health action.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Optimal mobility, defined as relative ease and freedom of movement in all of its forms, is central to healthy aging. Mobility is a significant consideration for research, practice, and policy in aging and public health. We examined the public health burdens of mobility disability, with a particular focus on leading public health interventions to enhance walking and driving, and the challenges and opportunities for public health action. We propose an integrated mobility agenda, which draws on the lived experience of older adults. New strategies for research, practice, and policy are needed to move beyond categorical promotion programs in walking and driving to establish a comprehensive program to enhance safe mobility in all its forms.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9cab4666d02137456110b41bcda30","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"22698013","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
{"journal":{"name":"","issnPrinted":"","issnOnline":"","issnLinking":"","ep":"","iss":"","sp":"","vol":"","edition":"","conferenceplace":"","conferencedate":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"author":[{"fullname":"Brown, Molly M.","name":"","surname":"","rank":1,"pid":[],"affiliation":[]},{"fullname":"Jason, Leonard A.","name":"","surname":"","rank":2,"pid":[],"affiliation":[]}],"resulttype":{"classid":"publication","classname":"publication","schemeid":"dnet:result_typologies","schemename":"dnet:result_typologies"},"language":{"classid":"und","classname":"Undetermined","schemeid":"dent:languages","schemename":"dent:languages"},"country":[],"subject":[],"title":[{"value":"Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia.","qualifier":{"classid":"main title","classname":"main title","schemeid":"dnet:dataCite_title","schemename":"dnet:dataCite_title"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"relevantdate":[{"value":"2018-11-13","qualifier":{"classid":"dnet:date","classname":"dnet:date","schemeid":"dnet:date","schemename":"dnet:date"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"description":[{"value":"Chronic fatigue syndrome (CFS), multiple chemical sensitivity (MCS), and fibromyalgia (FM) commonly co-occur. Some propose that CFS, MCS, and FM are manifestations of the same illness based on high rates of co-occurrence and overlapping diagnostic criteria. This study seeks to differentiate these diagnoses by comparing individuals with one or more illness on functioning, psychiatric comorbidity, coping style, and in vivo physical measures.","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"dateofacceptance":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"publisher":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"embargoenddate":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"source":[],"fulltext":[],"format":[],"contributor":[],"resourcetype":{"classid":"","classname":"","schemeid":"","schemename":""},"coverage":[],"refereed":{"value":"","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}},"context":[],"id":"50|scholexplore::ceb9ccc3ab67f8a9aa4a2f14692bc0be","originalId":[],"collectedfrom":[{"key":"10|openaire____::e034d6a11054f5ade9221ebac484e864","value":"scholExplorer","dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"pid":[{"value":"17540028","qualifier":{"classid":"pmid","classname":"pmid","schemeid":"dnet:pid_types","schemename":"dnet:pid_types"},"dataInfo":{"invisible":false,"inferred":false,"deletedbyinference":false,"inferenceprovenance":"","provenanceaction":{"classid":"","classname":"","schemeid":"","schemename":""}}}],"extraInfo":[],"dataInfo":{"invisible":false,"inferred":true,"deletedbyinference":true,"inferenceprovenance":"dedup-similarity-result-levenstein","provenanceaction":{"classid":"sysimport:actionset","classname":"sysimport:actionset","schemeid":"dnet:provenanceActions","schemename":"dnet:provenanceActions"}},"lastupdatetimestamp":0}
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